KR101324863B1 - 헤테로고리 화합물의 합성 방법 - Google Patents

헤테로고리 화합물의 합성 방법 Download PDF

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Publication number
KR101324863B1
KR101324863B1 KR1020077029274A KR20077029274A KR101324863B1 KR 101324863 B1 KR101324863 B1 KR 101324863B1 KR 1020077029274 A KR1020077029274 A KR 1020077029274A KR 20077029274 A KR20077029274 A KR 20077029274A KR 101324863 B1 KR101324863 B1 KR 101324863B1
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South Korea
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compound
formula
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solvent
vih
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Expired - Fee Related
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KR1020077029274A
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English (en)
Korean (ko)
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KR20080026106A (ko
Inventor
가브리엘 칼빈
에릭 하우드
데이비드 리크만
슈구앙 주
Original Assignee
노파르티스 아게
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Publication of KR101324863B1 publication Critical patent/KR101324863B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020077029274A 2005-05-17 2006-05-17 헤테로고리 화합물의 합성 방법 Expired - Fee Related KR101324863B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68189305P 2005-05-17 2005-05-17
US60/681,893 2005-05-17
PCT/US2006/019349 WO2006125130A1 (en) 2005-05-17 2006-05-17 Methods for synthesizing heterocyclic compounds

Publications (2)

Publication Number Publication Date
KR20080026106A KR20080026106A (ko) 2008-03-24
KR101324863B1 true KR101324863B1 (ko) 2013-11-01

Family

ID=37431595

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077029274A Expired - Fee Related KR101324863B1 (ko) 2005-05-17 2006-05-17 헤테로고리 화합물의 합성 방법

Country Status (15)

Country Link
US (1) US8222413B2 (https=)
EP (2) EP1888556B1 (https=)
JP (2) JP5545925B2 (https=)
KR (1) KR101324863B1 (https=)
CN (1) CN101223157B (https=)
AT (1) ATE530533T1 (https=)
AU (1) AU2006247062A1 (https=)
BR (1) BRPI0610355A2 (https=)
CA (1) CA2608087C (https=)
ES (1) ES2376347T3 (https=)
MX (1) MX2007014381A (https=)
PL (1) PL1888556T3 (https=)
PT (1) PT1888556E (https=)
RU (1) RU2437878C2 (https=)
WO (1) WO2006125130A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190143156A (ko) 2018-06-20 2019-12-30 강원대학교산학협력단 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
KR20200012586A (ko) 2018-07-27 2020-02-05 강원대학교산학협력단 Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5545925B2 (ja) * 2005-05-17 2014-07-09 ノバルティス アーゲー ヘテロ環化合物の合成方法
JP5541454B2 (ja) * 2009-09-16 2014-07-09 Ｊｓｒ株式会社 液晶配向剤および液晶表示素子

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WO2004018419A2 (en) * 2002-08-23 2004-03-04 Chiron Corporation Benzimidazole quinolinones and uses thereof
WO2004063170A1 (en) * 2003-01-09 2004-07-29 University Of Delhi A process for the synthesis of bisbenzimidazoles and its derivations

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Publication number Priority date Publication date Assignee Title
US20020165218A1 (en) * 2000-09-01 2002-11-07 James Halbrook Materials and methods to potentiate cancer treatment
WO2004018419A2 (en) * 2002-08-23 2004-03-04 Chiron Corporation Benzimidazole quinolinones and uses thereof
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190143156A (ko) 2018-06-20 2019-12-30 강원대학교산학협력단 4-[[4-[3-(사이클로프로필메톡시)-4-(디플루오로메톡시)페닐]-2-티아졸릴]아미노]페놀 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
KR20200012586A (ko) 2018-07-27 2020-02-05 강원대학교산학협력단 Ｇｅｂｒ―７ｂ 화합물을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
BRPI0610355A2 (pt) 2010-06-15
EP2465857B1 (en) 2014-06-04
JP2014012682A (ja) 2014-01-23
EP1888556A4 (en) 2009-12-02
MX2007014381A (es) 2008-02-06
JP2008540675A (ja) 2008-11-20
EP1888556B1 (en) 2011-10-26
CN101223157A (zh) 2008-07-16
ATE530533T1 (de) 2011-11-15
EP2465857A1 (en) 2012-06-20
KR20080026106A (ko) 2008-03-24
WO2006125130A1 (en) 2006-11-23
EP1888556A1 (en) 2008-02-20
RU2007146394A (ru) 2009-06-27
PL1888556T3 (pl) 2012-03-30
US8222413B2 (en) 2012-07-17
AU2006247062A1 (en) 2006-11-23
PT1888556E (pt) 2012-02-03
CA2608087A1 (en) 2006-11-23
JP5545925B2 (ja) 2014-07-09
US20110046376A1 (en) 2011-02-24
ES2376347T3 (es) 2012-03-13
CA2608087C (en) 2013-12-10
CN101223157B (zh) 2013-03-06
RU2437878C2 (ru) 2011-12-27

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