ATE520685T1 - Verbessertes verfahren zur herstellung von moxonidin - Google Patents
Verbessertes verfahren zur herstellung von moxonidinInfo
- Publication number
- ATE520685T1 ATE520685T1 AT08012788T AT08012788T ATE520685T1 AT E520685 T1 ATE520685 T1 AT E520685T1 AT 08012788 T AT08012788 T AT 08012788T AT 08012788 T AT08012788 T AT 08012788T AT E520685 T1 ATE520685 T1 AT E520685T1
- Authority
- AT
- Austria
- Prior art keywords
- sodium methoxide
- moxonidine
- dmaia
- solvent
- reaction
- Prior art date
Links
- WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229960003938 moxonidine Drugs 0.000 title abstract 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06013133A EP1873151B1 (de) | 2006-06-26 | 2006-06-26 | Verbessertes Verfahren zur Herstellung von Moxonidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520685T1 true ATE520685T1 (de) | 2011-09-15 |
Family
ID=37441287
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08012788T ATE520685T1 (de) | 2006-06-26 | 2006-06-26 | Verbessertes verfahren zur herstellung von moxonidin |
| AT06013133T ATE407931T1 (de) | 2006-06-26 | 2006-06-26 | Verbessertes verfahren zur herstellung von moxonidine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06013133T ATE407931T1 (de) | 2006-06-26 | 2006-06-26 | Verbessertes verfahren zur herstellung von moxonidine |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1873151B1 (de) |
| AT (2) | ATE520685T1 (de) |
| DE (1) | DE602006002738D1 (de) |
| ES (1) | ES2369113T3 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2586779A1 (de) | 2011-10-24 | 2013-05-01 | Hetero Research Foundation | Verfahren zur Herstellung von Moxonidine |
| DE102012215896A1 (de) * | 2012-09-07 | 2014-03-13 | Wörwag Pharma GmbH & Co.KG | Moxonidinsynthese mit Hilfe organischer Basen |
| EP2738165B1 (de) | 2012-12-03 | 2016-10-12 | WÖRWAG PHARMA GmbH & Co. KG | Verfahren mittels Phasentransferkatalyse |
| EP2765131B1 (de) | 2013-02-08 | 2016-11-23 | Arevipharma GmbH | Verfahren zur Herstellung von Moxonidin |
| CN105121431A (zh) * | 2013-03-14 | 2015-12-02 | 法尔马克有限公司 | 用于制造莫索尼定的改进方法 |
| EP2829540A1 (de) * | 2013-07-26 | 2015-01-28 | Abbott Healthcare Products B.V. | Synthese von substituierten Aminopyridinen |
| CN112608272A (zh) * | 2020-12-25 | 2021-04-06 | 山东埃森化学有限公司 | 一种氯氨吡啶酸钾盐原料药的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323570A (en) * | 1978-11-15 | 1982-04-06 | Beiersdorf Aktiengesellschaft | Substituted aminopyrimidines |
| DE2937023A1 (de) * | 1979-09-13 | 1981-04-02 | Beiersdorf Ag, 2000 Hamburg | Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung |
| DE2849537C2 (de) * | 1978-11-15 | 1983-03-17 | Beiersdorf Ag, 2000 Hamburg | Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE10249946B4 (de) * | 2002-10-26 | 2005-06-23 | Degussa Ag | Verfahren zur Herstellung von 2-Amino-4-chlor-6-alkoxypyrimidinen |
| CZ294649B6 (cs) | 2004-02-10 | 2005-02-16 | Farmak, A. S. | Způsob přípravy 4-chlor-N-(4,5-dihydro-1-H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinaminu |
-
2006
- 2006-06-26 EP EP06013133A patent/EP1873151B1/de not_active Revoked
- 2006-06-26 DE DE602006002738T patent/DE602006002738D1/de active Active
- 2006-06-26 EP EP08012788A patent/EP1982983B1/de not_active Not-in-force
- 2006-06-26 AT AT08012788T patent/ATE520685T1/de active
- 2006-06-26 ES ES08012788T patent/ES2369113T3/es active Active
- 2006-06-26 AT AT06013133T patent/ATE407931T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1873151A1 (de) | 2008-01-02 |
| EP1982983B1 (de) | 2011-08-17 |
| ES2369113T3 (es) | 2011-11-25 |
| ATE407931T1 (de) | 2008-09-15 |
| EP1982983A1 (de) | 2008-10-22 |
| EP1873151B1 (de) | 2008-09-10 |
| DE602006002738D1 (de) | 2008-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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