CN101035563B - 包括聚合物部分的多价vla-4拮抗剂 - Google Patents
包括聚合物部分的多价vla-4拮抗剂 Download PDFInfo
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- CN101035563B CN101035563B CN2005800298537A CN200580029853A CN101035563B CN 101035563 B CN101035563 B CN 101035563B CN 2005800298537 A CN2005800298537 A CN 2005800298537A CN 200580029853 A CN200580029853 A CN 200580029853A CN 101035563 B CN101035563 B CN 101035563B
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- substituted
- alkyl
- conjugate
- chemical compound
- polymer moieties
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- 0 CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O Chemical compound CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O 0.000 description 12
- CVQHSXPTARJNDG-UHFFFAOYSA-N CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O Chemical compound CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O CVQHSXPTARJNDG-UHFFFAOYSA-N 0.000 description 1
- JYNOZRWOLNYVCN-UHFFFAOYSA-N CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N Chemical compound CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N JYNOZRWOLNYVCN-UHFFFAOYSA-N 0.000 description 1
- FPEPRRGVRQSZEF-MHZLTWQESA-N CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O Chemical compound CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O FPEPRRGVRQSZEF-MHZLTWQESA-N 0.000 description 1
- LHGMCUVJFRBVBH-UHFFFAOYSA-N Nc(cncn1)c1Cl Chemical compound Nc(cncn1)c1Cl LHGMCUVJFRBVBH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/785—Polymers containing nitrogen
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
US60/586,975 | 2004-07-08 | ||
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101035563A CN101035563A (zh) | 2007-09-12 |
CN101035563B true CN101035563B (zh) | 2012-03-28 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800298537A Expired - Fee Related CN101035563B (zh) | 2004-07-08 | 2005-07-08 | 包括聚合物部分的多价vla-4拮抗剂 |
Country Status (20)
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1144384B1 (en) * | 1999-01-22 | 2007-10-31 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
WO2005070921A1 (en) * | 2004-01-23 | 2005-08-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
MX2007000228A (es) | 2004-07-08 | 2007-03-30 | Elan Pharm Inc | Antagonistas de vla-4 multivalentes que comprenden porsiones de polietilenglicol. |
CN101300255A (zh) * | 2005-05-20 | 2008-11-05 | 艾伦药物公司 | 咪唑啉酮苯丙氨酸衍生物vla-4拮抗剂 |
CN101505800A (zh) | 2005-07-08 | 2009-08-12 | 艾伦药物公司 | 经由Mitsunobu反应制备VLA-4拮抗剂的聚乙二醇化共轭物 |
BRPI0616687A2 (pt) * | 2005-09-29 | 2011-06-28 | Elan Pharm Inc | compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4 |
US7727996B2 (en) * | 2005-09-29 | 2010-06-01 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4 |
CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
JP5135235B2 (ja) * | 2006-02-27 | 2013-02-06 | エラン ファーマシューティカルズ,インコーポレイテッド | Val−4によって媒介される白血球の接着を阻害するピリミジニルスルホンアミド化合物 |
CA2641160A1 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
PL2676967T3 (pl) * | 2006-02-28 | 2019-12-31 | Biogen Ma Inc. | Metody leczenia chorób zapalnych i autoimmunologicznych za pomocą natalizumabu |
US20070231319A1 (en) | 2006-03-03 | 2007-10-04 | Yednock Theodore A | Methods of treating inflammatory and autoimmune diseases with natalizumab |
SG172604A1 (en) * | 2006-05-22 | 2011-07-28 | Elan Pharm Inc | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
US20080045521A1 (en) * | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
US20090062267A1 (en) * | 2007-01-29 | 2009-03-05 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS |
WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
WO2008153967A1 (en) * | 2007-06-08 | 2008-12-18 | Contec Therapeutics, Inc. | Bk1 antagonist conjugates |
JP2011506322A (ja) * | 2007-12-07 | 2011-03-03 | エラン ファーマシューティカルズ,インコーポレイテッド | 液性腫瘍を治療するための方法および組成物 |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
CN102459179A (zh) * | 2009-04-27 | 2012-05-16 | 艾伦药物公司 | α-4整联蛋白的吡啶酮拮抗剂 |
US20120258093A1 (en) * | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
FI3339865T5 (fi) | 2010-01-11 | 2023-04-15 | Jc-viruksen vasta-aineiden määritys | |
EP2525831B1 (en) * | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
JP2013525435A (ja) | 2010-04-30 | 2013-06-20 | エラン ファーマシューティカルズ,インコーポレイテッド | 選択的インテグリン阻害剤 |
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US9487485B2 (en) | 2013-02-28 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
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MX2015017467A (es) * | 2013-07-05 | 2016-04-25 | Biogen Ma Inc | Composiciones y métodos para el tratamiento de accidentes cerebrovasculares. |
US20150250883A1 (en) * | 2014-02-12 | 2015-09-10 | 7 Hills Pharma, Llc | Compositions and methods to improve the homing and grafting of hematopoetic stem cells |
WO2017015544A1 (en) * | 2015-07-23 | 2017-01-26 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
EP3873897A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
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