CN101023178A - 高琥珀酸产出细菌 - Google Patents

高琥珀酸产出细菌 Download PDF

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Publication number
CN101023178A
CN101023178A CNA2005800312322A CN200580031232A CN101023178A CN 101023178 A CN101023178 A CN 101023178A CN A2005800312322 A CNA2005800312322 A CN A2005800312322A CN 200580031232 A CN200580031232 A CN 200580031232A CN 101023178 A CN101023178 A CN 101023178A
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pta
poxb
bacterium
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ack
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K-Y·单
乔治·N·贝内特
亨利·林
艾伦·桑切斯
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William Marsh Rice University
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William Marsh Rice University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2005800312322A 2004-09-17 2005-09-16 高琥珀酸产出细菌 Pending CN101023178A (zh)

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US61075004P 2004-09-17 2004-09-17
US60/610,750 2004-09-17

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CN101023178A true CN101023178A (zh) 2007-08-22

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US (1) US20060073577A1 (cg-RX-API-DMAC7.html)
EP (1) EP1789569A2 (cg-RX-API-DMAC7.html)
JP (1) JP2008513023A (cg-RX-API-DMAC7.html)
KR (1) KR20070065870A (cg-RX-API-DMAC7.html)
CN (1) CN101023178A (cg-RX-API-DMAC7.html)
BR (1) BRPI0515273A (cg-RX-API-DMAC7.html)
WO (1) WO2006034156A2 (cg-RX-API-DMAC7.html)

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CN102286387A (zh) * 2011-06-21 2011-12-21 江南大学 一株产富马酸的光滑球拟酵母工程菌的构建方法及应用
CN101613669B (zh) * 2009-06-04 2012-01-25 山东大学 一株用于好氧发酵的大肠杆菌工程菌株
CN102365357A (zh) * 2009-03-24 2012-02-29 代谢探索者公司 通过发酵产生大量乙醇酸的方法
CN102618570A (zh) * 2012-03-20 2012-08-01 南京工业大学 构建产富马酸大肠杆菌基因工程菌的方法
CN102803470A (zh) * 2009-04-02 2012-11-28 佛罗里达大学研究基金会公司 针对生产琥珀酸路径的工程方法
WO2014187357A1 (zh) * 2013-05-24 2014-11-27 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
CN104651289A (zh) * 2015-01-28 2015-05-27 江南大学 一种弱化发酵过程中乙酸积累以增强l-色氨酸产量的基因工程菌及其构建方法
CN104854244A (zh) * 2012-10-02 2015-08-19 密歇根生物技术研究所 用于生产有机酸的重组微生物
US9605280B2 (en) 2013-05-24 2017-03-28 Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences Escherichia coli containing mutated lpdA gene and application thereof
CN111295446A (zh) * 2018-10-10 2020-06-16 韩国科学技术院 引入高活性苹果酸脱氢酶用以生产琥珀酸的突变型微生物及使用其生产琥珀酸的方法
CN112888776A (zh) * 2019-04-12 2021-06-01 绿色地球研究所株式会社 转基因微生物及使用其的目标物质的生产方法
CN113528417A (zh) * 2009-06-04 2021-10-22 基因组股份公司 生产1,4-丁二醇的微生物和相关方法

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CN102365357A (zh) * 2009-03-24 2012-02-29 代谢探索者公司 通过发酵产生大量乙醇酸的方法
CN102803470A (zh) * 2009-04-02 2012-11-28 佛罗里达大学研究基金会公司 针对生产琥珀酸路径的工程方法
CN101613669B (zh) * 2009-06-04 2012-01-25 山东大学 一株用于好氧发酵的大肠杆菌工程菌株
CN113528417A (zh) * 2009-06-04 2021-10-22 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
CN102286387A (zh) * 2011-06-21 2011-12-21 江南大学 一株产富马酸的光滑球拟酵母工程菌的构建方法及应用
CN102618570A (zh) * 2012-03-20 2012-08-01 南京工业大学 构建产富马酸大肠杆菌基因工程菌的方法
CN104854244A (zh) * 2012-10-02 2015-08-19 密歇根生物技术研究所 用于生产有机酸的重组微生物
CN104178443A (zh) * 2013-05-24 2014-12-03 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
US9605280B2 (en) 2013-05-24 2017-03-28 Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences Escherichia coli containing mutated lpdA gene and application thereof
CN104178443B (zh) * 2013-05-24 2017-04-12 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
US10006063B2 (en) 2013-05-24 2018-06-26 Tianjin Institute Of Industrial Biotechnology, Chinese Academy Of Sciences Recombinant Escherichia coli for producing succinate acid and application thereof
WO2014187357A1 (zh) * 2013-05-24 2014-11-27 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
CN104651289A (zh) * 2015-01-28 2015-05-27 江南大学 一种弱化发酵过程中乙酸积累以增强l-色氨酸产量的基因工程菌及其构建方法
CN104651289B (zh) * 2015-01-28 2017-09-26 江南大学 一种弱化发酵过程中乙酸积累以增强l‑色氨酸产量的基因工程菌及其构建方法
CN111295446A (zh) * 2018-10-10 2020-06-16 韩国科学技术院 引入高活性苹果酸脱氢酶用以生产琥珀酸的突变型微生物及使用其生产琥珀酸的方法
US11655462B2 (en) 2018-10-10 2023-05-23 Korea Advanced Institute Of Science And Technology Mutant microorganism introduced with highly active malate dehydrogenase for producing succinic acid and method of producing succinic acid using the same
CN111295446B (zh) * 2018-10-10 2023-11-28 韩国科学技术院 引入高活性苹果酸脱氢酶用以生产琥珀酸的突变型微生物及使用其生产琥珀酸的方法
CN112888776A (zh) * 2019-04-12 2021-06-01 绿色地球研究所株式会社 转基因微生物及使用其的目标物质的生产方法
US12600991B2 (en) 2019-04-12 2026-04-14 Green Earth Institute Co., Ltd. Genetically modified microorganism for production of aspartic acid and downstream metabolites from aspartic acid as target substance, and method for producing target substance using same

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