CN100488980C - 含有整联蛋白结合基序的肽及其用途 - Google Patents

含有整联蛋白结合基序的肽及其用途 Download PDF

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Publication number
CN100488980C
CN100488980C CNB018157939A CN01815793A CN100488980C CN 100488980 C CN100488980 C CN 100488980C CN B018157939 A CNB018157939 A CN B018157939A CN 01815793 A CN01815793 A CN 01815793A CN 100488980 C CN100488980 C CN 100488980C
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peptide
bone
formulation
seq
sequence
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Expired - Fee Related
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CN1458935A (zh
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熊谷是成
R·W·布拉谢
米田俊之
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Orr Toth Lo Fikes Ltd
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Big Bear Bio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Birds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CNB018157939A 2000-08-16 2001-08-14 含有整联蛋白结合基序的肽及其用途 Expired - Fee Related CN100488980C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64103400A 2000-08-16 2000-08-16
US09/641,034 2000-08-16
US09/812,485 2001-03-19
US09/812,485 US6911425B2 (en) 2000-08-16 2001-03-19 Integrin binding motif containing peptides and methods of treating skeletal diseases

Publications (2)

Publication Number Publication Date
CN1458935A CN1458935A (zh) 2003-11-26
CN100488980C true CN100488980C (zh) 2009-05-20

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CNB018157939A Expired - Fee Related CN100488980C (zh) 2000-08-16 2001-08-14 含有整联蛋白结合基序的肽及其用途

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US (5) US6911425B2 (enExample)
EP (1) EP1309616B1 (enExample)
JP (3) JP4318246B2 (enExample)
CN (1) CN100488980C (enExample)
AT (1) ATE430165T1 (enExample)
AU (2) AU2001286491B2 (enExample)
CA (1) CA2418716A1 (enExample)
DE (1) DE60138552D1 (enExample)
ES (1) ES2324153T3 (enExample)
MX (1) MXPA03001394A (enExample)
WO (1) WO2002014360A1 (enExample)

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JP4424575B2 (ja) * 1998-05-18 2010-03-03 ユニバーシティー カレッジ ロンドン 新規ポリペプチドホルモン・フォスファトニン
ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
US6911425B2 (en) * 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
DK1689350T3 (da) * 2003-12-01 2008-06-02 Arla Foods Amba Anvendelse af osteopontin i dentalformuleringer
US20060193916A1 (en) * 2005-01-07 2006-08-31 Acologix, Inc. Formulations of peptides for periodontal and dental treatments
US7638486B2 (en) * 2005-07-18 2009-12-29 Acologix, Inc. Method for promoting hard tissue formation
CN100366302C (zh) * 2006-09-14 2008-02-06 清华大学 一种用于骨修复的矿化多肽材料及其制备方法
EP2117578B1 (en) * 2007-01-22 2015-04-22 OrthoTrophix, Inc. A peptide composition and a method of promoting cartilage formation
JP5519121B2 (ja) * 2008-06-02 2014-06-11 学校法人東日本学園 新規ｒｇｄ含有ペプチドおよび象牙質再生剤、骨再生剤、歯周組織再生剤
BR112012030745A2 (pt) * 2010-06-01 2016-08-23 Belle Aire Fragrances Inc produto de higiene bucal ou nasal e seu método de fabricação
RU2503458C1 (ru) * 2012-08-27 2014-01-10 Сергей Васильевич Чуйкин Способ местного лечения и профилактики основных стоматологических заболеваний у детей с хронической почечной недостаточностью с применением жевательного фитосубстрата
JP6692676B2 (ja) * 2016-04-12 2020-05-13 学校法人東日本学園 ネフロネクチンを含むう蝕治療剤
CN106943311A (zh) * 2017-04-07 2017-07-14 缪来耿 一种用于预防和或治疗牙周炎的牙膏及其制备方法
PL3638204T3 (pl) 2017-06-14 2024-07-29 Orthotrophix, Inc. Peptyd tpx-100 łagodzący ból stawu kolanowego
US11963996B2 (en) 2018-10-24 2024-04-23 Orthotrophix, Inc. Method of treating knee pain
CN109762069B (zh) * 2018-11-05 2022-01-14 广州领晟医疗科技有限公司 一种融合蛋白、其药物组合物及用途
JP2022502356A (ja) 2018-12-04 2022-01-11 オルソトロフィックス インコーポレイテッド 変形性関節症の治療に使用するための製剤
CN111358935B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽在制备抗肿瘤和/或抑制肿瘤转移药物中的用途及药物
CN111265652B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽在制备治疗缺血性脑血管疾病的药物中的应用
CN111249446B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽及其盐的新用途
CN111569046B (zh) * 2020-04-14 2023-06-27 广州领晟医疗科技有限公司 多肽在制备治疗胰腺炎药物中的用途及含有其的药物
WO2022072156A1 (en) 2020-10-01 2022-04-07 Orthotrophix, Inc. Hard tissue therapeutics

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WO1999043844A1 (en) * 1998-02-27 1999-09-02 The Trustees Of Columbia University In The City Of New York Reciprocal subtraction differential display
WO1999060017A2 (en) * 1998-05-18 1999-11-25 University College London Human tumour-derived polypeptide hormone phosphatonin

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ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern

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WO1999060017A2 (en) * 1998-05-18 1999-11-25 University College London Human tumour-derived polypeptide hormone phosphatonin

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AU2001286491B2 (en) 2006-04-27
US20090042791A1 (en) 2009-02-12
CN1458935A (zh) 2003-11-26
EP1309616A1 (en) 2003-05-14
EP1309616B1 (en) 2009-04-29
JP2004506654A (ja) 2004-03-04
ES2324153T3 (es) 2009-07-31
EP1309616A4 (en) 2004-12-08
US20020197267A1 (en) 2002-12-26
AU8649101A (en) 2002-02-25
JP4318246B2 (ja) 2009-08-19
DE60138552D1 (de) 2009-06-10
WO2002014360A1 (en) 2002-02-21
US20070014742A1 (en) 2007-01-18
ATE430165T1 (de) 2009-05-15
US20050163728A1 (en) 2005-07-28
JP2011032286A (ja) 2011-02-17
US20090062201A1 (en) 2009-03-05
US7160862B2 (en) 2007-01-09
CA2418716A1 (en) 2002-02-21
US6911425B2 (en) 2005-06-28
JP2007302673A (ja) 2007-11-22
MXPA03001394A (es) 2004-12-13

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