CN1458935A - 含有整联蛋白结合基序的肽和治疗骨骼疾病的方法 - Google Patents
含有整联蛋白结合基序的肽和治疗骨骼疾病的方法 Download PDFInfo
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- CN1458935A CN1458935A CN01815793A CN01815793A CN1458935A CN 1458935 A CN1458935 A CN 1458935A CN 01815793 A CN01815793 A CN 01815793A CN 01815793 A CN01815793 A CN 01815793A CN 1458935 A CN1458935 A CN 1458935A
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4728—Calcium binding proteins, e.g. calmodulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- Health & Medical Sciences (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
组号 | 描述 | 处理 | 剂量水平 | 动物数量 |
1 | 伪装 | 载体 | - | 8 |
2 | Ovx | 载体 | - | 8 |
3 | Ovx+LD | D-00006 | 20μg/kg/天 | 8 |
4 | Ovx+HD | D-00006 | 200μg/kg/天 | 8 |
5 | Ovx+Est | 17β-雌二醇小丸植入物和载体 | 10μg/kg/天 | 8 |
Claims (13)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64103400A | 2000-08-16 | 2000-08-16 | |
US09/641,034 | 2000-08-16 | ||
US09/812,485 | 2001-03-19 | ||
US09/812,485 US6911425B2 (en) | 2000-08-16 | 2001-03-19 | Integrin binding motif containing peptides and methods of treating skeletal diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1458935A true CN1458935A (zh) | 2003-11-26 |
CN100488980C CN100488980C (zh) | 2009-05-20 |
Family
ID=27093672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018157939A Expired - Fee Related CN100488980C (zh) | 2000-08-16 | 2001-08-14 | 含有整联蛋白结合基序的肽及其用途 |
Country Status (11)
Country | Link |
---|---|
US (5) | US6911425B2 (zh) |
EP (1) | EP1309616B1 (zh) |
JP (3) | JP4318246B2 (zh) |
CN (1) | CN100488980C (zh) |
AT (1) | ATE430165T1 (zh) |
AU (2) | AU8649101A (zh) |
CA (1) | CA2418716A1 (zh) |
DE (1) | DE60138552D1 (zh) |
ES (1) | ES2324153T3 (zh) |
MX (1) | MXPA03001394A (zh) |
WO (1) | WO2002014360A1 (zh) |
Cited By (7)
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CN100366302C (zh) * | 2006-09-14 | 2008-02-06 | 清华大学 | 一种用于骨修复的矿化多肽材料及其制备方法 |
CN106943311A (zh) * | 2017-04-07 | 2017-07-14 | 缪来耿 | 一种用于预防和或治疗牙周炎的牙膏及其制备方法 |
CN109762069A (zh) * | 2018-11-05 | 2019-05-17 | 广州安辰新药研究院有限公司 | 一种融合蛋白、其药物组合物及用途 |
CN111249446A (zh) * | 2020-02-27 | 2020-06-09 | 广州领晟医疗科技有限公司 | 多肽及其盐的新用途 |
CN111265652A (zh) * | 2020-02-27 | 2020-06-12 | 广州领晟医疗科技有限公司 | 多肽在制备治疗缺血性脑血管疾病的药物中的应用 |
CN111358935A (zh) * | 2020-02-27 | 2020-07-03 | 广州领晟医疗科技有限公司 | 多肽在制备抗肿瘤和/或抑制肿瘤转移药物中的用途及药物 |
CN111569046A (zh) * | 2020-04-14 | 2020-08-25 | 广州领晟医疗科技有限公司 | 多肽在制备治疗胰腺炎药物中的用途及含有其的药物 |
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JP4424575B2 (ja) * | 1998-05-18 | 2010-03-03 | ユニバーシティー カレッジ ロンドン | 新規ポリペプチドホルモン・フォスファトニン |
AU8326801A (en) * | 2000-08-16 | 2002-02-25 | Big Bear Bio Inc | Dental products comprising bone growth enhancing peptide |
US6911425B2 (en) * | 2000-08-16 | 2005-06-28 | Acologix, Inc. | Integrin binding motif containing peptides and methods of treating skeletal diseases |
WO2005053628A1 (en) * | 2003-12-01 | 2005-06-16 | Arla Foods Amba | Use of osteopontin in dental formulations |
WO2006078464A2 (en) * | 2005-01-07 | 2006-07-27 | Acologix, Inc. | Formulations of peptides for periodontal and dental treatments |
WO2007011610A2 (en) * | 2005-07-18 | 2007-01-25 | Acologix, Inc. | Protein formulation for promoting hard tissue formation |
CA2674384C (en) * | 2007-01-22 | 2016-11-15 | Acologix, Inc. | A peptide composition and a method of promoting cartilage formation |
JP5519121B2 (ja) * | 2008-06-02 | 2014-06-11 | 学校法人東日本学園 | 新規rgd含有ペプチドおよび象牙質再生剤、骨再生剤、歯周組織再生剤 |
MX347042B (es) * | 2010-06-01 | 2017-04-10 | Belle-Aire Fragrances Inc | Producto y metodo para control de olor oral. |
RU2503458C1 (ru) * | 2012-08-27 | 2014-01-10 | Сергей Васильевич Чуйкин | Способ местного лечения и профилактики основных стоматологических заболеваний у детей с хронической почечной недостаточностью с применением жевательного фитосубстрата |
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US11963996B2 (en) | 2018-10-24 | 2024-04-23 | Orthotrophix, Inc. | Method of treating knee pain |
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US5015628A (en) | 1986-06-12 | 1991-05-14 | The University Of Melbourne | Anticariogenic phosphopeptides |
US5120829A (en) * | 1989-03-20 | 1992-06-09 | La Jolla Cancer Research Foundation | Hydrophobic attachment site for adhesion peptides |
JPH0474132A (ja) * | 1990-07-13 | 1992-03-09 | Lion Corp | 歯根膜ならびに歯槽骨組織再生修復促進剤 |
GB9203958D0 (en) | 1992-02-25 | 1992-04-08 | Norske Stats Oljeselskap | Catalytic multi-phase reactor |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US6103709A (en) | 1993-12-23 | 2000-08-15 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases |
US5770565A (en) * | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
US6027592A (en) | 1995-06-06 | 2000-02-22 | Gillette Canada Inc. | Dental floss |
US6300062B1 (en) | 1995-07-13 | 2001-10-09 | Biora Ab | Enamel matrix related polypeptide |
US5837674A (en) | 1996-07-03 | 1998-11-17 | Big Bear Bio, Inc. | Phosphopeptides and methods of treating bone diseases |
AU8783798A (en) | 1997-08-15 | 1999-03-08 | Children's Medical Center Corporation | Osteopontin coated surfaces and methods of use |
US6146655A (en) | 1997-08-29 | 2000-11-14 | Softy-Flex Inc. | Flexible intra-oral bandage and drug delivery system |
US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
WO1999043844A1 (en) * | 1998-02-27 | 1999-09-02 | The Trustees Of Columbia University In The City Of New York | Reciprocal subtraction differential display |
US6673900B2 (en) * | 1999-11-04 | 2004-01-06 | University College London | Polypeptide hormone-phosphatonin |
JP4424575B2 (ja) | 1998-05-18 | 2010-03-03 | ユニバーシティー カレッジ ロンドン | 新規ポリペプチドホルモン・フォスファトニン |
US6045780A (en) | 1998-06-22 | 2000-04-04 | Shemberg Marketing Corporation | Toothpaste composition |
AUPP893999A0 (en) * | 1999-03-01 | 1999-03-25 | Csl Limited | Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis |
US6145655A (en) * | 1999-10-04 | 2000-11-14 | Tsai; Allan | Lens cleaning kit |
US6790639B2 (en) | 2000-02-29 | 2004-09-14 | Pfizer Inc. | Mammalian osteoregulins |
AU2001245953A1 (en) | 2000-03-24 | 2001-10-08 | Genzyme Corporation | Oncogenic osteomalacia-related gene 1 |
AU7697701A (en) | 2000-07-19 | 2002-01-30 | Univ Texas | Stimulation of bone growth with thrombin peptide derivatives |
US6911425B2 (en) * | 2000-08-16 | 2005-06-28 | Acologix, Inc. | Integrin binding motif containing peptides and methods of treating skeletal diseases |
AU8326801A (en) * | 2000-08-16 | 2002-02-25 | Big Bear Bio Inc | Dental products comprising bone growth enhancing peptide |
-
2001
- 2001-03-19 US US09/812,485 patent/US6911425B2/en not_active Expired - Lifetime
- 2001-08-14 WO PCT/US2001/025542 patent/WO2002014360A1/en active Application Filing
- 2001-08-14 AU AU8649101A patent/AU8649101A/xx active Pending
- 2001-08-14 ES ES01965941T patent/ES2324153T3/es not_active Expired - Lifetime
- 2001-08-14 DE DE60138552T patent/DE60138552D1/de not_active Expired - Lifetime
- 2001-08-14 CN CNB018157939A patent/CN100488980C/zh not_active Expired - Fee Related
- 2001-08-14 AU AU2001286491A patent/AU2001286491B2/en not_active Ceased
- 2001-08-14 AT AT01965941T patent/ATE430165T1/de not_active IP Right Cessation
- 2001-08-14 JP JP2002519497A patent/JP4318246B2/ja not_active Expired - Fee Related
- 2001-08-14 MX MXPA03001394A patent/MXPA03001394A/es active IP Right Grant
- 2001-08-14 CA CA002418716A patent/CA2418716A1/en not_active Abandoned
- 2001-08-14 EP EP01965941A patent/EP1309616B1/en not_active Expired - Lifetime
-
2005
- 2005-01-24 US US11/042,492 patent/US7160862B2/en not_active Expired - Lifetime
-
2006
- 2006-09-13 US US11/531,583 patent/US20070014742A1/en not_active Abandoned
-
2007
- 2007-05-15 JP JP2007128730A patent/JP2007302673A/ja not_active Withdrawn
- 2007-10-26 US US11/925,411 patent/US20090042791A1/en not_active Abandoned
-
2008
- 2008-07-03 US US12/167,491 patent/US20090062201A1/en not_active Abandoned
-
2010
- 2010-11-11 JP JP2010252426A patent/JP2011032286A/ja active Pending
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100366302C (zh) * | 2006-09-14 | 2008-02-06 | 清华大学 | 一种用于骨修复的矿化多肽材料及其制备方法 |
CN106943311A (zh) * | 2017-04-07 | 2017-07-14 | 缪来耿 | 一种用于预防和或治疗牙周炎的牙膏及其制备方法 |
CN109762069A (zh) * | 2018-11-05 | 2019-05-17 | 广州安辰新药研究院有限公司 | 一种融合蛋白、其药物组合物及用途 |
CN109762069B (zh) * | 2018-11-05 | 2022-01-14 | 广州领晟医疗科技有限公司 | 一种融合蛋白、其药物组合物及用途 |
CN111249446A (zh) * | 2020-02-27 | 2020-06-09 | 广州领晟医疗科技有限公司 | 多肽及其盐的新用途 |
CN111265652A (zh) * | 2020-02-27 | 2020-06-12 | 广州领晟医疗科技有限公司 | 多肽在制备治疗缺血性脑血管疾病的药物中的应用 |
CN111358935A (zh) * | 2020-02-27 | 2020-07-03 | 广州领晟医疗科技有限公司 | 多肽在制备抗肿瘤和/或抑制肿瘤转移药物中的用途及药物 |
CN111249446B (zh) * | 2020-02-27 | 2023-06-27 | 广州领晟医疗科技有限公司 | 多肽及其盐的新用途 |
CN111265652B (zh) * | 2020-02-27 | 2023-06-27 | 广州领晟医疗科技有限公司 | 多肽在制备治疗缺血性脑血管疾病的药物中的应用 |
CN111569046A (zh) * | 2020-04-14 | 2020-08-25 | 广州领晟医疗科技有限公司 | 多肽在制备治疗胰腺炎药物中的用途及含有其的药物 |
CN111569046B (zh) * | 2020-04-14 | 2023-06-27 | 广州领晟医疗科技有限公司 | 多肽在制备治疗胰腺炎药物中的用途及含有其的药物 |
Also Published As
Publication number | Publication date |
---|---|
AU2001286491B2 (en) | 2006-04-27 |
US20020197267A1 (en) | 2002-12-26 |
US20070014742A1 (en) | 2007-01-18 |
US6911425B2 (en) | 2005-06-28 |
US20090062201A1 (en) | 2009-03-05 |
JP2004506654A (ja) | 2004-03-04 |
JP2011032286A (ja) | 2011-02-17 |
CA2418716A1 (en) | 2002-02-21 |
US7160862B2 (en) | 2007-01-09 |
EP1309616B1 (en) | 2009-04-29 |
WO2002014360A1 (en) | 2002-02-21 |
EP1309616A4 (en) | 2004-12-08 |
DE60138552D1 (de) | 2009-06-10 |
CN100488980C (zh) | 2009-05-20 |
US20090042791A1 (en) | 2009-02-12 |
JP4318246B2 (ja) | 2009-08-19 |
MXPA03001394A (es) | 2004-12-13 |
JP2007302673A (ja) | 2007-11-22 |
US20050163728A1 (en) | 2005-07-28 |
AU8649101A (en) | 2002-02-25 |
ATE430165T1 (de) | 2009-05-15 |
EP1309616A1 (en) | 2003-05-14 |
ES2324153T3 (es) | 2009-07-31 |
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