AU2001286491B2 - Integrin binding motif containing peptides and methods of treating skeletal diseases - Google Patents

Integrin binding motif containing peptides and methods of treating skeletal diseases Download PDF

Info

Publication number
AU2001286491B2
AU2001286491B2 AU2001286491A AU2001286491A AU2001286491B2 AU 2001286491 B2 AU2001286491 B2 AU 2001286491B2 AU 2001286491 A AU2001286491 A AU 2001286491A AU 2001286491 A AU2001286491 A AU 2001286491A AU 2001286491 B2 AU2001286491 B2 AU 2001286491B2
Authority
AU
Australia
Prior art keywords
bone
peptide
seq
binding motif
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001286491A
Other languages
English (en)
Other versions
AU2001286491A1 (en
Inventor
Russell Wayne Blacher
Yoshinari Kumagai
Toshiyuki Yoneda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OrthoTrophix Inc
Original Assignee
OrthoTrophix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OrthoTrophix Inc filed Critical OrthoTrophix Inc
Publication of AU2001286491A1 publication Critical patent/AU2001286491A1/en
Application granted granted Critical
Publication of AU2001286491B2 publication Critical patent/AU2001286491B2/en
Assigned to ORTHOTROPHIX, INC. reassignment ORTHOTROPHIX, INC. Request to Amend Deed and Register Assignors: ACOLOGIX INC
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4705Regulators; Modulating activity stimulating, promoting or activating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728Calcium binding proteins, e.g. calmodulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Birds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
AU2001286491A 2000-08-16 2001-08-14 Integrin binding motif containing peptides and methods of treating skeletal diseases Ceased AU2001286491B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64103400A 2000-08-16 2000-08-16
US09/641,034 2000-08-16
US09/812,485 2001-03-19
US09/812,485 US6911425B2 (en) 2000-08-16 2001-03-19 Integrin binding motif containing peptides and methods of treating skeletal diseases
PCT/US2001/025542 WO2002014360A1 (en) 2000-08-16 2001-08-14 Integrin binding motif containing peptides and methods of treating skeletal diseases

Publications (2)

Publication Number Publication Date
AU2001286491A1 AU2001286491A1 (en) 2002-05-23
AU2001286491B2 true AU2001286491B2 (en) 2006-04-27

Family

ID=27093672

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001286491A Ceased AU2001286491B2 (en) 2000-08-16 2001-08-14 Integrin binding motif containing peptides and methods of treating skeletal diseases
AU8649101A Pending AU8649101A (en) 2000-08-16 2001-08-14 Integrin binding motif containing peptides and methods of treating skeletal diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU8649101A Pending AU8649101A (en) 2000-08-16 2001-08-14 Integrin binding motif containing peptides and methods of treating skeletal diseases

Country Status (11)

Country Link
US (5) US6911425B2 (enExample)
EP (1) EP1309616B1 (enExample)
JP (3) JP4318246B2 (enExample)
CN (1) CN100488980C (enExample)
AT (1) ATE430165T1 (enExample)
AU (2) AU2001286491B2 (enExample)
CA (1) CA2418716A1 (enExample)
DE (1) DE60138552D1 (enExample)
ES (1) ES2324153T3 (enExample)
MX (1) MXPA03001394A (enExample)
WO (1) WO2002014360A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4424575B2 (ja) * 1998-05-18 2010-03-03 ユニバーシティー カレッジ ロンドン 新規ポリペプチドホルモン・フォスファトニン
ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
US6911425B2 (en) * 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
DK1689350T3 (da) * 2003-12-01 2008-06-02 Arla Foods Amba Anvendelse af osteopontin i dentalformuleringer
US20060193916A1 (en) * 2005-01-07 2006-08-31 Acologix, Inc. Formulations of peptides for periodontal and dental treatments
US7638486B2 (en) * 2005-07-18 2009-12-29 Acologix, Inc. Method for promoting hard tissue formation
CN100366302C (zh) * 2006-09-14 2008-02-06 清华大学 一种用于骨修复的矿化多肽材料及其制备方法
EP2117578B1 (en) * 2007-01-22 2015-04-22 OrthoTrophix, Inc. A peptide composition and a method of promoting cartilage formation
JP5519121B2 (ja) * 2008-06-02 2014-06-11 学校法人東日本学園 新規rgd含有ペプチドおよび象牙質再生剤、骨再生剤、歯周組織再生剤
BR112012030745A2 (pt) * 2010-06-01 2016-08-23 Belle Aire Fragrances Inc produto de higiene bucal ou nasal e seu método de fabricação
RU2503458C1 (ru) * 2012-08-27 2014-01-10 Сергей Васильевич Чуйкин Способ местного лечения и профилактики основных стоматологических заболеваний у детей с хронической почечной недостаточностью с применением жевательного фитосубстрата
JP6692676B2 (ja) * 2016-04-12 2020-05-13 学校法人東日本学園 ネフロネクチンを含むう蝕治療剤
CN106943311A (zh) * 2017-04-07 2017-07-14 缪来耿 一种用于预防和或治疗牙周炎的牙膏及其制备方法
PL3638204T3 (pl) 2017-06-14 2024-07-29 Orthotrophix, Inc. Peptyd tpx-100 łagodzący ból stawu kolanowego
US11963996B2 (en) 2018-10-24 2024-04-23 Orthotrophix, Inc. Method of treating knee pain
CN109762069B (zh) * 2018-11-05 2022-01-14 广州领晟医疗科技有限公司 一种融合蛋白、其药物组合物及用途
JP2022502356A (ja) 2018-12-04 2022-01-11 オルソトロフィックス インコーポレイテッド 変形性関節症の治療に使用するための製剤
CN111358935B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽在制备抗肿瘤和/或抑制肿瘤转移药物中的用途及药物
CN111265652B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽在制备治疗缺血性脑血管疾病的药物中的应用
CN111249446B (zh) * 2020-02-27 2023-06-27 广州领晟医疗科技有限公司 多肽及其盐的新用途
CN111569046B (zh) * 2020-04-14 2023-06-27 广州领晟医疗科技有限公司 多肽在制备治疗胰腺炎药物中的用途及含有其的药物
WO2022072156A1 (en) 2020-10-01 2022-04-07 Orthotrophix, Inc. Hard tissue therapeutics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014714A1 (en) * 1993-11-24 1995-06-01 La Jolla Cancer Research Foundation Novel integrin-binding peptides
US5849865A (en) * 1994-04-13 1998-12-15 La Jolla Cancer Research Foundation Peptides for altering bone resorption, angiogenesis and restenosis
WO1999008730A1 (en) * 1997-08-15 1999-02-25 Children's Medical Center Corporation Osteopontin coated surfaces and methods of use
WO1999060017A2 (en) * 1998-05-18 1999-11-25 University College London Human tumour-derived polypeptide hormone phosphatonin

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015628A (en) 1986-06-12 1991-05-14 The University Of Melbourne Anticariogenic phosphopeptides
US5120829A (en) * 1989-03-20 1992-06-09 La Jolla Cancer Research Foundation Hydrophobic attachment site for adhesion peptides
JPH0474132A (ja) * 1990-07-13 1992-03-09 Lion Corp 歯根膜ならびに歯槽骨組織再生修復促進剤
GB9203958D0 (en) 1992-02-25 1992-04-08 Norske Stats Oljeselskap Catalytic multi-phase reactor
US6103709A (en) 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
US6027592A (en) 1995-06-06 2000-02-22 Gillette Canada Inc. Dental floss
US6300062B1 (en) 1995-07-13 2001-10-09 Biora Ab Enamel matrix related polypeptide
US5837674A (en) 1996-07-03 1998-11-17 Big Bear Bio, Inc. Phosphopeptides and methods of treating bone diseases
US6146655A (en) 1997-08-29 2000-11-14 Softy-Flex Inc. Flexible intra-oral bandage and drug delivery system
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
WO1999043844A1 (en) * 1998-02-27 1999-09-02 The Trustees Of Columbia University In The City Of New York Reciprocal subtraction differential display
US6673900B2 (en) * 1999-11-04 2004-01-06 University College London Polypeptide hormone-phosphatonin
US6045780A (en) 1998-06-22 2000-04-04 Shemberg Marketing Corporation Toothpaste composition
AUPP893999A0 (en) * 1999-03-01 1999-03-25 Csl Limited Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis
US6145655A (en) * 1999-10-04 2000-11-14 Tsai; Allan Lens cleaning kit
EP1130098A3 (en) 2000-02-29 2003-09-10 Pfizer Products Inc. Mammalian osteoregulins
WO2001072826A2 (en) 2000-03-24 2001-10-04 Genzyme Corporation Oncogenic osteomalacia-related gene 1
TR200400260T4 (tr) 2000-07-19 2004-03-22 The Board Of Regents, The University Of Texas System Trombin peptid türevleri ile kemik büyümesinin uyarılması
US6911425B2 (en) * 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014714A1 (en) * 1993-11-24 1995-06-01 La Jolla Cancer Research Foundation Novel integrin-binding peptides
US5849865A (en) * 1994-04-13 1998-12-15 La Jolla Cancer Research Foundation Peptides for altering bone resorption, angiogenesis and restenosis
WO1999008730A1 (en) * 1997-08-15 1999-02-25 Children's Medical Center Corporation Osteopontin coated surfaces and methods of use
WO1999060017A2 (en) * 1998-05-18 1999-11-25 University College London Human tumour-derived polypeptide hormone phosphatonin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ferris et al biomaterials (1999) 20:2323-2331 *
Lopez et al., Biocehmica et Biophysica Acta (1996): 1317:183-191 *
Yang et al., Journal Peptide Research (2000) 55(3): 203-215 *

Also Published As

Publication number Publication date
US20090042791A1 (en) 2009-02-12
CN1458935A (zh) 2003-11-26
EP1309616A1 (en) 2003-05-14
EP1309616B1 (en) 2009-04-29
JP2004506654A (ja) 2004-03-04
ES2324153T3 (es) 2009-07-31
EP1309616A4 (en) 2004-12-08
US20020197267A1 (en) 2002-12-26
AU8649101A (en) 2002-02-25
JP4318246B2 (ja) 2009-08-19
DE60138552D1 (de) 2009-06-10
WO2002014360A1 (en) 2002-02-21
US20070014742A1 (en) 2007-01-18
ATE430165T1 (de) 2009-05-15
US20050163728A1 (en) 2005-07-28
JP2011032286A (ja) 2011-02-17
US20090062201A1 (en) 2009-03-05
US7160862B2 (en) 2007-01-09
CA2418716A1 (en) 2002-02-21
CN100488980C (zh) 2009-05-20
US6911425B2 (en) 2005-06-28
JP2007302673A (ja) 2007-11-22
MXPA03001394A (es) 2004-12-13

Similar Documents

Publication Publication Date Title
US20090042791A1 (en) Integrin binding motif containing peptides and methods of treating skeletal diseases
AU2001286491A1 (en) Integrin binding motif containing peptides and methods of treating skeletal diseases
US20090163413A1 (en) Dental products comprising bone growth enhancing peptide
AU2020363214B2 (en) Active polypeptide compound
EP0289314A2 (en) Use of IGF-II in the treatment of bone disorders
AU2001283268A1 (en) Dental products comprising bone growth enhancing peptide
CN117503628A (zh) 用于缓解牙本质感觉过敏的牙膏组合物
JP5529014B2 (ja) 部位特異的なペグ化をされた直鎖状のサケカルシトニン類似体
CN116082483B (zh) 一种具有改善骨质疏松、增强骨密度的多肽制备方法及应用
JPH07258110A (ja) 骨疾患治療剤
HK40085189A (en) Pharmaceutical composition for preventing or treating a periodontal disease or dislocated traumatic tooth

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE CO-INVENTOR FROM YONEDA, TOSHIYUNKI TO YONEDA, TOSHIYUKI .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND CO-INVENTOR NAME FROM YONEDA, TOSHIYUKI TO TOSHIYUKI, YONEDA

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired