CN100471492C - 羟油酸及相关化合物在制备药物中的应用 - Google Patents

羟油酸及相关化合物在制备药物中的应用 Download PDF

Info

Publication number
CN100471492C
CN100471492C CNB028201132A CN02820113A CN100471492C CN 100471492 C CN100471492 C CN 100471492C CN B028201132 A CNB028201132 A CN B028201132A CN 02820113 A CN02820113 A CN 02820113A CN 100471492 C CN100471492 C CN 100471492C
Authority
CN
China
Prior art keywords
acid
hydroxyoleic acid
hydroxyoleic
proteins
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028201132A
Other languages
English (en)
Chinese (zh)
Other versions
CN1688302A (zh
Inventor
P·V·埃斯克里瓦鲁伊斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat de les Illes Balears
Original Assignee
Universitat de les Illes Balears
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat de les Illes Balears filed Critical Universitat de les Illes Balears
Publication of CN1688302A publication Critical patent/CN1688302A/zh
Application granted granted Critical
Publication of CN100471492C publication Critical patent/CN100471492C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028201132A 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用 Expired - Lifetime CN100471492C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200102269A ES2186576B1 (es) 2001-10-11 2001-10-11 Acido 2-hidroxioleico para utilizar como medicamento.
ESP200102269 2001-10-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2008100917941A Division CN101259122B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用
CN2008100917937A Division CN101259121B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用

Publications (2)

Publication Number Publication Date
CN1688302A CN1688302A (zh) 2005-10-26
CN100471492C true CN100471492C (zh) 2009-03-25

Family

ID=8499164

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB028201132A Expired - Lifetime CN100471492C (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用
CN2008100917937A Expired - Fee Related CN101259121B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用
CN2008100917941A Expired - Fee Related CN101259122B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2008100917937A Expired - Fee Related CN101259121B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用
CN2008100917941A Expired - Fee Related CN101259122B (zh) 2001-10-11 2002-10-09 羟油酸及相关化合物在制备药物中的应用

Country Status (13)

Country Link
US (3) US20050014831A1 (https=)
EP (1) EP1435235B1 (https=)
JP (1) JP4737931B2 (https=)
CN (3) CN100471492C (https=)
AT (1) ATE322261T1 (https=)
BR (1) BRPI0213165B8 (https=)
CA (1) CA2463348C (https=)
DE (1) DE60210488T2 (https=)
ES (2) ES2186576B1 (https=)
MX (1) MXPA04003255A (https=)
PT (1) PT1435235E (https=)
RU (1) RU2310445C2 (https=)
WO (1) WO2003030891A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2229935B1 (es) * 2003-10-10 2006-10-01 Universitat De Les Illes Balears Utilizacion del acido hidroxioleico y compuestos analagos del mismo como aditivos alimentarios funcionales.
JP2009051732A (ja) * 2005-12-13 2009-03-12 Meiji Seika Kaisha Ltd Ｐｐａｒリガンド活性を有する組成物
CN101570481B (zh) * 2008-04-30 2012-02-01 上海医药工业研究院 一种多羟基长链脂肪酸及其分离提取方法和在抑制芳香化酶活性中的应用
ES2342997B1 (es) 2008-12-09 2011-06-06 Universitat De Les Illes Balears Alpha derivados de acidos grasos cis-monoinsaturados para ser usados como medicamento.
ES2345241B1 (es) * 2009-03-16 2011-09-08 Lipopharma Therapeutics Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos.
WO2011089265A1 (en) 2010-01-25 2011-07-28 Bridge Bioresearch Plc Use of fatty acid compounds for lowering blood glucose levels
CN101985420B (zh) * 2010-01-29 2014-04-30 苏州润新生物科技有限公司 油酸酯及其制备方法和在制备用于治疗高血压及其并发症的药物中的应用
ES2401629B1 (es) * 2011-10-07 2014-03-04 Universitat De Les Illes Balears Enantiómeros de 2-hidroxiderivados de ácidos grasos y su uso como medicamentos.
EP2805717A4 (en) * 2012-01-19 2015-06-10 Nippon Suisan Kaisha Ltd APPETITE IN HOUR
WO2013132092A1 (en) 2012-03-09 2013-09-12 Pensieve International Plc Use of monounsaturated fatty acid compounds for controlling the body weight of a dog or a cat
NZ706067A (en) * 2012-09-26 2016-07-29 Tangent Reprofiling Ltd Modulators of androgen synthesis
GB201217296D0 (en) 2012-09-27 2012-11-14 Alta Innovations Ltd Method of treatment and/or prevention
WO2016062746A1 (en) * 2014-10-21 2016-04-28 Universitat De Les Illes Balears Method for the synthesis of hydroxy-triglycerides and uses thereof for the prevention and treatment of diseases
US10756968B2 (en) 2015-01-26 2020-08-25 Rapid7, Inc. Network resource management devices methods and systems
CN121041235A (zh) * 2025-11-03 2025-12-02 云南绿A生物工程有限公司 一种藻蓝蛋白软胶囊及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001100A1 (en) * 1992-07-01 1994-01-20 Arch Development Corporation METHODS AND COMPOSITIONS FOR INHIBITING 5α-REDUCTASE ACTIVITY
US6214875B1 (en) * 1998-04-14 2001-04-10 Zhenhua Yang Anticancer effects of specific branched-chain fatty acids and related production process

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61297A (ja) * 1984-06-12 1986-01-06 日本油脂株式会社 オレイン酸の製造法
GB8603621D0 (en) * 1986-02-14 1986-03-19 Habib N Modifying lipid structure of cell membranes
JPS6344843A (ja) * 1986-08-13 1988-02-25 Kao Corp 油中水中油型乳化油脂組成物
CN1035925C (zh) * 1988-11-16 1997-09-24 许正 亲细胞非均质分子脂质的制备方法
CN1118228A (zh) * 1995-03-16 1996-03-13 姜训书 松籽果酱
CN1118218A (zh) * 1995-03-16 1996-03-13 姜训书 松籽油的制作方法及松籽保健食用油
GB9506837D0 (en) * 1995-04-03 1995-05-24 Scotia Holdings Plc Triglycerides
ES2192221T3 (es) * 1995-10-30 2003-10-01 Oleoyl Estrone Developments S Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso.
US5856537A (en) * 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
DE19727636C1 (de) * 1997-06-28 1998-11-19 Rwe Dea Ag Verfahren zur Herstellung von 2-Alkylcarbonsäuren
CN1212867A (zh) * 1997-09-29 1999-04-07 宋凤亭 防治心脑血管疾病的组合物
NO308197B1 (no) * 1998-01-21 2000-08-14 Fideline Sammensetning og oppløsning derav for Õ minske stress, angst og agressivitet hos pattedyr inneholdende en blanding av fettsyrer eller derivater derav
WO1999058120A1 (en) * 1998-05-08 1999-11-18 Rolf Berge USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS
GB2389788B (en) * 2000-12-23 2005-07-20 Univ Creighton Methods for inducing apoptosis and inhibiting proliferation in cancer cells
DE10130491A1 (de) * 2001-06-25 2003-04-17 Heirler Horst Verwendung von mittelkettigen Triglyceriden zur Prävention und Therapie von Adipositas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001100A1 (en) * 1992-07-01 1994-01-20 Arch Development Corporation METHODS AND COMPOSITIONS FOR INHIBITING 5α-REDUCTASE ACTIVITY
US6214875B1 (en) * 1998-04-14 2001-04-10 Zhenhua Yang Anticancer effects of specific branched-chain fatty acids and related production process

Also Published As

Publication number Publication date
BR0213165A (pt) 2004-09-14
ES2186576B1 (es) 2004-09-16
DE60210488T2 (de) 2006-12-14
ES2186576A1 (es) 2003-05-01
US20090082446A1 (en) 2009-03-26
BRPI0213165B8 (pt) 2021-05-25
CA2463348A1 (en) 2003-04-17
WO2003030891A1 (es) 2003-04-17
JP2005527479A (ja) 2005-09-15
CN101259121A (zh) 2008-09-10
JP4737931B2 (ja) 2011-08-03
MXPA04003255A (es) 2005-01-25
CA2463348C (en) 2011-04-05
CN1688302A (zh) 2005-10-26
BRPI0213165B1 (pt) 2018-01-23
US20050014831A1 (en) 2005-01-20
US8778995B2 (en) 2014-07-15
CN101259122A (zh) 2008-09-10
CN101259122B (zh) 2011-04-06
RU2004114229A (ru) 2005-04-20
ES2261752T3 (es) 2006-11-16
PT1435235E (pt) 2006-08-31
US7851507B2 (en) 2010-12-14
EP1435235B1 (en) 2006-04-05
EP1435235A1 (en) 2004-07-07
CN101259121B (zh) 2011-04-06
ATE322261T1 (de) 2006-04-15
US20110136906A1 (en) 2011-06-09
RU2310445C2 (ru) 2007-11-20
DE60210488D1 (de) 2006-05-18

Similar Documents

Publication Publication Date Title
US7851507B2 (en) Use of hydroxyoleic acid and related compounds in the manufacture of drugs
US8329646B2 (en) Methods for the treatment of muscle loss
CN102356057A (zh) 多不饱和脂肪酸的衍生物作为药物的用途
JP5371426B2 (ja) ワートマニン類似体及び化学療法薬と組み合わせた同一物を使用する方法
He et al. Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner
US20240423948A1 (en) 5-hydroxymethylfurfural for the treatment of mitochondrial dysfunction
JP7518819B2 (ja) 歯周病予防、改善又は治療剤
CN1330303C (zh) 金雀异黄素在生产一种治疗骨质疏松症和肥胖症的药物中的用途 ,以及含有金雀异黄素与维生素 d和 k的组合的组合物
CN100496478C (zh) 羟基油酸及相关化合物作为功能性食品添加剂的应用
CN101316584A (zh) 用于预防及治疗由血管通透性亢进引起的眼病的医药
WO1999038534A1 (en) Neurotrophic factor secretion promoters
JP4276842B2 (ja) Ｐｐａｒ−ガンマ受容体の活性化に応答する症状の治療に有用な組成物
US20250235415A1 (en) Modulation of human breast milk composition
WO2006010085A1 (en) Use of neurosteroids to treat neuropathic pain
JPH04352720A (ja) 癌患者用アミノ酸製剤
WO2017202297A1 (zh) 三乙酰基-3-羟基苯基腺苷在治疗血管炎症或改善血管内皮功能中的应用
JP4883753B2 (ja) 医薬
TW200800165A (en) Breast cancer cell inhibiting agents
WO2005074911A1 (ja) プロテインキナーゼc活性化剤
JP2007137838A (ja) オキソリン化合物を有効成分とする医薬
JP2014024807A (ja) Ｔｒｐｖ４活性抑制剤

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20090325