CN100462351C - 对α2δ-蛋白质具有亲和性的氨基酸 - Google Patents

对α2δ-蛋白质具有亲和性的氨基酸 Download PDF

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Publication number
CN100462351C
CN100462351C CNB038112698A CN03811269A CN100462351C CN 100462351 C CN100462351 C CN 100462351C CN B038112698 A CNB038112698 A CN B038112698A CN 03811269 A CN03811269 A CN 03811269A CN 100462351 C CN100462351 C CN 100462351C
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methyl
amino
acid
purposes
phenyl
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Expired - Fee Related
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Chinese (zh)
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CN1653036A (zh
Inventor
南希·S·巴塔
雅各布·B·施瓦茨
安德鲁·J·索普
戴维·J·伍斯特罗
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Warner Lambert Co LLC
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Warner Lambert Co LLC
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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07C2601/14—The ring being saturated
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CNB038112698A 2002-03-28 2003-03-17 对α2δ-蛋白质具有亲和性的氨基酸 Expired - Fee Related CN100462351C (zh)

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US36841302P 2002-03-28 2002-03-28
US60/368,413 2002-03-28

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CN1653036A CN1653036A (zh) 2005-08-10
CN100462351C true CN100462351C (zh) 2009-02-18

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CNA2006100070283A Pending CN1817854A (zh) 2002-03-28 2003-03-17 对α2δ－蛋白质具有亲和性的氨基酸

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DE10129693A1 (de) * 2001-06-22 2003-01-02 Jan Loock Verfahren zur extrakorporalen qualitativen und/oder quantitativen Erfassung neurotoxischer Substanzen im Blutplasma eines Individuums
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
WO2005002585A1 (en) * 2003-07-02 2005-01-13 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
OA13258A (en) * 2003-09-25 2007-01-31 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
CA2539976A1 (en) * 2003-09-25 2005-04-07 Warner-Lambert Company Llc Therapeutic beta aminoacids
ES2292107T3 (es) * 2004-03-12 2008-03-01 Warner-Lambert Company Llc Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina.
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