CN100439336C - 制备环状苯甲脒衍生物的方法 - Google Patents

制备环状苯甲脒衍生物的方法 Download PDF

Info

Publication number
CN100439336C
CN100439336C CNB2004800105008A CN200480010500A CN100439336C CN 100439336 C CN100439336 C CN 100439336C CN B2004800105008 A CNB2004800105008 A CN B2004800105008A CN 200480010500 A CN200480010500 A CN 200480010500A CN 100439336 C CN100439336 C CN 100439336C
Authority
CN
China
Prior art keywords
compound
expression
salt
formula
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800105008A
Other languages
English (en)
Chinese (zh)
Other versions
CN1777583A (zh
Inventor
下村直之
佐生学
栢野明生
吉泽一洋
辻井昌彦
黑田浩史
布留川健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R&amp D Management Co Ltd
Original Assignee
Sanitary Material R&d Management Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanitary Material R&d Management Co ltd filed Critical Sanitary Material R&d Management Co ltd
Publication of CN1777583A publication Critical patent/CN1777583A/zh
Application granted granted Critical
Publication of CN100439336C publication Critical patent/CN100439336C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
CNB2004800105008A 2003-02-19 2004-02-10 制备环状苯甲脒衍生物的方法 Expired - Fee Related CN100439336C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003040949 2003-02-19
JP040949/2003 2003-02-19

Publications (2)

Publication Number Publication Date
CN1777583A CN1777583A (zh) 2006-05-24
CN100439336C true CN100439336C (zh) 2008-12-03

Family

ID=32958626

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800105008A Expired - Fee Related CN100439336C (zh) 2003-02-19 2004-02-10 制备环状苯甲脒衍生物的方法

Country Status (10)

Country Link
US (1) US7375236B2 (cg-RX-API-DMAC7.html)
EP (2) EP2444393A1 (cg-RX-API-DMAC7.html)
JP (1) JP4549970B2 (cg-RX-API-DMAC7.html)
KR (1) KR20050104376A (cg-RX-API-DMAC7.html)
CN (1) CN100439336C (cg-RX-API-DMAC7.html)
AU (1) AU2004218187C1 (cg-RX-API-DMAC7.html)
CA (1) CA2515715C (cg-RX-API-DMAC7.html)
IL (1) IL170175A (cg-RX-API-DMAC7.html)
TW (1) TW200500340A (cg-RX-API-DMAC7.html)
WO (1) WO2004078721A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106905388A (zh) * 2017-02-16 2017-06-30 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040242627A1 (en) 2001-04-19 2004-12-02 Shuichi Suzuki 2-Iminoimidazole derivatives (1)
EP2444393A1 (en) 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
EP1787983B1 (en) 2004-08-16 2011-03-09 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
CN101811940B (zh) 2004-08-17 2012-01-04 卫材R&D管理有限公司 用于制备二溴氟苯衍生物的中间体化合物
US7786330B2 (en) 2005-02-28 2010-08-31 Asahi Glass Company, Limited Process for producing 1,2-dialkoxy-3-fluorobenzene
DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
JPWO2008023438A1 (ja) 2006-08-25 2010-01-07 旭硝子株式会社 １，２−ジアルコキシ−３−フルオロベンゼンの製造方法
KR20100119862A (ko) 2008-01-11 2010-11-11 에자이 알앤드디 매니지먼트 가부시키가이샤 의약 조성물, 의약 조성물 제조를 위한 2-이미노피롤리딘 유도체의 사용 및 심질환의 치료용 또는 개선용 키트
PL2240486T3 (pl) 2008-02-05 2016-02-29 Sanofi Sa Sole triazoliowe jako inhibitory PAR1, ich wytwarzanie i zastosowanie jako lek
DK2242740T3 (da) 2008-02-05 2013-03-25 Sanofi Sa SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler
AU2009211887B2 (en) 2008-02-05 2013-09-19 Sanofi Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
CA2769045A1 (en) 2009-05-04 2010-11-11 University Of Maryland, Baltimore Method for binding site identification by molecular dynamics simulation (silcs:site identification by ligand competitive saturation)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
US20150095007A1 (en) * 2012-03-20 2015-04-02 University Of Maryland, Baltimore Site-specific fragment identification guided by single-step free energy perturbation calculations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085855A1 (fr) * 2001-04-19 2002-10-31 Eisai Co., Ltd. Derives de 2-iminopyrrolidine

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) * 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
FR8129M (cg-RX-API-DMAC7.html) 1968-08-02 1970-08-10
JPS4842875B1 (cg-RX-API-DMAC7.html) 1969-01-29 1973-12-14
US3717648A (en) * 1970-10-21 1973-02-20 Sterling Drug Inc 1-phenyl-azacarbocyclic-2-imines
US4118504A (en) * 1970-11-05 1978-10-03 Carlo Erba Isoindoline derivatives for treating pain
DE2154525A1 (de) 1970-11-05 1972-06-15 Carlo Erba S.P.A., Mailand (Italien) Isoindolinderivate und Verfahren zu ihrer Herstellung
GB1344663A (en) 1970-11-10 1974-01-23 Erba Carlo Spa Isoindoline compounds
ZA722407B (en) * 1971-05-13 1973-01-31 Richardson Merrell Inc Substituted cycloalkyl lactamimides
JPS512868B2 (cg-RX-API-DMAC7.html) 1971-09-30 1976-01-29
US3773788A (en) * 1971-11-26 1973-11-20 Standard Oil Co Method for the preparation of n-(substituted phenyl)-2-iminopyrrolidines
US3920688A (en) * 1973-02-05 1975-11-18 Monsanto Co 2-imino derivatives of substituted imidazoles
US3859302A (en) * 1973-02-05 1975-01-07 Monsanto Co Preparation of 2-imino-imidazole derivatives
US3904395A (en) * 1973-02-05 1975-09-09 Monsanto Co 2-Imino derivatives of substituted imidazoles
US3887577A (en) * 1973-07-05 1975-06-03 Monsanto Co Process for the preparation of 2-imino derivatives of substituted imidazoles
DE2430354A1 (de) 1974-06-25 1976-01-15 Basf Ag Neue substituierte 1-amino-isoindole, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zubereitungen
JPS5122720A (ja) 1974-08-19 1976-02-23 Sumitomo Chemical Co Jukyobaifuanteigatadofutaroshianinganryono seizoho
GB1476949A (en) * 1974-11-20 1977-06-16 Wyeth John & Brother Ltd Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
GB1484615A (en) 1974-11-23 1977-09-01 Lepetit Spa Tricyclic n-containing derivatives
US4004016A (en) * 1975-08-11 1977-01-18 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
JPS5371063A (en) 1976-12-03 1978-06-24 Grelan Pharmaceut Co Ltd Preparation of 4-(1-9x9-2-isoindolinyl)acetophenone
US4521793A (en) * 1982-02-27 1985-06-04 Asahi Kasei Kogyo Kabushiki Kaisha Coloring method and color-forming material
FR2550192B1 (fr) * 1983-08-03 1986-04-04 Sanofi Sa Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs
JPS6222760A (ja) 1985-07-24 1987-01-30 Sankyo Co Ltd イソインドリン誘導体及びそれを有効成分とする農園芸用殺菌剤
US5002941A (en) 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
JP2805867B2 (ja) 1989-07-19 1998-09-30 日本電気株式会社 電子写真感光体
CA2048003A1 (en) * 1990-08-21 1992-02-22 Serge Burner Tricyclic pyridone derivatives
US5258387A (en) * 1990-08-21 1993-11-02 Hoffmann-La Roche Inc. Tricyclic pyridone derivatives
WO1993019066A1 (fr) 1992-03-17 1993-09-30 Nippon Shinyaku Co., Ltd. Derive de l'imidazopyridine et medicament
CN1037842C (zh) 1993-02-26 1998-03-25 大制药株式会社 取代的噻唑烷衍生物及其药物组合物和用途
JPH0732103A (ja) 1993-07-19 1995-02-03 Sumitomo Metal Ind Ltd 溶融金属の鋳造用ノズル
US5854234A (en) * 1993-10-21 1998-12-29 G. D. Searle & Co. Amidino dervatives useful as nitric oxide synthase inhibitors
AU692583B2 (en) * 1994-08-12 1998-06-11 Toyama Chemical Co. Ltd. Novel quinolone- or naphthyridonecarboxylic acid derivative or salt thereof
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
JP3666922B2 (ja) 1995-02-21 2005-06-29 山本化成株式会社 カルボン酸塩、その製造方法および該塩化合物を用いる感熱記録材料
TW401408B (en) 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
WO1998000408A1 (en) 1996-07-02 1998-01-08 Novartis Ag N-phenylimino heterocyclic derivatives and their use as herbicides
JP2707239B2 (ja) 1996-07-26 1998-01-28 日本バイエルアグロケム株式会社 シアノアルキルーヘテロ環式化合物及び殺虫剤
KR100520002B1 (ko) * 1996-10-02 2005-10-13 얀센 파마슈티카 엔.브이. Ｐｄｅ ｉｖ 를 억제하는 2-시아노이미노이미다졸 유도체
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
FR2757053B1 (fr) * 1996-12-12 1999-01-22 Oreal Utilisation de derives de la di-imino-isoindoline ou de la 3-amino-isoindolone pour la teinture des fibres keratiniques et compositions de teinture les renfermant
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
CO4990946A1 (es) 1997-11-25 2000-12-26 Schering Corp Antagonistas del receptor de trombina
US6124507A (en) * 1997-12-10 2000-09-26 Union Carbide Chemicals & Plastics Technology Corporation Electron donors
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
EP1060166A1 (de) 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
DE69924493T2 (de) 1998-07-02 2005-09-15 Neurosearch A/S Kaliumkanal-blockierende mittel
EP1176141A4 (en) 1999-03-05 2002-08-14 Suntory Ltd HETEROCYCLIC COMPOUNDS HAVING AN EFFECT ACTIVATING THE NICOTINE ACETYL CHOLINE -g (a) 4-g (b) 2-RECEPTOR
US6376530B1 (en) * 1999-05-10 2002-04-23 Merck & Co., Inc. Cyclic amidines useful as NMDA NR2B antagonists
JP2002155060A (ja) 2000-11-15 2002-05-28 Japan Tobacco Inc イミダゾール化合物及びその用途
JP4151310B2 (ja) 2001-05-22 2008-09-17 Ｄｉｃ株式会社 硬化性不飽和樹脂組成物
US6726177B2 (en) * 2002-07-02 2004-04-27 Value Valves Co., Ltd. Valve with improved junk ring structure
JP3725843B2 (ja) * 2002-07-05 2005-12-14 ローム株式会社 反射型センサ
EP2444393A1 (en) 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
EP1787983B1 (en) 2004-08-16 2011-03-09 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
CN101811940B (zh) 2004-08-17 2012-01-04 卫材R&D管理有限公司 用于制备二溴氟苯衍生物的中间体化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085855A1 (fr) * 2001-04-19 2002-10-31 Eisai Co., Ltd. Derives de 2-iminopyrrolidine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106905388A (zh) * 2017-02-16 2017-06-30 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

Also Published As

Publication number Publication date
US20060058370A1 (en) 2006-03-16
CA2515715A1 (en) 2004-09-16
JP4549970B2 (ja) 2010-09-22
AU2004218187B2 (en) 2010-09-30
KR20050104376A (ko) 2005-11-02
JPWO2004078721A1 (ja) 2006-06-08
CA2515715C (en) 2012-05-08
US7375236B2 (en) 2008-05-20
TWI305774B (cg-RX-API-DMAC7.html) 2009-02-01
AU2004218187A1 (en) 2004-09-16
EP2444393A1 (en) 2012-04-25
EP1602646A1 (en) 2005-12-07
HK1091494A1 (zh) 2007-01-19
AU2004218187C1 (en) 2011-04-07
TW200500340A (en) 2005-01-01
IL170175A (en) 2010-12-30
EP1602646A4 (en) 2010-07-28
CN1777583A (zh) 2006-05-24
WO2004078721A1 (ja) 2004-09-16

Similar Documents

Publication Publication Date Title
CN100439336C (zh) 制备环状苯甲脒衍生物的方法
KR102041442B1 (ko) 중수소화된 디아미노피리미딘 화합물 및 이 화합물을 함유하는 약물 조성물
TWI411602B (zh) 製造整合酶抑制劑的方法及彼所用的中間物
CN104159898A (zh) 用于制备取代的5-氟-1h-吡唑并吡啶类化合物的方法
WO2023198191A1 (zh) 一种六元并六元化合物、制备方法、药物组合物和应用
TWI895686B (zh) 合成喹唑啉化合物之方法
Dabiri et al. Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones
ES2863923T3 (es) Formas cristalinas de la sal mesilato de derivado de piridinilaminopirimidina, métodos de preparación para las mismas, y aplicaciones de las mismas
KR20180100211A (ko) 퀴나졸리논 유도체, 이의 제조방법, 약학 조성물 및 적용
CN105693746B (zh) 噁唑烷酮类化合物的制备方法及其中间体
TW202024059A (zh) 吡啶並〔２，３－ｄ〕嘧啶－７（８ｈ）－酮的合成
JP2024501429A (ja) プラルセチニブの調製方法
CN111825700A (zh) 一种吡嗪并噻唑类化合物、其应用及含其的药物组合物
CN111440142A (zh) 吗啉基喹唑啉化合物的制备方法及其中间体
WO2014024950A1 (ja) １，４－ベンゾオキサジン化合物の製法
JP7241682B2 (ja) 重水素化イミダゾリジンジオン系化合物を調製する方法
JPWO2008093853A1 (ja) マクロライド系化合物の固体およびその製造法並びにその医薬組成物
JP5305593B2 (ja) 高化学的ｒ−５−（２−（２−エトキシフェノキシエチルアミノ）プロピル）−２−メトキシベンゼンスルホンアミド塩酸塩の調製
JP2022511303A (ja) 免疫調節剤、並びにその組成物及び調製方法
CN119836419A (zh) 取代的四氢芳庚并[e]吲哚衍生物、其制备方法及其治疗用途
HK1091494B (en) Methods for producing cyclic benzamidine derivatives
WO2017147893A1 (zh) 泊沙康唑、组合物、中间体及其制备方法和用途
CN115677666A (zh) 一种吲哚联嘧啶类化合物、其中间体、制备方法及其应用
JPH11147879A (ja) 非対称４，６−ビス（アリールオキシ）ピリミジン化合物の改良された製造方法
WO2022260062A1 (ja) ジヒドロピリダジン－３，５－ジオン誘導体の製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1091494

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: WEI CAI & D MANAGEMENT CO., LTD.

Free format text: FORMER OWNER: EISAI CO., LTD.

Effective date: 20070622

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20070622

Address after: Tokyo, Japan, Japan

Applicant after: R&amp D Management Co., Ltd.

Address before: Tokyo, Japan, Japan

Applicant before: Eisai co., Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1091494

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20081203

Termination date: 20140210