AU2004218187C1 - Methods for producing cyclic benzamidine derivatives - Google Patents

Methods for producing cyclic benzamidine derivatives Download PDF

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Publication number
AU2004218187C1
AU2004218187C1 AU2004218187A AU2004218187A AU2004218187C1 AU 2004218187 C1 AU2004218187 C1 AU 2004218187C1 AU 2004218187 A AU2004218187 A AU 2004218187A AU 2004218187 A AU2004218187 A AU 2004218187A AU 2004218187 C1 AU2004218187 C1 AU 2004218187C1
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formula
eto
compound represented
group
compound
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AU2004218187A
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AU2004218187B2 (en
AU2004218187A1 (en
Inventor
Ken Furukawa
Akio Kayano
Hiroshi Kuroda
Manabu Sasho
Naoyuki Shimomura
Masahiko Tsujii
Kazuhiro Yoshizawa
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Assigned to EISAI R&D MANAGEMENT CO., LTD. reassignment EISAI R&D MANAGEMENT CO., LTD. Request for Assignment Assignors: EISAI CO., LTD
Publication of AU2004218187B2 publication Critical patent/AU2004218187B2/en
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Publication of AU2004218187C1 publication Critical patent/AU2004218187C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
AU2004218187A 2003-02-19 2004-02-10 Methods for producing cyclic benzamidine derivatives Ceased AU2004218187C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003040949 2003-02-19
JP2003-040949 2003-02-19
PCT/JP2004/001396 WO2004078721A1 (ja) 2003-02-19 2004-02-10 環状ベンズアミジン誘導体の製造方法

Publications (3)

Publication Number Publication Date
AU2004218187A1 AU2004218187A1 (en) 2004-09-16
AU2004218187B2 AU2004218187B2 (en) 2010-09-30
AU2004218187C1 true AU2004218187C1 (en) 2011-04-07

Family

ID=32958626

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004218187A Ceased AU2004218187C1 (en) 2003-02-19 2004-02-10 Methods for producing cyclic benzamidine derivatives

Country Status (10)

Country Link
US (1) US7375236B2 (cg-RX-API-DMAC7.html)
EP (2) EP2444393A1 (cg-RX-API-DMAC7.html)
JP (1) JP4549970B2 (cg-RX-API-DMAC7.html)
KR (1) KR20050104376A (cg-RX-API-DMAC7.html)
CN (1) CN100439336C (cg-RX-API-DMAC7.html)
AU (1) AU2004218187C1 (cg-RX-API-DMAC7.html)
CA (1) CA2515715C (cg-RX-API-DMAC7.html)
IL (1) IL170175A (cg-RX-API-DMAC7.html)
TW (1) TW200500340A (cg-RX-API-DMAC7.html)
WO (1) WO2004078721A1 (cg-RX-API-DMAC7.html)

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US20040242627A1 (en) 2001-04-19 2004-12-02 Shuichi Suzuki 2-Iminoimidazole derivatives (1)
EP2444393A1 (en) 2003-02-19 2012-04-25 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
EP1787983B1 (en) 2004-08-16 2011-03-09 Eisai R&D Management Co., Ltd. Methods for producing isoindole derivatives
CN101811940B (zh) 2004-08-17 2012-01-04 卫材R&D管理有限公司 用于制备二溴氟苯衍生物的中间体化合物
US7786330B2 (en) 2005-02-28 2010-08-31 Asahi Glass Company, Limited Process for producing 1,2-dialkoxy-3-fluorobenzene
DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
JPWO2008023438A1 (ja) 2006-08-25 2010-01-07 旭硝子株式会社 １，２−ジアルコキシ−３−フルオロベンゼンの製造方法
KR20100119862A (ko) 2008-01-11 2010-11-11 에자이 알앤드디 매니지먼트 가부시키가이샤 의약 조성물, 의약 조성물 제조를 위한 2-이미노피롤리딘 유도체의 사용 및 심질환의 치료용 또는 개선용 키트
PL2240486T3 (pl) 2008-02-05 2016-02-29 Sanofi Sa Sole triazoliowe jako inhibitory PAR1, ich wytwarzanie i zastosowanie jako lek
DK2242740T3 (da) 2008-02-05 2013-03-25 Sanofi Sa SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler
AU2009211887B2 (en) 2008-02-05 2013-09-19 Sanofi Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
US20100056519A1 (en) * 2008-07-15 2010-03-04 Serebruany Victor L Composition and method for reducing platelet activation and for the treatment of thrombotic events
CA2769045A1 (en) 2009-05-04 2010-11-11 University Of Maryland, Baltimore Method for binding site identification by molecular dynamics simulation (silcs:site identification by ligand competitive saturation)
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
CN102757396B (zh) * 2011-04-28 2014-10-15 天津药物研究院 含苯并五元杂环的环外亚胺化合物、其制备方法和用途
US20150095007A1 (en) * 2012-03-20 2015-04-02 University Of Maryland, Baltimore Site-specific fragment identification guided by single-step free energy perturbation calculations
CN106905388B (zh) * 2017-02-16 2021-01-01 重庆西南制药二厂有限责任公司 一种天麻素的合成方法

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Also Published As

Publication number Publication date
CN100439336C (zh) 2008-12-03
US20060058370A1 (en) 2006-03-16
CA2515715A1 (en) 2004-09-16
JP4549970B2 (ja) 2010-09-22
AU2004218187B2 (en) 2010-09-30
KR20050104376A (ko) 2005-11-02
JPWO2004078721A1 (ja) 2006-06-08
CA2515715C (en) 2012-05-08
US7375236B2 (en) 2008-05-20
TWI305774B (cg-RX-API-DMAC7.html) 2009-02-01
AU2004218187A1 (en) 2004-09-16
EP2444393A1 (en) 2012-04-25
EP1602646A1 (en) 2005-12-07
HK1091494A1 (zh) 2007-01-19
TW200500340A (en) 2005-01-01
IL170175A (en) 2010-12-30
EP1602646A4 (en) 2010-07-28
CN1777583A (zh) 2006-05-24
WO2004078721A1 (ja) 2004-09-16

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Owner name: EISAI R&D MANAGEMENT CO., LTD.

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