CN100436407C - 大叶蒟有效部位的制备及其在医疗、保健领域的应用 - Google Patents
大叶蒟有效部位的制备及其在医疗、保健领域的应用 Download PDFInfo
- Publication number
- CN100436407C CN100436407C CNB031159117A CN03115911A CN100436407C CN 100436407 C CN100436407 C CN 100436407C CN B031159117 A CNB031159117 A CN B031159117A CN 03115911 A CN03115911 A CN 03115911A CN 100436407 C CN100436407 C CN 100436407C
- Authority
- CN
- China
- Prior art keywords
- preparation
- effective part
- extract
- piper laetispicum
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 241000746610 Piper laetispicum Species 0.000 title abstract 3
- 238000013160 medical therapy Methods 0.000 title 1
- 239000000284 extract Substances 0.000 claims abstract description 14
- -1 amide alkaloid Chemical class 0.000 claims abstract description 11
- 229930013930 alkaloid Natural products 0.000 claims abstract description 8
- 239000011347 resin Substances 0.000 claims abstract description 8
- 229920005989 resin Polymers 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 239000003463 adsorbent Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims 1
- 239000000287 crude extract Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 3
- 230000008451 emotion Effects 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
- 239000000935 antidepressant agent Substances 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 230000001519 thymoleptic effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 208000024732 dysthymic disease Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 229940035613 prozac Drugs 0.000 description 4
- 208000017194 Affective disease Diseases 0.000 description 3
- 241000790917 Dioxys <bee> Species 0.000 description 3
- 208000019022 Mood disease Diseases 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-N trans-cinnamic acid Chemical compound OC(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-N 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000013210 evaluation model Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031159117A CN100436407C (zh) | 2003-03-20 | 2003-03-20 | 大叶蒟有效部位的制备及其在医疗、保健领域的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031159117A CN100436407C (zh) | 2003-03-20 | 2003-03-20 | 大叶蒟有效部位的制备及其在医疗、保健领域的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1532182A CN1532182A (zh) | 2004-09-29 |
CN100436407C true CN100436407C (zh) | 2008-11-26 |
Family
ID=34284491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031159117A Expired - Lifetime CN100436407C (zh) | 2003-03-20 | 2003-03-20 | 大叶蒟有效部位的制备及其在医疗、保健领域的应用 |
Country Status (1)
Country | Link |
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CN (1) | CN100436407C (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100356940C (zh) * | 2004-12-01 | 2007-12-26 | 蒋毅 | 制备大叶蒟提取物的方法、提取物及其应用 |
CN102240281B (zh) * | 2010-05-12 | 2014-05-14 | 天士力制药集团股份有限公司 | 5′-甲氧基-3′,4′-次甲二氧基桂皮酸异丁基酰胺在制备抗抑郁药物中的应用 |
CN102429962A (zh) * | 2010-09-29 | 2012-05-02 | 王全福 | 大叶蒟提取物的制备方法、提取物及其应用 |
CN102475746B (zh) * | 2010-11-23 | 2015-05-06 | 天士力制药集团股份有限公司 | 大叶蒟有效组分的制备方法 |
CN102850317B (zh) * | 2011-06-27 | 2017-02-08 | 天士力制药集团股份有限公司 | 一种取代桂皮酰胺衍生物、制备方法及其应用 |
CN103063789B (zh) * | 2011-10-19 | 2016-06-08 | 天士力制药集团股份有限公司 | 同时检测大叶蒟中12个酰胺类生物碱的液相分析方法 |
CN113209165A (zh) * | 2017-11-01 | 2021-08-06 | 苏州颐华生物医药技术股份有限公司 | 一种大叶蒟提取物及其制备方法与应用 |
CN107884488B (zh) * | 2017-11-01 | 2019-05-03 | 苏州颐华生物医药技术股份有限公司 | 一种大叶蒟提取物、药材及其相关产品中抗抑郁有效成分的含量测定方法 |
CN112156134B (zh) * | 2020-10-29 | 2022-04-08 | 健民药业集团股份有限公司 | 大叶蒟提取物用于制备透明质酸酶抑制剂的用途 |
CN112107606B (zh) * | 2020-11-05 | 2022-06-28 | 陈乃宏 | 香青藤或其提取物在制备抗抑郁药物中的用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291481A (zh) * | 2000-07-14 | 2001-04-18 | 复旦大学 | 中草药大叶蒟及其提取物在制备药物组合物中的应用 |
CN1389462A (zh) * | 2002-07-12 | 2003-01-08 | 复旦大学 | 大叶蒟素及其同系物,和在制备药物组合物中的应用 |
-
2003
- 2003-03-20 CN CNB031159117A patent/CN100436407C/zh not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291481A (zh) * | 2000-07-14 | 2001-04-18 | 复旦大学 | 中草药大叶蒟及其提取物在制备药物组合物中的应用 |
WO2002022144A1 (fr) * | 2000-07-14 | 2002-03-21 | Fudan University | Medicament chinois naturel a base de piper laetispicum c. dc et applications des extraits de piper laetispicum c. dc dans la preparation d'une composition pharmaceutique |
CN1389462A (zh) * | 2002-07-12 | 2003-01-08 | 复旦大学 | 大叶蒟素及其同系物,和在制备药物组合物中的应用 |
Also Published As
Publication number | Publication date |
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CN1532182A (zh) | 2004-09-29 |
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Owner name: SHANGHAI KAIRUN BIOMEDICAL CO. LTD Free format text: FORMER OWNER: HAITIAN MEDICINE SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD., SHANGHAI Effective date: 20050325 |
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Effective date of registration: 20050325 Address after: Shanghai city GuoShouJing Road No. 351 Building No. 2 room 678-09 Applicant after: SHANGHAI KAIRUN BIO-PHARMACEUTICAL Co.,Ltd. Address before: Shanghai city Ruijin road Haixing Plaza No. 1 16A Applicant before: Shanghai Haitian Medical Technology Development Co.,Ltd. |
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Owner name: JIANG YI Free format text: FORMER OWNER: SHANGHAI KAIRUN BIOMEDICAL CO. LTD Effective date: 20080613 |
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Effective date of registration: 20080613 Address after: Shanghai city of Yokohama Road 206 Lane 5 Building Room 301 post encoding: 200081 Applicant after: Jiang Yi Address before: Shanghai city GuoShouJing Road No. 351 Building No. 2 room 678-09 post encoding: 201203 Applicant before: SHANGHAI KAIRUN BIO-PHARMACEUTICAL Co.,Ltd. |
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Owner name: SUZHOU YIHUA BIOMEDICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: JIANG YI Effective date: 20150403 |
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Free format text: CORRECT: ADDRESS; FROM: 200081 HONGKOU, SHANGHAI TO: 215123 SUZHOU, JIANGSU PROVINCE |
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Effective date of registration: 20150403 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 No. 218 BioBAY A2 building room 230-230A Patentee after: Suzhou Yihua biological medicine technology Limited by Share Ltd. Address before: 200081 Shanghai City Yokohama Road 206 Lane 5 Building Room 301 Patentee before: Jiang Yi |
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Effective date of registration: 20190111 Address after: No. 107, No. 2 Building, 918 Lane, Wenshui East Road, Hongkou District, Shanghai, 2004 Patentee after: Shanghai Yiling Investment Management Consulting Co.,Ltd. Address before: Room 230-230A, A2 Floor, Bio-nano Park, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Patentee before: Suzhou Yihua biological medicine technology Limited by Share Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190902 Address after: No. 107, No. 2 Building, 918 Lane, Wenshui East Road, Hongkou District, Shanghai, 2004 Patentee after: Shanghai Yihua Biopharmaceutical Co.,Ltd. Address before: No. 107, No. 2 Building, 918 Lane, Wenshui East Road, Hongkou District, Shanghai, 2004 Patentee before: Shanghai Yiling Investment Management Consulting Co.,Ltd. |
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TR01 | Transfer of patent right | ||
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Effective date of registration: 20220831 Address after: 200434 room 107, building 2, Lane 918, Wenshui East Road, Hongkou District, Shanghai Patentee after: Shanghai Yida Biopharmaceutical Co.,Ltd. Address before: 200434 room 107, building 2, Lane 918, Wenshui East Road, Hongkou District, Shanghai Patentee before: Shanghai Yihua Biopharmaceutical Co.,Ltd. |
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CX01 | Expiry of patent term |
Granted publication date: 20081126 |
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CX01 | Expiry of patent term |