CN100430398C - 二氮杂二环中枢神经系统活性剂 - Google Patents

二氮杂二环中枢神经系统活性剂 Download PDF

Info

Publication number
CN100430398C
CN100430398C CNB018117112A CN01811711A CN100430398C CN 100430398 C CN100430398 C CN 100430398C CN B018117112 A CNB018117112 A CN B018117112A CN 01811711 A CN01811711 A CN 01811711A CN 100430398 C CN100430398 C CN 100430398C
Authority
CN
China
Prior art keywords
pyridyl
cis
compound
chloro
pyrroles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018117112A
Other languages
English (en)
Chinese (zh)
Other versions
CN1440410A (zh
Inventor
M·R·施林普夫
K·R·蒂特杰
R·B·图彭斯
纪建国
A·巴沙
W·H·布涅尔莱
J·F·达南
J·M·佩斯
K·B·西普皮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/833,914 external-priority patent/US6809105B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CN1440410A publication Critical patent/CN1440410A/zh
Application granted granted Critical
Publication of CN100430398C publication Critical patent/CN100430398C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB018117112A 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂 Expired - Fee Related CN100430398C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55994300A 2000-04-27 2000-04-27
US09/559,943 2000-04-27
US09/833,914 2001-04-12
US09/833,914 US6809105B2 (en) 2000-04-27 2001-04-12 Diazabicyclic central nervous system active agents

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN2012103509141A Division CN102863441A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CNB2005100778625A Division CN100355755C (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CN2010102450796A Division CN101935322A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CN2008102138788A Division CN101357915B (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂

Publications (2)

Publication Number Publication Date
CN1440410A CN1440410A (zh) 2003-09-03
CN100430398C true CN100430398C (zh) 2008-11-05

Family

ID=27072208

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB018117112A Expired - Fee Related CN100430398C (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CN2012103509141A Pending CN102863441A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CN2010102450796A Pending CN101935322A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2012103509141A Pending CN102863441A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂
CN2010102450796A Pending CN101935322A (zh) 2000-04-27 2001-04-27 二氮杂二环中枢神经系统活性剂

Country Status (22)

Country Link
EP (3) EP1284976A2 (https=)
JP (2) JP4981232B2 (https=)
KR (4) KR100947187B1 (https=)
CN (3) CN100430398C (https=)
AR (1) AR030421A1 (https=)
AU (2) AU2001266559C1 (https=)
BG (2) BG66151B1 (https=)
BR (1) BR0107246A (https=)
CA (2) CA2407094C (https=)
CZ (4) CZ302072B6 (https=)
HK (1) HK1054375A1 (https=)
HU (1) HUP0300602A3 (https=)
IL (3) IL152231A0 (https=)
MX (1) MXPA02010594A (https=)
MY (3) MY145722A (https=)
NO (1) NO324250B1 (https=)
NZ (1) NZ521734A (https=)
PE (1) PE20011305A1 (https=)
PL (2) PL358340A1 (https=)
SK (2) SK287658B6 (https=)
TW (4) TWI357903B (https=)
WO (1) WO2001081347A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60037345T2 (de) 1999-12-10 2008-11-13 Pfizer Products Inc., Groton Pyrrolo(2,3-d)pyrimidin-Verbindungen
SE0100326D0 (sv) * 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
AU2003278529A1 (en) * 2002-11-21 2004-06-15 Pfizer Products Inc. 3-amino-piperidine derivatives and processes for their preparation
US20040242641A1 (en) 2003-05-27 2004-12-02 Buckley Michael J. (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US7354937B2 (en) 2004-05-21 2008-04-08 Abbott Laboratories (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane
US20050261348A1 (en) * 2004-05-21 2005-11-24 Buckley Michael J (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
GB0322140D0 (en) * 2003-09-22 2003-10-22 Pfizer Ltd Combinations
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050171079A1 (en) 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
CA2565211A1 (en) 2004-04-29 2005-11-24 Abbott Laboratories Amino-tetrazoles analogues and methods of use
US7351833B2 (en) 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
US7425556B2 (en) * 2005-12-20 2008-09-16 Astrazeneca Ab Compounds and uses thereof
US20070184490A1 (en) * 2006-01-17 2007-08-09 Marleen Verlinden Neuronal nicotinic receptor ligands and their use
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2008028903A2 (en) 2006-09-04 2008-03-13 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
EP2129672B1 (en) 2007-03-23 2011-05-18 Abbott Laboratories Azaadamantane ester and carbamate derivatives and methods of use thereof
CN101809021B (zh) 2007-09-11 2013-04-24 雅培制药有限公司 八氢-吡咯并[3,4-b]吡咯n-氧化物
AR069126A1 (es) 2007-10-31 2009-12-30 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
WO2009067586A1 (en) * 2007-11-21 2009-05-28 Abbott Laboratories Biaryl substituted diazabicycloalkane derivatives
CA2707671C (en) 2007-12-07 2016-02-02 Abbott Gmbh & Co. Kg 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
CA2707669C (en) 2007-12-07 2016-07-05 Wilfried Braje 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
US8703775B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
PL2245028T3 (pl) 2007-12-18 2012-07-31 Actelion Pharmaceuticals Ltd Pochodne 5-aminocyklilometyloksazolidyn-2-onu
MY157597A (en) 2008-04-11 2016-06-30 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
US8148408B2 (en) 2008-05-09 2012-04-03 Abbott Laboratories Selective substituted pyridine ligands for neuronal nicotinic receptors
US8263632B2 (en) * 2009-03-24 2012-09-11 Vertex Pharmaceuticals Incoporated Aminopyridine derivatives having Aurora A selective inhibitory action
US8399465B2 (en) 2009-05-14 2013-03-19 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase
EP2435080A2 (en) 2009-05-29 2012-04-04 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
WO2010151815A2 (en) 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
NZ598985A (en) 2009-09-04 2013-07-26 Biogen Idec Inc Bruton's tyrosine kinase inhibitors
WO2011050202A1 (en) * 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
JP5847087B2 (ja) * 2009-10-23 2016-01-20 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての縮合複素環式化合物
ME03452B (me) 2009-10-23 2020-01-20 Janssen Pharmaceutica Nv Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
KR101655787B1 (ko) 2014-05-08 2016-09-22 대우조선해양 주식회사 선박의 하이브리드 공기조화시스템 및 그 방법, 그리고 이를 포함하는 선박 또는 해양구조물
KR20160021679A (ko) 2014-08-18 2016-02-26 대우조선해양 주식회사 극저온 환경의 장비용 히팅장치 및 방법 그리고 이를 구비하는 선박
RU2017118562A (ru) 2014-10-31 2018-11-30 Индивиор ЮКей Лимитед Соединения-антагонисты дофаминового d3-рецептора
MD3426251T2 (ro) 2016-03-10 2022-09-30 Janssen Pharmaceutica Nv Metode de tratament al depresiei utilizând antagoniști ai receptorului orexină-2
JP7214632B2 (ja) 2016-07-21 2023-01-30 バイオジェン エムエー インク． ブルトン型チロシンキナーゼ阻害剤のコハク酸塩形態および組成物
US11266640B2 (en) * 2017-09-20 2022-03-08 Hangzhou Innogate Pharma Co., Ltd. Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
WO2020100011A1 (en) 2018-11-14 2020-05-22 Janssen Pharmaceutica Nv Improved synthetic methods of making fused heterocyclic compounds as orexin receptor modulators
CN112010859B (zh) * 2019-05-30 2022-07-19 中国科学院上海药物研究所 一种并环化合物、其制备方法和用途
PH12022550295A1 (en) 2019-08-07 2022-11-21 Janssen Pharmaceutica Nv Improved synthetic methods of making (2h-1,2,3-triazol-2-yl)phenyl compounds as orexin receptor modulators
CN112047878B (zh) * 2020-10-15 2022-04-19 郑州猫眼农业科技有限公司 4-溴-6-氯吡啶-2-羧酸的制备方法
WO2024189472A1 (en) 2023-03-14 2024-09-19 Janssen Pharmaceutica Nv Improved synthetic methods of making substituted pyrimidine intermediates for synthesis of orexin receptor modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO1998054181A1 (en) * 1997-05-30 1998-12-03 Neurosearch A/S 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
WO1998054182A1 (en) * 1997-05-30 1998-12-03 Neurosearch A/S 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2079391T3 (es) * 1989-04-17 1996-01-16 Bayer Ag Procedimiento para la obtencion de 2,7-diazabiciclo(3.3.0)octanos.
NL9201810A (nl) 1992-10-19 1994-05-16 Dsm Nv Werkwijze voor de omzetting van een olefine of een olefinemengsel.
CA2112165C (en) 1992-12-25 2003-04-08 Makoto Takemura Bicyclic amine derivatives
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5472958A (en) 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
EP0842178B1 (en) * 1995-07-28 2001-03-28 Abbott Laboratories Furopyridine, thienopyridine, pyrrolopyridine and related pyrimidine, pyridazine and triazine compounds useful in controlling chemical synaptic transmission
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
JPH09172344A (ja) 1995-12-19 1997-06-30 Murata Mfg Co Ltd 圧電共振子
US5733912A (en) 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
GB9722343D0 (en) * 1997-10-22 1997-12-17 British Telecomm Distributed virtual environment
EE04588B1 (et) * 1997-10-27 2006-02-15 Neurosearch A/S Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
WO1999051602A1 (en) * 1998-04-02 1999-10-14 R.J. Reynolds Tobacco Company Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
JP2000026408A (ja) 1998-07-02 2000-01-25 Dai Ichi Seiyaku Co Ltd 対掌体的に純粋なピロリジン誘導体、その塩、それらの製造方法
US6804251B1 (en) 1998-11-12 2004-10-12 Broadcom Corporation System and method for multiplexing data from multiple sources
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
ES2305373T3 (es) * 1999-01-29 2008-11-01 Abbott Laboratories Derivados diazabiciclicos como ligandos del receptor nicotinico de la acetilcolina.
NZ513575A (en) * 1999-05-04 2003-07-25 Neurosearch As Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators
WO2000071534A1 (en) * 1999-05-21 2000-11-30 Abbott Laboratories Heterocyclic substituted aminoazacycles useful as central nervous system agents
US6815438B2 (en) * 1999-12-14 2004-11-09 Neurosearch A/S Heteroaryl-diazabicycloalkanes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO1998054181A1 (en) * 1997-05-30 1998-12-03 Neurosearch A/S 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
WO1998054182A1 (en) * 1997-05-30 1998-12-03 Neurosearch A/S 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS

Also Published As

Publication number Publication date
WO2001081347A3 (en) 2002-01-31
BG66151B1 (bg) 2011-08-31
PE20011305A1 (es) 2001-12-31
BR0107246A (pt) 2002-10-01
MY168244A (en) 2018-10-15
TW200909432A (en) 2009-03-01
CZ302795B6 (cs) 2011-11-16
NO20025107L (no) 2002-12-19
KR20090013833A (ko) 2009-02-05
NO324250B1 (no) 2007-09-17
CZ20023765A3 (cs) 2003-02-12
CA2407094C (en) 2009-11-17
TW201141871A (en) 2011-12-01
HK1054375A1 (zh) 2003-11-28
CN101935322A (zh) 2011-01-05
PL358340A1 (en) 2004-08-09
CA2683045A1 (en) 2001-11-01
HUP0300602A3 (en) 2005-12-28
TWI311137B (en) 2009-06-21
TWI357903B (en) 2012-02-11
BG110620A (bg) 2010-07-30
EP2298775A1 (en) 2011-03-23
CA2407094A1 (en) 2001-11-01
SK287273B6 (sk) 2010-05-07
TW200617013A (en) 2006-06-01
WO2001081347A2 (en) 2001-11-01
KR20090121385A (ko) 2009-11-25
CZ302072B6 (cs) 2010-09-29
IL152231A0 (en) 2003-05-29
AU2001266559C1 (en) 2005-11-17
JP4981232B2 (ja) 2012-07-18
AU2001266559B2 (en) 2005-03-03
CN102863441A (zh) 2013-01-09
IL203035A (en) 2010-12-30
KR100961406B1 (ko) 2010-06-09
NZ521734A (en) 2004-10-29
SK287658B6 (sk) 2011-05-06
IL177316A (en) 2010-06-30
BG107303A (bg) 2003-07-31
EP2295437A1 (en) 2011-03-16
JP2003531210A (ja) 2003-10-21
KR100947187B1 (ko) 2010-03-12
KR100947188B1 (ko) 2010-03-12
PL398491A1 (pl) 2012-06-04
AR030421A1 (es) 2003-08-20
CZ302038B6 (cs) 2010-09-15
JP2012041349A (ja) 2012-03-01
MY145722A (en) 2012-03-30
IL177316A0 (en) 2006-12-10
SK16812002A3 (sk) 2003-04-01
HUP0300602A2 (hu) 2003-06-28
KR100899950B1 (ko) 2009-05-28
MY137020A (en) 2008-12-31
AU6655901A (en) 2001-11-07
NO20025107D0 (no) 2002-10-24
CN1440410A (zh) 2003-09-03
KR20020093955A (ko) 2002-12-16
KR20090071654A (ko) 2009-07-01
TWI323733B (en) 2010-04-21
CZ301324B6 (cs) 2010-01-13
MXPA02010594A (es) 2003-05-14
EP1284976A2 (en) 2003-02-26

Similar Documents

Publication Publication Date Title
CN100430398C (zh) 二氮杂二环中枢神经系统活性剂
US7598236B2 (en) Diazabicyclic central nervous system active agents
CN107849017B (zh) 作为magl抑制剂的1,1,1-三氟-3-羟基丙-2-基氨基甲酸酯衍生物及1,1,1-三氟-4-羟基丁-2-基氨基甲酸酯衍生物
JP2018515612A (ja) 置換キノキサリン誘導体
CN110036004A (zh) 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
ES2226844T3 (es) Aminoazaciclos heterociclicos sustituidos utiles como agentes activos sobre el sistema nervioso central.
CN109153643A (zh) 取代的吲哚mcl-1抑制剂
AU2001266559A1 (en) Diazabicyclic central nervous system active agents
AU2008279759A1 (en) Pyrazolo[1,5-a]pyrimidine derivatives
CN104854092A (zh) 可用作cb2激动剂的吡啶-2-酰胺类
JP2021504380A (ja) Ｐｄｅ１阻害剤としての置換フラノピリミジン化合物
TW201932470A (zh) 具有抗ｒｓｖ活性之吡唑并嘧啶
CN101258154B (zh) 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物
CN118574821A (zh) 化合物以及它们在治疗癌症中的用途
CN101357915B (zh) 二氮杂二环中枢神经系统活性剂
WO2025087274A1 (zh) 氮杂双环类衍生物及其制备方法和用途
HK40010369A (en) 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are jak inhibitors
HK40012363A (en) Inhibitors of cyclin-dependent kinase 7 (cdk7)
HK1204619B (en) 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
HK1204619A1 (en) 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ABBOTT PHARMACEUTICAL CO., LTD.

Free format text: FORMER NAME: ABBOTT LAB

CP01 Change in the name or title of a patent holder

Address after: Illinois State

Patentee after: ABBOTT LABORATORIES

Address before: Illinois State

Patentee before: ABBOTT LABORATORIES

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20081105

Termination date: 20140427