CN100412073C - 新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 - Google Patents
新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 Download PDFInfo
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- CN100412073C CN100412073C CNB038161168A CN03816116A CN100412073C CN 100412073 C CN100412073 C CN 100412073C CN B038161168 A CNB038161168 A CN B038161168A CN 03816116 A CN03816116 A CN 03816116A CN 100412073 C CN100412073 C CN 100412073C
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- methyl
- alkyl
- thiophene
- phenyl
- compound
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D495/04—Ortho-condensed systems
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38313002P | 2002-05-28 | 2002-05-28 | |
| US60/383,130 | 2002-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1665800A CN1665800A (zh) | 2005-09-07 |
| CN100412073C true CN100412073C (zh) | 2008-08-20 |
Family
ID=29584510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038161168A Expired - Fee Related CN100412073C (zh) | 2002-05-28 | 2003-05-28 | 新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7109354B2 (https=) |
| EP (1) | EP1549632A4 (https=) |
| JP (1) | JP2005538953A (https=) |
| KR (1) | KR20050009720A (https=) |
| CN (1) | CN100412073C (https=) |
| AR (1) | AR039891A1 (https=) |
| AU (1) | AU2003251384B2 (https=) |
| BR (1) | BR0311419A (https=) |
| CA (1) | CA2484822A1 (https=) |
| CO (1) | CO5640081A2 (https=) |
| HR (1) | HRP20041220A2 (https=) |
| IL (1) | IL164890A0 (https=) |
| MX (1) | MX249034B (https=) |
| MY (1) | MY137509A (https=) |
| NO (1) | NO20045403L (https=) |
| NZ (1) | NZ537346A (https=) |
| PL (1) | PL372246A1 (https=) |
| RU (1) | RU2359967C2 (https=) |
| TW (1) | TW200406395A (https=) |
| UA (1) | UA80131C2 (https=) |
| WO (1) | WO2003099805A1 (https=) |
| ZA (1) | ZA200408711B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624391A (zh) * | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
| DE10162114A1 (de) * | 2001-12-12 | 2003-06-26 | Schering Ag | Neue Amidin-Derivate und deren Verwendung in Arzneimitteln |
| HRP20041220A2 (hr) | 2002-05-28 | 2006-04-30 | 3-Dimensional Pharmaceuticals | Novi tiofen amidini, njihovi pripravci i postupci liječenja komplementom posredovanih bolesti i stanja |
| US7402608B2 (en) * | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| GB0305575D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| MXPA06015049A (es) | 2004-07-08 | 2007-02-08 | Novo Nordisk As | Marcadores prolongadores de polipeptidos que comprenden una porcion tetrazol. |
| US7662910B2 (en) * | 2004-10-20 | 2010-02-16 | The Regents Of The University Of California | Inhibitors for the soluble epoxide hydrolase |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| BRPI0610283A2 (pt) * | 2005-05-13 | 2010-10-19 | Virochem Pharma Inc | composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica |
| CA2634198C (en) * | 2005-12-20 | 2014-06-03 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CN102532180B (zh) * | 2005-12-30 | 2016-06-29 | 安纳考尔医药公司 | 含硼的小分子 |
| ME02188B (me) | 2006-02-16 | 2016-02-20 | Anacor Pharmaceuticals Inc | Mali molekuli koji sadrže boron kao antiinflamatorni agensi |
| US20080146624A1 (en) * | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
| CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
| PL2148691T3 (pl) | 2007-02-05 | 2015-12-31 | Apellis Pharmaceuticals Inc | Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
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| RU2004138787A (ru) | 2005-07-10 |
| AU2003251384B2 (en) | 2009-01-29 |
| RU2359967C2 (ru) | 2009-06-27 |
| ZA200408711B (en) | 2006-10-25 |
| MX249034B (es) | 2007-09-14 |
| EP1549632A4 (en) | 2005-11-09 |
| MXPA04011671A (es) | 2005-03-07 |
| MY137509A (en) | 2009-02-27 |
| BR0311419A (pt) | 2005-04-05 |
| JP2005538953A (ja) | 2005-12-22 |
| NO20045403L (no) | 2004-12-10 |
| HRP20041220A2 (hr) | 2006-04-30 |
| WO2003099805A1 (en) | 2003-12-04 |
| AR039891A1 (es) | 2005-03-09 |
| TW200406395A (en) | 2004-05-01 |
| CO5640081A2 (es) | 2006-05-31 |
| PL372246A1 (en) | 2005-07-11 |
| NZ537346A (en) | 2006-12-22 |
| US20050234081A1 (en) | 2005-10-20 |
| EP1549632A1 (en) | 2005-07-06 |
| UA80131C2 (en) | 2007-08-27 |
| KR20050009720A (ko) | 2005-01-25 |
| US7109354B2 (en) | 2006-09-19 |
| US20040009995A1 (en) | 2004-01-15 |
| AU2003251384A1 (en) | 2003-12-12 |
| HK1081187A1 (zh) | 2006-05-12 |
| CN1665800A (zh) | 2005-09-07 |
| CA2484822A1 (en) | 2003-12-04 |
| IL164890A0 (en) | 2005-12-18 |
| US7138530B2 (en) | 2006-11-21 |
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