CO5640081A2 - Tiofeno amidinas novedosas, composiciones de esta y metodos para tratar enfermedades y condiciones medianas por complemento - Google Patents

Tiofeno amidinas novedosas, composiciones de esta y metodos para tratar enfermedades y condiciones medianas por complemento

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Publication number
CO5640081A2
CO5640081A2 CO04126948A CO04126948A CO5640081A2 CO 5640081 A2 CO5640081 A2 CO 5640081A2 CO 04126948 A CO04126948 A CO 04126948A CO 04126948 A CO04126948 A CO 04126948A CO 5640081 A2 CO5640081 A2 CO 5640081A2
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Colombia
Prior art keywords
alkyl
phenyl
hydrogen
novedous
amidines
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CO04126948A
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English (en)
Inventor
Heather Rae Hufnagel
Jeremy M Travnis
Shelley K Ballentine
Maxwell D Cummings
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Dimensional Pharm Inc
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Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of CO5640081A2 publication Critical patent/CO5640081A2/es

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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

Abstract

1.- Un compuesto de Fórmula I: o un solvato, hidrato o sal farmacéuticamente aceptable de los mismos, en donde:Z es -S(O)- o -S (O2)-;R1 es alquil C1-4, halo, amino, alquiltio C1-6, alqueniltio C2-6, alcoxi C1-6, trifluorometil, metilsulfonil, o benciltio; Ar es fenil, naftil, piridil, imidazolil, tiazolil, furanil, tienil, benzotiazolil, pirazolil, pirimidinil, benzimidazolil, benzofuranil, indolil, benzotiofenil o benzo[c]cromenil, cualquiera de los cuales está opcionalmente sustituido;R2, R3 y R4 son independientemente hidrógeno, alquil C1-4, aril C6-10, hidroxialquil C1-4, aminoalquil C1-4, monoalquilamino (C1-4) alquil (C2-6), dialquilamino (C1-4) alquil (C2-6), carboxialquil (C1-4), ciano, nitro, amino, alcoxi C1-4, hidroxi, o -CO2RW, en dondeRW es hidrógeno, hidroxi, alcoxi C1-4, ciano, alcoxicarbonil C1-4, alquil C1-4, cicloalquil C3-8, fenil, bencil, en donde Rd y Re son independientemente hidrógeno, alquil C1-6, alquenil C2-6 alquenil o fenil,Rf es hidrógeno, alquil C1-6, alquenil C2-6 o fenil, yRg es hidrógeno, alquil C1-6, alquenil C2-6 o fenil, yRh es ar C6-10 alquil (C1-4) o alquil C1-6; y R7 es hidrógeno, cloro, fluoro o amino.2.- Un compuesto de la reivindicación 1, en donde R1 es halo, alquiltio C1-4 o alqueniltio C2-4.
CO04126948A 2002-05-28 2004-12-20 Tiofeno amidinas novedosas, composiciones de esta y metodos para tratar enfermedades y condiciones medianas por complemento CO5640081A2 (es)

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EP (1) EP1549632A4 (es)
JP (1) JP2005538953A (es)
KR (1) KR20050009720A (es)
CN (1) CN100412073C (es)
AR (1) AR039891A1 (es)
AU (1) AU2003251384B2 (es)
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IL (1) IL164890A0 (es)
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