CA2484822A1 - Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions - Google Patents

Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Download PDF

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Publication number
CA2484822A1
CA2484822A1 CA002484822A CA2484822A CA2484822A1 CA 2484822 A1 CA2484822 A1 CA 2484822A1 CA 002484822 A CA002484822 A CA 002484822A CA 2484822 A CA2484822 A CA 2484822A CA 2484822 A1 CA2484822 A1 CA 2484822A1
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Canada
Prior art keywords
methyl
alkyl
compound
methylsulfanyl
thiophene
Prior art date
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Abandoned
Application number
CA002484822A
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English (en)
French (fr)
Inventor
Nalin Subasinghe
Ehab Khalil
Kristi Leonard
Farah Ali
Heather Rae Hufnagel
Jeremy M. Travins
Shelley K. Ballentine
Kenneth J. Wilson
Maxwell D. Cummings
Wenxi Pan
Joan Gushue
Sanath Meegalla
Mark Wall
Jinsheng Chen
M. Jonathan Rudolph
Hui Huang
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Janssen Research and Development LLC
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Individual
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Publication of CA2484822A1 publication Critical patent/CA2484822A1/en
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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CA002484822A 2002-05-28 2003-05-28 Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Abandoned CA2484822A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38313002P 2002-05-28 2002-05-28
US60/383,130 2002-05-28
PCT/US2003/016888 WO2003099805A1 (en) 2002-05-28 2003-05-28 Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions

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CA2484822A1 true CA2484822A1 (en) 2003-12-04

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CA002484822A Abandoned CA2484822A1 (en) 2002-05-28 2003-05-28 Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions

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US (2) US7138530B2 (https=)
EP (1) EP1549632A4 (https=)
JP (1) JP2005538953A (https=)
KR (1) KR20050009720A (https=)
CN (1) CN100412073C (https=)
AR (1) AR039891A1 (https=)
AU (1) AU2003251384B2 (https=)
BR (1) BR0311419A (https=)
CA (1) CA2484822A1 (https=)
CO (1) CO5640081A2 (https=)
HR (1) HRP20041220A2 (https=)
IL (1) IL164890A0 (https=)
MX (1) MX249034B (https=)
MY (1) MY137509A (https=)
NO (1) NO20045403L (https=)
NZ (1) NZ537346A (https=)
PL (1) PL372246A1 (https=)
RU (1) RU2359967C2 (https=)
TW (1) TW200406395A (https=)
UA (1) UA80131C2 (https=)
WO (1) WO2003099805A1 (https=)
ZA (1) ZA200408711B (https=)

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US7138530B2 (en) 2002-05-28 2006-11-21 3-Dimensional Pharmaceuticals, Inc. Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
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GB0305575D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
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PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
WO2006119646A1 (en) * 2005-05-13 2006-11-16 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
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MX335993B (es) * 2005-12-30 2016-01-07 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro.
PT1988779E (pt) 2006-02-16 2015-09-04 Anacor Pharmaceuticals Inc Moléculas pequenas contendo boro como agentes antiinflamatórios
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