CN100347193C - 用于重构表面活性剂制备的改良的合成脂质混合物 - Google Patents

用于重构表面活性剂制备的改良的合成脂质混合物 Download PDF

Info

Publication number
CN100347193C
CN100347193C CNB038112531A CN03811253A CN100347193C CN 100347193 C CN100347193 C CN 100347193C CN B038112531 A CNB038112531 A CN B038112531A CN 03811253 A CN03811253 A CN 03811253A CN 100347193 C CN100347193 C CN 100347193C
Authority
CN
China
Prior art keywords
dppc
reconstituted surfactant
surfactant according
popg
artificial peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB038112531A
Other languages
English (en)
Chinese (zh)
Other versions
CN1653088A (zh
Inventor
T·库斯泰德特
J·约翰松
B·罗伯特松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of CN1653088A publication Critical patent/CN1653088A/zh
Application granted granted Critical
Publication of CN100347193C publication Critical patent/CN100347193C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB038112531A 2002-05-17 2003-05-12 用于重构表面活性剂制备的改良的合成脂质混合物 Expired - Lifetime CN100347193C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI02A001058 2002-05-17
IT2002MI001058A ITMI20021058A1 (it) 2002-05-17 2002-05-17 Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito

Publications (2)

Publication Number Publication Date
CN1653088A CN1653088A (zh) 2005-08-10
CN100347193C true CN100347193C (zh) 2007-11-07

Family

ID=11449919

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038112531A Expired - Lifetime CN100347193C (zh) 2002-05-17 2003-05-12 用于重构表面活性剂制备的改良的合成脂质混合物

Country Status (26)

Country Link
US (2) US7511011B2 (enExample)
EP (1) EP1506234B1 (enExample)
JP (1) JP4883906B2 (enExample)
KR (1) KR101028927B1 (enExample)
CN (1) CN100347193C (enExample)
AT (1) ATE353919T1 (enExample)
AU (1) AU2003233320B2 (enExample)
CA (1) CA2486152C (enExample)
CY (1) CY1106667T1 (enExample)
DE (1) DE60311798T2 (enExample)
DK (1) DK1506234T3 (enExample)
EA (1) EA007928B1 (enExample)
ES (1) ES2282627T3 (enExample)
HR (1) HRP20041058B1 (enExample)
IL (2) IL165239A0 (enExample)
IT (1) ITMI20021058A1 (enExample)
MA (1) MA27960A1 (enExample)
MX (1) MXPA04011369A (enExample)
NZ (1) NZ536606A (enExample)
PL (1) PL209649B1 (enExample)
PT (1) PT1506234E (enExample)
SI (1) SI1506234T1 (enExample)
TN (1) TNSN04219A1 (enExample)
UA (1) UA79609C2 (enExample)
WO (1) WO2003097695A1 (enExample)
ZA (1) ZA200409215B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021058A1 (it) * 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
ATE413178T1 (de) 2003-03-24 2008-11-15 Actimis Pharmaceuticals Inc 2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungen
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
UA76074C2 (en) * 2005-11-09 2006-06-15 O V Palladin Inst Of Biochemis Calmophil, pharmaceutical composition for substitution therapy aimed at recovering malfunctioned surfactant system of lungs
BRPI0715317B1 (pt) 2006-10-13 2021-10-05 Chiesi Farmaceutici S.P.A. Surfactantes reconstituídos com propriedades aperfeiçoadas
EP2142196A4 (en) 2007-03-29 2010-06-30 Nat Jewish Health SURFACTANTLIPIDS, COMPOSITIONS AND THEIR USE
EP1997502A1 (en) * 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
EP2022798A1 (en) * 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides
US8287887B2 (en) 2008-04-02 2012-10-16 The University Of Tokushima Antigen-and-drug vehicle comprising synthetic peptide, and mucosal vaccine using the same
US8399406B2 (en) * 2009-06-05 2013-03-19 Chiesi Farmaceutici S.P.A. Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C)
EP2611418A2 (en) * 2010-08-30 2013-07-10 F.Hoffmann-La Roche Ag Tetranectin-apolipoprotein a-1, lipid particles containing it and its use
BR112013033562A2 (pt) 2011-08-25 2017-02-14 Hoffmann La Roche proteína de fusão de tetranectina-apolipoproteína a-i encurtada, uma partícula de lipídio que a contém e uso das mesmas
BR112015009486B1 (pt) 2012-11-21 2022-06-14 Chiesi Farmaceutici S.P.A Surfactante reconstituído, formulação farmacêutica, kit e uso de surfactante reconstituído

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047623A1 (en) * 1999-02-12 2000-08-17 Chiesi Farmaceutici S.P.A. Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant
WO2001076617A2 (en) * 2000-03-15 2001-10-18 Advanced Research And Technology Institute Oral tolerance induction by collagen to prevent allograft rejection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706374B1 (en) * 1993-06-30 1997-12-10 Genentech, Inc. Method for preparing liposomes
AU2322097A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
CA2405811C (en) * 2000-04-12 2011-09-27 Altana Pharma Ag Novel use of pulmonary surfactant for the prophylaxis or early treatment of acute pulmonary diseases
ITMI20021058A1 (it) * 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
EP1997502A1 (en) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047623A1 (en) * 1999-02-12 2000-08-17 Chiesi Farmaceutici S.P.A. Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant
WO2001076617A2 (en) * 2000-03-15 2001-10-18 Advanced Research And Technology Institute Oral tolerance induction by collagen to prevent allograft rejection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Effect of pulmonary surfactant protein B(SP-B) and calcium onphospholipid adsorption and squeeze-out ofphosphatidylglycerol form binary phospholipid monolayercontaining dipalmitoylphosphatidylcholine. YU S H et al.Biochimica et Biophysica Acta.,Vol.1126 No.1. 1992 *

Also Published As

Publication number Publication date
US7511011B2 (en) 2009-03-31
EP1506234A1 (en) 2005-02-16
EA007928B1 (ru) 2007-02-27
PL372751A1 (en) 2005-08-08
ES2282627T3 (es) 2007-10-16
MXPA04011369A (es) 2005-02-17
DE60311798D1 (de) 2007-03-29
EP1506234B1 (en) 2007-02-14
DK1506234T3 (da) 2007-06-11
AU2003233320B2 (en) 2008-06-19
US7842664B2 (en) 2010-11-30
HRP20041058A2 (en) 2005-02-28
CA2486152C (en) 2012-09-11
ZA200409215B (en) 2006-02-22
TNSN04219A1 (en) 2007-03-12
IL165239A0 (en) 2005-12-18
WO2003097695A1 (en) 2003-11-27
US20050176625A1 (en) 2005-08-11
ITMI20021058A1 (it) 2003-11-17
ITMI20021058A0 (it) 2002-05-17
EA200401385A1 (ru) 2005-08-25
NZ536606A (en) 2006-10-27
UA79609C2 (en) 2007-07-10
AU2003233320A2 (en) 2003-12-02
HRP20041058B1 (hr) 2013-11-22
KR101028927B1 (ko) 2011-04-12
SI1506234T1 (sl) 2007-06-30
IL165239A (en) 2012-10-31
CN1653088A (zh) 2005-08-10
PT1506234E (pt) 2007-05-31
AU2003233320A1 (en) 2003-12-02
CY1106667T1 (el) 2012-05-23
CA2486152A1 (en) 2003-11-27
DE60311798T2 (de) 2007-10-31
HK1079221A1 (zh) 2006-03-31
PL209649B1 (pl) 2011-09-30
ATE353919T1 (de) 2007-03-15
JP2006504635A (ja) 2006-02-09
KR20050016408A (ko) 2005-02-21
JP4883906B2 (ja) 2012-02-22
MA27960A1 (fr) 2006-07-03
US20080242589A1 (en) 2008-10-02

Similar Documents

Publication Publication Date Title
CN100347193C (zh) 用于重构表面活性剂制备的改良的合成脂质混合物
JP4754073B2 (ja) 表面活性をもつ人工ペプチドおよび人工のサーファクタントの製造におけるその使用
EP0055041B1 (en) Composition for curing respiratory diseases
CN101687006B (zh) 具有改善特性的重建表面活性剂
DE69332654T2 (de) Fragmente eines oberflächenaktiven lungenproteins
CN1037350C (zh) 制备多肽衍生物的方法
CN114159546B (zh) 新一代合成肺表面活性物质制剂及其临床应用
JP3376582B2 (ja) 合成ペプチド、それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤
CN1809338A (zh) 用于合成性表面活性剂的新颖的脂质混合物
HK1079221B (en) Improved synthetic lipid mixtures for the preparation of a reconstituted surfactant
KR101721309B1 (ko) 계면활성 단백질 ｂ(ｓｐ－ｂ) 및 계면활성 단백질 ｃ(ｓｐ－ｃ)의 유사체를 포함하는 합성 폐 계면활성제 조성물
KR101784651B1 (ko) 계면활성 단백질 ｂ(ｓｐ－ｂ) 및 계면활성 단백질 ｃ(ｓｐ－ｃ)의 유사체를 포함하는 합성 폐 계면활성제 조성물

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1079221

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1079221

Country of ref document: HK

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20071107