CN100335619C - 大规模生产病毒抗原的方法 - Google Patents

大规模生产病毒抗原的方法 Download PDF

Info

Publication number
CN100335619C
CN100335619C CNB028279778A CN02827977A CN100335619C CN 100335619 C CN100335619 C CN 100335619C CN B028279778 A CNB028279778 A CN B028279778A CN 02827977 A CN02827977 A CN 02827977A CN 100335619 C CN100335619 C CN 100335619C
Authority
CN
China
Prior art keywords
virus
cell
biomass
cells
cell culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028279778A
Other languages
English (en)
Chinese (zh)
Other versions
CN1617924A (zh
Inventor
M·赖特
W·蒙德特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Co
Nanomedicine
Original Assignee
Baxter Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100335619(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA filed Critical Baxter Healthcare SA
Publication of CN1617924A publication Critical patent/CN1617924A/zh
Application granted granted Critical
Publication of CN100335619C publication Critical patent/CN100335619C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151Methods of production or purification of viral material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CNB028279778A 2001-12-10 2002-12-10 大规模生产病毒抗原的方法 Expired - Lifetime CN100335619C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen
US10/006,881 2001-12-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2007101271424A Division CN101100657B (zh) 2001-12-10 2002-12-10 大规模生产病毒抗原的方法

Publications (2)

Publication Number Publication Date
CN1617924A CN1617924A (zh) 2005-05-18
CN100335619C true CN100335619C (zh) 2007-09-05

Family

ID=21723079

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB028279778A Expired - Lifetime CN100335619C (zh) 2001-12-10 2002-12-10 大规模生产病毒抗原的方法
CN2007101271424A Expired - Lifetime CN101100657B (zh) 2001-12-10 2002-12-10 大规模生产病毒抗原的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2007101271424A Expired - Lifetime CN101100657B (zh) 2001-12-10 2002-12-10 大规模生产病毒抗原的方法

Country Status (17)

Country Link
US (2) US6951752B2 (enExample)
EP (3) EP1894998A1 (enExample)
JP (2) JP4370511B2 (enExample)
CN (2) CN100335619C (enExample)
AT (1) ATE447010T2 (enExample)
AU (1) AU2002358662B2 (enExample)
CA (1) CA2469644C (enExample)
DE (2) DE60234211D1 (enExample)
DK (2) DK2330189T3 (enExample)
ES (2) ES2488818T3 (enExample)
FR (1) FR10C0026I1 (enExample)
HU (1) HU225791B1 (enExample)
MX (1) MXPA04005644A (enExample)
NO (1) NO20042910L (enExample)
PL (1) PL208232B1 (enExample)
RU (1) RU2314344C2 (enExample)
WO (1) WO2003054174A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101100657B (zh) * 2001-12-10 2012-05-30 巴克斯特健康护理股份有限公司 大规模生产病毒抗原的方法

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
WO2003054175A1 (en) * 2001-12-20 2003-07-03 Bavarian Nordic A/S Method for the recovery and purification of poxviruses from infected cells
HK1080507B (zh) 2002-09-05 2011-10-07 巴法里安诺迪克有限公司 在无血清条件下培养原代细胞和扩增病毒的方法
CN101857851A (zh) * 2002-12-23 2010-10-13 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法
US20050153419A1 (en) * 2003-12-23 2005-07-14 Schering Corporation Methods for producing cell lines stable in serum-free medium suspension culture
DE602005015332D1 (de) 2004-02-23 2009-08-20 Crucell Holland Bv Verfahren zur Reinigung von Viren
CN1914314B (zh) * 2004-04-19 2012-06-27 电化生研株式会社 病毒的生产方法
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
CA2592120A1 (en) * 2004-12-23 2006-07-06 Medimmune Vaccines, Inc. Non-tumorigenic mdck cell line for propagating viruses
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
JP2009532352A (ja) 2006-03-31 2009-09-10 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ワクチンのための高力価組み換えインフルエンザ・ウィルス
KR20140075022A (ko) 2006-09-15 2014-06-18 메디뮨 엘엘씨 높은 역가로 바이러스 증식을 지원하는 mdck 세포주 및 이를 이용한 생물반응기 공정
JP5084214B2 (ja) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 Ipvワクチン
MX2009011899A (es) * 2007-05-04 2010-03-30 Baxter Int Perfil de temperatura de dos pasos para la propagacion de virus.
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
JP2011512877A (ja) * 2008-03-12 2011-04-28 ワイス・エルエルシー 組換えタンパク質の大スケール産生に適した細胞を同定する方法
JP5689796B2 (ja) 2008-08-01 2015-03-25 ガマ ワクチンズ ピーティワイ リミテッド インフルエンザワクチン
WO2010036774A1 (en) 2008-09-24 2010-04-01 Medimmune, Llc Methods for purification of viruses
US8202726B2 (en) 2008-09-24 2012-06-19 Medimmune, Llc Methods for cultivating cells, propagating and purifying viruses
CA3150404A1 (en) 2009-07-31 2011-02-03 Pnuvax Inc. High yield yellow fever virus strain with increased propagation in cells
ES2813347T3 (es) 2009-10-26 2021-03-23 Wisconsin Alumni Res Found Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero
WO2011077035A1 (fr) * 2009-12-23 2011-06-30 Sanofi Pasteur Procede de culture de cellules adherentes
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
WO2011130119A2 (en) 2010-04-14 2011-10-20 Millipore Corporation Methods of producing high titer, high purity virus stocks and methods of use thereof
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
CN101979517B (zh) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 一种利用生物反应器大规模生产流感病毒的方法
US20140079732A1 (en) 2011-01-27 2014-03-20 Gamma Vaccines Pty Limited Combination vaccines
EP2747778B1 (en) 2011-08-26 2017-12-06 Wisconsin Alumni Research Foundation Influenza viruses with mutant pb2 gene segment as live attenuated vaccines
CN102492659A (zh) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 一种疫苗生产用甲肝病毒的生产方法
AU2014290203B2 (en) 2013-07-15 2020-12-24 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
CN103387958B (zh) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 人胚肺成纤维细胞sv-7在病毒培养中的应用
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
KR101961580B1 (ko) 2015-01-26 2019-03-22 우베 고산 가부시키가이샤 물질의 생산 방법
CA2969197C (en) 2015-01-26 2020-08-18 Ube Industries, Ltd. Method, device and kit for mass cultivation of cells using polyimide porous membrane
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11197925B2 (en) 2016-02-19 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US20190264156A1 (en) 2016-07-25 2019-08-29 Ube Industries, Ltd. Siphon type cultivation method
US11932841B2 (en) 2016-07-25 2024-03-19 Ube Corporation Cell cultivation module
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US11612648B2 (en) * 2018-01-18 2023-03-28 Yisheng Biopharma (Singapore) Pte Ltd Method for adapting influenza viruses to Vero cells
EP3749757A4 (en) * 2018-02-07 2021-11-24 Bharat Biotech International Limited PROCESS FOR PURIFICATION AND INACTIVATION OF ENTERVIRUSES AND VACCINE COMPOSITIONS OBTAINED THEREOF
WO2020033527A2 (en) 2018-08-07 2020-02-13 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
WO2020041311A1 (en) 2018-08-20 2020-02-27 Wisconsin Alumni Research Foundation Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein
WO2020167432A2 (en) 2019-01-23 2020-08-20 Yoshihiro Kawaoka Mutations that confer genetic stability to additional genes in influenza viruses
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
AU2020221305A1 (en) * 2019-02-15 2021-08-26 Ology Bioservices, Inc. Method for virus production
WO2020223699A1 (en) 2019-05-01 2020-11-05 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
TW202122569A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
WO2021041624A2 (en) 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
WO2021150874A1 (en) 2020-01-24 2021-07-29 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN111850169B (zh) * 2020-07-16 2022-09-27 华农(肇庆)生物产业技术研究院有限公司 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
AT393356B (de) 1989-12-22 1991-10-10 Immuno Ag Verfahren zur herstellung von fsme-virus-antigen
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
ATE542891T1 (de) 1994-11-10 2012-02-15 Baxter Healthcare Sa Verfahren zur herstellung von biologischen produkten in protein-freier kultur
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
AU6028898A (en) * 1997-01-31 1998-08-25 Schering Corporation Methods for cultivating cells and propagating viruses
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NOVEL MAMMALIAN CELL DERIVED INF LUEZYVIRUS VACCINE WIENER KLINISCHE WOCHENSCHRIFT,Vol.111 No.5 1999 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101100657B (zh) * 2001-12-10 2012-05-30 巴克斯特健康护理股份有限公司 大规模生产病毒抗原的方法

Also Published As

Publication number Publication date
CA2469644C (en) 2013-07-23
EP1453956B8 (en) 2010-02-10
AU2002358662B2 (en) 2008-05-15
CN101100657B (zh) 2012-05-30
EP1894998A1 (en) 2008-03-05
EP2330189A1 (en) 2011-06-08
WO2003054174A1 (en) 2003-07-03
US7524676B2 (en) 2009-04-28
RU2314344C2 (ru) 2008-01-10
US6951752B2 (en) 2005-10-04
HK1115609A1 (en) 2008-12-05
ES2488818T3 (es) 2014-08-29
EP1453956B1 (en) 2009-10-28
EP2330189B1 (en) 2014-05-21
EP1453956A1 (en) 2004-09-08
HUP0402415A3 (en) 2005-07-28
RU2004121178A (ru) 2005-10-10
US20030108860A1 (en) 2003-06-12
JP2005512564A (ja) 2005-05-12
HUP0402415A2 (hu) 2005-02-28
PL208232B1 (pl) 2011-04-29
EP1894998A8 (en) 2008-04-23
HU225791B1 (en) 2007-09-28
ES2335395T3 (es) 2010-03-26
HK1158691A1 (en) 2012-07-20
CN1617924A (zh) 2005-05-18
DK2330189T3 (da) 2014-06-16
JP4370511B2 (ja) 2009-11-25
US20050181495A1 (en) 2005-08-18
FR10C0026I1 (fr) 2011-01-14
EP1453956B2 (en) 2017-01-18
DK1453956T3 (da) 2010-01-11
AU2002358662A1 (en) 2003-07-09
PL373487A1 (en) 2005-09-05
JP5021000B2 (ja) 2012-09-05
ES2335395T5 (es) 2017-08-31
CN101100657A (zh) 2008-01-09
CA2469644A1 (en) 2003-07-03
JP2009261410A (ja) 2009-11-12
NO20042910L (no) 2004-07-09
DE60234211D1 (de) 2009-12-10
DE122010000025I1 (de) 2010-08-12
MXPA04005644A (es) 2005-04-19
ATE447010T2 (de) 2009-11-15

Similar Documents

Publication Publication Date Title
CN100335619C (zh) 大规模生产病毒抗原的方法
CN101058800A (zh) 用于细胞培养的无动物蛋白质培养基
CN1147833A (zh) 甲型肝炎病毒培养工艺
CN104178459A (zh) 一种无血清悬浮培养狂犬病毒的方法
CN1966076A (zh) 大规模生产狂犬病疫苗的方法
CN113583968A (zh) 传染性胰脏坏死病疫苗及其病毒在大鳞大麻哈鱼胚胎细胞上扩增的方法
US9932562B2 (en) Drain down and re-feed of microcarrier bioreactor
CN1301297A (zh) 用于病毒繁殖和增殖的培养基和方法
CN104109654A (zh) 一种筛选病毒毒种的方法
HK1115609B (en) Method for large scale production of virus antigen
HK1158691B (en) Method for large scale production of virus
HK1116825A (en) Method for large scale production of virus

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP02 Change in the address of a patent holder

Address after: Swiss Aupu

Patentee after: Baxter Healthcare S.A.

Address before: Wallisellen Switzerland

Patentee before: Baxter Healthcare S.A.

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20160920

Address after: American Florida

Patentee after: nanomedicine

Address before: Swiss Aupu

Patentee before: Baxter Co.

Effective date of registration: 20160920

Address after: Swiss Aupu

Patentee after: Baxter Co.

Address before: Swiss Aupu

Patentee before: Baxter Healthcare S.A.

CX01 Expiry of patent term

Granted publication date: 20070905

CX01 Expiry of patent term