CL2019000681A1 - Combinaciones terapéuticas que comprenden un inhibidor de raf y un inhibidor de erk. - Google Patents

Combinaciones terapéuticas que comprenden un inhibidor de raf y un inhibidor de erk.

Info

Publication number
CL2019000681A1
CL2019000681A1 CL2019000681A CL2019000681A CL2019000681A1 CL 2019000681 A1 CL2019000681 A1 CL 2019000681A1 CL 2019000681 A CL2019000681 A CL 2019000681A CL 2019000681 A CL2019000681 A CL 2019000681A CL 2019000681 A1 CL2019000681 A1 CL 2019000681A1
Authority
CL
Chile
Prior art keywords
inhibitor
combination
erk
raf
preferibly
Prior art date
Application number
CL2019000681A
Other languages
English (en)
Inventor
Giordano Caponigro
Vesselina Cooke
Matthew John Meyer
Darrin Stuart
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2019000681A1 publication Critical patent/CL2019000681A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN TRATAMIENTO DE COMBINACIÓN QUE COMPRENDE (A) AL MENOS UN INHIBIDOR DE ERK, PREFERIBLEMENTE EL COMPUESTO B COMO SE DESCRIBE EN EL PRESENTE DOCUMENTO, Y (B) UN INHIBIDOR DE C–RAF O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, PREFERIBLEMENTE EL COMPUESTO A, QUE PUEDEN COMBINARSE EN UNA SOLA COMPOSICIÓN FARMACÉUTICA O PREPARARSE PARA ADMINISTRACIÓN SEPARADA O SECUENCIAL. INCLUYE UN INHIBIDOR DE C–RAF Y UN INHIBIDOR DE ERK PREPARADOS PARA LA ADMINISTRACIÓN SIMULTÁNEA, SEPARADA O SECUENCIAL PARA EL TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA, EN PARTICULAR UN TUMOR SÓLIDO AVANZADO QUE ALBERGA UNA ALTERACIÓN DE LA PROTEÍNA QUINASA ACTIVADA POR MITÓGENOS (MAPK), E INCLUYE MÉTODOS DE USO DE ESTOS COMPUESTOS EN COMBINACIÓN, ASÍ COMO UN PAQUETE COMERCIAL QUE COMPRENDE DICHA COMBINACIÓN.
CL2019000681A 2016-09-19 2019-03-15 Combinaciones terapéuticas que comprenden un inhibidor de raf y un inhibidor de erk. CL2019000681A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662396504P 2016-09-19 2016-09-19

Publications (1)

Publication Number Publication Date
CL2019000681A1 true CL2019000681A1 (es) 2019-05-17

Family

ID=60009675

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000681A CL2019000681A1 (es) 2016-09-19 2019-03-15 Combinaciones terapéuticas que comprenden un inhibidor de raf y un inhibidor de erk.

Country Status (13)

Country Link
US (2) US10973829B2 (es)
EP (1) EP3515446B1 (es)
JP (1) JP7114575B2 (es)
KR (1) KR102341660B1 (es)
CN (1) CN109715163B (es)
AU (1) AU2017329090B9 (es)
BR (1) BR112019005046A2 (es)
CA (1) CA3037456A1 (es)
CL (1) CL2019000681A1 (es)
ES (1) ES2974991T3 (es)
IL (1) IL264931B (es)
MX (1) MX2019003095A (es)
WO (1) WO2018051306A1 (es)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
CA3049926A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
JP7309614B2 (ja) * 2017-05-02 2023-07-18 ノバルティス アーゲー 組み合わせ療法
BR112020019577A2 (pt) * 2018-03-30 2021-01-05 Novartis Ag Combinação farmacêutica tripla compreendendo dabrafenibe, trametinibe e um inibidor de erk
JP2022500385A (ja) * 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
JP2022540921A (ja) * 2019-07-15 2022-09-20 メモリアル スローン ケタリング キャンサー センター Ｋｒａｓまたはｈｒａｓ変異若しくは増幅を有するがんを処置する際に有用な方法
WO2021165849A1 (en) * 2020-02-18 2021-08-26 Novartis Ag Therapeutic combinations comprising a raf inhibitor for use in treating braf mutant nsclc
JP2023516155A (ja) * 2020-02-28 2023-04-18 ノバルティス アーゲー ダブラフェニブ、ｅｒｋ阻害剤及びｒａｆ阻害剤又はｐｄ－１阻害剤を含む三重の医薬品の組合せ
CN113440616A (zh) * 2020-03-25 2021-09-28 上海科州药物研发有限公司 Ras或raf突变型癌症的联合疗法
US20240000789A1 (en) * 2020-05-12 2024-01-04 Novartis Ag Therapeutic combinations comprising a craf inhibitor
EP4225316A1 (en) * 2020-10-08 2023-08-16 Novartis AG Use of an erk inhibitor for the treatment of myelofibrosis
US20240000777A1 (en) * 2020-10-08 2024-01-04 Novartis Ag Use of an erk inhibitor for the treatment of myelofibrosis
TW202408463A (zh) * 2022-08-10 2024-03-01 瑞士商諾華公司 醫藥組合物

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