AR108317A1 - Composiciones que comprenden coformulación de anticuerpos anti-pd-l1 y anti-ctla-4 - Google Patents
Composiciones que comprenden coformulación de anticuerpos anti-pd-l1 y anti-ctla-4Info
- Publication number
- AR108317A1 AR108317A1 ARP170101046A ARP170101046A AR108317A1 AR 108317 A1 AR108317 A1 AR 108317A1 AR P170101046 A ARP170101046 A AR P170101046A AR P170101046 A ARP170101046 A AR P170101046A AR 108317 A1 AR108317 A1 AR 108317A1
- Authority
- AR
- Argentina
- Prior art keywords
- approximately
- antibody
- antigen
- ctla
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se proporcionan aquí composiciones que comprenden la coformulación de anticuerpos anti-PD-L1 y anti-CTLA-4, o fragmentos de unión a antígeno de los mismos, y métodos para fabricar y usar tales composiciones. En diversos aspectos, se proporcionan coformulaciones estables del anticuerpo anti-PD-L1 durvalumab (MEDI4736) y el anticuerpo anti-CTLA-4 tremelimumab. Reivindicación 1: Una composición que comprende durvalumab, o un fragmento de unión a antígeno del mismo, y tremelimumab, o un fragmento de unión a antígeno del mismo, en el que la concentración de durvalumab, o un fragmento de unión a antígeno del mismo, es de aproximadamente 18,7 mg/mL a aproximadamente 44,4 mg/mL y en el que la concentración de tremelimumab, o un fragmento de unión a antígeno del mismo, es de aproximadamente 2,2 mg/mL a aproximadamente 12,5 mg/mL. Reivindicación 17: Una composición farmacéutica que comprende o que consiste de aproximadamente 44,4 mg/mL de durvalumab, o un fragmento de anticuerpo del mismo, aproximadamente 2,2 mg/mL de tremelimumab, o un fragmento de anticuerpo del mismo, aproximadamente 25 mM de Histidina / Histidina-HCl, aproximadamente 269 mM de deshidrato de trehalosa aproximadamente 0,03 mM de EDTA y aproximadamente 0,02% p/v de PS80 a un pH de aproximadamente 6,0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662327214P | 2016-04-25 | 2016-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108317A1 true AR108317A1 (es) | 2018-08-08 |
Family
ID=60089975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101046A AR108317A1 (es) | 2016-04-25 | 2017-04-25 | Composiciones que comprenden coformulación de anticuerpos anti-pd-l1 y anti-ctla-4 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10421811B2 (es) |
| EP (1) | EP3448428A4 (es) |
| JP (1) | JP2019514889A (es) |
| KR (1) | KR20180135475A (es) |
| CN (1) | CN109069631A (es) |
| AR (1) | AR108317A1 (es) |
| AU (1) | AU2017257505B2 (es) |
| BR (1) | BR112018071287A2 (es) |
| CA (1) | CA3020893A1 (es) |
| CL (1) | CL2018002998A1 (es) |
| CO (1) | CO2018011195A2 (es) |
| IL (1) | IL262344A (es) |
| MA (1) | MA44783A (es) |
| MX (1) | MX2018012651A (es) |
| RU (1) | RU2018140960A (es) |
| SG (1) | SG11201807474SA (es) |
| TW (1) | TW201740976A (es) |
| WO (1) | WO2017189433A1 (es) |
| ZA (1) | ZA201807888B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210143932A (ko) | 2013-09-11 | 2021-11-29 | 메디뮨 리미티드 | 종양 치료용 항-ｂ7-ｈ1 항체 |
| EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| CA2960824A1 (en) | 2014-09-13 | 2016-03-17 | Novartis Ag | Combination therapies of alk inhibitors |
| PE20171067A1 (es) | 2014-10-14 | 2017-07-24 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
| CN114702586A (zh) | 2015-03-13 | 2022-07-05 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| EP3389714A4 (en) | 2015-12-14 | 2019-11-13 | MacroGenics, Inc. | BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY TO PD-1 AND CTLA-4 AND METHODS OF USE |
| WO2017215590A1 (en) | 2016-06-13 | 2017-12-21 | I-Mab | Anti-pd-l1 antibodies and uses thereof |
| JP2020507596A (ja) * | 2017-02-16 | 2020-03-12 | メディミューン，エルエルシー | 膀胱癌の抗ｐｄ−ｌ１抗体治療 |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| MX2019014265A (es) | 2017-06-01 | 2020-08-03 | Compugen Ltd | Tratamientos conjuntos triples con anticuerpos. |
| CN112004553A (zh) * | 2018-04-25 | 2020-11-27 | 免疫医疗有限公司 | 人抗pd-l1抗体的配制品 |
| CN112041348B (zh) | 2018-07-25 | 2023-09-22 | 天境生物科技(上海)有限公司 | 抗cd73抗pd-l1双特异性抗体 |
| CA3203441A1 (en) * | 2020-12-30 | 2022-07-07 | Jing Zhu | Formulations of anti-cd73 antibodies |
| WO2024094831A1 (en) * | 2022-11-04 | 2024-05-10 | Astrazeneca Ab | Anti-ctla antibody compositions and related methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053026A1 (es) * | 2005-03-08 | 2007-04-18 | Pharmacia & Upjohn Co Llc | Composiciones de anticuerpos anti factor de estimulacion de colonias de macrofagos (anti-m csf) |
| EP2007423A2 (en) * | 2006-04-05 | 2008-12-31 | Pfizer Products Incorporated | Ctla4 antibody combination therapy |
| CN102245640B (zh) * | 2008-12-09 | 2014-12-31 | 霍夫曼-拉罗奇有限公司 | 抗-pd-l1抗体及它们用于增强t细胞功能的用途 |
| MX359551B (es) * | 2009-11-24 | 2018-10-02 | Medimmune Ltd | Agentes de union diana contra b7-h1. |
| RS61082B1 (sr) * | 2010-02-26 | 2020-12-31 | Novo Nordisk As | Stabilno antitelo koje sadrži kompozicije |
| ES2721882T3 (es) * | 2011-12-23 | 2019-08-06 | Pfizer | Regiones constantes de anticuerpo modificadas por ingeniería genética para conjugación específica de sitio y procedimientos y usos de las mismas |
| RU2675824C2 (ru) * | 2013-09-11 | 2018-12-25 | Игл Байолоджикс, Инк. | Жидкие белковые составы, содержащие ионные жидкости |
| KR20220162844A (ko) * | 2014-05-13 | 2022-12-08 | 메디뮨 리미티드 | 비-소세포 폐암을 치료하기 위한 항-ｂ7-ｈ1 및 항-ｃｔｌａ-4 항체 |
| WO2016030455A1 (en) * | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
| US20190194654A1 (en) * | 2014-10-24 | 2019-06-27 | Astrazeneca Ab | Combination |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
-
2017
- 2017-04-24 JP JP2018555566A patent/JP2019514889A/ja active Pending
- 2017-04-24 MX MX2018012651A patent/MX2018012651A/es unknown
- 2017-04-24 AU AU2017257505A patent/AU2017257505B2/en not_active Ceased
- 2017-04-24 CA CA3020893A patent/CA3020893A1/en not_active Abandoned
- 2017-04-24 CN CN201780023036.3A patent/CN109069631A/zh active Pending
- 2017-04-24 US US15/495,388 patent/US10421811B2/en not_active Expired - Fee Related
- 2017-04-24 WO PCT/US2017/029143 patent/WO2017189433A1/en active Application Filing
- 2017-04-24 EP EP17790189.9A patent/EP3448428A4/en not_active Withdrawn
- 2017-04-24 BR BR112018071287-6A patent/BR112018071287A2/pt not_active IP Right Cessation
- 2017-04-24 MA MA044783A patent/MA44783A/fr unknown
- 2017-04-24 SG SG11201807474SA patent/SG11201807474SA/en unknown
- 2017-04-24 KR KR1020187033315A patent/KR20180135475A/ko not_active Application Discontinuation
- 2017-04-24 RU RU2018140960A patent/RU2018140960A/ru not_active Application Discontinuation
- 2017-04-25 TW TW106113795A patent/TW201740976A/zh unknown
- 2017-04-25 AR ARP170101046A patent/AR108317A1/es unknown
-
2018
- 2018-10-14 IL IL262344A patent/IL262344A/en unknown
- 2018-10-19 CO CONC2018/0011195A patent/CO2018011195A2/es unknown
- 2018-10-22 CL CL2018002998A patent/CL2018002998A1/es unknown
- 2018-11-22 ZA ZA2018/07888A patent/ZA201807888B/en unknown
-
2019
- 2019-08-28 US US16/553,670 patent/US20190382494A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MA44783A (fr) | 2019-03-06 |
| CL2018002998A1 (es) | 2018-12-07 |
| TW201740976A (zh) | 2017-12-01 |
| EP3448428A1 (en) | 2019-03-06 |
| EP3448428A4 (en) | 2019-11-27 |
| US10421811B2 (en) | 2019-09-24 |
| JP2019514889A (ja) | 2019-06-06 |
| CA3020893A1 (en) | 2017-11-02 |
| US20170306025A1 (en) | 2017-10-26 |
| AU2017257505A1 (en) | 2018-12-06 |
| IL262344A (en) | 2018-11-29 |
| AU2017257505B2 (en) | 2020-05-14 |
| SG11201807474SA (en) | 2018-11-29 |
| RU2018140960A3 (es) | 2020-08-03 |
| CO2018011195A2 (es) | 2018-10-31 |
| BR112018071287A2 (pt) | 2019-02-19 |
| CN109069631A (zh) | 2018-12-21 |
| RU2018140960A (ru) | 2020-05-26 |
| US20190382494A1 (en) | 2019-12-19 |
| KR20180135475A (ko) | 2018-12-20 |
| WO2017189433A1 (en) | 2017-11-02 |
| ZA201807888B (en) | 2019-08-28 |
| MX2018012651A (es) | 2019-01-30 |
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Legal Events
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|---|---|---|---|
| FB | Suspension of granting procedure |