CL2019002056A1 - Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo o un polipéptido anti leucocidina lukd, lukd aislado o un polipétido del mismo, o una combinación de ambos y portador farmaceuticamente aceptable.(divisional solicitud 201303650) - Google Patents
Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo o un polipéptido anti leucocidina lukd, lukd aislado o un polipétido del mismo, o una combinación de ambos y portador farmaceuticamente aceptable.(divisional solicitud 201303650)Info
- Publication number
- CL2019002056A1 CL2019002056A1 CL2019002056A CL2019002056A CL2019002056A1 CL 2019002056 A1 CL2019002056 A1 CL 2019002056A1 CL 2019002056 A CL2019002056 A CL 2019002056A CL 2019002056 A CL2019002056 A CL 2019002056A CL 2019002056 A1 CL2019002056 A1 CL 2019002056A1
- Authority
- CL
- Chile
- Prior art keywords
- polypeptide
- lukd
- leukocidin
- treatment
- staphylococcus aureus
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A—HUMAN NECESSITIES
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- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56938—Staphylococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
- G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A MÉTODOS Y COMPOSICIONES PARA LA PREVENCIÓN Y EL TRATAMIENTO DE STAPHYLOCOCCUS AUREUS EN UN SUJETO. LAS COMPOSICIONES TERAPÉUTICAS DE LA PRESCITO INVENCIÓN COMPRENDEN PROTEÍNAS O POLIPÉPTIDOS DE LEUCOCIDINA E Y/O D Y ANTICUERPOS ANTI-LEUCOCIDINA E Y/O D. LA INVENCIÓN SE REFIERE ADEMÁS A MÉTODOS PARA IDENTIFICAR INHIBIDORES DE CITOTOXICIDAD DE LUKE/D E INHIBIDORES DE UNIÓN DE LUKE/D A LEUCOCITOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161498596P | 2011-06-19 | 2011-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019002056A1 true CL2019002056A1 (es) | 2019-11-29 |
Family
ID=47423177
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013003650A CL2013003650A1 (es) | 2011-06-19 | 2013-12-19 | Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo anti leucocidina luke y un portador farmaceuticamente aceptable. |
CL2019002056A CL2019002056A1 (es) | 2011-06-19 | 2019-07-23 | Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo o un polipéptido anti leucocidina lukd, lukd aislado o un polipétido del mismo, o una combinación de ambos y portador farmaceuticamente aceptable.(divisional solicitud 201303650) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013003650A CL2013003650A1 (es) | 2011-06-19 | 2013-12-19 | Composición para el tratamiento de una infección por staphylococcus aureus que contiene solo un anticuerpo anti leucocidina luke y un portador farmaceuticamente aceptable. |
Country Status (20)
Country | Link |
---|---|
US (7) | US9091689B2 (es) |
EP (3) | EP3403669B1 (es) |
JP (4) | JP6170913B2 (es) |
KR (1) | KR102050267B1 (es) |
CN (3) | CN103717234A (es) |
AU (1) | AU2012273123C1 (es) |
BR (2) | BR112013032774B1 (es) |
CA (1) | CA2839554C (es) |
CL (2) | CL2013003650A1 (es) |
DK (1) | DK3403669T3 (es) |
ES (2) | ES2812181T3 (es) |
HR (1) | HRP20201265T1 (es) |
HU (1) | HUE051832T2 (es) |
IL (2) | IL229922B (es) |
LT (1) | LT3403669T (es) |
MX (2) | MX340446B (es) |
NZ (1) | NZ764564A (es) |
RU (1) | RU2635462C2 (es) |
SI (1) | SI3403669T1 (es) |
WO (1) | WO2012177658A2 (es) |
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CN103717234A (zh) * | 2011-06-19 | 2014-04-09 | 纽约大学 | 治疗和预防金黄色葡萄球菌感染及相关病状的方法 |
CN104428000A (zh) | 2012-05-02 | 2015-03-18 | 纽约大学 | 治疗和预防金黄色葡萄球菌感染和相关病状的方法 |
US10301378B2 (en) * | 2013-06-18 | 2019-05-28 | New York University | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets |
CA2925071A1 (en) * | 2013-10-17 | 2015-04-23 | Arsanis Biosciences Gmbh | Cross-reactive staphylococcus aureus antibody sequences |
JP2017502002A (ja) * | 2013-12-09 | 2017-01-19 | ニューヨーク・ユニバーシティ | 抗ブドウ球菌剤の食細胞送達用組成物及び方法 |
BE1022875B1 (fr) * | 2014-03-26 | 2016-09-30 | Glaxosmithkline Biologicals S.A. | Compositions pour une immunisation contre staphylococcus aureus |
EP3180620B1 (en) * | 2014-08-12 | 2020-01-01 | X4 Pharmaceuticals (Austria) GmbH | Predicting s. aureus disease |
JP2018513168A (ja) * | 2015-04-17 | 2018-05-24 | アルサニス・バイオサイエンスズ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 抗スタフィロコッカス・アウレウス抗体組み合わせ製剤 |
JP2018517708A (ja) * | 2015-06-05 | 2018-07-05 | ニューヨーク・ユニバーシティ | 抗ブドウ球菌生物学的薬剤のための組成物及び方法 |
CN105641689A (zh) * | 2016-01-21 | 2016-06-08 | 浙江海隆生物科技有限公司 | 一种奶牛金黄色葡萄球菌β-溶血素亚单位疫苗的制备方法及应用 |
EP3464349A4 (en) | 2016-05-23 | 2020-08-26 | New York University | COMPOSITIONS AND METHODS ASSOCIATED WITH ANTIBODIES TARGETING STAPHYLOCCAL LEUCOTOXINS |
AU2017346974B2 (en) | 2016-10-21 | 2022-03-31 | Socpra Sciences Et Génie S.E.C. | Vaccine constructs and uses thereof against staphylococcus infections |
EP3582683A4 (en) * | 2017-02-20 | 2021-03-17 | The Regents of The University of California | SEROLOGICAL TEST FOR SILENT BRAIN ISEMIA |
CN107224575B (zh) * | 2017-03-06 | 2018-11-09 | 浙江海隆生物科技有限公司 | 奶牛金黄色葡萄球菌乳房炎亚单位疫苗的组合物及其制备方法和应用 |
CN106749652A (zh) * | 2017-03-14 | 2017-05-31 | 天津喜诺生物医药有限公司 | 一种金黄色葡萄球菌肽聚糖的多克隆抗体 |
WO2020023644A2 (en) | 2018-07-24 | 2020-01-30 | Medimmune, Llc | Antibody directed against s. aureus clumping factor a (clfa) |
BR112021016996A8 (pt) * | 2019-02-28 | 2022-11-22 | Dandi Bioscience Inc | Polipeptídeo com atividade antibacteriana, composição para prevenir ou tratar sepsis compreendendo a mesma e composição antibacteriana |
CN111423516B (zh) * | 2020-04-01 | 2022-02-11 | 广州佰斯伦医疗器械有限公司 | 一种蛋白及其在创口修复及抑菌中的应用 |
CN111398194B (zh) * | 2020-04-10 | 2020-11-03 | 上海华茂药业有限公司 | 一种用于测定艾考糊精中肽聚糖的方法 |
CN112851770B (zh) * | 2021-02-05 | 2022-10-04 | 中国人民解放军陆军军医大学 | 一种用于诊断或防治金黄色葡萄球菌感染的α溶血素抗原表位肽及其应用 |
CN114317787A (zh) * | 2021-12-29 | 2022-04-12 | 成都大学 | 吸附磁珠及其试剂盒和用途以及检测金黄色葡萄球菌的方法 |
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SI2510947T1 (sl) * | 2009-04-14 | 2016-05-31 | Glaxosmithkline Biologicals S.A. | Sestavki za imunizacijo proti Staphylococcus aureus |
US8409584B2 (en) * | 2009-05-05 | 2013-04-02 | New York University | Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins |
EP2488198B1 (en) | 2009-10-13 | 2016-09-28 | Rutgers, the State University of New Jersey | Treatment and diagnosis of autoimmune disorders |
US9783582B2 (en) * | 2010-05-05 | 2017-10-10 | New York University | Staphylococcus aureus leukocidins, therapeutic compositions, and uses thereof |
CN103717234A (zh) * | 2011-06-19 | 2014-04-09 | 纽约大学 | 治疗和预防金黄色葡萄球菌感染及相关病状的方法 |
BR112013032911A2 (pt) * | 2011-06-19 | 2017-01-24 | Univ New York | leucotoxina e/d como um novo agente anti-inflamatório e microbicida |
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