CL2018003107A1 - Procedimiento para la preparación de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo - Google Patents
Procedimiento para la preparación de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquiloInfo
- Publication number
- CL2018003107A1 CL2018003107A1 CL2018003107A CL2018003107A CL2018003107A1 CL 2018003107 A1 CL2018003107 A1 CL 2018003107A1 CL 2018003107 A CL2018003107 A CL 2018003107A CL 2018003107 A CL2018003107 A CL 2018003107A CL 2018003107 A1 CL2018003107 A1 CL 2018003107A1
- Authority
- CL
- Chile
- Prior art keywords
- preparation
- phenyl
- triazol
- hydroxyalkyl
- triazole derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CGRLXLHYYDSTKR-UHFFFAOYSA-N 1-phenyl-1H-1,2,4-triazole Chemical group N1=CN=CN1C1=CC=CC=C1 CGRLXLHYYDSTKR-UHFFFAOYSA-N 0.000 title 1
- -1 MONOFLUORMETHYL Chemical class 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16168163 | 2016-05-03 | ||
| EP16168172 | 2016-05-03 | ||
| EP16168165 | 2016-05-03 | ||
| EP16168169 | 2016-05-03 | ||
| EP16168166 | 2016-05-03 | ||
| EP17160086 | 2017-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018003107A1 true CL2018003107A1 (es) | 2019-02-22 |
Family
ID=58633014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003107A CL2018003107A1 (es) | 2016-05-03 | 2018-10-31 | Procedimiento para la preparación de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10703742B2 (enExample) |
| EP (1) | EP3452467A1 (enExample) |
| JP (2) | JP6921863B2 (enExample) |
| KR (1) | KR20190003536A (enExample) |
| CN (2) | CN109071500B (enExample) |
| AU (2) | AU2017259872B2 (enExample) |
| BR (1) | BR112018072528A2 (enExample) |
| CA (1) | CA3022789A1 (enExample) |
| CL (1) | CL2018003107A1 (enExample) |
| CO (1) | CO2018011948A2 (enExample) |
| IL (1) | IL262534B (enExample) |
| MX (2) | MX379555B (enExample) |
| PE (1) | PE20190202A1 (enExample) |
| RU (1) | RU2742885C2 (enExample) |
| SG (1) | SG11201809672YA (enExample) |
| TW (1) | TWI755393B (enExample) |
| UY (1) | UY37222A (enExample) |
| WO (1) | WO2017191104A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| US10703742B2 (en) * | 2016-05-03 | 2020-07-07 | Bayer Pharma Aktiengesellschaft | Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4-triazole derivatives |
| CN109071464A (zh) * | 2016-05-03 | 2018-12-21 | 拜耳制药股份公司 | 氧代烷基取代的苯基三唑衍生物及其用途 |
| WO2021259852A1 (en) | 2020-06-25 | 2021-12-30 | Bayer Aktiengesellschaft | Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007139968A2 (en) * | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP2341776A4 (en) * | 2008-09-19 | 2012-05-30 | Inst Oneworld Health | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOL AND TRIAZOL DERIVATIVES |
| DE102010001064A1 (de) * | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| JP5826773B2 (ja) * | 2010-02-27 | 2015-12-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | ビスアリール−結合アリールトリアゾロン及びその用途 |
| PE20142453A1 (es) * | 2012-05-08 | 2015-01-17 | Bayer Pharma AG | Proceso preparativo |
| UY36383A (es) * | 2014-11-03 | 2016-06-01 | Bayer Pharma AG | Derivados de feniltriazol sustituido con hidroxialquilo y sus usos |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| US10703742B2 (en) * | 2016-05-03 | 2020-07-07 | Bayer Pharma Aktiengesellschaft | Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4-triazole derivatives |
| CN109071464A (zh) * | 2016-05-03 | 2018-12-21 | 拜耳制药股份公司 | 氧代烷基取代的苯基三唑衍生物及其用途 |
-
2017
- 2017-05-02 US US16/098,238 patent/US10703742B2/en not_active Expired - Fee Related
- 2017-05-02 RU RU2018142264A patent/RU2742885C2/ru active
- 2017-05-02 MX MX2018013336A patent/MX379555B/es unknown
- 2017-05-02 JP JP2018557408A patent/JP6921863B2/ja not_active Expired - Fee Related
- 2017-05-02 WO PCT/EP2017/060367 patent/WO2017191104A1/de not_active Ceased
- 2017-05-02 KR KR1020187031568A patent/KR20190003536A/ko not_active Ceased
- 2017-05-02 CN CN201780027607.0A patent/CN109071500B/zh not_active Expired - Fee Related
- 2017-05-02 UY UY0001037222A patent/UY37222A/es not_active Application Discontinuation
- 2017-05-02 MX MX2020010365A patent/MX391356B/es unknown
- 2017-05-02 BR BR112018072528-5A patent/BR112018072528A2/pt active Search and Examination
- 2017-05-02 CA CA3022789A patent/CA3022789A1/en active Pending
- 2017-05-02 AU AU2017259872A patent/AU2017259872B2/en not_active Ceased
- 2017-05-02 PE PE2018002254A patent/PE20190202A1/es unknown
- 2017-05-02 CN CN202110424553.XA patent/CN113105403A/zh active Pending
- 2017-05-02 TW TW106114435A patent/TWI755393B/zh not_active IP Right Cessation
- 2017-05-02 SG SG11201809672YA patent/SG11201809672YA/en unknown
- 2017-05-02 EP EP17719636.7A patent/EP3452467A1/de not_active Withdrawn
-
2018
- 2018-10-23 IL IL262534A patent/IL262534B/en active IP Right Grant
- 2018-10-31 CL CL2018003107A patent/CL2018003107A1/es unknown
- 2018-11-02 CO CONC2018/0011948A patent/CO2018011948A2/es unknown
-
2020
- 2020-05-21 US US16/880,933 patent/US20200299271A1/en not_active Abandoned
-
2021
- 2021-06-14 JP JP2021098486A patent/JP2021143193A/ja not_active Withdrawn
- 2021-09-22 AU AU2021236502A patent/AU2021236502A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021143193A (ja) | 2021-09-24 |
| UY37222A (es) | 2017-11-30 |
| WO2017191104A1 (de) | 2017-11-09 |
| RU2018142264A3 (enExample) | 2020-08-19 |
| SG11201809672YA (en) | 2018-11-29 |
| US20200299271A1 (en) | 2020-09-24 |
| CA3022789A1 (en) | 2017-11-09 |
| PE20190202A1 (es) | 2019-02-05 |
| TWI755393B (zh) | 2022-02-21 |
| RU2018142264A (ru) | 2020-06-03 |
| MX2018013336A (es) | 2019-05-09 |
| RU2742885C2 (ru) | 2021-02-11 |
| MX391356B (es) | 2025-03-19 |
| CN109071500A (zh) | 2018-12-21 |
| CO2018011948A2 (es) | 2018-11-22 |
| AU2017259872B2 (en) | 2021-06-24 |
| KR20190003536A (ko) | 2019-01-09 |
| MX379555B (es) | 2025-03-11 |
| JP2019514948A (ja) | 2019-06-06 |
| CN113105403A (zh) | 2021-07-13 |
| AU2017259872A1 (en) | 2018-11-22 |
| IL262534B (en) | 2021-04-29 |
| IL262534A (en) | 2018-12-31 |
| US20190144431A1 (en) | 2019-05-16 |
| EP3452467A1 (de) | 2019-03-13 |
| MX2020010365A (es) | 2022-04-06 |
| AU2021236502A1 (en) | 2021-10-21 |
| CN109071500B (zh) | 2021-05-18 |
| JP6921863B2 (ja) | 2021-08-18 |
| BR112018072528A2 (pt) | 2019-03-26 |
| TW201815782A (zh) | 2018-05-01 |
| US10703742B2 (en) | 2020-07-07 |
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