BR112018072528A2 - método para produzir derivados de 1-fenil-1,2,4-triazol substituídos por 5-hidroxialquila - Google Patents
método para produzir derivados de 1-fenil-1,2,4-triazol substituídos por 5-hidroxialquilaInfo
- Publication number
- BR112018072528A2 BR112018072528A2 BR112018072528-5A BR112018072528A BR112018072528A2 BR 112018072528 A2 BR112018072528 A2 BR 112018072528A2 BR 112018072528 A BR112018072528 A BR 112018072528A BR 112018072528 A2 BR112018072528 A2 BR 112018072528A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- triazole derivatives
- producing
- hydroxyalkyl substituted
- triazol
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CGRLXLHYYDSTKR-UHFFFAOYSA-N 1-phenyl-1H-1,2,4-triazole Chemical class N1=CN=CN1C1=CC=CC=C1 CGRLXLHYYDSTKR-UHFFFAOYSA-N 0.000 title 1
- -1 monofluoromethyl Chemical group 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16168169.7 | 2016-05-03 | ||
| EP16168172 | 2016-05-03 | ||
| EP16168163.0 | 2016-05-03 | ||
| EP16168165 | 2016-05-03 | ||
| EP16168165.5 | 2016-05-03 | ||
| EP16168169 | 2016-05-03 | ||
| EP16168163 | 2016-05-03 | ||
| EP16168166.3 | 2016-05-03 | ||
| EP16168166 | 2016-05-03 | ||
| EP16168172.1 | 2016-05-03 | ||
| EP17160086.9 | 2017-03-09 | ||
| EP17160086 | 2017-03-09 | ||
| PCT/EP2017/060367 WO2017191104A1 (de) | 2016-05-03 | 2017-05-02 | Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018072528A2 true BR112018072528A2 (pt) | 2019-03-26 |
Family
ID=58633014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018072528-5A BR112018072528A2 (pt) | 2016-05-03 | 2017-05-02 | método para produzir derivados de 1-fenil-1,2,4-triazol substituídos por 5-hidroxialquila |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10703742B2 (enExample) |
| EP (1) | EP3452467A1 (enExample) |
| JP (2) | JP6921863B2 (enExample) |
| KR (1) | KR20190003536A (enExample) |
| CN (2) | CN109071500B (enExample) |
| AU (2) | AU2017259872B2 (enExample) |
| BR (1) | BR112018072528A2 (enExample) |
| CA (1) | CA3022789A1 (enExample) |
| CL (1) | CL2018003107A1 (enExample) |
| CO (1) | CO2018011948A2 (enExample) |
| IL (1) | IL262534B (enExample) |
| MX (2) | MX379555B (enExample) |
| PE (1) | PE20190202A1 (enExample) |
| RU (1) | RU2742885C2 (enExample) |
| SG (1) | SG11201809672YA (enExample) |
| TW (1) | TWI755393B (enExample) |
| UY (1) | UY37222A (enExample) |
| WO (1) | WO2017191104A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3452457B1 (en) * | 2016-05-03 | 2020-03-18 | Bayer Pharma Aktiengesellschaft | Oxoalkyl-substituted phenyltriazole derivatives and uses thereof |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CN109071500B (zh) * | 2016-05-03 | 2021-05-18 | 拜耳制药股份公司 | 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法 |
| WO2021259852A1 (en) | 2020-06-25 | 2021-12-30 | Bayer Aktiengesellschaft | Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2038262B1 (en) * | 2006-05-25 | 2014-11-12 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| WO2010033626A1 (en) * | 2008-09-19 | 2010-03-25 | Institute For Oneworld Health | Compounds, compositions and methods comprising imidazole and triazole derivatives |
| DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| CA2791100C (en) * | 2010-02-27 | 2018-01-30 | Bayer Intellectual Property Gmbh | Bisaryl-bonded aryltriazolones and use thereof |
| CA2872726C (en) * | 2012-05-08 | 2020-07-07 | Hans-Christian Militzer | Method for the preparation of triazole compounds |
| SG11201703199UA (en) | 2014-11-03 | 2017-05-30 | Bayer Pharma AG | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
| EP3452457B1 (en) * | 2016-05-03 | 2020-03-18 | Bayer Pharma Aktiengesellschaft | Oxoalkyl-substituted phenyltriazole derivatives and uses thereof |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CN109071500B (zh) * | 2016-05-03 | 2021-05-18 | 拜耳制药股份公司 | 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法 |
-
2017
- 2017-05-02 CN CN201780027607.0A patent/CN109071500B/zh not_active Expired - Fee Related
- 2017-05-02 KR KR1020187031568A patent/KR20190003536A/ko not_active Ceased
- 2017-05-02 WO PCT/EP2017/060367 patent/WO2017191104A1/de not_active Ceased
- 2017-05-02 TW TW106114435A patent/TWI755393B/zh not_active IP Right Cessation
- 2017-05-02 UY UY0001037222A patent/UY37222A/es not_active Application Discontinuation
- 2017-05-02 MX MX2018013336A patent/MX379555B/es unknown
- 2017-05-02 JP JP2018557408A patent/JP6921863B2/ja not_active Expired - Fee Related
- 2017-05-02 CA CA3022789A patent/CA3022789A1/en active Pending
- 2017-05-02 US US16/098,238 patent/US10703742B2/en not_active Expired - Fee Related
- 2017-05-02 PE PE2018002254A patent/PE20190202A1/es unknown
- 2017-05-02 AU AU2017259872A patent/AU2017259872B2/en not_active Ceased
- 2017-05-02 SG SG11201809672YA patent/SG11201809672YA/en unknown
- 2017-05-02 RU RU2018142264A patent/RU2742885C2/ru active
- 2017-05-02 BR BR112018072528-5A patent/BR112018072528A2/pt active Search and Examination
- 2017-05-02 MX MX2020010365A patent/MX391356B/es unknown
- 2017-05-02 CN CN202110424553.XA patent/CN113105403A/zh active Pending
- 2017-05-02 EP EP17719636.7A patent/EP3452467A1/de not_active Withdrawn
-
2018
- 2018-10-23 IL IL262534A patent/IL262534B/en active IP Right Grant
- 2018-10-31 CL CL2018003107A patent/CL2018003107A1/es unknown
- 2018-11-02 CO CONC2018/0011948A patent/CO2018011948A2/es unknown
-
2020
- 2020-05-21 US US16/880,933 patent/US20200299271A1/en not_active Abandoned
-
2021
- 2021-06-14 JP JP2021098486A patent/JP2021143193A/ja not_active Withdrawn
- 2021-09-22 AU AU2021236502A patent/AU2021236502A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20190202A1 (es) | 2019-02-05 |
| RU2018142264A3 (enExample) | 2020-08-19 |
| CA3022789A1 (en) | 2017-11-09 |
| MX2020010365A (es) | 2022-04-06 |
| WO2017191104A1 (de) | 2017-11-09 |
| TW201815782A (zh) | 2018-05-01 |
| CL2018003107A1 (es) | 2019-02-22 |
| MX379555B (es) | 2025-03-11 |
| IL262534B (en) | 2021-04-29 |
| SG11201809672YA (en) | 2018-11-29 |
| CO2018011948A2 (es) | 2018-11-22 |
| JP2019514948A (ja) | 2019-06-06 |
| KR20190003536A (ko) | 2019-01-09 |
| US20190144431A1 (en) | 2019-05-16 |
| JP6921863B2 (ja) | 2021-08-18 |
| AU2017259872B2 (en) | 2021-06-24 |
| CN109071500A (zh) | 2018-12-21 |
| RU2018142264A (ru) | 2020-06-03 |
| CN109071500B (zh) | 2021-05-18 |
| AU2021236502A1 (en) | 2021-10-21 |
| MX2018013336A (es) | 2019-05-09 |
| MX391356B (es) | 2025-03-19 |
| AU2017259872A1 (en) | 2018-11-22 |
| UY37222A (es) | 2017-11-30 |
| JP2021143193A (ja) | 2021-09-24 |
| US10703742B2 (en) | 2020-07-07 |
| TWI755393B (zh) | 2022-02-21 |
| IL262534A (en) | 2018-12-31 |
| CN113105403A (zh) | 2021-07-13 |
| US20200299271A1 (en) | 2020-09-24 |
| RU2742885C2 (ru) | 2021-02-11 |
| EP3452467A1 (de) | 2019-03-13 |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |