JP2014070075A5 - - Google Patents
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- Publication number
- JP2014070075A5 JP2014070075A5 JP2013228826A JP2013228826A JP2014070075A5 JP 2014070075 A5 JP2014070075 A5 JP 2014070075A5 JP 2013228826 A JP2013228826 A JP 2013228826A JP 2013228826 A JP2013228826 A JP 2013228826A JP 2014070075 A5 JP2014070075 A5 JP 2014070075A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydrobenzo
- triazol
- oxazepin
- imidazo
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1- (2,4-Difluorophenyl) -1H-1,2,4-triazol-5-yl Chemical group 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- LWZYUACNWRVDDJ-UHFFFAOYSA-N 1-benzoxepine Chemical group O1C=CC=CC2=CC=CC=C12 LWZYUACNWRVDDJ-UHFFFAOYSA-N 0.000 claims 3
- FSGDNSSAEHNEAS-UHFFFAOYSA-N 2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]ethanol Chemical compound CC(C)N1N=C(C)N=C1C1=CN(CCOC=2C3=CC=C(C=2)C2=CN(CCO)N=C2)C3=N1 FSGDNSSAEHNEAS-UHFFFAOYSA-N 0.000 claims 3
- QKZHALLNBLDACB-UHFFFAOYSA-N 2-methyl-1-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propan-2-ol Chemical compound CC(C)N1N=CN=C1C1=CN(CCOC=2C3=CC=C(C=2)C2=CN(CC(C)(C)O)N=C2)C3=N1 QKZHALLNBLDACB-UHFFFAOYSA-N 0.000 claims 3
- BEUQXVWXFDOSAQ-UHFFFAOYSA-N 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide Chemical compound CC(C)N1N=C(C)N=C1C1=CN(CCOC=2C3=CC=C(C=2)C2=CN(N=C2)C(C)(C)C(N)=O)C3=N1 BEUQXVWXFDOSAQ-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 0 CC(C(*)CC=C1)N=C1NC Chemical compound CC(C(*)CC=C1)N=C1NC 0.000 description 7
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24638109P | 2009-09-28 | 2009-09-28 | |
| US61/246,381 | 2009-09-28 | ||
| US33068510P | 2010-05-03 | 2010-05-03 | |
| US61/330,685 | 2010-05-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530282A Division JP5540101B2 (ja) | 2009-09-28 | 2010-09-27 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014070075A JP2014070075A (ja) | 2014-04-21 |
| JP2014070075A5 true JP2014070075A5 (enExample) | 2014-08-07 |
| JP5625101B2 JP5625101B2 (ja) | 2014-11-12 |
Family
ID=43037239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530282A Active JP5540101B2 (ja) | 2009-09-28 | 2010-09-27 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
| JP2013228826A Active JP5625101B2 (ja) | 2009-09-28 | 2013-11-01 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530282A Active JP5540101B2 (ja) | 2009-09-28 | 2010-09-27 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US8242104B2 (enExample) |
| EP (3) | EP2711368B1 (enExample) |
| JP (2) | JP5540101B2 (enExample) |
| KR (1) | KR101428346B1 (enExample) |
| CN (2) | CN104744491B (enExample) |
| AR (1) | AR078187A1 (enExample) |
| AU (1) | AU2010299816C1 (enExample) |
| BR (1) | BR112012006807A2 (enExample) |
| CA (1) | CA2772691C (enExample) |
| CL (1) | CL2012000754A1 (enExample) |
| CO (1) | CO6491026A2 (enExample) |
| CR (1) | CR20120121A (enExample) |
| DK (1) | DK2483278T3 (enExample) |
| EC (1) | ECSP12011755A (enExample) |
| ES (2) | ES2570569T3 (enExample) |
| HR (1) | HRP20140229T1 (enExample) |
| IL (2) | IL217558A (enExample) |
| MA (1) | MA33531B1 (enExample) |
| MX (1) | MX2012003591A (enExample) |
| MY (2) | MY160064A (enExample) |
| NZ (1) | NZ597833A (enExample) |
| PE (1) | PE20121025A1 (enExample) |
| PL (1) | PL2483278T3 (enExample) |
| PT (1) | PT2483278E (enExample) |
| RS (1) | RS53164B (enExample) |
| RU (2) | RU2600927C2 (enExample) |
| SG (1) | SG10201405049RA (enExample) |
| SI (1) | SI2483278T1 (enExample) |
| TW (1) | TWI423980B (enExample) |
| WO (1) | WO2011036280A1 (enExample) |
| ZA (1) | ZA201202199B (enExample) |
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| BR112013024122A2 (pt) * | 2011-03-21 | 2019-09-24 | Hoffmann La Roche | compostos de benzoxazepina seletivos para p110 delta pi3k e métodos de uso |
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| WO2012156379A1 (en) | 2011-05-13 | 2012-11-22 | Universität Zürich | PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING |
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| CN104870454B (zh) * | 2012-08-07 | 2020-03-03 | 詹森药业有限公司 | 用于制备杂环酯衍生物的方法 |
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| RU2506267C2 (ru) | 2008-03-31 | 2014-02-10 | Дженентек, Инк. | Бензопирановые и бензоксепиновые ингибиторы рi3k и их применение |
| WO2010043676A1 (en) * | 2008-10-17 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor |
| CA2772691C (en) * | 2009-09-28 | 2017-10-03 | F. Hoffmann-La Roche Ag | Benzoxazepin pi3k inhibitor compounds and methods of use |
| AU2010299820A1 (en) * | 2009-09-28 | 2012-04-19 | F. Hoffmann-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
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