IL262534B - A method for the production of 5-hydroxyalkyl substituted 1-phenyl-4,2,1-triazole derivatives - Google Patents

A method for the production of 5-hydroxyalkyl substituted 1-phenyl-4,2,1-triazole derivatives

Info

Publication number
IL262534B
IL262534B IL262534A IL26253418A IL262534B IL 262534 B IL262534 B IL 262534B IL 262534 A IL262534 A IL 262534A IL 26253418 A IL26253418 A IL 26253418A IL 262534 B IL262534 B IL 262534B
Authority
IL
Israel
Prior art keywords
hydroxyalkyl
phenyl
substituted
producing
triazole derivatives
Prior art date
Application number
IL262534A
Other languages
English (en)
Hebrew (he)
Other versions
IL262534A (en
Original Assignee
Bayer Pharma AG
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Cropscience Ag filed Critical Bayer Pharma AG
Publication of IL262534A publication Critical patent/IL262534A/en
Publication of IL262534B publication Critical patent/IL262534B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL262534A 2016-05-03 2018-10-23 A method for the production of 5-hydroxyalkyl substituted 1-phenyl-4,2,1-triazole derivatives IL262534B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16168172 2016-05-03
EP16168163 2016-05-03
EP16168169 2016-05-03
EP16168165 2016-05-03
EP16168166 2016-05-03
EP17160086 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (de) 2016-05-03 2017-05-02 Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen

Publications (2)

Publication Number Publication Date
IL262534A IL262534A (en) 2018-12-31
IL262534B true IL262534B (en) 2021-04-29

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
IL262534A IL262534B (en) 2016-05-03 2018-10-23 A method for the production of 5-hydroxyalkyl substituted 1-phenyl-4,2,1-triazole derivatives

Country Status (19)

Country Link
US (2) US10703742B2 (enExample)
EP (1) EP3452467A1 (enExample)
JP (2) JP6921863B2 (enExample)
KR (1) KR20190003536A (enExample)
CN (2) CN109071500B (enExample)
AU (2) AU2017259872B2 (enExample)
BR (1) BR112018072528A2 (enExample)
CA (1) CA3022789A1 (enExample)
CL (1) CL2018003107A1 (enExample)
CO (1) CO2018011948A2 (enExample)
IL (1) IL262534B (enExample)
JO (1) JOP20170103A1 (enExample)
MX (2) MX379555B (enExample)
PE (1) PE20190202A1 (enExample)
RU (1) RU2742885C2 (enExample)
SG (1) SG11201809672YA (enExample)
TW (1) TWI755393B (enExample)
UY (1) UY37222A (enExample)
WO (1) WO2017191104A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3452457B1 (en) * 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
CN118894815A (zh) * 2024-07-12 2024-11-05 西北师范大学 一种含三氟甲基的1,2,4-三氮唑啉类衍生物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490212B (zh) * 2006-05-25 2015-07-01 Synta Pharmaceuticals Corp 調節ｈｓｐ９０活性之三唑化合物
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
DE102010001064A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
ES2635340T3 (es) * 2010-02-27 2017-10-03 Bayer Intellectual Property Gmbh Ariltriazolonas ligadas a bis-arilo y su uso
UA116349C2 (uk) * 2012-05-08 2018-03-12 Байєр Фарма Акцієнгезелльшафт Спосіб одержання морфолінпіримідинових похідних піразолу
US20170313665A1 (en) * 2014-11-03 2017-11-02 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
EP3452457B1 (en) * 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof

Also Published As

Publication number Publication date
JOP20170103A1 (ar) 2017-11-03
SG11201809672YA (en) 2018-11-29
RU2018142264A (ru) 2020-06-03
CN109071500A (zh) 2018-12-21
CL2018003107A1 (es) 2019-02-22
RU2742885C2 (ru) 2021-02-11
UY37222A (es) 2017-11-30
MX379555B (es) 2025-03-11
TW201815782A (zh) 2018-05-01
EP3452467A1 (de) 2019-03-13
AU2021236502A1 (en) 2021-10-21
KR20190003536A (ko) 2019-01-09
MX2018013336A (es) 2019-05-09
CN113105403A (zh) 2021-07-13
US20200299271A1 (en) 2020-09-24
IL262534A (en) 2018-12-31
MX2020010365A (es) 2022-04-06
TWI755393B (zh) 2022-02-21
AU2017259872A1 (en) 2018-11-22
PE20190202A1 (es) 2019-02-05
MX391356B (es) 2025-03-19
JP6921863B2 (ja) 2021-08-18
US20190144431A1 (en) 2019-05-16
CN109071500B (zh) 2021-05-18
JP2019514948A (ja) 2019-06-06
CA3022789A1 (en) 2017-11-09
BR112018072528A2 (pt) 2019-03-26
AU2017259872B2 (en) 2021-06-24
JP2021143193A (ja) 2021-09-24
US10703742B2 (en) 2020-07-07
CO2018011948A2 (es) 2018-11-22
RU2018142264A3 (enExample) 2020-08-19
WO2017191104A1 (de) 2017-11-09

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