EA201492032A1 - Способ получения соединений триазола - Google Patents

Способ получения соединений триазола

Info

Publication number
EA201492032A1
EA201492032A1 EA201492032A EA201492032A EA201492032A1 EA 201492032 A1 EA201492032 A1 EA 201492032A1 EA 201492032 A EA201492032 A EA 201492032A EA 201492032 A EA201492032 A EA 201492032A EA 201492032 A1 EA201492032 A1 EA 201492032A1
Authority
EA
Eurasian Patent Office
Prior art keywords
morpholin
triazol
pyrimidin
triazole compounds
pyrazol
Prior art date
Application number
EA201492032A
Other languages
English (en)
Other versions
EA027804B1 (ru
Inventor
Ханс-Кристиан Милитцер
Ёханнес Эггерт
Original Assignee
Байер Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48325714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201492032(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Фарма Акциенгезельшафт filed Critical Байер Фарма Акциенгезельшафт
Publication of EA201492032A1 publication Critical patent/EA201492032A1/ru
Publication of EA027804B1 publication Critical patent/EA027804B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Abstract

Настоящее изобретение касается способа получения 1-[6-(морфолин-4-ил)пиримидин-4-ил]-4-(1Н-1,2,3-триазол-1-ил)-1Н-пиразол-5-ола (I - енольная форма) или 2-[6-(морфолин-4-ил)пиримидин-4-ил]-4-(1H-1,2,3-триазол-1-ил)-1,2-дигидро-3H-пиразол-3-она (I - кетоформа) и натрий-1-[6-(морфолин-4-ил)пиримидин-4-ил]-4-(1Н-1,2,3-триазол-1-ил)-1H-пиразол-5-олата (II), исходя из 1,2,3-триазола (III), метилового эфира бромуксусной кислоты (IV-Me-Br) или этилового эфира бромуксусной кислоты (IV-Et-Br), 4,6-дихлорпиримидина (VIII), морфолина (IX) и гидразина (XII).
EA201492032A 2012-05-08 2013-05-06 Способ получения соединений триазола EA027804B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12167152 2012-05-08
PCT/EP2013/059418 WO2013167552A1 (de) 2012-05-08 2013-05-06 Verfahren zur herstellung von triazol-verbindungen

Publications (2)

Publication Number Publication Date
EA201492032A1 true EA201492032A1 (ru) 2015-04-30
EA027804B1 EA027804B1 (ru) 2017-09-29

Family

ID=48325714

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492032A EA027804B1 (ru) 2012-05-08 2013-05-06 Способ получения соединений триазола

Country Status (36)

Country Link
US (1) US10301289B2 (ru)
EP (1) EP2847183B1 (ru)
JP (1) JP6149104B2 (ru)
KR (1) KR102086389B1 (ru)
CN (1) CN104411704B (ru)
AP (1) AP2014008089A0 (ru)
AU (1) AU2013258107B2 (ru)
BR (1) BR112014027564B1 (ru)
CA (1) CA2872726C (ru)
CL (2) CL2014003003A1 (ru)
CO (1) CO7121324A2 (ru)
CR (1) CR20140514A (ru)
CU (1) CU20140128A7 (ru)
DK (1) DK2847183T3 (ru)
DO (1) DOP2014000254A (ru)
EA (1) EA027804B1 (ru)
ES (1) ES2641205T3 (ru)
HK (1) HK1208027A1 (ru)
HR (1) HRP20171321T1 (ru)
HU (1) HUE034430T2 (ru)
IL (1) IL235441A (ru)
LT (1) LT2847183T (ru)
MX (1) MX350519B (ru)
MY (1) MY184577A (ru)
NZ (1) NZ701661A (ru)
PE (1) PE20142453A1 (ru)
PH (1) PH12014502482A1 (ru)
PL (1) PL2847183T3 (ru)
PT (1) PT2847183T (ru)
RS (1) RS56255B1 (ru)
SG (2) SG10201609319YA (ru)
SI (1) SI2847183T1 (ru)
TN (1) TN2014000469A1 (ru)
UA (1) UA116349C2 (ru)
WO (1) WO2013167552A1 (ru)
ZA (1) ZA201408571B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY37222A (es) * 2016-05-03 2017-11-30 Bayer Pharma AG PROCEDIMIENTO PARA LA PREPARACIÓN DE DERIVADOS DE 1-FENILO-1,2,4-TRIAZOL SUSTITUIDOS POR 5-HIdroxIalQUILO
CN108084099B (zh) * 2017-12-20 2019-01-29 天驰药业有限公司 一种1,2,3-三氮唑化合物的合成方法
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents
EP3888684A1 (en) 2020-03-31 2021-10-06 Bayer Animal Health GmbH Composition having improved voluntary acceptance
CN114264752B (zh) * 2021-12-29 2023-08-15 北京金城泰尔制药有限公司 溴乙酸甲酯的检测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135184A (da) 1983-03-03 1984-10-10 Riker Laboratories Inc Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner
US4572910A (en) * 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4752910A (en) 1984-10-30 1988-06-21 Prime Computer, Inc. Method and apparatus for continuous after-imaging
UY27813A1 (es) 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
TWI335913B (en) 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
WO2005044785A1 (en) * 2003-10-30 2005-05-19 Merck & Co., Inc. Aralkyl amines as cannabinoid receptor modulators
US7745630B2 (en) 2003-12-22 2010-06-29 Justin Stephen Bryans Triazolyl piperidine arginine vasopressin receptor modulators
DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
EP1877399A1 (en) 2005-04-26 2008-01-16 Pfizer Limited Triazole derivatives as vasopressin antagonists
US20080234252A1 (en) 2005-05-18 2008-09-25 Pfizer Inc Compounds Useful in Therapy
DE102006050516A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102010041236A1 (de) * 2010-09-23 2012-03-29 Osram Ag Optoelektronisches Halbleiterbauelement
DE102010044131A1 (de) * 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Also Published As

Publication number Publication date
ES2641205T3 (es) 2017-11-08
LT2847183T (lt) 2017-09-25
CA2872726A1 (en) 2013-11-14
PE20142453A1 (es) 2015-01-17
MY184577A (en) 2021-04-06
CR20140514A (es) 2014-12-02
UA116349C2 (uk) 2018-03-12
BR112014027564B1 (pt) 2022-05-03
CA2872726C (en) 2020-07-07
CN104411704B (zh) 2017-12-22
JP6149104B2 (ja) 2017-06-14
CN104411704A (zh) 2015-03-11
PH12014502482A1 (en) 2015-01-12
NZ701661A (en) 2016-08-26
AP2014008089A0 (en) 2014-11-30
US10301289B2 (en) 2019-05-28
JP2015516403A (ja) 2015-06-11
MX2014013448A (es) 2014-12-08
PT2847183T (pt) 2017-10-02
KR102086389B1 (ko) 2020-03-09
HUE034430T2 (en) 2018-02-28
HK1208027A1 (en) 2016-02-19
IL235441A (en) 2017-09-28
AU2013258107A1 (en) 2014-11-27
SG10201609319YA (en) 2016-12-29
KR20150018534A (ko) 2015-02-23
SI2847183T1 (sl) 2017-10-30
CL2016001165A1 (es) 2016-12-02
BR112014027564A2 (ru) 2017-08-22
TN2014000469A1 (en) 2016-03-30
WO2013167552A1 (de) 2013-11-14
DOP2014000254A (es) 2016-01-31
EP2847183B1 (de) 2017-06-21
ZA201408571B (en) 2016-03-30
EA027804B1 (ru) 2017-09-29
AU2013258107B2 (en) 2017-06-22
DK2847183T3 (en) 2017-10-02
PL2847183T3 (pl) 2017-11-30
CO7121324A2 (es) 2014-11-20
EP2847183A1 (de) 2015-03-18
RS56255B1 (sr) 2017-11-30
HRP20171321T1 (hr) 2017-10-20
CU20140128A7 (es) 2015-03-30
CL2014003003A1 (es) 2015-02-13
SG11201407043PA (en) 2014-12-30
MX350519B (es) 2017-09-08
US20150087827A1 (en) 2015-03-26

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