CL2014001346A1 - Compuestos derivados de 3-amino-5-[(2-amino-2-oxoetil)amino]pirazina-2-carboxamida, inhibidores de pirazina cinasa; composicion y metodo para tratar una afeccion como enfermedad cardiovascular, trastorno de proliferacion, entre otros - Google Patents

Compuestos derivados de 3-amino-5-[(2-amino-2-oxoetil)amino]pirazina-2-carboxamida, inhibidores de pirazina cinasa; composicion y metodo para tratar una afeccion como enfermedad cardiovascular, trastorno de proliferacion, entre otros

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Publication number
CL2014001346A1
CL2014001346A1 CL2014001346A CL2014001346A CL2014001346A1 CL 2014001346 A1 CL2014001346 A1 CL 2014001346A1 CL 2014001346 A CL2014001346 A CL 2014001346A CL 2014001346 A CL2014001346 A CL 2014001346A CL 2014001346 A1 CL2014001346 A1 CL 2014001346A1
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CL
Chile
Prior art keywords
amino
pyrazine
treat
composition
cardiovascular disease
Prior art date
Application number
CL2014001346A
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English (en)
Spanish (es)
Inventor
Yonghong Song
Qing Xu
Zhaozhong J Jia
Brian Kane
Shawn M Bauer
Anjali Pandey
Original Assignee
Portola Pharm Inc
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Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of CL2014001346A1 publication Critical patent/CL2014001346A1/es

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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CL2014001346A 2011-11-23 2014-05-22 Compuestos derivados de 3-amino-5-[(2-amino-2-oxoetil)amino]pirazina-2-carboxamida, inhibidores de pirazina cinasa; composicion y metodo para tratar una afeccion como enfermedad cardiovascular, trastorno de proliferacion, entre otros CL2014001346A1 (es)

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Application Number Priority Date Filing Date Title
US201161563466P 2011-11-23 2011-11-23

Publications (1)

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CL2014001346A1 true CL2014001346A1 (es) 2015-03-13

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CL2014001346A CL2014001346A1 (es) 2011-11-23 2014-05-22 Compuestos derivados de 3-amino-5-[(2-amino-2-oxoetil)amino]pirazina-2-carboxamida, inhibidores de pirazina cinasa; composicion y metodo para tratar una afeccion como enfermedad cardiovascular, trastorno de proliferacion, entre otros

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US (2) US9359308B2 (cg-RX-API-DMAC7.html)
EP (1) EP2782579B1 (cg-RX-API-DMAC7.html)
JP (1) JP6039683B2 (cg-RX-API-DMAC7.html)
KR (1) KR102019530B1 (cg-RX-API-DMAC7.html)
CN (1) CN104066431B (cg-RX-API-DMAC7.html)
AU (1) AU2012340555B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014012396B1 (cg-RX-API-DMAC7.html)
CA (2) CA3094793A1 (cg-RX-API-DMAC7.html)
CL (1) CL2014001346A1 (cg-RX-API-DMAC7.html)
CO (1) CO6990735A2 (cg-RX-API-DMAC7.html)
EA (1) EA026939B1 (cg-RX-API-DMAC7.html)
IL (1) IL232701A (cg-RX-API-DMAC7.html)
IN (1) IN2014CN04065A (cg-RX-API-DMAC7.html)
MX (1) MX363551B (cg-RX-API-DMAC7.html)
SG (2) SG10201601352UA (cg-RX-API-DMAC7.html)
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BR112014012396B1 (pt) 2011-11-23 2020-08-25 Portola Pharmaceuticals, Inc inibidores de pirazina quinase, composição, método in vitro para inibição de quinase syk ou via de transdução de sinal, uso dos referidos inibidores e kit
US20130310387A1 (en) * 2012-05-16 2013-11-21 Novartis Ag Monocyclic Heteroaryl Cycloalkyldiamine Derivatives
HK1211024A1 (en) 2012-10-19 2016-05-13 霍夫曼-拉罗奇有限公司 Inhibitors of syk
AU2014360446A1 (en) 2013-12-05 2016-06-09 Pharmacyclics, Llc Inhibitors of Bruton's tyrosine kinase
EP3116506B1 (en) * 2014-03-13 2019-04-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CZ306322B6 (cs) 2014-12-17 2016-11-30 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující
EP3310776A4 (en) * 2015-06-02 2019-01-16 Pharmacyclics LLC BRUTON TYROSINE KINASE HEMMER
EP3801525A4 (en) * 2018-06-08 2022-03-23 The General Hospital Corporation PROLYL TRNA SYNTHETASE INHIBITORS
CN112047899A (zh) * 2020-10-19 2020-12-08 成都睿智化学研究有限公司 一种合成3-取代氨基苯并[c]异噻唑衍生物的方法
IL315365A (en) * 2022-03-14 2024-11-01 Purdue Research Foundation Spleen tyrosine kinase inhibitor, composition and methods of use

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