CH676237A5 - Antiinflammatory nabumetone prodn. - Google Patents

Antiinflammatory nabumetone prodn. Download PDF

Info

Publication number
CH676237A5
CH676237A5 CH465188A CH465188A CH676237A5 CH 676237 A5 CH676237 A5 CH 676237A5 CH 465188 A CH465188 A CH 465188A CH 465188 A CH465188 A CH 465188A CH 676237 A5 CH676237 A5 CH 676237A5
Authority
CH
Switzerland
Prior art keywords
palladium
formula
halogen
methoxy
buten
Prior art date
Application number
CH465188A
Other languages
German (de)
English (en)
Inventor
John Carl Rose
John Robert Mansfield Dales
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878729667A external-priority patent/GB8729667D0/en
Priority claimed from GB888823561A external-priority patent/GB8823561D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of CH676237A5 publication Critical patent/CH676237A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CH465188A 1987-12-19 1988-12-16 Antiinflammatory nabumetone prodn. CH676237A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878729667A GB8729667D0 (en) 1987-12-19 1987-12-19 Novel process
GB888823561A GB8823561D0 (en) 1988-10-07 1988-10-07 Novel process

Publications (1)

Publication Number Publication Date
CH676237A5 true CH676237A5 (en) 1990-12-28

Family

ID=26293222

Family Applications (1)

Application Number Title Priority Date Filing Date
CH465188A CH676237A5 (en) 1987-12-19 1988-12-16 Antiinflammatory nabumetone prodn.

Country Status (6)

Country Link
JP (1) JPH02101038A (nl)
CH (1) CH676237A5 (nl)
DK (1) DK702388A (nl)
ES (1) ES2012173A6 (nl)
GR (1) GR1000163B (nl)
NL (1) NL8803088A (nl)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024747A1 (en) * 1996-12-03 1998-06-11 Recordati S.A. Chemical And Pharmaceutical Company A process for the preparation of nabumetone
WO1998037048A1 (en) * 1997-02-21 1998-08-27 Albemarle Corporation Production of alkyl aralkyl ketones from allylic-aralkenyl secondary alcohols

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2004042C (en) * 1988-12-08 1999-11-02 Napp Technologies, Inc. Method of preparation of nabumetone
US5756851A (en) * 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1476721A (en) * 1974-08-20 1977-06-16 Beecham Group Ltd 4-6-methoxy-2-naphthyl-butan-2-one
US4070374A (en) * 1975-06-16 1978-01-24 Givaudan Corporation Process for the preparation of aryl substituted aldehydes, ketones and alcohols

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024747A1 (en) * 1996-12-03 1998-06-11 Recordati S.A. Chemical And Pharmaceutical Company A process for the preparation of nabumetone
WO1998037048A1 (en) * 1997-02-21 1998-08-27 Albemarle Corporation Production of alkyl aralkyl ketones from allylic-aralkenyl secondary alcohols

Also Published As

Publication number Publication date
DK702388A (da) 1989-06-20
DK702388D0 (da) 1988-12-16
ES2012173A6 (es) 1990-03-01
JPH02101038A (ja) 1990-04-12
GR1000163B (el) 1991-10-10
NL8803088A (nl) 1989-07-17

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Legal Events

Date Code Title Description
PL Patent ceased