CH665834A5 - Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen. - Google Patents

Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen. Download PDF

Info

Publication number
CH665834A5
CH665834A5 CH145/85A CH14585A CH665834A5 CH 665834 A5 CH665834 A5 CH 665834A5 CH 145/85 A CH145/85 A CH 145/85A CH 14585 A CH14585 A CH 14585A CH 665834 A5 CH665834 A5 CH 665834A5
Authority
CH
Switzerland
Prior art keywords
dihydroxy
compound
trans
hydroxyvitamin
dihydroxyvitamin
Prior art date
Application number
CH145/85A
Other languages
German (de)
English (en)
Inventor
Hector F Deluca
Heinrich K Schnoes
Rafal R Sicinski
Yoko Tanaka
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of CH665834A5 publication Critical patent/CH665834A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CH145/85A 1983-05-09 1984-05-09 Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen. CH665834A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49286383A 1983-05-09 1983-05-09
US60732784A 1984-05-04 1984-05-04

Publications (1)

Publication Number Publication Date
CH665834A5 true CH665834A5 (de) 1988-06-15

Family

ID=27050897

Family Applications (1)

Application Number Title Priority Date Filing Date
CH145/85A CH665834A5 (de) 1983-05-09 1984-05-09 Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen.

Country Status (7)

Country Link
JP (3) JPH0610188B2 (ja)
AU (1) AU568549B2 (ja)
CH (1) CH665834A5 (ja)
DE (4) DE3490215C2 (ja)
DK (3) DK171397B1 (ja)
NL (1) NL193245C (ja)
WO (1) WO1984004527A1 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582789B2 (en) * 1984-10-04 1989-04-13 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
CA1341408C (en) * 1988-08-02 2002-12-10 Charles W. Bishop Method for treating and preventing loss of bone mass
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
IN171449B (ja) * 1990-02-14 1992-10-17 Wisconsin Alumni Res Found
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
EP0600079B1 (en) * 1992-06-22 2002-01-02 Bone Care International, Inc. Oral 1alpha-hydroxyprevitamin d
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
AU750451B2 (en) 1997-02-13 2002-07-18 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
EP2262765B1 (en) 2008-03-12 2016-03-09 OPKO Ireland Global Holdings, Limited Stabilized 1,25-dihydroxyvitamin d2 and method of making same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same

Also Published As

Publication number Publication date
JPH0339505B2 (ja) 1991-06-14
AU3011584A (en) 1984-12-04
DE3490215T (de) 1985-05-15
NL193245B (nl) 1998-12-01
NL193245C (nl) 1999-04-02
DK8685D0 (da) 1985-01-08
WO1984004527A1 (en) 1984-11-22
DK171397B1 (da) 1996-10-14
DE3490215C2 (ja) 1991-07-25
JPH02288854A (ja) 1990-11-28
DK8685A (da) 1985-01-08
JPH02288829A (ja) 1990-11-28
AU568549B2 (en) 1988-01-07
DK183291A (da) 1991-11-07
JPH0610188B2 (ja) 1994-02-09
DE3448412C2 (ja) 1991-12-12
DK184588D0 (da) 1988-04-06
DK183291D0 (da) 1991-11-07
DE3448360C2 (ja) 1991-10-02
JPH0651624B2 (ja) 1994-07-06
NL8420137A (nl) 1985-04-01
DK172567B1 (da) 1999-01-18
JPH02288873A (ja) 1990-11-28
DK172733B1 (da) 1999-06-21
DK184588A (da) 1988-04-06

Similar Documents

Publication Publication Date Title
DE3250034C2 (ja)
DE60130640T2 (de) 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen
DE69807852T2 (de) 2-alkyliden-19-nor-vitamin d-verbindungen
DE69415690T2 (de) (e)-20(22)-dehydrovitamin-d-verbindungen
DE69006052T2 (de) 19-Nor-Vitamin-D-Derivate.
DE69819312T2 (de) 2-alkyl-19-nor-vitamin d-verbindungen
DE69400495T2 (de) 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
DE69233074T2 (de) Verfahren zur Herstellung von 1-alpha-24-dihydroxy-Vitamin D2
DE60031666T2 (de) NICHT-CALCEMISCHE, TRANSKRIPTIONELL-AKTIVE, SCHWEFELHALTIGE ANALOGA VON 1-alpha, 25-DIHYDROXYVITAMIN D3 MIT ANTIPROLIFERATIVER WIRKUNG
EP0832063B1 (de) Vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln
DE69300196T2 (de) 24-Cyclopropan-Vitamin-D-Derivate.
DE3490215C2 (ja)
DE69409811T2 (de) Neue vitamin d-derivate
DE3590232C2 (de) 1,24-Dihydroxy- 22-Vitamin D3-Derivate, diese enthaltende Arzneimittel sowie Cholesterinderivate alsZwischenprodukte
DE69316910T2 (de) Neue vitamin d derivate
DE69410112T2 (de) 26,28-methylen-1alpha,25-dihydroxy-vitamin-d2-verbindungen
DE69109006T2 (de) HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN.
DE3490636C2 (de) Hydroxyvitamin D¶2¶-Isomere, Zwischenprodukt zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69712086T2 (de) Vitamin d derivate
DE69608701T2 (de) Vitamin d analoge
DE69721123T2 (de) Fluorinierte Vitamin D3 Analoge
CH653995A5 (de) 2beta-fluorcholecalciferole.
DE69707121T2 (de) Neue vitamin-d-analoga
DE3590021C2 (de) 1alpha-Hydroxyvitamin D-Derivat und dieses enthaltendes Arzneimittel
JPH0364498B2 (ja)

Legal Events

Date Code Title Description
PL Patent ceased