DE69109006T2 - HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN. - Google Patents

HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN.

Info

Publication number
DE69109006T2
DE69109006T2 DE69109006T DE69109006T DE69109006T2 DE 69109006 T2 DE69109006 T2 DE 69109006T2 DE 69109006 T DE69109006 T DE 69109006T DE 69109006 T DE69109006 T DE 69109006T DE 69109006 T2 DE69109006 T2 DE 69109006T2
Authority
DE
Germany
Prior art keywords
compounds
vitamin
hydroxylated
1alpha
homologated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69109006T
Other languages
English (en)
Other versions
DE69109006D1 (de
Inventor
Hector Deluca
Heinrich Schnoes
Kato Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69109006D1 publication Critical patent/DE69109006D1/de
Publication of DE69109006T2 publication Critical patent/DE69109006T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69109006T 1990-02-14 1991-02-13 HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN. Expired - Fee Related DE69109006T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/481,990 US5030772A (en) 1990-02-14 1990-02-14 Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
PCT/US1991/000974 WO1991012239A1 (en) 1990-02-14 1991-02-13 HOMOLOGATED VITAMIN D2 COMPOUNDS AND THE CORRESPONDING 1α-HYDROXYLATED DERIVATIVES

Publications (2)

Publication Number Publication Date
DE69109006D1 DE69109006D1 (de) 1995-05-24
DE69109006T2 true DE69109006T2 (de) 1995-08-31

Family

ID=23914203

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69109006T Expired - Fee Related DE69109006T2 (de) 1990-02-14 1991-02-13 HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN.

Country Status (7)

Country Link
US (1) US5030772A (de)
EP (1) EP0468042B1 (de)
JP (1) JP2731839B2 (de)
AT (1) ATE121387T1 (de)
DE (1) DE69109006T2 (de)
ES (1) ES2071303T3 (de)
WO (1) WO1991012239A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
IL104201A0 (en) * 1991-12-26 1993-05-13 Wisconsin Alumni Res Found 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
IL139354A (en) * 1998-05-29 2005-08-31 Bone Care Internat Inc Method for making hydroxy-25 ene-vitamin d compounds
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
SG173119A1 (en) * 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN105663146B (zh) 2009-08-14 2020-09-11 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
US20110240840A1 (en) 2009-12-11 2011-10-06 Quest Diagnostics Investments Incorporated Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d
JP5739903B2 (ja) 2009-12-11 2015-06-24 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド 複合試料中のステロイド化合物の質量分析
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585221A (en) * 1969-03-24 1971-06-15 Wisconsin Alumni Res Found 25-hydroxyergocalciferol
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
JPS51108046A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
FR2545824B1 (fr) * 1983-05-09 1987-11-20 Wisconsin Alumni Res Found Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
NL8520021A (nl) * 1984-03-05 1986-02-03 Wisconsin Alumni Res Found 1alpha-hydroxyvitamine d2 analoga en werkwijze voor het bereiden daarvan.
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
NL8520265A (nl) * 1984-10-04 1986-09-01 Wisconsin Alumni Res Found Derivaten van vitamine d en werkwijzen voor het bereiden daarvan.
US4554106A (en) * 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
DE3687377T2 (de) * 1985-01-17 1993-04-29 Wisconsin Alumni Res Found Vitamin-d-abkoemmlinge und deren herstellungsverfahren.
JPS62501505A (ja) * 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
JP2711161B2 (ja) * 1988-04-21 1998-02-10 レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ／エス（レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ） 新規ビタミンｄ類似体
WO1989010352A1 (en) * 1988-04-29 1989-11-02 Wisconsin Alumni Research Foundation SIDE CHAIN UNSATURATED 1alpha-HYDROXYVITAMIN D HOMOLOGS
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
ES2062299T3 (es) * 1989-06-15 1994-12-16 Duphar Int Res Aldehido aducto y su uso para la preparacion de un compuesto de vitamina d.
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0468042B1 (de) 1995-04-19
ES2071303T3 (es) 1995-06-16
ATE121387T1 (de) 1995-05-15
EP0468042A1 (de) 1992-01-29
JPH04505468A (ja) 1992-09-24
DE69109006D1 (de) 1995-05-24
US5030772A (en) 1991-07-09
WO1991012239A1 (en) 1991-08-22
JP2731839B2 (ja) 1998-03-25

Similar Documents

Publication Publication Date Title
DE69109006T2 (de) HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN.
MA21682A1 (fr) Procede de preparation d'agents therapeutiques derives de la quainclidine.
KR890701107A (ko) 알쯔하이머 병 치료용 화합물들
ES2141787T3 (es) Derivados de la 1,2,3,4-tetrahidro-9-acridinamina.
FI93117C (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
DZ1407A1 (fr) Dérivés d-substitués des n,n'-ditriméthoxybenzoylepipérazine ainsi que leur procédé de préparation.
NO175745C (no) Analogifremgangsmåte for fremstilling av dibenzo(1,5)-dioksocin-5-oner
ES2129580T3 (es) Procedimiento de preparacion de compuestos de alcoxiiminoacetamida.
HU913248D0 (en) Process for preparing vitamin d compounds and the corresponding 1 alphahydroxylated derivatives
ATE147749T1 (de) Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen
MA23081A1 (fr) Procede de preparation de derives d'indolone
ES2138734T3 (es) Procedimiento para la preparacion de derivados de 1-(3-trialquilsililfenil)-2,2,2-trifluormetil etanona.
FR2648675B1 (fr) Compositions propres a influencer le developpement et la floraison de plantes, procede de traitement de plantes par ces compositions et plantes modifiees obtenues
ES2082890T3 (es) Procedimiento para la preparacion de derivados 6-(aminopropionilo sustituido) de forskolina.
DZ1655A1 (fr) Dérivés de la benzofuranylimidazole ainsi que leurprocédé de préparation.
FR2618781B2 (fr) Procede de preparation de derives de la 4,4-dimethyl tetrahydro pyr-2-one
ES2067621T3 (es) Procedimiento para la preparacion de compuestos molusquicidas de 2,4,5-tribromopirrol-3-carbonitrilo.
FR2647450B1 (fr) Procede de preparation des derives de 2(prime), 3(prime)-dideshydro-2(prime),3(prime)-didesoxynucleoside
HUT58519A (en) Process for producing pharmaceutical composition suitable for treating alzheimer disease
OA09202A (fr) Procédé de préparation des nouveaux dérivés de la thiéno-triazolo-diazépine.
OA09208A (fr) "Procédé de préparation de dérivés de la thiéno-triazolo-diazépine".
PT94432A (pt) Processo para a producao sulfonamidas substituidas e compostos afins uteis no tratamento da asma, artrite e doencas afins
DE69216479T2 (de) Verbindungen und Verfahren zur Behandlung thromboembolischer Störungen
DZ1415A1 (fr) Procédé de préparation de dérivés de la thiéno-triazolo-diazépine.
UA10737A (uk) Спосіб виготовлеhhя ксеhотраhсплаhтатів

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee