ATE147749T1 - Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen - Google Patents

Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen

Info

Publication number
ATE147749T1
ATE147749T1 AT90403010T AT90403010T ATE147749T1 AT E147749 T1 ATE147749 T1 AT E147749T1 AT 90403010 T AT90403010 T AT 90403010T AT 90403010 T AT90403010 T AT 90403010T AT E147749 T1 ATE147749 T1 AT E147749T1
Authority
AT
Austria
Prior art keywords
deoxythymidine
azt
azido
producing
related compounds
Prior art date
Application number
AT90403010T
Other languages
English (en)
Inventor
Stanislas Czernecki
Jean-Marc Valery
Original Assignee
Univ Paris Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Paris Curie filed Critical Univ Paris Curie
Application granted granted Critical
Publication of ATE147749T1 publication Critical patent/ATE147749T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT90403010T 1989-10-27 1990-10-25 Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen ATE147749T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914132A FR2653771B1 (fr) 1989-10-27 1989-10-27 Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.

Publications (1)

Publication Number Publication Date
ATE147749T1 true ATE147749T1 (de) 1997-02-15

Family

ID=9386862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90403010T ATE147749T1 (de) 1989-10-27 1990-10-25 Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen

Country Status (8)

Country Link
US (1) US5124442A (de)
EP (1) EP0427587B1 (de)
JP (1) JPH03209393A (de)
KR (1) KR910007919A (de)
AT (1) ATE147749T1 (de)
CA (1) CA2028648A1 (de)
DE (1) DE69029708D1 (de)
FR (1) FR2653771B1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545629A (en) * 1994-04-12 1996-08-13 Montefiore Medical Center 5-ethoxy-2'-deoxyuridines
WO2000075154A2 (en) * 1999-06-04 2000-12-14 Alliedsignal Inc. Protected nucleosides
CN101190934B (zh) * 2006-11-27 2010-12-15 上海迪赛诺化学制药有限公司 相转移法制备齐多夫定叠氮中间体的方法
CN101376667B (zh) * 2007-08-27 2011-01-12 上海迪赛诺医药发展有限公司 一种合成齐多夫定的中间体及其制备方法和该中间体在合成齐多夫定中的应用
CN103443095B (zh) * 2011-11-07 2016-01-20 上海迪赛诺药业有限公司 制备齐多夫定及其中间体的方法
CN103201278B (zh) * 2011-11-07 2016-01-20 上海迪赛诺药业有限公司 制备齐多夫定及其中间体的方法
CN103864870A (zh) * 2013-11-28 2014-06-18 安徽一帆香料有限公司 一种齐多夫定的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5914040B2 (ja) * 1976-04-05 1984-04-02 ヤマサ醤油株式会社 Ｏ↑２，３′−サイクロピリミジンヌクレオシド類の製造法
EP0199451B1 (de) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutische Nukleoside
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4681933A (en) * 1986-05-01 1987-07-21 University Of Georgia Research Foundation, Inc. 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
AU601437B2 (en) * 1986-07-09 1990-09-13 Sumitomo Chemical Company, Limited Cyclohexane derivatives, herbicides containing the same and process for producing the derivatives
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues

Also Published As

Publication number Publication date
CA2028648A1 (fr) 1991-04-28
FR2653771B1 (fr) 1994-09-23
EP0427587A1 (de) 1991-05-15
DE69029708D1 (de) 1997-02-27
FR2653771A1 (fr) 1991-05-03
EP0427587B1 (de) 1997-01-15
US5124442A (en) 1992-06-23
KR910007919A (ko) 1991-05-30
JPH03209393A (ja) 1991-09-12

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