DE69029708D1 - Verfahren zur Herstellung von AZT(3'-azido-3'-desoxythymidin) und diebezüglichen Verbindungen - Google Patents

Verfahren zur Herstellung von AZT(3'-azido-3'-desoxythymidin) und diebezüglichen Verbindungen

Info

Publication number
DE69029708D1
DE69029708D1 DE69029708T DE69029708T DE69029708D1 DE 69029708 D1 DE69029708 D1 DE 69029708D1 DE 69029708 T DE69029708 T DE 69029708T DE 69029708 T DE69029708 T DE 69029708T DE 69029708 D1 DE69029708 D1 DE 69029708D1
Authority
DE
Germany
Prior art keywords
preparation
deoxythymidine
azt
azido
related compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69029708T
Other languages
English (en)
Inventor
Stanislas Czernecki
Jean-Marc Valery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Pierre et Marie Curie Paris 6
Original Assignee
Universite Pierre et Marie Curie Paris 6
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Pierre et Marie Curie Paris 6 filed Critical Universite Pierre et Marie Curie Paris 6
Application granted granted Critical
Publication of DE69029708D1 publication Critical patent/DE69029708D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69029708T 1989-10-27 1990-10-25 Verfahren zur Herstellung von AZT(3'-azido-3'-desoxythymidin) und diebezüglichen Verbindungen Expired - Lifetime DE69029708D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914132A FR2653771B1 (fr) 1989-10-27 1989-10-27 Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.

Publications (1)

Publication Number Publication Date
DE69029708D1 true DE69029708D1 (de) 1997-02-27

Family

ID=9386862

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029708T Expired - Lifetime DE69029708D1 (de) 1989-10-27 1990-10-25 Verfahren zur Herstellung von AZT(3'-azido-3'-desoxythymidin) und diebezüglichen Verbindungen

Country Status (8)

Country Link
US (1) US5124442A (de)
EP (1) EP0427587B1 (de)
JP (1) JPH03209393A (de)
KR (1) KR910007919A (de)
AT (1) ATE147749T1 (de)
CA (1) CA2028648A1 (de)
DE (1) DE69029708D1 (de)
FR (1) FR2653771B1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545629A (en) * 1994-04-12 1996-08-13 Montefiore Medical Center 5-ethoxy-2'-deoxyuridines
WO2000075154A2 (en) * 1999-06-04 2000-12-14 Alliedsignal Inc. Protected nucleosides
CN101190934B (zh) * 2006-11-27 2010-12-15 上海迪赛诺化学制药有限公司 相转移法制备齐多夫定叠氮中间体的方法
CN101376667B (zh) * 2007-08-27 2011-01-12 上海迪赛诺医药发展有限公司 一种合成齐多夫定的中间体及其制备方法和该中间体在合成齐多夫定中的应用
CN103443095B (zh) * 2011-11-07 2016-01-20 上海迪赛诺药业有限公司 制备齐多夫定及其中间体的方法
WO2013067669A1 (zh) * 2011-11-07 2013-05-16 上海迪赛诺药业有限公司 制备齐多夫定及其中间体的方法
CN103864870A (zh) * 2013-11-28 2014-06-18 安徽一帆香料有限公司 一种齐多夫定的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5914040B2 (ja) * 1976-04-05 1984-04-02 ヤマサ醤油株式会社 Ｏ↑２，３′−サイクロピリミジンヌクレオシド類の製造法
DK166805B1 (da) * 1985-03-16 1993-07-19 Wellcome Found Threo-isomeren af 3'-azido-3'-deoxythymidin til anvendelse ved behandling af eller profylakse for humane retrovirusinfektioner, anvendelse af forbindelsen til fremstilling af et laegemiddel med naevnte indikation og farmaceutisk praeparat indeholdende forbindelsen
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4681933A (en) * 1986-05-01 1987-07-21 University Of Georgia Research Foundation, Inc. 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
AU601437B2 (en) * 1986-07-09 1990-09-13 Sumitomo Chemical Company, Limited Cyclohexane derivatives, herbicides containing the same and process for producing the derivatives
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues

Also Published As

Publication number Publication date
FR2653771B1 (fr) 1994-09-23
US5124442A (en) 1992-06-23
KR910007919A (ko) 1991-05-30
CA2028648A1 (fr) 1991-04-28
JPH03209393A (ja) 1991-09-12
FR2653771A1 (fr) 1991-05-03
EP0427587B1 (de) 1997-01-15
EP0427587A1 (de) 1991-05-15
ATE147749T1 (de) 1997-02-15

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Legal Events

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8332 No legal effect for de