KR890701107A - 알쯔하이머 병 치료용 화합물들 - Google Patents
알쯔하이머 병 치료용 화합물들Info
- Publication number
- KR890701107A KR890701107A KR1019880701794A KR880701794A KR890701107A KR 890701107 A KR890701107 A KR 890701107A KR 1019880701794 A KR1019880701794 A KR 1019880701794A KR 880701794 A KR880701794 A KR 880701794A KR 890701107 A KR890701107 A KR 890701107A
- Authority
- KR
- South Korea
- Prior art keywords
- disease
- compounds
- alzheimer
- treatment
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processing Of Meat And Fish (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compression Or Coding Systems Of Tv Signals (AREA)
- Eye Examination Apparatus (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4652287A | 1987-05-04 | 1987-05-04 | |
US046,522 | 1987-05-04 | ||
PCT/US1988/001542 WO1988008708A1 (en) | 1987-05-04 | 1988-05-04 | Compounds for the treatment of alzheimer's disease |
CA000569641A CA1338326C (en) | 1987-05-04 | 1988-06-16 | Compounds for the treatment of alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890701107A true KR890701107A (ko) | 1989-12-19 |
KR100195399B1 KR100195399B1 (ko) | 1999-06-15 |
Family
ID=42046403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880701794A KR100195399B1 (ko) | 1987-05-04 | 1988-05-04 | 알쯔하이머 병 치료용 의약 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0363415B1 (ko) |
JP (1) | JP2755403B2 (ko) |
KR (1) | KR100195399B1 (ko) |
AT (1) | ATE411026T1 (ko) |
AU (1) | AU632458B2 (ko) |
CA (1) | CA1338326C (ko) |
DE (1) | DE3856594D1 (ko) |
DK (1) | DK175839B1 (ko) |
FI (1) | FI102756B (ko) |
WO (1) | WO1988008708A1 (ko) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69229781T2 (de) * | 1991-05-14 | 2000-01-05 | Ernir Snorrason | Behandlung des ermüdungssyndroms mit cholinesteraseinhibitoren |
US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
US6316439B1 (en) * | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
US6323195B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
US6323196B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
EP0787115B1 (de) * | 1994-10-21 | 2000-01-05 | Sanochemia Pharmazeutika AG | VERFAHREN ZUM HERSTELLEN VON DERIVATEN DES 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINS |
AT401058B (de) * | 1994-10-21 | 1996-06-25 | Waldheim Pharmazeutika Gmbh | Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins |
US6407229B1 (en) | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
GB9506843D0 (en) | 1995-04-03 | 1995-05-24 | Chiroscience Ltd | Oxidative process and products thereof |
GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
GB9519267D0 (en) * | 1995-09-21 | 1995-11-22 | Chiroscience Ltd | Preparation of alkaloids |
AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
AU2004242546B2 (en) * | 1998-11-23 | 2008-05-15 | Bonnie Davis | Dosage formulations for acetylcholinesterase inhibitors |
WO2000030446A1 (en) | 1998-11-23 | 2000-06-02 | Bonnie Davis | Dosage formulations for acetylcholinesterase inhibitors |
SI1140105T1 (en) | 1998-12-24 | 2004-04-30 | Janssen Pharmaceutica N.V. | Controlled release galantamine composition |
EP2311463A1 (en) | 1999-12-10 | 2011-04-20 | Bonnie M. Davis | Analogs of galanthamine and lycoramine as modulators of nicotinic receptors |
MXPA01012275A (es) * | 2000-03-31 | 2003-06-24 | Sanochemia Pharmazeutika Ag | Derivados y analogos novedosos de galantamina. |
US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
ATE473219T1 (de) * | 2005-09-22 | 2010-07-15 | Galantos Pharma Gmbh | Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen |
EP1777222A1 (en) * | 2005-09-22 | 2007-04-25 | Galantos Pharma GmbH | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
ES2463715T3 (es) | 2008-04-14 | 2014-05-29 | Neurodyn Life Sciences Inc. | Derivados de galantamina como profármacos para el tratamiento de enfermedades del cerebro humano |
EP2344505A2 (en) | 2008-09-29 | 2011-07-20 | Abbott Laboratories | Indole and indoline derivatives and methods of use thereof |
US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
AP2015008498A0 (en) | 2012-12-13 | 2015-05-31 | Lundbeck & Co As H | Compositions comprising vortioxetine and donepezil |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2016191288A1 (en) | 2015-05-22 | 2016-12-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3673177A (en) * | 1970-05-04 | 1972-06-27 | American Cyanamid Co | Substituted 4-(anilinomethylene)-3-galanthamaninones |
PL122665B1 (en) * | 1978-11-21 | 1982-08-31 | Edinen Zentar Chim | Process for preparing novel dienones of narvedine type and their derivatives |
US4663318A (en) * | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
NL8800350A (nl) * | 1988-02-12 | 1989-09-01 | Stichting Biomedical Research | Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen. |
-
1988
- 1988-05-04 AT AT88905083T patent/ATE411026T1/de not_active IP Right Cessation
- 1988-05-04 DE DE3856594T patent/DE3856594D1/de not_active Expired - Lifetime
- 1988-05-04 AU AU18084/88A patent/AU632458B2/en not_active Expired
- 1988-05-04 KR KR1019880701794A patent/KR100195399B1/ko active IP Right Review Request
- 1988-05-04 EP EP88905083A patent/EP0363415B1/en not_active Expired - Lifetime
- 1988-05-04 JP JP63504783A patent/JP2755403B2/ja not_active Expired - Fee Related
- 1988-05-04 WO PCT/US1988/001542 patent/WO1988008708A1/en active IP Right Grant
- 1988-06-16 CA CA000569641A patent/CA1338326C/en not_active Expired - Lifetime
-
1989
- 1989-11-02 FI FI895213A patent/FI102756B/fi not_active IP Right Cessation
- 1989-11-03 DK DK198905491A patent/DK175839B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK175839B1 (da) | 2005-03-21 |
DK549189D0 (da) | 1989-11-03 |
DE3856594D1 (de) | 2008-11-27 |
FI102756B1 (fi) | 1999-02-15 |
EP0363415B1 (en) | 2008-10-15 |
CA1338326C (en) | 1996-05-14 |
EP0363415A1 (en) | 1990-04-18 |
AU632458B2 (en) | 1993-01-07 |
FI102756B (fi) | 1999-02-15 |
DK549189A (da) | 1990-01-03 |
EP0363415A4 (en) | 1993-03-17 |
ATE411026T1 (de) | 2008-10-15 |
KR100195399B1 (ko) | 1999-06-15 |
JP2755403B2 (ja) | 1998-05-20 |
FI895213A0 (fi) | 1989-11-02 |
JPH02503794A (ja) | 1990-11-08 |
AU1808488A (en) | 1988-12-06 |
WO1988008708A1 (en) | 1988-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
AMND | Amendment | ||
E902 | Notification of reason for refusal | ||
AMND | Amendment | ||
E601 | Decision to refuse application | ||
J2X1 | Appeal (before the patent court) |
Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL |
|
E902 | Notification of reason for refusal | ||
B701 | Decision to grant | ||
GRNT | Written decision to grant | ||
J204 | Request for invalidation trial [patent] | ||
J301 | Trial decision |
Free format text: TRIAL DECISION FOR INVALIDATION REQUESTED 20070531 Effective date: 20080417 |
|
G170 | Re-publication after modification of scope of protection [patent] | ||
FPAY | Annual fee payment |
Payment date: 20120208 Year of fee payment: 14 |
|
FPAY | Annual fee payment |
Payment date: 20130117 Year of fee payment: 15 |