FI102756B1 - Menetelmä terapeuttisesti käyttökelpoisten 6H-bentsfuro[3a,3,3-ef][2]bentsatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 6H-bentsfuro[3a,3,3-ef][2]bentsatsepiinijohdannaisten valmistamiseksi

Info

Publication number
FI102756B1
FI102756B1 FI895213A FI895213A FI102756B1 FI 102756 B1 FI102756 B1 FI 102756B1 FI 895213 A FI895213 A FI 895213A FI 895213 A FI895213 A FI 895213A FI 102756 B1 FI102756 B1 FI 102756B1
Authority
FI
Finland
Prior art keywords
benzofuro
benzazepine derivatives
therapeutically utilizable
preparing therapeutically
preparing
Prior art date
Application number
FI895213A
Other languages
English (en)
Swedish (sv)
Other versions
FI895213A0 (fi
FI102756B (fi
Inventor
Bonnie Davis
Madeleine Joullie
Original Assignee
Bonnie Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonnie Davis filed Critical Bonnie Davis
Publication of FI895213A0 publication Critical patent/FI895213A0/fi
Application granted granted Critical
Publication of FI102756B publication Critical patent/FI102756B/fi
Publication of FI102756B1 publication Critical patent/FI102756B1/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Eye Examination Apparatus (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Processing Of Meat And Fish (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI895213A 1987-05-04 1989-11-02 Menetelmä terapeuttisesti käyttökelpoisten 6H-bentsfuro[3a,3,3-ef][2]bentsatsepiinijohdannaisten valmistamiseksi FI102756B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US4652287A 1987-05-04 1987-05-04
US4652287 1987-05-04
PCT/US1988/001542 WO1988008708A1 (en) 1987-05-04 1988-05-04 Compounds for the treatment of alzheimer's disease
US8801542 1988-05-04
CA000569641A CA1338326C (en) 1987-05-04 1988-06-16 Compounds for the treatment of alzheimer's disease
CA569641 1988-06-16

Publications (3)

Publication Number Publication Date
FI895213A0 FI895213A0 (fi) 1989-11-02
FI102756B FI102756B (fi) 1999-02-15
FI102756B1 true FI102756B1 (fi) 1999-02-15

Family

ID=42046403

Family Applications (1)

Application Number Title Priority Date Filing Date
FI895213A FI102756B1 (fi) 1987-05-04 1989-11-02 Menetelmä terapeuttisesti käyttökelpoisten 6H-bentsfuro[3a,3,3-ef][2]bentsatsepiinijohdannaisten valmistamiseksi

Country Status (10)

Country Link
EP (1) EP0363415B1 (fi)
JP (1) JP2755403B2 (fi)
KR (1) KR100195399B1 (fi)
AT (1) ATE411026T1 (fi)
AU (1) AU632458B2 (fi)
CA (1) CA1338326C (fi)
DE (1) DE3856594D1 (fi)
DK (1) DK175839B1 (fi)
FI (1) FI102756B1 (fi)
WO (1) WO1988008708A1 (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
CA2108880A1 (en) * 1991-05-14 1992-11-15 Ernir Snorrason Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US6316439B1 (en) * 1993-10-15 2001-11-13 Aventis Pharamaceuticals Inc. Galanthamine derivatives as acetylcholinesterase inhibitors
US6323195B1 (en) * 1993-10-15 2001-11-27 Aventis Pharmaceuticals Inc. Galanthamine derivatives as acetylcholinesterase inhibitors
US6323196B1 (en) * 1993-10-15 2001-11-27 Aventis Pharmaceuticals Inc. Galanthamine derivatives as acetylcholinesterase inhibitors
US6407229B1 (en) 1994-10-21 2002-06-18 Sanochemia Pharmazeutika Ag Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
AT401058B (de) * 1994-10-21 1996-06-25 Waldheim Pharmazeutika Gmbh Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins
NZ294191A (en) * 1994-10-21 1998-10-28 Waldheim Pharmazeutika Gmbh Process for preparing 4a,5,9,10,11,12-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine derivatives and intermediates thereof
GB9506843D0 (en) 1995-04-03 1995-05-24 Chiroscience Ltd Oxidative process and products thereof
GB9514821D0 (en) * 1995-07-19 1995-09-20 Sod Conseils Rech Applic Galanthamine derivatives
GB9519267D0 (en) * 1995-09-21 1995-11-22 Chiroscience Ltd Preparation of alkaloids
AT403803B (de) * 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
AU1738800A (en) 1998-11-23 2000-06-13 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
AU2004242546B2 (en) * 1998-11-23 2008-05-15 Bonnie Davis Dosage formulations for acetylcholinesterase inhibitors
HUP0104778A3 (en) 1998-12-24 2004-05-28 Janssen Pharmaceutica Nv Controlled release galantamine composition
MXPA02005667A (es) 1999-12-10 2004-09-10 Bonnie Davis Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos.
CA2368966A1 (en) 2000-03-31 2001-10-11 Sanochemia Pharmazeutika Aktiengesellschaft New derivatives and analogues of galanthamine
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
EP1777222A1 (en) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
ATE473219T1 (de) * 2005-09-22 2010-07-15 Galantos Pharma Gmbh Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
JP5504253B2 (ja) 2008-04-14 2014-05-28 ニューロダイン ライフ サイエンス インコーポレイテッド ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体
UY32147A (es) 2008-09-29 2010-04-30 Abbott Lab Derivados de indol y de indolina y métodos para usarlos
US9625475B2 (en) 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
EA037187B1 (ru) 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
MX362886B (es) 2012-12-13 2019-02-22 H Lundbeck As Composición sinérgica que comprende vortioxetina y donepezilo para incrementar los niveles de acetilcolina en el cerebro, y el uso de la misma en el tratamiento de una disfunción cognitiva.
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673177A (en) * 1970-05-04 1972-06-27 American Cyanamid Co Substituted 4-(anilinomethylene)-3-galanthamaninones
PL122665B1 (en) * 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) * 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
NL8800350A (nl) * 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.

Also Published As

Publication number Publication date
ATE411026T1 (de) 2008-10-15
KR890701107A (ko) 1989-12-19
JP2755403B2 (ja) 1998-05-20
DK549189D0 (da) 1989-11-03
FI895213A0 (fi) 1989-11-02
AU1808488A (en) 1988-12-06
KR100195399B1 (ko) 1999-06-15
JPH02503794A (ja) 1990-11-08
CA1338326C (en) 1996-05-14
EP0363415A4 (en) 1993-03-17
DK549189A (da) 1990-01-03
EP0363415B1 (en) 2008-10-15
AU632458B2 (en) 1993-01-07
FI102756B (fi) 1999-02-15
DE3856594D1 (de) 2008-11-27
EP0363415A1 (en) 1990-04-18
DK175839B1 (da) 2005-03-21
WO1988008708A1 (en) 1988-11-17

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: DAVIS, BONNIE

MA Patent expired