ATE121387T1 - Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. - Google Patents

Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Info

Publication number
ATE121387T1
ATE121387T1 AT91905084T AT91905084T ATE121387T1 AT E121387 T1 ATE121387 T1 AT E121387T1 AT 91905084 T AT91905084 T AT 91905084T AT 91905084 T AT91905084 T AT 91905084T AT E121387 T1 ATE121387 T1 AT E121387T1
Authority
AT
Austria
Prior art keywords
compounds
vitamin
hydroxylated
homologate
1alpha
Prior art date
Application number
AT91905084T
Other languages
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE121387T1 publication Critical patent/ATE121387T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91905084T 1990-02-14 1991-02-13 Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. ATE121387T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,990 US5030772A (en) 1990-02-14 1990-02-14 Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Publications (1)

Publication Number Publication Date
ATE121387T1 true ATE121387T1 (de) 1995-05-15

Family

ID=23914203

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91905084T ATE121387T1 (de) 1990-02-14 1991-02-13 Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Country Status (7)

Country Link
US (1) US5030772A (de)
EP (1) EP0468042B1 (de)
JP (1) JP2731839B2 (de)
AT (1) ATE121387T1 (de)
DE (1) DE69109006T2 (de)
ES (1) ES2071303T3 (de)
WO (1) WO1991012239A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
DE69214617T2 (de) * 1991-12-26 1997-05-28 Wisconsin Alumni Res Found 26,27-Dimethylen-1-Alpha, 25-Dihydroxyvitamin-D2 und 26,27-Dihydroxyvitamin-D2 und Verfahren zu ihrer Herstellung
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
CN1148347C (zh) * 1998-05-29 2004-05-05 骨疗国际公司 羟基-25-烯-维生素d类化合物的制备方法
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
CN102812356B (zh) 2009-12-11 2017-08-08 奎斯特诊断投资公司 多重样品中的甾族化合物的质谱法
CA2783797C (en) 2009-12-11 2021-06-08 Quest Diagnostics Investments Incorporated Mass spectrometric determination of non-derivatized, non-metabolized vitamin d
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585221A (en) * 1969-03-24 1971-06-15 Wisconsin Alumni Res Found 25-hydroxyergocalciferol
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
JPS51108046A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
GB2139627B (en) * 1983-05-09 1987-02-04 Wisconsin Alumni Res Found 1 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
DE3590080C2 (de) * 1984-03-05 1992-08-06 Wisconsin Alumni Research Foundation, Madison, Wis., Us
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
DE3590488T (de) * 1984-10-04 1986-10-09 Wisconsin Alumni Research Foundation, Madison, Wis. Vitamin D-Derivate und Verfahren zu deren Herstellung
US4554106A (en) * 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
WO1986004333A1 (en) * 1985-01-17 1986-07-31 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
JPS62501505A (ja) * 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
EP0412110B1 (de) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin d analoge
AU629831B2 (en) * 1988-04-29 1992-10-15 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
DE69005709T2 (de) * 1989-06-15 1994-05-19 Duphar Int Res Adduktaldehyd und seine Anwendung in der Herstellung von Vitamin-D-Derivaten.
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0468042B1 (de) 1995-04-19
DE69109006D1 (de) 1995-05-24
US5030772A (en) 1991-07-09
EP0468042A1 (de) 1992-01-29
ES2071303T3 (es) 1995-06-16
JP2731839B2 (ja) 1998-03-25
WO1991012239A1 (en) 1991-08-22
DE69109006T2 (de) 1995-08-31
JPH04505468A (ja) 1992-09-24

Similar Documents

Publication Publication Date Title
ATE121387T1 (de) Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.
MA21682A1 (fr) Procede de preparation d'agents therapeutiques derives de la quainclidine.
ES2101331T3 (es) Derivados de k-252a.
MX9201419A (es) Derivados de benzo isoxazol-piperidina.
KR890701107A (ko) 알쯔하이머 병 치료용 화합물들
NO892762D0 (no) Fremgangsmaate for fremstilling av nye difosfonsyrederivater.
EE02979B1 (et) Formoterool ja tema ühendid ning nende valmistamise meetod
FI884553A0 (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
ES2141787T3 (es) Derivados de la 1,2,3,4-tetrahidro-9-acridinamina.
ES2086065T3 (es) Preparacion de tetrahidropiridinas sustituidas.
NO891703L (no) Farmasoeytiske sammensetninger for behandling av psoriasis.
NO20000771L (no) Anvendelse av fankinon for behandling av Alzheimers sykdom
DZ1407A1 (fr) Dérivés d-substitués des n,n'-ditriméthoxybenzoylepipérazine ainsi que leur procédé de préparation.
NO180537C (no) Fremgangsmåte for fremstilling av vitamin D2-forbindelser og de tilsvarende <alfa>-hydroksylerte derivater
DE69215588D1 (de) Inositol-Phosphat-Analog als kalzium-antagonistische Substanz
FR2648675B1 (fr) Compositions propres a influencer le developpement et la floraison de plantes, procede de traitement de plantes par ces compositions et plantes modifiees obtenues
ES2082890T3 (es) Procedimiento para la preparacion de derivados 6-(aminopropionilo sustituido) de forskolina.
ES2089176T3 (es) Procedimiento para la preparacion de carboditioatos de piperidina fluorometil-sustituidos.
ES2067621T3 (es) Procedimiento para la preparacion de compuestos molusquicidas de 2,4,5-tribromopirrol-3-carbonitrilo.
FR2618781B2 (fr) Procede de preparation de derives de la 4,4-dimethyl tetrahydro pyr-2-one
FR2647450B1 (fr) Procede de preparation des derives de 2(prime), 3(prime)-dideshydro-2(prime),3(prime)-didesoxynucleoside
OA09202A (fr) Procédé de préparation des nouveaux dérivés de la thiéno-triazolo-diazépine.
OA09208A (fr) "Procédé de préparation de dérivés de la thiéno-triazolo-diazépine".
DZ1415A1 (fr) Procédé de préparation de dérivés de la thiéno-triazolo-diazépine.
DE69216479D1 (de) Verbindungen und Verfahren zur Behandlung thromboembolischer Störungen