CH646995A5 - Verfahren zur herstellung von 12beta-hydroxycardenolidderivaten auf mikrobiologischem wege. - Google Patents
Verfahren zur herstellung von 12beta-hydroxycardenolidderivaten auf mikrobiologischem wege. Download PDFInfo
- Publication number
- CH646995A5 CH646995A5 CH962579A CH962579A CH646995A5 CH 646995 A5 CH646995 A5 CH 646995A5 CH 962579 A CH962579 A CH 962579A CH 962579 A CH962579 A CH 962579A CH 646995 A5 CH646995 A5 CH 646995A5
- Authority
- CH
- Switzerland
- Prior art keywords
- streptomyces
- formula
- violet
- purpurascens
- blue
- Prior art date
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 229930188389 Lanatoside Natural products 0.000 description 1
- 241000907681 Morpho Species 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000142915 Streptomyces diastatochromogenes Species 0.000 description 1
- 241000187435 Streptomyces griseolus Species 0.000 description 1
- 241000810879 Streptomyces owasiensis Species 0.000 description 1
- 241000946804 Streptomyces praecox Species 0.000 description 1
- 241001655322 Streptomycetales Species 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 241001121161 Trichocladium asperum Species 0.000 description 1
- 235000005811 Viola adunca Nutrition 0.000 description 1
- 240000009038 Viola odorata Species 0.000 description 1
- 235000013487 Viola odorata Nutrition 0.000 description 1
- 235000002254 Viola papilionacea Nutrition 0.000 description 1
- 241000394605 Viola striata Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000025938 carbohydrate utilization Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- GUXZNBKFWVYHTD-UHFFFAOYSA-N deacetyllanatoside B Natural products CC1OC(OC2CC3C(C4C(C5(CC(O)C(C5(C)CC4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(O)C1OC1OC(CO)C(O)C(O)C1O GUXZNBKFWVYHTD-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229930190842 purpurea glycoside Natural products 0.000 description 1
- BZJBLHNKKRCQEQ-UHFFFAOYSA-N purpurea glycoside A Natural products CC1OC(CC(O)C1OC2CC(O)C(OC3CC(O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CCC8(C)C(CCC78O)C9=CC(=O)OC9)C5 BZJBLHNKKRCQEQ-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO001428 HU176250B (en) | 1978-10-30 | 1978-10-30 | Process for producing mikrobiologically 12-beta-hydroxycardenolide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH646995A5 true CH646995A5 (de) | 1984-12-28 |
Family
ID=10996878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH962579A CH646995A5 (de) | 1978-10-30 | 1979-10-26 | Verfahren zur herstellung von 12beta-hydroxycardenolidderivaten auf mikrobiologischem wege. |
Country Status (6)
| Country | Link |
|---|---|
| CH (1) | CH646995A5 (enrdf_load_stackoverflow) |
| DD (1) | DD147113A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2943817A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2034716B (enrdf_load_stackoverflow) |
| HU (1) | HU176250B (enrdf_load_stackoverflow) |
| NL (1) | NL7907937A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190784B (en) * | 1981-09-28 | 1986-11-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for the intensification of the microbiological transformation of steroid compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU175474B (hu) * | 1978-05-23 | 1980-08-28 | Gyogyszerkutato Intezet | Novyjj mikrobiologicheskijj sposob poluchenija proizvodnykh kardenolida soderzhahhikh gruppu 12-beta-gidroksila |
| HU175601B (hu) * | 1978-08-11 | 1980-09-28 | Gyogyszerkutato Intezet | Mikrobiologocheskij sposob poluchenija vtorichnykh gljukozidov iz pervichnykh digitalis gljukozidov |
| CA2037985A1 (en) * | 1990-03-23 | 1991-09-24 | Robert C. Gmelin | Economical air separator |
| EP0449448B1 (en) * | 1990-03-29 | 1997-01-22 | The Boc Group, Inc. | Process for producing oxygen enriched product stream |
| ZA911499B (en) * | 1990-03-30 | 1991-12-24 | Boc Group Inc | Purifying fluids by adsorption |
| JPH04222611A (ja) * | 1990-12-21 | 1992-08-12 | Matsushita Electric Ind Co Ltd | フィルター装置 |
| JPH04224498A (ja) * | 1990-12-26 | 1992-08-13 | Kayseven Co Ltd | 船灯状態異常の警報装置 |
-
1978
- 1978-10-30 HU HUGO001428 patent/HU176250B/hu not_active IP Right Cessation
-
1979
- 1979-10-26 CH CH962579A patent/CH646995A5/de not_active IP Right Cessation
- 1979-10-26 DD DD21649079A patent/DD147113A5/de not_active IP Right Cessation
- 1979-10-29 GB GB7937475A patent/GB2034716B/en not_active Expired
- 1979-10-29 NL NL7907937A patent/NL7907937A/nl not_active Application Discontinuation
- 1979-10-30 DE DE19792943817 patent/DE2943817A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| HU176250B (en) | 1981-01-28 |
| DE2943817C2 (enrdf_load_stackoverflow) | 1988-01-14 |
| GB2034716B (en) | 1983-01-12 |
| NL7907937A (nl) | 1980-05-02 |
| DE2943817A1 (de) | 1980-05-14 |
| GB2034716A (en) | 1980-06-11 |
| DD147113A5 (de) | 1981-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |