CH633301A5 - Process for preparing novel 21-salicylic acid esters or 21-acetylsalicylic acid esters of steroids of the pregnane series - Google Patents

Process for preparing novel 21-salicylic acid esters or 21-acetylsalicylic acid esters of steroids of the pregnane series Download PDF

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Publication number
CH633301A5
CH633301A5 CH1632977A CH1632977A CH633301A5 CH 633301 A5 CH633301 A5 CH 633301A5 CH 1632977 A CH1632977 A CH 1632977A CH 1632977 A CH1632977 A CH 1632977A CH 633301 A5 CH633301 A5 CH 633301A5
Authority
CH
Switzerland
Prior art keywords
acid esters
prednisolone
salicylate
steroids
salicylic acid
Prior art date
Application number
CH1632977A
Other languages
German (de)
English (en)
Inventor
Albert L G Meli
Gaetano Palladino
Marco Da Col
Pier Paolo Castelli
Original Assignee
Lark Spa
Menarini Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lark Spa, Menarini Sas filed Critical Lark Spa
Publication of CH633301A5 publication Critical patent/CH633301A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CH1632977A 1976-12-31 1977-12-30 Process for preparing novel 21-salicylic acid esters or 21-acetylsalicylic acid esters of steroids of the pregnane series CH633301A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB54510/76A GB1593978A (en) 1976-12-31 1976-12-31 Anti-inflammatory steroids

Publications (1)

Publication Number Publication Date
CH633301A5 true CH633301A5 (en) 1982-11-30

Family

ID=10471258

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1632977A CH633301A5 (en) 1976-12-31 1977-12-30 Process for preparing novel 21-salicylic acid esters or 21-acetylsalicylic acid esters of steroids of the pregnane series

Country Status (10)

Country Link
JP (1) JPS53144561A (ja)
BE (1) BE862507A (ja)
CH (1) CH633301A5 (ja)
DK (1) DK155673C (ja)
FI (1) FI63422C (ja)
FR (1) FR2376160A1 (ja)
GB (1) GB1593978A (ja)
NL (1) NL7714482A (ja)
NO (1) NO148491C (ja)
SE (1) SE430607B (ja)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Also Published As

Publication number Publication date
JPS53144561A (en) 1978-12-15
NO774525L (no) 1978-07-03
FR2376160A1 (fr) 1978-07-28
DK155673C (da) 1989-09-04
FI63422B (fi) 1983-02-28
NO148491C (no) 1983-10-19
NO148491B (no) 1983-07-11
FR2376160B1 (ja) 1980-11-14
BE862507A (fr) 1978-04-14
FI773929A (fi) 1978-07-01
NL7714482A (nl) 1978-07-04
SE7714976L (sv) 1978-07-02
GB1593978A (en) 1981-07-22
FI63422C (fi) 1983-06-10
DK581677A (da) 1978-07-01
JPS6220197B2 (ja) 1987-05-06
SE430607B (sv) 1983-11-28
DK155673B (da) 1989-05-01

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