CH624956A5 - Verfahren zur entfernung von verunreinigungen aus clavulansaeure. - Google Patents

Verfahren zur entfernung von verunreinigungen aus clavulansaeure. Download PDF

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Publication number
CH624956A5
CH624956A5 CH148776A CH148776A CH624956A5 CH 624956 A5 CH624956 A5 CH 624956A5 CH 148776 A CH148776 A CH 148776A CH 148776 A CH148776 A CH 148776A CH 624956 A5 CH624956 A5 CH 624956A5
Authority
CH
Switzerland
Prior art keywords
salt
lithium
clavulanic acid
water
clavulanate
Prior art date
Application number
CH148776A
Other languages
German (de)
English (en)
Inventor
Ian Dunlop Fleming
David Noble
Hazel Mary Noble-Gillett
Wilfred Frank Wall
Original Assignee
Glaxo Operations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB540975A external-priority patent/GB1543563A/en
Application filed by Glaxo Operations Ltd filed Critical Glaxo Operations Ltd
Publication of CH624956A5 publication Critical patent/CH624956A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CH148776A 1975-02-07 1976-02-06 Verfahren zur entfernung von verunreinigungen aus clavulansaeure. CH624956A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB540975A GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form
GB1107675 1975-03-17

Publications (1)

Publication Number Publication Date
CH624956A5 true CH624956A5 (de) 1981-08-31

Family

ID=26239868

Family Applications (1)

Application Number Title Priority Date Filing Date
CH148776A CH624956A5 (de) 1975-02-07 1976-02-06 Verfahren zur entfernung von verunreinigungen aus clavulansaeure.

Country Status (15)

Country Link
US (3) US4490294A (cs)
JP (2) JPS51101994A (cs)
AT (1) AT353409B (cs)
AU (1) AU509313B2 (cs)
CH (1) CH624956A5 (cs)
DE (1) DE2604697A1 (cs)
DK (1) DK141099B (cs)
ES (1) ES444948A1 (cs)
FI (1) FI63580C (cs)
FR (1) FR2368276A1 (cs)
IE (1) IE43790B1 (cs)
IT (2) IT1059403B (cs)
NL (1) NL7601227A (cs)
SE (1) SE421796B (cs)
YU (1) YU40452B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1542405A (en) * 1975-04-15 1979-03-21 Beecham Group Ltd Clavulanic acid derivatives
DE2862254D1 (en) * 1977-12-02 1983-06-16 Beecham Group Plc A process for the preparation of ether derivatives of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB9702218D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
GB9702216D0 (en) * 1997-02-04 1997-03-26 Smithkline Beecham Plc Novel product
PT867515E (pt) * 1997-03-24 2000-05-31 Cipan Companhia Ind P De Antib Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
JPH11254368A (ja) * 1998-03-12 1999-09-21 Central Motor Co Ltd 部材保持装置
CA2336363A1 (en) * 1998-07-03 2000-01-13 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
PT102181A (pt) * 1998-07-20 2000-01-31 Dsm Nv Processo melhorado para a producao de acido clavulanico
PL361230A1 (en) * 2000-10-05 2004-10-04 Biogal Gyogyszergyar Rt. Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
KR100461278B1 (ko) * 2002-10-23 2004-12-10 현대자동차주식회사 용접 대상물의 위치규제 및 취출장치
BR112020006001A2 (pt) 2017-10-02 2020-10-13 Metabolic Explorer método para produção de sais de ácido orgânico a partir de caldo de fermentação

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754693A (fr) * 1969-08-12 1971-02-11 Lilly Co Eli Nouvel antibiotique et procede pour le preparer
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Also Published As

Publication number Publication date
DE2604697C2 (cs) 1992-10-29
IT1066098B (it) 1985-03-04
DK141099C (cs) 1980-07-21
SE421796B (sv) 1982-02-01
AU509313B2 (en) 1980-05-08
AT353409B (de) 1979-11-12
JPS51101994A (cs) 1976-09-08
IT1059403B (it) 1982-05-31
US4490294A (en) 1984-12-25
IE43790B1 (en) 1981-06-03
ES444948A1 (es) 1977-08-16
SE7601337L (sv) 1976-11-03
DE2604697A1 (de) 1976-08-19
DK141099B (da) 1980-01-14
FR2368276A1 (fr) 1978-05-19
NL7601227A (nl) 1976-08-10
FI760285A7 (cs) 1976-08-08
FI63580B (fi) 1983-03-31
US4367175A (en) 1983-01-04
ATA83476A (de) 1979-04-15
IE43790L (en) 1976-08-07
JPH0222281A (ja) 1990-01-25
AU1089176A (en) 1977-08-11
FI63580C (fi) 1983-07-11
YU29076A (en) 1982-08-31
YU40452B (en) 1986-02-28
DK49876A (cs) 1976-08-08
FR2368276B1 (cs) 1979-03-16
US4490295A (en) 1984-12-25

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PUE Assignment

Owner name: BEECHAM GROUP PLC

PL Patent ceased