CH378467A - Verfahren zur Herstellung von basischen, wenig toxischen Salzen des Kanamycins - Google Patents
Verfahren zur Herstellung von basischen, wenig toxischen Salzen des KanamycinsInfo
- Publication number
- CH378467A CH378467A CH7730359A CH7730359A CH378467A CH 378467 A CH378467 A CH 378467A CH 7730359 A CH7730359 A CH 7730359A CH 7730359 A CH7730359 A CH 7730359A CH 378467 A CH378467 A CH 378467A
- Authority
- CH
- Switzerland
- Prior art keywords
- kanamycin
- salts
- acid
- acids
- acylamino
- Prior art date
Links
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 title claims description 49
- 229960000318 kanamycin Drugs 0.000 title claims description 35
- 229930027917 kanamycin Natural products 0.000 title claims description 32
- 229930182823 kanamycin A Natural products 0.000 title claims description 31
- 150000003839 salts Chemical class 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 12
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 231100000331 toxic Toxicity 0.000 title 1
- 230000002588 toxic effect Effects 0.000 title 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 13
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 125000003277 amino group Chemical group 0.000 claims description 8
- 235000019161 pantothenic acid Nutrition 0.000 claims description 8
- 239000011713 pantothenic acid Substances 0.000 claims description 7
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 6
- 229940055726 pantothenic acid Drugs 0.000 claims description 6
- WXNXCEHXYPACJF-ZETCQYMHSA-N N-acetyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(C)=O WXNXCEHXYPACJF-ZETCQYMHSA-N 0.000 claims description 4
- 229960000669 acetylleucine Drugs 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 3
- -1 alkaline earth metal salts Chemical class 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 8
- 238000004108 freeze drying Methods 0.000 description 8
- 238000000354 decomposition reaction Methods 0.000 description 7
- 239000000155 melt Substances 0.000 description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 6
- 229960002079 calcium pantothenate Drugs 0.000 description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 5
- JKDQPYCPZMVHLV-USIDBOKESA-N (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O.OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N JKDQPYCPZMVHLV-USIDBOKESA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 description 4
- 229960002064 kanamycin sulfate Drugs 0.000 description 4
- WJZXFAPKSJNIPW-FWTPEUPTSA-N (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N WJZXFAPKSJNIPW-FWTPEUPTSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 150000001447 alkali salts Chemical class 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241000187132 Streptomyces kanamyceticus Species 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229940000635 beta-alanine Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC17506A DE1133709B (de) | 1958-09-16 | 1958-09-16 | Verfahren zur Herstellung von basischen, wenig giftigen Salzen des Kanamycins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH378467A true CH378467A (de) | 1964-06-15 |
Family
ID=7016262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH7730359A CH378467A (de) | 1958-09-16 | 1959-08-24 | Verfahren zur Herstellung von basischen, wenig toxischen Salzen des Kanamycins |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH378467A (en, 2012) |
| DE (1) | DE1133709B (en, 2012) |
| DK (1) | DK113081B (en, 2012) |
| ES (1) | ES252065A1 (en, 2012) |
| FR (1) | FR489M (en, 2012) |
-
1958
- 1958-09-16 DE DEC17506A patent/DE1133709B/de active Pending
-
1959
- 1959-08-24 CH CH7730359A patent/CH378467A/de unknown
- 1959-09-15 DK DK328859AA patent/DK113081B/da unknown
- 1959-09-15 ES ES0252065A patent/ES252065A1/es not_active Expired
-
1960
- 1960-08-30 FR FR837256A patent/FR489M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR489M (en, 2012) | 1961-05-08 |
| DE1133709B (de) | 1962-07-26 |
| ES252065A1 (es) | 1960-01-01 |
| DK113081B (da) | 1969-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3019350C2 (en, 2012) | ||
| DE2332840A1 (de) | Alpha-sulfobenzylpenicillindiaminsalze und verfahren zu ihrer herstellung | |
| DE2240782A1 (de) | Verfahren zur herstellung eines eisensaccharid-komplexes | |
| DE1767891B2 (de) | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat | |
| DE1768806C3 (de) | Komplexe bzw. Salze aus einer antikoagulierend bzw. antilipämisch wirkenden sauren Heparinoidsäure-Komponente und einer nicht-toxischen Aminosäure bzw. organischen Base | |
| DE2635843A1 (de) | Injizierbare waessrige acetylsalicylsaeureloesung | |
| AT210995B (de) | Verfahren zur Herstellung von basischen, wenig toxischen Salzen des Kanamycins | |
| CH378467A (de) | Verfahren zur Herstellung von basischen, wenig toxischen Salzen des Kanamycins | |
| DE1768655A1 (de) | Neue Salze der N-Carbamylglutaminsaeure und der N-Carbamylasparaginsaeure | |
| DE1770697C3 (de) | 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel | |
| DE2901914C2 (de) | Zinksalz der 6-N-Acetylamino-capronsäure, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel | |
| DE2001731A1 (de) | Neues wasserloesliches Erythromycinderivat | |
| DE951567C (de) | Verfahren zur Herstellung von Antibiotikappantothenaten | |
| DE929665C (de) | Verfahren zur Herstellung von therapeutisch wirksamen Streptomycin- und Dihydrostreptomycinsalzen | |
| DE2148986A1 (de) | Chondroitinschwefelsaeuresalze und ein Verfahren zu ihrer Herstellung | |
| DE410055C (de) | Verfahren zur Herstellung von Doppelverbindungen aus Dimethylxanthinen und Erdalkalisalicylaten | |
| AT207999B (de) | Verfahren zur Herstellung von wenig toxischen Verbindungen der basischen Streptomyces-Antibiotika | |
| DE3110190A1 (de) | Cephapirinsalze mit aminosaeuren und verfahren zu deren herstellung | |
| DE637261C (de) | Verfahren zur Herstellung von Chinin- bzw. Chinidinsalzen bzw. deren Loesungen | |
| AT267053B (de) | Verfahren zur Herstellung des neuen Chloramphenicolbernsteinsäureestersalzes von Pyrrolidinomethyl-tetracyclin | |
| AT319463B (de) | Röntgenkontrastmittel | |
| DE255030C (en, 2012) | ||
| AT147483B (de) | Verfahren zur Darstellung von Verbindungen des N-Methyltetrahydronicotinsäuremethylesters. | |
| DE82951C (en, 2012) | ||
| DE275092C (en, 2012) |