CA3088326A1 - Fap inhibitor - Google Patents
Fap inhibitor Download PDFInfo
- Publication number
- CA3088326A1 CA3088326A1 CA3088326A CA3088326A CA3088326A1 CA 3088326 A1 CA3088326 A1 CA 3088326A1 CA 3088326 A CA3088326 A CA 3088326A CA 3088326 A CA3088326 A CA 3088326A CA 3088326 A1 CA3088326 A1 CA 3088326A1
- Authority
- CA
- Canada
- Prior art keywords
- fapi
- alkyl
- group
- compound
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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Applications Claiming Priority (7)
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| EP18155420.5 | 2018-02-06 | ||
| EP18155420 | 2018-02-06 | ||
| EP18199641.4 | 2018-10-10 | ||
| EP18199641 | 2018-10-10 | ||
| PCT/EP2019/052952 WO2019154886A1 (en) | 2018-02-06 | 2019-02-06 | Fap inhibitor |
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| JP (2) | JP2021512949A (enExample) |
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| CN116617420A (zh) | 2017-10-23 | 2023-08-22 | 约翰霍普金斯大学 | 靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途 |
| EP3723753A4 (en) | 2017-12-15 | 2022-01-26 | Praxis Biotech LLC | FIBROBLAST ACTIVATION PROTEIN INHIBITORS |
| DE102018126558A1 (de) * | 2018-10-24 | 2020-04-30 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Markierungsvorläufer mit Quadratsäure-Kopplung |
| CN113811529A (zh) | 2018-12-21 | 2021-12-17 | 普拉西斯生物技术有限责任公司 | 成纤维细胞激活蛋白抑制剂 |
| JP2022548155A (ja) * | 2019-09-17 | 2022-11-16 | パーデュー・リサーチ・ファウンデーション | 線維芽細胞活性化タンパク質（ｆａｐ）を標的とする、がんならびに他の線維性疾患および炎症性疾患の画像化および治療の方法 |
| US20240002408A1 (en) * | 2020-01-31 | 2024-01-04 | Purdue Research Foundation | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| CN118812631A (zh) * | 2020-02-12 | 2024-10-22 | 菲洛谢姆股份公司 | 用于靶向递送应用的成纤维细胞激活蛋白配体 |
| DK3891138T3 (da) | 2020-02-12 | 2022-04-04 | Philochem Ag | Fibroblastaktiveringsproteinligander til målrettede indgivelsesanvendelser |
| TW202202150A (zh) * | 2020-03-24 | 2022-01-16 | 美商杜夫特學院信託管理公司 | 靶向fap之放射性藥品及造影劑，與其相關用途 |
| WO2021234181A1 (en) * | 2020-05-22 | 2021-11-25 | Universität Heidelberg | Use of fap inhibitor in a method of diagnosis |
| CN111991570B (zh) * | 2020-07-24 | 2021-05-18 | 北京大学 | 一种FAP-α特异性肿瘤诊断SPECT显像剂 |
| CN114073781A (zh) * | 2020-08-11 | 2022-02-22 | 上海健康医学院 | 一种肿瘤间质显像剂及其制备方法 |
| CN112138175A (zh) * | 2020-09-01 | 2020-12-29 | 上海市质子重离子临床技术研发中心 | 一种放射性核素99mTc标记FAPI的化合物的制备方法 |
| CN112972707A (zh) * | 2020-09-10 | 2021-06-18 | 广州呼吸健康研究院 | 18F-FDG和68Ga-FAPI的应用 |
| CN112194651B (zh) * | 2020-10-12 | 2021-11-09 | 南方医科大学南方医院 | 一种pet示踪剂的前体化合物及其应用 |
| CN114380795A (zh) * | 2020-10-22 | 2022-04-22 | 四川大学华西医院 | 氘代fap抑制剂及其应用 |
| CN112023064A (zh) * | 2020-11-03 | 2020-12-04 | 南京大为科创服务有限责任公司 | 用于标记核素211At的成纤维细胞活化蛋白抑制剂的锡基衍生物及其制备方法和应用 |
| CN112933253A (zh) * | 2020-11-13 | 2021-06-11 | 上海市质子重离子临床技术研发中心 | 一种放射性核素标记fapi的化合物及其合成工艺方法 |
| CN112409414B (zh) * | 2020-12-01 | 2021-10-26 | 北京师范大学 | 锝-99m标记含异腈的FAPI衍生物及制备方法和应用 |
| PE20232046A1 (es) | 2020-12-17 | 2023-12-27 | Astrazeneca Ab | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas |
| CN112522388A (zh) * | 2020-12-18 | 2021-03-19 | 上海市东方医院（同济大学附属东方医院） | 成纤维细胞激活蛋白作为药物靶点在治疗骨关节炎中的用途 |
| CN114790193B (zh) * | 2020-12-21 | 2024-05-10 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| CN114790194B (zh) * | 2020-12-21 | 2024-03-26 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| CN114790195B (zh) * | 2020-12-21 | 2024-05-17 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| US20240139350A1 (en) * | 2021-02-01 | 2024-05-02 | Five Eleven Pharma, Inc | Radioactively labeled ligand for fibroblast activation protein-alpha imaging agent and preparation method therefor |
| CA3210863C (en) * | 2021-02-10 | 2024-06-04 | Yantai Lannacheng Biotechnology Co., Ltd. | Truncated evans blue modified fibroblast activation protein inhibitor, preparation method and application thereof |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN113582975A (zh) * | 2021-07-03 | 2021-11-02 | 上海蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN116917278A (zh) * | 2021-02-12 | 2023-10-20 | 菲罗化学股份公司 | 用于靶向递送应用的二价成纤维细胞活化蛋白配体 |
| EP4043452A1 (en) | 2021-02-12 | 2022-08-17 | Philochem AG | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| EP4291554A1 (en) | 2021-02-12 | 2023-12-20 | Philochem AG | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| BR112023020123A2 (pt) * | 2021-04-02 | 2024-01-23 | Univ Johns Hopkins | Agentes heterobivalentes e homobivalentes que alvejam proteína alfa de ativação de fibroblasto alfa e/ou antígeno de membrana específico da próstata |
| MX2021005089A (es) * | 2021-04-30 | 2022-11-01 | Instituto Nac De Investigaciones Nucleares | Radiofarmacos basados en el acido ((r)-1-((6-hidrazinilnicotinoil) d-alanil)pirrolidin-2-il)boronico (hynic-ifap) para la deteccion de la sobreexpresion de la proteina de activacion de fibrolastos. |
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