CA3003143A1 - 8-substituted benzoazepines as toll-like receptor modulators - Google Patents

8-substituted benzoazepines as toll-like receptor modulators Download PDF

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Publication number
CA3003143A1
CA3003143A1 CA3003143A CA3003143A CA3003143A1 CA 3003143 A1 CA3003143 A1 CA 3003143A1 CA 3003143 A CA3003143 A CA 3003143A CA 3003143 A CA3003143 A CA 3003143A CA 3003143 A1 CA3003143 A1 CA 3003143A1
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CA
Canada
Prior art keywords
alkyl
compound
alkenyl
alkynyl
nr6r7
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA3003143A
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English (en)
French (fr)
Inventor
George A. Doherty
C. Todd Eary
Robert D. Groneberg
Zachary Jones
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Array Biopharma Inc
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Array Biopharma Inc
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Publication of CA3003143A1 publication Critical patent/CA3003143A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA3003143A 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators Abandoned CA3003143A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71000405P 2005-08-19 2005-08-19
US60/710,004 2005-08-19
CA2865331A CA2865331C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2865331A Division CA2865331C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators

Publications (1)

Publication Number Publication Date
CA3003143A1 true CA3003143A1 (en) 2007-03-01

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Family Applications (3)

Application Number Title Priority Date Filing Date
CA2865331A Active CA2865331C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators
CA2619581A Active CA2619581C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators
CA3003143A Abandoned CA3003143A1 (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA2865331A Active CA2865331C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators
CA2619581A Active CA2619581C (en) 2005-08-19 2006-08-17 8-substituted benzoazepines as toll-like receptor modulators

Country Status (31)

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US (2) US8153622B2 (US06780888-20040824-C00057.png)
EP (3) EP2322510A3 (US06780888-20040824-C00057.png)
JP (1) JP5138592B2 (US06780888-20040824-C00057.png)
KR (2) KR101442846B1 (US06780888-20040824-C00057.png)
CN (6) CN101309906A (US06780888-20040824-C00057.png)
AP (1) AP2008004386A0 (US06780888-20040824-C00057.png)
AU (1) AU2006283620B2 (US06780888-20040824-C00057.png)
BR (1) BRPI0614941B8 (US06780888-20040824-C00057.png)
CA (3) CA2865331C (US06780888-20040824-C00057.png)
CR (2) CR9809A (US06780888-20040824-C00057.png)
DK (1) DK1940797T3 (US06780888-20040824-C00057.png)
EA (1) EA018543B1 (US06780888-20040824-C00057.png)
EC (1) ECSP088292A (US06780888-20040824-C00057.png)
ES (1) ES2391031T3 (US06780888-20040824-C00057.png)
HK (1) HK1122017A1 (US06780888-20040824-C00057.png)
HR (1) HRP20120695T1 (US06780888-20040824-C00057.png)
IL (2) IL189467A (US06780888-20040824-C00057.png)
MA (1) MA29838B1 (US06780888-20040824-C00057.png)
MX (1) MX2008002141A (US06780888-20040824-C00057.png)
MY (1) MY146567A (US06780888-20040824-C00057.png)
NO (1) NO342587B1 (US06780888-20040824-C00057.png)
NZ (1) NZ565907A (US06780888-20040824-C00057.png)
PL (1) PL1940797T3 (US06780888-20040824-C00057.png)
PT (1) PT1940797E (US06780888-20040824-C00057.png)
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TW (2) TWI404537B (US06780888-20040824-C00057.png)
UA (1) UA92754C2 (US06780888-20040824-C00057.png)
WO (1) WO2007024612A2 (US06780888-20040824-C00057.png)
ZA (1) ZA200802496B (US06780888-20040824-C00057.png)

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