CA2966634C - Engineered gamma delta t-cells - Google Patents

Engineered gamma delta t-cells Download PDF

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Publication number
CA2966634C
CA2966634C CA2966634A CA2966634A CA2966634C CA 2966634 C CA2966634 C CA 2966634C CA 2966634 A CA2966634 A CA 2966634A CA 2966634 A CA2966634 A CA 2966634A CA 2966634 C CA2966634 C CA 2966634C
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Prior art keywords
cells
cell
engineered
antigen
tumor
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French (fr)
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CA2966634A1 (en
Inventor
Aya Jakobovits
Orit Foord
Andy An-Deh Lin
Marianne Theresa Santaguida
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Adicet Therapeutics Inc
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Adicet Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CA2966634A 2014-11-17 2015-11-17 Engineered gamma delta t-cells Active CA2966634C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080500P 2014-11-17 2014-11-17
US62/080,500 2014-11-17
PCT/US2015/061189 WO2016081518A2 (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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Publication Number Publication Date
CA2966634A1 CA2966634A1 (en) 2016-05-26
CA2966634C true CA2966634C (en) 2024-04-23

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CA2966634A Active CA2966634C (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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US (2) US11135245B2 (Direct)
EP (2) EP4545639A3 (Direct)
JP (2) JP7146397B2 (Direct)
KR (1) KR102660362B1 (Direct)
CN (2) CN107249605A (Direct)
AU (2) AU2015350103A1 (Direct)
CA (1) CA2966634C (Direct)
DK (1) DK3220926T3 (Direct)
ES (1) ES3023783T3 (Direct)
IL (2) IL297773B2 (Direct)
MX (1) MX2017006408A (Direct)
RU (1) RU2756247C2 (Direct)
WO (1) WO2016081518A2 (Direct)
ZA (1) ZA201703505B (Direct)

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ES2601896T3 (es) 2004-11-24 2017-02-16 Fred Hutchinson Cancer Research Center Procedimientos de uso de la IL-21 en la inmunoterapia adoptiva y la identificación de antígenos tumorales
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
IL297773B2 (en) 2014-11-17 2024-07-01 Adicet Bio Inc Engineered gamma delta t-cells
JP6743051B2 (ja) 2015-01-27 2020-08-19 ラヴァ・セラピューティクス・ベー・フェー Ｃｄ１ｄを標的とする単一ドメイン抗体
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
ES2908840T3 (es) 2015-06-09 2022-05-04 Lymphact Lymphocyte Activation Tech S A Procedimiento para la producción de células T TCR gamma delta+
AU2016318163B2 (en) 2015-09-03 2022-07-14 Children's Healthcare Of Atlanta, Inc. Genetically-engineered drug resistant T cells and methods of using the same
CN118421557A (zh) * 2016-05-12 2024-08-02 阿迪塞特治疗公司 选择性扩增γδT细胞群的方法及其组合物
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
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