CA2907045C - Antimicrobial polyamide compositions and mastitis treatment - Google Patents

Antimicrobial polyamide compositions and mastitis treatment Download PDF

Info

Publication number
CA2907045C
CA2907045C CA2907045A CA2907045A CA2907045C CA 2907045 C CA2907045 C CA 2907045C CA 2907045 A CA2907045 A CA 2907045A CA 2907045 A CA2907045 A CA 2907045A CA 2907045 C CA2907045 C CA 2907045C
Authority
CA
Canada
Prior art keywords
veterinary composition
acid
composition
dissolved
diamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2907045A
Other languages
English (en)
French (fr)
Other versions
CA2907045A1 (en
Inventor
Susan Mancini Cady
Izabela Galeska
Pradeep K. Dhal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Genzyme Corp
Boehringer Ingelheim Animal Health USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Boehringer Ingelheim Animal Health USA Inc filed Critical Genzyme Corp
Publication of CA2907045A1 publication Critical patent/CA2907045A1/en
Application granted granted Critical
Publication of CA2907045C publication Critical patent/CA2907045C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/672—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0273—Polyamines containing heterocyclic moieties in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0622—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0627—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only one nitrogen atom in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CA2907045A 2013-03-15 2014-03-11 Antimicrobial polyamide compositions and mastitis treatment Active CA2907045C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790231P 2013-03-15 2013-03-15
US61/790,231 2013-03-15
PCT/US2014/023299 WO2014150451A1 (en) 2013-03-15 2014-03-11 Antimicrobial polyamide compositions and mastitis treatment

Publications (2)

Publication Number Publication Date
CA2907045A1 CA2907045A1 (en) 2014-09-25
CA2907045C true CA2907045C (en) 2020-12-08

Family

ID=50390295

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2907045A Active CA2907045C (en) 2013-03-15 2014-03-11 Antimicrobial polyamide compositions and mastitis treatment
CA2906334A Active CA2906334C (en) 2013-03-15 2014-03-11 Amine functional polyamides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2906334A Active CA2906334C (en) 2013-03-15 2014-03-11 Amine functional polyamides

Country Status (22)

Country Link
US (3) US10131744B2 (enExample)
EP (2) EP2970586B1 (enExample)
JP (4) JP6359630B2 (enExample)
KR (2) KR102233537B1 (enExample)
CN (2) CN105338976B (enExample)
AR (1) AR095366A1 (enExample)
AU (2) AU2014237169B2 (enExample)
BR (1) BR112015022224A2 (enExample)
CA (2) CA2907045C (enExample)
CL (1) CL2015002762A1 (enExample)
EA (1) EA030750B1 (enExample)
ES (1) ES2835382T3 (enExample)
HK (1) HK1220711A1 (enExample)
IL (1) IL241405A0 (enExample)
MX (2) MX364611B (enExample)
NZ (1) NZ712876A (enExample)
RU (1) RU2644554C2 (enExample)
SG (1) SG11201506359UA (enExample)
TW (2) TWI624263B (enExample)
UA (1) UA119642C2 (enExample)
WO (2) WO2014150451A1 (enExample)
ZA (1) ZA201506808B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2644554C2 (ru) 2013-03-15 2018-02-13 Джензим Корпорейшн Амин-функциональные полиамиды
AU2015287661B2 (en) * 2014-07-11 2019-07-11 Genzyme Corporation Main chain polyamines
CN104292148A (zh) * 2014-09-22 2015-01-21 西南科技大学 一种橡胶或树脂光稳定剂的制备方法
KR20180029224A (ko) * 2015-07-09 2018-03-20 헨켈 아이피 앤드 홀딩 게엠베하 저점도 투명 폴리아미드
JP6864001B2 (ja) * 2015-11-03 2021-04-21 ゾエティス・サービシーズ・エルエルシー ゾル−ゲルポリマー組成物及びそれらの使用
CA3020634C (en) * 2016-04-14 2025-06-17 Genzyme Corporation MULTIDOSE COMPOSITIONS CONTAINING AN ANTIMICROBIAL PRESERVATIVE BASED ON POLYAMIDE OR OCTENIDINE
KR20190018317A (ko) * 2017-08-14 2019-02-22 한국생명공학연구원 모노아세틸디아실글리세롤 화합물을 함유하는 슈도모나스 속 미생물 감염증의 예방 또는 치료용 조성물
US10743537B2 (en) 2017-12-12 2020-08-18 International Business Machines Corporation Monomer compositions with antimicrobial functionality
US10595527B2 (en) 2017-12-12 2020-03-24 International Business Machines Corporation Antimicrobial polymers capable of supramolecular assembly
US10653142B2 (en) 2017-12-12 2020-05-19 International Business Machines Corporation Polymers with antimicrobial functionalities
US10687528B2 (en) 2017-12-12 2020-06-23 International Business Machines Corporation Antimicrobial polymers with enhanced functionalities
US10836864B2 (en) 2017-12-12 2020-11-17 International Business Machines Corporation Chemical compositions with antimicrobial functionality
US10667514B2 (en) 2017-12-12 2020-06-02 International Business Machines Corporation Antimicrobial ionene compositions with a variety of functional groups
US10687530B2 (en) 2017-12-12 2020-06-23 International Business Machines Corporation Hydrophilic polymers with antimicrobial functionalities
RU2732206C2 (ru) * 2018-12-29 2020-09-14 Вероника Андреевна Гусева Способ лечения маститов у крупного рогатого скота
KR102052086B1 (ko) * 2019-07-25 2019-12-04 복세원 젖소 유두 보호제 및 그 제조방법
CN111471630B (zh) * 2020-06-11 2021-11-02 鲁东大学 一株棒杆菌Ytld-phe09及其应用
CN114796583B (zh) * 2022-03-25 2023-02-10 浙江大学 一种基于聚硫辛酸的生物医用贴片材料及其制备方法
CN115531518B (zh) * 2022-09-22 2023-05-23 湖南科技学院 一种用于防治奶牛乳房炎的中药软膏及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3583946A (en) * 1969-04-24 1971-06-08 Monsanto Co Polyureas derived from dipiperidines
IT981412B (it) * 1973-03-15 1974-10-10 Montedison Spa Poliammidi da acidi eterociclici aromatici ortocarbossilici e pro cedimento per prepararle
US4070400A (en) * 1975-10-16 1978-01-24 Merck & Co., Inc. Diphenyl polyamides having a cyclohexylene moiety
DE2942680C2 (de) * 1979-10-23 1986-02-27 Schering AG, 1000 Berlin und 4709 Bergkamen Schmelzkleber auf Basis von Polyesteramiden und deren Verwendung zum Verkleben von organischen und anorganischen Substraten
JPS591531A (ja) * 1982-06-25 1984-01-06 Daicel Chem Ind Ltd 感温性高分子材料
JPS596220A (ja) * 1982-07-01 1984-01-13 Daicel Chem Ind Ltd 新規ポリアミド共重合体
US4462942A (en) * 1982-07-30 1984-07-31 Eli Lilly And Company A47934 Antibiotic and process for production thereof
JPH01252633A (ja) * 1987-12-03 1989-10-09 Ricoh Co Ltd ポリアミドを用いた熱転写記録媒体及び新規なポリアミド
JPH0228208A (ja) * 1988-04-28 1990-01-30 Japan Synthetic Rubber Co Ltd 感放射線性共重合体およびその製造方法
JPH03258832A (ja) * 1990-03-08 1991-11-19 Mitsubishi Kasei Corp 不飽和ポリアミド
US6369049B1 (en) * 1998-04-30 2002-04-09 Eli Lilly And Company Treatment of mastitis
US6203812B1 (en) 1998-06-29 2001-03-20 Hydromer, Inc. Hydrophilic polymer blends used to prevent cow skin infections
AUPP584298A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Antimicrobial and antiparasitic agents
US20020009491A1 (en) * 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
PT1395289E (pt) * 2000-06-08 2011-03-16 Sang Dr Christine Tratamento da dor neuropática com antagonistas do receptor de n-metil-d-aspartato (nmda)
DE60127401T2 (de) * 2000-06-12 2008-01-03 University Of Saskatchewan, Saskatoon Milchvieh immunisierung mit mig protein
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US20040013698A1 (en) * 2001-07-09 2004-01-22 Aust Duncan T Method for preparing topical preparations containing skin protective agents with enhanced barrier properties
WO2004046109A2 (en) * 2002-11-19 2004-06-03 Genzyme Corporation Ionene oligomers and polymers
DE102004054873A1 (de) * 2004-11-12 2006-05-18 Bayer Healthcare Ag Behandlung von Mastitis
AU2009225253B2 (en) * 2008-03-13 2015-03-19 Agriculture Victoria Services Pty Ltd Method of treatment using antimicrobial composition
EP2138171A1 (en) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Veterinarian compositions containing terpinen-4-ol for the treatment and prevention of mastitis
US8278482B2 (en) * 2008-11-07 2012-10-02 Novabay Pharmaceuticals, Inc. Antimicrobial N-chlorinated compositions
JP5808082B2 (ja) * 2010-04-30 2015-11-10 株式会社Adeka 細胞への水溶性高分子量物質の導入方法及び導入剤
US8758778B2 (en) 2010-09-16 2014-06-24 The Regents Of The University Of California Polymeric nano-carriers with a linear dual response mechanism and uses thereof
CN102653779B (zh) 2011-03-04 2014-02-19 北京科润三联生物技术有限责任公司 一种新型重组抗菌多肽药物的制备方法
WO2012151555A1 (en) * 2011-05-04 2012-11-08 President And Fellows Of Harvard College Methods and coatings for treating biofilms
MX2013013330A (es) * 2011-05-16 2014-07-09 Cellceutix Corp Compuestos para utilizar en el tratamiento de mucositis.
BR112014031866A2 (pt) 2012-06-29 2022-02-01 Bayer Animal Health Gmbh Composição farmacêutica intramamária para utilização no tratamento ou prevenção da mastite em um mamífero não humano e composição farmacêutica de fosfomicina e de pelo menos um anti-microbiano
RU2644554C2 (ru) 2013-03-15 2018-02-13 Джензим Корпорейшн Амин-функциональные полиамиды

Also Published As

Publication number Publication date
CA2907045A1 (en) 2014-09-25
RU2644554C2 (ru) 2018-02-13
US10131744B2 (en) 2018-11-20
BR112015023445A8 (pt) 2022-06-28
MX373164B (es) 2020-05-07
EA201591812A1 (ru) 2016-02-29
EP2970586A1 (en) 2016-01-20
UA119642C2 (uk) 2019-07-25
CL2015002762A1 (es) 2016-04-08
TW201513873A (zh) 2015-04-16
JP7000021B2 (ja) 2022-01-19
IL241405A0 (en) 2015-11-30
KR102233537B1 (ko) 2021-03-29
ZA201506808B (en) 2017-11-29
RU2015144224A (ru) 2017-04-21
US20140271526A1 (en) 2014-09-18
JP2020045493A (ja) 2020-03-26
HK1220711A1 (zh) 2017-05-12
ES2835382T3 (es) 2021-06-22
TWI667028B (zh) 2019-08-01
CN105338976A (zh) 2016-02-17
KR20150131354A (ko) 2015-11-24
US20160208046A1 (en) 2016-07-21
JP2016514192A (ja) 2016-05-19
HK1215537A1 (zh) 2016-09-02
JP2016516700A (ja) 2016-06-09
MX2015012119A (es) 2016-05-18
AU2014237169A1 (en) 2015-10-29
MX364611B (es) 2019-05-02
CA2906334C (en) 2023-03-14
EP2968231A1 (en) 2016-01-20
BR112015023445A2 (enExample) 2017-08-29
TW201513872A (zh) 2015-04-16
MX2015013262A (es) 2016-04-04
US20140275469A1 (en) 2014-09-18
KR20150132325A (ko) 2015-11-25
AR095366A1 (es) 2015-10-14
JP6359630B2 (ja) 2018-07-18
US10113032B2 (en) 2018-10-30
TWI624263B (zh) 2018-05-21
AU2014237232A1 (en) 2015-10-22
EP2968231B1 (en) 2020-07-01
CA2906334A1 (en) 2014-09-25
CN105189607A (zh) 2015-12-23
CN105189607B (zh) 2018-06-15
AU2014237232B9 (en) 2018-02-01
NZ712876A (en) 2016-09-30
AU2014237169B2 (en) 2017-02-16
EP2970586B1 (en) 2022-12-07
CN105338976B (zh) 2018-12-04
WO2014150451A1 (en) 2014-09-25
AU2014237232B2 (en) 2018-01-18
WO2014150338A1 (en) 2014-09-25
SG11201506359UA (en) 2015-09-29
BR112015022224A2 (pt) 2017-07-18
US9326994B2 (en) 2016-05-03
EA030750B1 (ru) 2018-09-28
JP2018188662A (ja) 2018-11-29

Similar Documents

Publication Publication Date Title
CA2907045C (en) Antimicrobial polyamide compositions and mastitis treatment
JP5512279B2 (ja) 面状両親媒性ポリマー及びオリゴマーの眼科用及び耳科用組成物とその使用
CN102215690B (zh) 抗微生物组合物
CN105287607A (zh) 兽用复方盐酸多西环素氟苯尼考缓释微球混悬注射液
RU2397753C1 (ru) Композиция для лечения бактериальных инфекций у животных
CN100384422C (zh) 包含金属离子螯合剂的抗微生物组合物
WO2016005223A1 (en) Low substituted polymyxins and compositions thereof
CN107668062A (zh) 基于透明质酸的奥兰西丁水溶液及其制备方法和应用
JPH06510042A (ja) ロイコトリエンレセプター拮抗剤−抗ヒスタミン剤複合体
CN107303393A (zh) 丙泊酚聚乙二醇缀合前药的制备与应用
CN100536843C (zh) 含有法罗培南的注射用药物组合物
BR112015023445B1 (pt) Composições de poliamida antimicrobiana e tratamento de mastite
WO2023040397A1 (zh) 一种万古霉素凝胶剂及其制备方法
JP2012523450A (ja) 硫酸フラミセチンクリーム剤およびキトサンを使用して製造された薬用クリーム剤ならびにそれを製造する方法
CN101933927A (zh) 一种含恩诺沙星六水合物组合物及其在制备治疗或预防家畜疾病的药物中的应用
WO2011088532A1 (pt) Composições farmacêuticas para tratamento de infecções bacterianas
CN107646862A (zh) 基于抗坏血酸的奥兰西丁水溶液及其制备方法和应用
EP0097580A1 (fr) Nouveau médicament vétérinaire destiné au traitement des mammites infectieuses des bovins et caprins
WO2023132793A2 (en) Polyimidazolium-based cationic antimicrobial polymers for novel mastitis prophylactic solutions
HK40060969B (zh) 抗微生物化合物、组合物及其用途
CN120643503A (zh) 复合纳米酶水凝胶的制备方法及其在制备防治细菌性角膜炎的产品中的应用
CN107595847A (zh) 一种恩诺沙星注射液
WO2007099431A2 (en) An aqueous liquid pharmaceutical compositions of gatifloxacin
CN102796125A (zh) 他唑巴坦氨苄青霉素酰胺复合物及其制备方法与应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180406