RU2644554C2 - Амин-функциональные полиамиды - Google Patents

Амин-функциональные полиамиды Download PDF

Info

Publication number
RU2644554C2
RU2644554C2 RU2015144224A RU2015144224A RU2644554C2 RU 2644554 C2 RU2644554 C2 RU 2644554C2 RU 2015144224 A RU2015144224 A RU 2015144224A RU 2015144224 A RU2015144224 A RU 2015144224A RU 2644554 C2 RU2644554 C2 RU 2644554C2
Authority
RU
Russia
Prior art keywords
alkyl
formula
equal
compound according
poly
Prior art date
Application number
RU2015144224A
Other languages
English (en)
Russian (ru)
Other versions
RU2015144224A (ru
Inventor
Прадип Дхал
Каньвэнь ЯН
Роберт Дж. МИЛЛЕР
Стефен Рэндалл Холмс-Фарли
Original Assignee
Джензим Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джензим Корпорейшн filed Critical Джензим Корпорейшн
Publication of RU2015144224A publication Critical patent/RU2015144224A/ru
Application granted granted Critical
Publication of RU2644554C2 publication Critical patent/RU2644554C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/672—Dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0273—Polyamines containing heterocyclic moieties in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0622—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0627—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only one nitrogen atom in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
RU2015144224A 2013-03-15 2014-03-11 Амин-функциональные полиамиды RU2644554C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790231P 2013-03-15 2013-03-15
US61/790,231 2013-03-15
PCT/US2014/022984 WO2014150338A1 (en) 2013-03-15 2014-03-11 Amine functional polyamides

Publications (2)

Publication Number Publication Date
RU2015144224A RU2015144224A (ru) 2017-04-21
RU2644554C2 true RU2644554C2 (ru) 2018-02-13

Family

ID=50390295

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015144224A RU2644554C2 (ru) 2013-03-15 2014-03-11 Амин-функциональные полиамиды

Country Status (22)

Country Link
US (3) US10131744B2 (enExample)
EP (2) EP2970586B1 (enExample)
JP (4) JP7000021B2 (enExample)
KR (2) KR102233537B1 (enExample)
CN (2) CN105338976B (enExample)
AR (1) AR095366A1 (enExample)
AU (2) AU2014237232B9 (enExample)
BR (1) BR112015022224A2 (enExample)
CA (2) CA2907045C (enExample)
CL (1) CL2015002762A1 (enExample)
EA (1) EA030750B1 (enExample)
ES (1) ES2835382T3 (enExample)
HK (1) HK1220711A1 (enExample)
IL (1) IL241405A0 (enExample)
MX (2) MX373164B (enExample)
NZ (1) NZ712876A (enExample)
RU (1) RU2644554C2 (enExample)
SG (1) SG11201506359UA (enExample)
TW (2) TWI624263B (enExample)
UA (1) UA119642C2 (enExample)
WO (2) WO2014150338A1 (enExample)
ZA (1) ZA201506808B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970586B1 (en) 2013-03-15 2022-12-07 Genzyme Corporation Amine functional polyamides
MX2017000447A (es) * 2014-07-11 2017-04-27 Genzyme Corp Poliaminas de cadena principal.
CN104292148A (zh) * 2014-09-22 2015-01-21 西南科技大学 一种橡胶或树脂光稳定剂的制备方法
CN107735426A (zh) * 2015-07-09 2018-02-23 汉高知识产权控股有限责任公司 低粘度透明聚酰胺
CA3002214C (en) * 2015-11-03 2022-01-04 Zoetis Services Llc Sol-gel polymer composites and uses thereof
CA3020634C (en) * 2016-04-14 2025-06-17 Genzyme Corporation MULTIDOSE COMPOSITIONS CONTAINING AN ANTIMICROBIAL PRESERVATIVE BASED ON POLYAMIDE OR OCTENIDINE
KR20190018317A (ko) * 2017-08-14 2019-02-22 한국생명공학연구원 모노아세틸디아실글리세롤 화합물을 함유하는 슈도모나스 속 미생물 감염증의 예방 또는 치료용 조성물
US10836864B2 (en) 2017-12-12 2020-11-17 International Business Machines Corporation Chemical compositions with antimicrobial functionality
US10743537B2 (en) 2017-12-12 2020-08-18 International Business Machines Corporation Monomer compositions with antimicrobial functionality
US10687530B2 (en) 2017-12-12 2020-06-23 International Business Machines Corporation Hydrophilic polymers with antimicrobial functionalities
US10667514B2 (en) 2017-12-12 2020-06-02 International Business Machines Corporation Antimicrobial ionene compositions with a variety of functional groups
US10653142B2 (en) 2017-12-12 2020-05-19 International Business Machines Corporation Polymers with antimicrobial functionalities
US10595527B2 (en) 2017-12-12 2020-03-24 International Business Machines Corporation Antimicrobial polymers capable of supramolecular assembly
US10687528B2 (en) 2017-12-12 2020-06-23 International Business Machines Corporation Antimicrobial polymers with enhanced functionalities
RU2732206C2 (ru) * 2018-12-29 2020-09-14 Вероника Андреевна Гусева Способ лечения маститов у крупного рогатого скота
KR102052086B1 (ko) * 2019-07-25 2019-12-04 복세원 젖소 유두 보호제 및 그 제조방법
CN111471630B (zh) * 2020-06-11 2021-11-02 鲁东大学 一株棒杆菌Ytld-phe09及其应用
CN114796583B (zh) * 2022-03-25 2023-02-10 浙江大学 一种基于聚硫辛酸的生物医用贴片材料及其制备方法
CN115531518B (zh) * 2022-09-22 2023-05-23 湖南科技学院 一种用于防治奶牛乳房炎的中药软膏及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001093878A2 (en) * 2000-06-08 2001-12-13 Geltex Pharmaceuticals, Inc. Bismuth compounds for the treatment and prevention of mucositis
WO2012151554A1 (en) * 2011-05-04 2012-11-08 President And Fellows Of Harvard College Polyamines for treating biofilms
US20120295922A1 (en) * 2011-05-16 2012-11-22 Polymedix, Inc. Compounds For Use In Treatment Of Mucositis

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3583946A (en) * 1969-04-24 1971-06-08 Monsanto Co Polyureas derived from dipiperidines
IT981412B (it) * 1973-03-15 1974-10-10 Montedison Spa Poliammidi da acidi eterociclici aromatici ortocarbossilici e pro cedimento per prepararle
US4070400A (en) * 1975-10-16 1978-01-24 Merck & Co., Inc. Diphenyl polyamides having a cyclohexylene moiety
DE2942680C2 (de) * 1979-10-23 1986-02-27 Schering AG, 1000 Berlin und 4709 Bergkamen Schmelzkleber auf Basis von Polyesteramiden und deren Verwendung zum Verkleben von organischen und anorganischen Substraten
JPS591531A (ja) * 1982-06-25 1984-01-06 Daicel Chem Ind Ltd 感温性高分子材料
JPS596220A (ja) * 1982-07-01 1984-01-13 Daicel Chem Ind Ltd 新規ポリアミド共重合体
US4462942A (en) * 1982-07-30 1984-07-31 Eli Lilly And Company A47934 Antibiotic and process for production thereof
JPH01252633A (ja) * 1987-12-03 1989-10-09 Ricoh Co Ltd ポリアミドを用いた熱転写記録媒体及び新規なポリアミド
JPH0228208A (ja) * 1988-04-28 1990-01-30 Japan Synthetic Rubber Co Ltd 感放射線性共重合体およびその製造方法
JPH03258832A (ja) * 1990-03-08 1991-11-19 Mitsubishi Kasei Corp 不飽和ポリアミド
US6369049B1 (en) * 1998-04-30 2002-04-09 Eli Lilly And Company Treatment of mastitis
US6203812B1 (en) * 1998-06-29 2001-03-20 Hydromer, Inc. Hydrophilic polymer blends used to prevent cow skin infections
AUPP584298A0 (en) * 1998-09-14 1998-10-08 Starpharma Limited Antimicrobial and antiparasitic agents
US20020009491A1 (en) * 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
CA2411925C (en) * 2000-06-12 2011-08-16 University Of Saskatchewan Immunization of dairy cattle with mig protein
US6998115B2 (en) * 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US20040013698A1 (en) * 2001-07-09 2004-01-22 Aust Duncan T Method for preparing topical preparations containing skin protective agents with enhanced barrier properties
AU2003291087A1 (en) * 2002-11-19 2004-06-15 Genzyme Corporation Ionene oligomers and polymers
DE102004054873A1 (de) * 2004-11-12 2006-05-18 Bayer Healthcare Ag Behandlung von Mastitis
WO2009111838A1 (en) * 2008-03-13 2009-09-17 Agriculture Victoria Services Pty Limited Method of treatment using antimicrobial composition
EP2138171A1 (en) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Veterinarian compositions containing terpinen-4-ol for the treatment and prevention of mastitis
JP5599808B2 (ja) * 2008-11-07 2014-10-01 ノバベイ・ファーマシューティカルズ・インコーポレイテッド 抗菌性ｎ−塩素化組成物
JP5808082B2 (ja) * 2010-04-30 2015-11-10 株式会社Adeka 細胞への水溶性高分子量物質の導入方法及び導入剤
US8758778B2 (en) 2010-09-16 2014-06-24 The Regents Of The University Of California Polymeric nano-carriers with a linear dual response mechanism and uses thereof
CN102653779B (zh) 2011-03-04 2014-02-19 北京科润三联生物技术有限责任公司 一种新型重组抗菌多肽药物的制备方法
AU2013283375B2 (en) 2012-06-29 2018-04-26 Elanco Animal Health Gmbh Pharmaceutical compositions and treatment of mastitis
EP2970586B1 (en) 2013-03-15 2022-12-07 Genzyme Corporation Amine functional polyamides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001093878A2 (en) * 2000-06-08 2001-12-13 Geltex Pharmaceuticals, Inc. Bismuth compounds for the treatment and prevention of mucositis
WO2012151554A1 (en) * 2011-05-04 2012-11-08 President And Fellows Of Harvard College Polyamines for treating biofilms
US20120295922A1 (en) * 2011-05-16 2012-11-22 Polymedix, Inc. Compounds For Use In Treatment Of Mucositis

Also Published As

Publication number Publication date
KR102233537B1 (ko) 2021-03-29
NZ712876A (en) 2016-09-30
EP2970586B1 (en) 2022-12-07
AU2014237232B9 (en) 2018-02-01
EP2970586A1 (en) 2016-01-20
AU2014237169B2 (en) 2017-02-16
SG11201506359UA (en) 2015-09-29
CA2906334A1 (en) 2014-09-25
JP6359630B2 (ja) 2018-07-18
MX2015012119A (es) 2016-05-18
HK1220711A1 (zh) 2017-05-12
AU2014237232B2 (en) 2018-01-18
AU2014237169A1 (en) 2015-10-29
AR095366A1 (es) 2015-10-14
HK1215537A1 (zh) 2016-09-02
JP2020045493A (ja) 2020-03-26
CA2907045A1 (en) 2014-09-25
JP2016516700A (ja) 2016-06-09
RU2015144224A (ru) 2017-04-21
EP2968231A1 (en) 2016-01-20
JP2016514192A (ja) 2016-05-19
US20140275469A1 (en) 2014-09-18
EA201591812A1 (ru) 2016-02-29
TWI667028B (zh) 2019-08-01
US10131744B2 (en) 2018-11-20
JP2018188662A (ja) 2018-11-29
CN105338976B (zh) 2018-12-04
BR112015022224A2 (pt) 2017-07-18
ZA201506808B (en) 2017-11-29
CA2906334C (en) 2023-03-14
CA2907045C (en) 2020-12-08
BR112015023445A2 (enExample) 2017-08-29
MX2015013262A (es) 2016-04-04
BR112015023445A8 (pt) 2022-06-28
KR20150131354A (ko) 2015-11-24
US10113032B2 (en) 2018-10-30
IL241405A0 (en) 2015-11-30
CN105189607B (zh) 2018-06-15
UA119642C2 (uk) 2019-07-25
US20160208046A1 (en) 2016-07-21
EA030750B1 (ru) 2018-09-28
MX373164B (es) 2020-05-07
CL2015002762A1 (es) 2016-04-08
TWI624263B (zh) 2018-05-21
US20140271526A1 (en) 2014-09-18
WO2014150338A1 (en) 2014-09-25
TW201513872A (zh) 2015-04-16
US9326994B2 (en) 2016-05-03
ES2835382T3 (es) 2021-06-22
KR20150132325A (ko) 2015-11-25
TW201513873A (zh) 2015-04-16
CN105338976A (zh) 2016-02-17
JP7000021B2 (ja) 2022-01-19
AU2014237232A1 (en) 2015-10-22
CN105189607A (zh) 2015-12-23
EP2968231B1 (en) 2020-07-01
WO2014150451A1 (en) 2014-09-25
MX364611B (es) 2019-05-02

Similar Documents

Publication Publication Date Title
US10113032B2 (en) Amine functional polyamides
CN114340597B (zh) 用于治疗中枢神经系统障碍的组合物和方法
US9713597B2 (en) Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone
JP6765363B2 (ja) 主鎖ポリアミン
US20220151999A1 (en) Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
ES3040101T3 (en) New molecular tweezers against neurological disorders and viral infections
JP7475144B2 (ja) 分画抗菌組成物およびその使用
US11214550B2 (en) Bis-cyclic guanidines as antibacterial agents
CN113354561A (zh) 双胍衍生物及其应用与制剂
HK40060969B (en) Antimicrobial compounds, compositions, and uses thereof
WO2016023911A1 (en) Use of 1,3-propanedisulfonic acid or salts thereof to prevent the onset of amyloidosis in select populations
CN110698457A (zh) 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-叔丁酯及其用途
CN110818685A (zh) 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-异己基及其用途

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20190312