CA2878442A1 - Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases - Google Patents

Info

Publication number

CA2878442A1

CA2878442A1 CA2878442A CA2878442A CA2878442A1 CA 2878442 A1 CA2878442 A1 CA 2878442A1 CA 2878442 A CA2878442 A CA 2878442A CA 2878442 A CA2878442 A CA 2878442A CA 2878442 A1 CA2878442 A1 CA 2878442A1

Authority

CA

Canada

Prior art keywords

carbonyl

pyrrolo

benzotriazole

hexahydro

substituted

Prior art date

2012-09-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 150000001875 compounds Chemical class 0.000 title claims abstract description 275
• 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title description 29
• 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title description 26
• WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 title description 21
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 title description 21
• 238000004519 manufacturing process Methods 0.000 title description 9
• 239000003112 inhibitor Substances 0.000 title description 5
• HWUGBMMPIAIJJC-UHFFFAOYSA-N 1,2,3,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole Chemical class N1CC2CNCC2=C1 HWUGBMMPIAIJJC-UHFFFAOYSA-N 0.000 title 1
• 208000017169 kidney disease Diseases 0.000 title 1
• 238000000034 method Methods 0.000 claims abstract description 32
• -1 2,3-dihydro-1H-isoindol-2-yl Chemical group 0.000 claims description 374
• WRHZVMBBRYBTKZ-UHFFFAOYSA-N Minaline Natural products OC(=O)C1=CC=CN1 WRHZVMBBRYBTKZ-UHFFFAOYSA-N 0.000 claims description 125
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 123
• 125000000217 alkyl group Chemical group 0.000 claims description 118
• DOYOPBSXEIZLRE-UHFFFAOYSA-N pyrrole-3-carboxylic acid Natural products OC(=O)C=1C=CNC=1 DOYOPBSXEIZLRE-UHFFFAOYSA-N 0.000 claims description 81
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims description 65
• 238000006243 chemical reaction Methods 0.000 claims description 58
• HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims description 53
• 125000001188 haloalkyl group Chemical group 0.000 claims description 50
• 229910052736 halogen Inorganic materials 0.000 claims description 49
• 150000002367 halogens Chemical class 0.000 claims description 47
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 44
• 125000003545 alkoxy group Chemical group 0.000 claims description 39
• 150000003839 salts Chemical class 0.000 claims description 37
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
• 229910052739 hydrogen Inorganic materials 0.000 claims description 34
• 229910052757 nitrogen Inorganic materials 0.000 claims description 34
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 32
• 125000004076 pyridyl group Chemical group 0.000 claims description 32
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 31
• 201000010099 disease Diseases 0.000 claims description 30
• 125000003884 phenylalkyl group Chemical group 0.000 claims description 30
• 230000003176 fibrotic effect Effects 0.000 claims description 24
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 22
• 238000011282 treatment Methods 0.000 claims description 22
• 230000001684 chronic effect Effects 0.000 claims description 21
• 238000011321 prophylaxis Methods 0.000 claims description 21
• 125000005359 phenoxyalkyl group Chemical group 0.000 claims description 20
• 125000004122 cyclic group Chemical group 0.000 claims description 19
• 230000001154 acute effect Effects 0.000 claims description 18
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 18
• 210000004185 liver Anatomy 0.000 claims description 18
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 17
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 15
• 125000004439 haloalkylsulfanyl group Chemical group 0.000 claims description 15
• 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims description 15
• 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims description 15
• 210000000653 nervous system Anatomy 0.000 claims description 15
• 210000000056 organ Anatomy 0.000 claims description 15
• UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims description 15
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 14
• 230000004968 inflammatory condition Effects 0.000 claims description 14
• 125000001424 substituent group Chemical group 0.000 claims description 14
• 206010052779 Transplant rejections Diseases 0.000 claims description 13
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
• 125000001624 naphthyl group Chemical group 0.000 claims description 12
• 125000005083 alkoxyalkoxy group Chemical group 0.000 claims description 11
• 125000000000 cycloalkoxy group Chemical group 0.000 claims description 11
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims description 11
• 125000001544 thienyl group Chemical group 0.000 claims description 11
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 10
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 10
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 10
• 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims description 9
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 8
• 125000004193 piperazinyl group Chemical group 0.000 claims description 8
• 125000003386 piperidinyl group Chemical group 0.000 claims description 8
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 8
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 8
• 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims description 7
• 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 7
• 125000004414 alkyl thio group Chemical group 0.000 claims description 7
• 239000003795 chemical substances by application Substances 0.000 claims description 7
• 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims description 7
• 239000003814 drug Substances 0.000 claims description 7
• 230000008569 process Effects 0.000 claims description 7
• JQDSZGNVNWMBLL-HZPDHXFCSA-N (3,5-dichlorophenyl)methyl (3aR,7aS)-5-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate Chemical compound Clc1cc(Cl)cc(COC(=O)N2C[C@H]3CCN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1 JQDSZGNVNWMBLL-HZPDHXFCSA-N 0.000 claims description 6
• ZBGBHRWGQMRDOU-FHIIMIHHSA-N (3,5-dichlorophenyl)methyl (3aS,7aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound C1CN(C[C@H]2[C@@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=CC(=CC(=C5)Cl)Cl ZBGBHRWGQMRDOU-FHIIMIHHSA-N 0.000 claims description 6
• ZRNBBRKTIMLWGP-HZPDHXFCSA-N (3,5-dichlorophenyl)methyl (3aS,7aS)-2-(2-oxo-3H-1,3-benzoxazole-6-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound Clc1cc(Cl)cc(COC(=O)N2CC[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]c(=O)oc3c2)c1 ZRNBBRKTIMLWGP-HZPDHXFCSA-N 0.000 claims description 6
• XOEPAVBRZGXVRN-UUVAVEHKSA-N (3,5-dichlorophenyl)methyl (3ar,6as)-5-[(2-oxo-3h-1,3-benzoxazol-6-yl)oxy]-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrole-2-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@H]3CC(C[C@H]3C2)OC=2C=C3OC(=O)NC3=CC=2)=C1 XOEPAVBRZGXVRN-UUVAVEHKSA-N 0.000 claims description 6
• 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 claims description 6
• 125000004858 cycloalkoxyalkyl group Chemical group 0.000 claims description 6
• 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims description 6
• 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims description 6
• 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims description 6
• 229910052760 oxygen Inorganic materials 0.000 claims description 6
• ZBGBHRWGQMRDOU-MSIAFNQFSA-N (3,5-dichlorophenyl)methyl (3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound C1CN(C[C@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=CC(=CC(=C5)Cl)Cl ZBGBHRWGQMRDOU-MSIAFNQFSA-N 0.000 claims description 5
• XVUYSZPNVSHRJU-HZPDHXFCSA-N (3,5-dichlorophenyl)methyl (3aS,7aS)-2-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound Clc1cc(Cl)cc(COC(=O)N2CC[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1 XVUYSZPNVSHRJU-HZPDHXFCSA-N 0.000 claims description 5
• 238000002360 preparation method Methods 0.000 claims description 4
• 239000013543 active substance Substances 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims description 3
• VOWJAUDBMHGNNB-HUUCEWRRSA-N (3,5-dichlorophenyl)methyl (3aR,6aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1[C@H](C2)CN(C1)C(=O)OCC1=CC(=CC(=C1)Cl)Cl VOWJAUDBMHGNNB-HUUCEWRRSA-N 0.000 claims description 2
• QDTWOKYDHUWMLD-HDICACEKSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-2-(1H-indole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound N1C=CC2=CC(=CC=C12)C(=O)N1C[C@@H]2[C@H](C1)CN(C2)C(=O)OCC2=CC(=CC(=C2)Cl)Cl QDTWOKYDHUWMLD-HDICACEKSA-N 0.000 claims description 2
• VOWJAUDBMHGNNB-GASCZTMLSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@H](C2)CN(C1)C(=O)OCC1=CC(=CC(=C1)Cl)Cl VOWJAUDBMHGNNB-GASCZTMLSA-N 0.000 claims description 2
• PFMODUJVVVCJKM-UUVAVEHKSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-5-[(2-oxo-3H-1,3-benzoxazol-6-yl)amino]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@H]3CC(C[C@H]3C2)NC=2C=C3OC(=O)NC3=CC=2)=C1 PFMODUJVVVCJKM-UUVAVEHKSA-N 0.000 claims description 2
• JQDSZGNVNWMBLL-JKSUJKDBSA-N (3,5-dichlorophenyl)methyl (3aR,7aR)-5-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate Chemical compound Clc1cc(Cl)cc(COC(=O)N2C[C@@H]3CCN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1 JQDSZGNVNWMBLL-JKSUJKDBSA-N 0.000 claims description 2
• JDLSOJXDGSQIHO-KDURUIRLSA-N (3,5-dichlorophenyl)methyl (3aS,6aR)-2-(9H-carbazole-3-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1=CC(=CC=2C3=CC=CC=C3NC12)C(=O)N1C[C@@H]2[C@H](C1)CN(C2)C(=O)OCC2=CC(=CC(=C2)Cl)Cl JDLSOJXDGSQIHO-KDURUIRLSA-N 0.000 claims description 2
• ZZIZSFHXVAEBIR-CALCHBBNSA-N (3,5-dichlorophenyl)methyl (3ar,6as)-2-(1h-indazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C=2C=C3C=NNC3=CC=2)=C1 ZZIZSFHXVAEBIR-CALCHBBNSA-N 0.000 claims description 2
• KPTSQRRRWWBAJP-GASCZTMLSA-N (3,5-dichlorophenyl)methyl (3ar,6as)-2-(2-oxo-3h-1,3-benzoxazole-6-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C=2C=C3OC(=O)NC3=CC=2)=C1 KPTSQRRRWWBAJP-GASCZTMLSA-N 0.000 claims description 2
• DOFXWCKKIGOXAZ-IYBDPMFKSA-N (3,5-dichlorophenyl)methyl (3ar,6as)-2-(3h-benzimidazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C=2C=C3NC=NC3=CC=2)=C1 DOFXWCKKIGOXAZ-IYBDPMFKSA-N 0.000 claims description 2
• ZNRUXBLWISFAAT-CALCHBBNSA-N (3,5-dichlorophenyl)methyl (3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 ZNRUXBLWISFAAT-CALCHBBNSA-N 0.000 claims description 2
• BNEDHPRPWWTLKY-CALCHBBNSA-N (3,5-dichlorophenyl)methyl (3ar,8as)-6-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CCN(CC[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 BNEDHPRPWWTLKY-CALCHBBNSA-N 0.000 claims description 2
• DWORKKHQTJBXFV-IYBDPMFKSA-N (3-chloro-5-methoxyphenyl)methyl (3ar,6as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound COC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 DWORKKHQTJBXFV-IYBDPMFKSA-N 0.000 claims description 2
• ACKWHXWLAFGNDL-CALCHBBNSA-N (3-cyano-5-fluorophenyl)methyl (3ar,6as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound N#CC1=CC(F)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 ACKWHXWLAFGNDL-CALCHBBNSA-N 0.000 claims description 2
• CQHSZWLIQZBASW-QZTJIDSGSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)c1ccccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 CQHSZWLIQZBASW-QZTJIDSGSA-N 0.000 claims description 2
• JCJXPQUDQXMSLG-UHFFFAOYSA-N 3a,4,5,6,7,7a-hexahydro-1h-[1,3]oxazolo[5,4-c]pyridin-2-one Chemical compound C1CNCC2OC(=O)NC21 JCJXPQUDQXMSLG-UHFFFAOYSA-N 0.000 claims description 2
• 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims description 2
• 125000005956 isoquinolyl group Chemical group 0.000 claims description 2
• 125000005493 quinolyl group Chemical group 0.000 claims description 2
• 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 8
• 125000004244 benzofuran-2-yl group Chemical group [H]C1=C(*)OC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 4
• CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims 4
• LAHAZVKTDIUJQM-LGNKUTNCSA-N (e)-1-[(3as,7as)-5-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1C[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)CC[C@@H]2C1 LAHAZVKTDIUJQM-LGNKUTNCSA-N 0.000 claims 3
• UTYYEESWVZZXSP-IAGOWNOFSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=CC=C(C=C1)OC(F)(F)F)=O UTYYEESWVZZXSP-IAGOWNOFSA-N 0.000 claims 2
• YVIMXMIOEDDRKU-IAGOWNOFSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound FC(F)(F)Oc1ccc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1 YVIMXMIOEDDRKU-IAGOWNOFSA-N 0.000 claims 2
• FGMDUHGAZHCPQC-HUUCEWRRSA-N 1-[(3aR,6aR)-5-(4-fluoro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound Fc1c(ccc2[nH]nnc12)C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)CCc1ccc(OC(F)(F)F)cc1 FGMDUHGAZHCPQC-HUUCEWRRSA-N 0.000 claims 2
• YVIMXMIOEDDRKU-CALCHBBNSA-N 1-[(3aR,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1[C@@H](C2)CN(C1)C(CCC1=CC=C(C=C1)OC(F)(F)F)=O YVIMXMIOEDDRKU-CALCHBBNSA-N 0.000 claims 2
• YPPJLUKKDPCSDF-IAGOWNOFSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C1=CC(C(F)(F)F)=CC=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 YPPJLUKKDPCSDF-IAGOWNOFSA-N 0.000 claims 2
• VQCXQKSVJKXTLZ-QZTJIDSGSA-N 1-[(3as,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1OCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 VQCXQKSVJKXTLZ-QZTJIDSGSA-N 0.000 claims 2
• DIWXYYOVYLRVDT-IYBDPMFKSA-N (1-fluorocyclohexyl)methyl (3ar,6as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C([C@@H]1CN(C[C@@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)OCC1(F)CCCCC1 DIWXYYOVYLRVDT-IYBDPMFKSA-N 0.000 claims 1
• YMJCEHVQHGMQMO-HDICACEKSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-2-(1H-indazol-5-ylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound N1N=CC2=CC(=CC=C12)CN1C[C@@H]2[C@H](C1)CN(C2)C(=O)OCC2=CC(=CC(=C2)Cl)Cl YMJCEHVQHGMQMO-HDICACEKSA-N 0.000 claims 1
• JJLGQTHSBRDTHA-OCZCAGDBSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-2-(triazolidin-4-ylmethylcarbamoyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1[C@@H]2CN(C[C@@H]2CN1C(=O)NCC3CNNN3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl JJLGQTHSBRDTHA-OCZCAGDBSA-N 0.000 claims 1
• SMUNCGSCZAWARG-IYBDPMFKSA-N (3,5-dichlorophenyl)methyl (3aR,6aS)-2-[(2-oxo-3H-1,3-benzoxazol-6-yl)methyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound O=C1OC2=C(N1)C=CC(=C2)CN2C[C@@H]1[C@H](C2)CN(C1)C(=O)OCC1=CC(=CC(=C1)Cl)Cl SMUNCGSCZAWARG-IYBDPMFKSA-N 0.000 claims 1
• XVUYSZPNVSHRJU-CVEARBPZSA-N (3,5-dichlorophenyl)methyl (3aR,7aS)-2-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound Clc1cc(Cl)cc(COC(=O)N2CC[C@@H]3CN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c1 XVUYSZPNVSHRJU-CVEARBPZSA-N 0.000 claims 1
• MJWHZFIKGOOVNS-JDBPCZOCSA-N (3,5-dichlorophenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC(=C5)Cl)Cl)NNN2 MJWHZFIKGOOVNS-JDBPCZOCSA-N 0.000 claims 1
• MEZBGAODORWMII-CALCHBBNSA-N (3,5-dichlorophenyl)methyl (3as,6ar)-2-(3h-benzimidazol-5-ylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@H]3CN(CC=4C=C5NC=NC5=CC=4)C[C@H]3C2)=C1 MEZBGAODORWMII-CALCHBBNSA-N 0.000 claims 1
• XVUYSZPNVSHRJU-JKSUJKDBSA-N (3,5-dichlorophenyl)methyl (3as,7ar)-2-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound ClC1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 XVUYSZPNVSHRJU-JKSUJKDBSA-N 0.000 claims 1
• TXXVMTGXHIQUIS-IXHKABCMSA-N (3-chloro-5-cyanophenyl)methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC(=C5)Cl)C#N)NNN2 TXXVMTGXHIQUIS-IXHKABCMSA-N 0.000 claims 1
• WOPHYMKVNPQFJZ-RLDYUYOSSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3aS,6aS)-2-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CS(=O)(=O)C1=CC(=CC(=C1)COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)[C@@H]4CCC5C(C4)NNN5)Cl WOPHYMKVNPQFJZ-RLDYUYOSSA-N 0.000 claims 1
• WXPXYSNSDKKHRC-NIDBYGFPSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound CS(=O)(=O)C1=CC(=CC(=C1)COC(=O)N2CC[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5)Cl WXPXYSNSDKKHRC-NIDBYGFPSA-N 0.000 claims 1
• LPJLZGBOQZJWAX-IYBDPMFKSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3as,6ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CS(=O)(=O)C1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 LPJLZGBOQZJWAX-IYBDPMFKSA-N 0.000 claims 1
• BCKZMIGLJIDPOE-GJZGRUSLSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3as,6as)-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CS(=O)(=O)C1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)N2CC3=NNN=C3CC2)=C1 BCKZMIGLJIDPOE-GJZGRUSLSA-N 0.000 claims 1
• LPJLZGBOQZJWAX-HOTGVXAUSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3as,6as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CS(=O)(=O)C1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 LPJLZGBOQZJWAX-HOTGVXAUSA-N 0.000 claims 1
• UATVXIUZPVYUSV-IRXDYDNUSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3as,7ar)-5-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridine-2-carboxylate Chemical compound CS(=O)(=O)C1=CC(Cl)=CC(COC(=O)N2C[C@@H]3CN(CC[C@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 UATVXIUZPVYUSV-IRXDYDNUSA-N 0.000 claims 1
• PRIDUUZUQRLXCV-HDICACEKSA-N (3-chloro-5-methylsulfonylphenyl)methyl (3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound CS(=O)(=O)C1=CC(Cl)=CC(COC(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 PRIDUUZUQRLXCV-HDICACEKSA-N 0.000 claims 1
• NEMWEJYMFXGCSN-UKYQJIBSSA-N (3aR,7aR)-5-[(3aR,6aR)-2-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-1,3a,4,6,7,7a-hexahydro-[1,3]oxazolo[5,4-c]pyridin-2-one Chemical compound FC(OC1=CC=C(C=C1)/C=C/C(=O)N1C[C@H]2[C@H](C1)CN(C2)C(=O)N2C[C@@H]1[C@@H](CC2)NC(O1)=O)(F)F NEMWEJYMFXGCSN-UKYQJIBSSA-N 0.000 claims 1
• MZUCYPKPXJJMFQ-PSBWJHGTSA-N (3aR,7aR)-5-[(3aR,6aR)-2-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-1,3a,4,6,7,7a-hexahydro-[1,3]oxazolo[5,4-c]pyridin-2-one Chemical compound FC(OC1=CC=C(C=C1)CCC(=O)N1C[C@H]2[C@H](C1)CN(C2)C(=O)N2C[C@@H]1[C@@H](CC2)NC(O1)=O)(F)F MZUCYPKPXJJMFQ-PSBWJHGTSA-N 0.000 claims 1
• IBKITHJNRZHJEL-HDICACEKSA-N (3aR,8aS)-6-[3-(3-chlorophenyl)-2,2-dimethylpropanoyl]-N-(2H-triazol-4-ylmethyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound N1=NNC(=C1)CNC(=O)N1C[C@@H]2CCN(CC[C@@H]2C1)C(C(CC1=CC(=CC=C1)Cl)(C)C)=O IBKITHJNRZHJEL-HDICACEKSA-N 0.000 claims 1
• RAMLSDVGSQCTHM-OPHDVJQKSA-N (3aS,8aR)-6-[(E)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]prop-2-enoyl]-N-methyl-N-(2H-triazol-4-ylmethyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound C([C@H]1CN(C[C@H]1CC1)C(=O)N(C)Cc2[nH]nnc2)CN1C(=O)\C=C\c1cc(F)c(OC(F)(F)F)cc1 RAMLSDVGSQCTHM-OPHDVJQKSA-N 0.000 claims 1
• MHFWGSAZSASMMM-CALCHBBNSA-N (3aS,8aR)-N-(1H-1,2,4-triazol-5-ylmethyl)-6-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound N=1N=C(NC1)CNC(=O)N1C[C@@H]2CCN(CC[C@@H]2C1)C(C=CC1=CC=C(C=C1)OC(F)(F)F)=O MHFWGSAZSASMMM-CALCHBBNSA-N 0.000 claims 1
• JZZUKJOKTSICNE-HDICACEKSA-N (3aS,8aR)-N-[2-(2H-triazol-4-yl)ethyl]-6-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound N1N=NC=C1CCNC(=O)N1C[C@H]2CCN(CC[C@H]2C1)C(C=CC1=CC=C(C=C1)OC(F)(F)F)=O JZZUKJOKTSICNE-HDICACEKSA-N 0.000 claims 1
• XGRBHGWCFQVTNW-HDICACEKSA-N (3aS,8aR)-N-[2-(2H-triazol-4-yl)ethyl]-6-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound N1=NNC(=C1)CCNC(=O)N1C[C@@H]2CCN(CC[C@@H]2C1)C(CCC1=CC=C(C=C1)OC(F)(F)F)=O XGRBHGWCFQVTNW-HDICACEKSA-N 0.000 claims 1
• XFYXGIHTHNMYPM-HDICACEKSA-N (3aS,8aR)-N-methyl-N-(2H-triazol-4-ylmethyl)-6-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound N1N=NC=C1CN(C(=O)N1C[C@H]2CCN(CC[C@H]2C1)C(CCC1=CC=C(C=C1)OC(F)(F)F)=O)C XFYXGIHTHNMYPM-HDICACEKSA-N 0.000 claims 1
• UMTMYIQYAIDNPH-IYBDPMFKSA-N (3ar,6as)-n-methyl-n-(2h-triazol-4-ylmethyl)-2-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxamide Chemical compound C([C@H]1CN(C[C@H]1C1)C(=O)CCC=2C=CC(OC(F)(F)F)=CC=2)N1C(=O)N(C)CC=1C=NNN=1 UMTMYIQYAIDNPH-IYBDPMFKSA-N 0.000 claims 1
• VQBQIPYDHAEKKV-HEFRTPBCSA-N (3ar,7ar)-5-[(3ar,8as)-6-[(e)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carbonyl]-1,3a,4,6,7,7a-hexahydro-[1,3]oxazolo[5,4-c]pyridin-2-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)N3C[C@H]4OC(=O)N[C@@H]4CC3)C[C@H]2CC1 VQBQIPYDHAEKKV-HEFRTPBCSA-N 0.000 claims 1
• XJHUFHDZHQYYIZ-PLHMQQLSSA-N (3as,6ar)-n-(2h-triazol-4-ylmethyl)-2-[(e)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1C[C@H]2CN(C(=O)NCC3=NNN=C3)C[C@H]2C1 XJHUFHDZHQYYIZ-PLHMQQLSSA-N 0.000 claims 1
• KCLKXBWTHGPXQQ-CALCHBBNSA-N (3as,8ar)-6-[3-[3-fluoro-4-(trifluoromethoxy)phenyl]propanoyl]-n-methyl-n-(2h-triazol-4-ylmethyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound C([C@@H]1CCN(CC[C@@H]1C1)C(=O)CCC=2C=C(F)C(OC(F)(F)F)=CC=2)N1C(=O)N(C)CC=1C=NNN=1 KCLKXBWTHGPXQQ-CALCHBBNSA-N 0.000 claims 1
• JWZXPHAJLAAASP-PSUYNTKASA-N (3as,8ar)-n-(2h-triazol-4-ylmethyl)-6-[(e)-3-[3-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carboxamide Chemical compound FC(F)(F)OC1=CC=CC(\C=C\C(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)NCC2=NNN=C2)=C1 JWZXPHAJLAAASP-PSUYNTKASA-N 0.000 claims 1
• LCWRJXRFWXMJMJ-CHIVTJRZSA-N (4-chloro-2-ethoxy-5-fluorophenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CCOC1=CC(=C(C=C1COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5)F)Cl LCWRJXRFWXMJMJ-CHIVTJRZSA-N 0.000 claims 1
• ZTZYLMOJZODFLD-UTMFKZGHSA-N (4-cyano-2-cyclobutyloxyphenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC(C1)OC2=C(C=CC(=C2)C#N)COC(=O)N3C[C@@H]4CN(C[C@H]4C3)C(=O)C5CCC6C(C5)NNN6 ZTZYLMOJZODFLD-UTMFKZGHSA-N 0.000 claims 1
• LLNPMAMFAKYRKX-ZXWVRGDJSA-N (4-cyano-2-ethoxy-5-fluorophenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CCOC1=CC(=C(C=C1COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5)F)C#N LLNPMAMFAKYRKX-ZXWVRGDJSA-N 0.000 claims 1
• SXYSIHXUTNMGIJ-OALUTQOASA-N (4-cyano-2-ethoxyphenyl)methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CCOc1cc(ccc1COC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C#N SXYSIHXUTNMGIJ-OALUTQOASA-N 0.000 claims 1
• UWYFFOVYEQIFRT-IJGWXJKBSA-N (4-cyano-2-methylsulfonylphenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CS(=O)(=O)C1=C(C=CC(=C1)C#N)COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5 UWYFFOVYEQIFRT-IJGWXJKBSA-N 0.000 claims 1
• XPUPHHZIDHKWRV-LWVPTCNOSA-N (4-cyano-2-propan-2-yloxyphenyl)methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CC(C)OC1=C(C=CC(=C1)C#N)COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5 XPUPHHZIDHKWRV-LWVPTCNOSA-N 0.000 claims 1
• DDBSEYRCMKNNES-PMACEKPBSA-N (4-cyano-2-propan-2-ylphenyl)methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C(#N)C1=CC(=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2)C=C1)C(C)C DDBSEYRCMKNNES-PMACEKPBSA-N 0.000 claims 1
• OUPYINAOCUGXPV-FIOFULKASA-N (4-cyano-2-propan-2-ylphenyl)methyl (3aS,6aS)-2-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CC(C)C1=C(C=CC(=C1)C#N)COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)[C@@H]4CCC5C(C4)NNN5 OUPYINAOCUGXPV-FIOFULKASA-N 0.000 claims 1
• VYAJODCVACVCOG-SFTDATJTSA-N (4-cyano-5-methyl-2-propan-2-ylphenyl)methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C(#N)C1=CC(=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2)C=C1C)C(C)C VYAJODCVACVCOG-SFTDATJTSA-N 0.000 claims 1
• BADAMGFWJCASDD-QZSWCXLLSA-N (4-cyano-5-methyl-2-propan-2-ylphenyl)methyl (3aS,6aS)-2-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CC1=CC(=C(C=C1C#N)C(C)C)COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)[C@@H]4CCC5C(C4)NNN5 BADAMGFWJCASDD-QZSWCXLLSA-N 0.000 claims 1
• IKUQVPUGEDAROP-ROUUACIJSA-N (4-cyanophenyl)methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound O=C(OCc1ccc(cc1)C#N)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 IKUQVPUGEDAROP-ROUUACIJSA-N 0.000 claims 1
• ZHIHDBAWRYHVQC-HFPBVCCTSA-N (E)-1-[(3aR,6aR)-5-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)N3CCc4[nH]nnc4C3)C[C@H]2C1 ZHIHDBAWRYHVQC-HFPBVCCTSA-N 0.000 claims 1
• OWTGEEVHPZXUCF-HZPDHXFCSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(3,5-dichlorophenyl)prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=CC(=CC(=C1)Cl)Cl)=O OWTGEEVHPZXUCF-HZPDHXFCSA-N 0.000 claims 1
• BHKMDFWMIICFKF-YNDRMARASA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(3,5-dimethoxyphenyl)prop-2-en-1-one Chemical compound c1c(OC)cc(OC)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 BHKMDFWMIICFKF-YNDRMARASA-N 0.000 claims 1
• MIHXQMICCOXRFH-UDGBAXKXSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(3-chloro-5-methoxyphenyl)prop-2-en-1-one Chemical compound c1c(OC)cc(Cl)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 MIHXQMICCOXRFH-UDGBAXKXSA-N 0.000 claims 1
• DSWLUUSSHCWFPR-UDGBAXKXSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(3-chloro-5-methylsulfonylphenyl)prop-2-en-1-one Chemical compound c1c(S(=O)(=O)C)cc(Cl)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 DSWLUUSSHCWFPR-UDGBAXKXSA-N 0.000 claims 1
• ANFKZMALNZWPBM-HZPDHXFCSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-chloro-2-fluorophenyl)prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=C(C=C(C=C1)Cl)F)=O ANFKZMALNZWPBM-HZPDHXFCSA-N 0.000 claims 1
• PVYRSHQLFYIZHW-HZPDHXFCSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[2-fluoro-4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=C(C=C(C=C1)OC(F)(F)F)F)=O PVYRSHQLFYIZHW-HZPDHXFCSA-N 0.000 claims 1
• QANAQSFQDCBDSO-IAGOWNOFSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=CC(=CC=C1)OC(F)(F)F)=O QANAQSFQDCBDSO-IAGOWNOFSA-N 0.000 claims 1
• NIXXGDDDPMOJCG-UVZPHGAJSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-chloro-5-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1c(OC(F)(F)F)cc(Cl)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 NIXXGDDDPMOJCG-UVZPHGAJSA-N 0.000 claims 1
• SCWGKWPEWZQOCK-UDGBAXKXSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-methoxy-5-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1c(OC)cc(OC(F)(F)F)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 SCWGKWPEWZQOCK-UDGBAXKXSA-N 0.000 claims 1
• CZSHBMVLDVFKII-IAGOWNOFSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(difluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(C=CC1=CC=C(C=C1)OC(F)F)=O CZSHBMVLDVFKII-IAGOWNOFSA-N 0.000 claims 1
• YIJHNHKMWLMTKL-RYRNWLTQSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one Chemical compound c1cc(C(F)(F)F)ccc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 YIJHNHKMWLMTKL-RYRNWLTQSA-N 0.000 claims 1
• AOJDITKGNUSRGB-OKMWKSJFSA-N (E)-1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-phenylprop-2-en-1-one Chemical compound C([C@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)C1)N1C(=O)\C=C\c1ccccc1 AOJDITKGNUSRGB-OKMWKSJFSA-N 0.000 claims 1
• ZHIHDBAWRYHVQC-LOACFLACSA-N (E)-1-[(3aR,6aS)-5-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1C[C@H]2CN(C(=O)N3CCc4[nH]nnc4C3)C[C@H]2C1 ZHIHDBAWRYHVQC-LOACFLACSA-N 0.000 claims 1
• SHPUAKCKPSPUEC-ALOPSCKCSA-N (E)-1-[(3aR,6aS)-5-(4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1CCC(C2)C(=O)N2C[C@@H]1[C@H](C2)CN(C1)C(C=CC1=CC=C(C=C1)OC(F)(F)F)=O SHPUAKCKPSPUEC-ALOPSCKCSA-N 0.000 claims 1
• QHWUWQIBLYFHKA-IINIBRLJSA-N (E)-1-[(3aR,7aR)-2-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 QHWUWQIBLYFHKA-IINIBRLJSA-N 0.000 claims 1
• KQUGYMPLDLGIDY-UQSHSLTASA-N (E)-1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2-cyclopropylphenyl)prop-2-en-1-one Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)/C=C/C5=CC=CC=C5C6CC6 KQUGYMPLDLGIDY-UQSHSLTASA-N 0.000 claims 1
• LKQNXNQBHGAIEY-PRZFEDHESA-N (E)-1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(3-fluoro-4-methoxyphenyl)prop-2-en-1-one Chemical compound COC1=C(C=C(C=C1)/C=C/C(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5)F LKQNXNQBHGAIEY-PRZFEDHESA-N 0.000 claims 1
• YXKAJXDUZFKNQH-IPNIZCGTSA-N (E)-1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[2-methyl-4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound CC1=C(C=CC(=C1)OC(F)(F)F)/C=C/C(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5 YXKAJXDUZFKNQH-IPNIZCGTSA-N 0.000 claims 1
• WYVUGPWMIKBTBG-CNBBVRPYSA-N (E)-1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-methoxy-2-(trifluoromethyl)phenyl]prop-2-en-1-one Chemical compound COC1=CC(=C(C=C1)/C=C/C(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5)C(F)(F)F WYVUGPWMIKBTBG-CNBBVRPYSA-N 0.000 claims 1
• NYKGDUJARIYPCV-XBJXIVSDSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2,4-dichlorophenyl)prop-2-en-1-one Chemical compound Clc1cc(Cl)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 NYKGDUJARIYPCV-XBJXIVSDSA-N 0.000 claims 1
• XTWCSTPYPWEDGI-XBJXIVSDSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2,4-difluorophenyl)prop-2-en-1-one Chemical compound Fc1cc(F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 XTWCSTPYPWEDGI-XBJXIVSDSA-N 0.000 claims 1
• UWJZQJZKGSTTKQ-DEHXBRSFSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(3,4-dichlorophenyl)prop-2-en-1-one Chemical compound c1c(Cl)c(Cl)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 UWJZQJZKGSTTKQ-DEHXBRSFSA-N 0.000 claims 1
• AXVIWZXHVLAOEO-NPYXICJMSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(3-chlorophenyl)prop-2-en-1-one Chemical compound c1c(Cl)cccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 AXVIWZXHVLAOEO-NPYXICJMSA-N 0.000 claims 1
• DGJKGXVDEUMDOT-YNVNCNJYSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(4-methoxyphenyl)prop-2-en-1-one Chemical compound c1cc(OC)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 DGJKGXVDEUMDOT-YNVNCNJYSA-N 0.000 claims 1
• FRHFXVDBDFFPIM-YNVNCNJYSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(4-methylsulfonylphenyl)prop-2-en-1-one Chemical compound c1cc(S(=O)(=O)C)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 FRHFXVDBDFFPIM-YNVNCNJYSA-N 0.000 claims 1
• AEMXVXBFWVHIHP-WLHPFZOASA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(difluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 AEMXVXBFWVHIHP-WLHPFZOASA-N 0.000 claims 1
• AYKODDZXSBIGNF-FMNOIEFDSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-phenylprop-2-en-1-one Chemical compound C([C@@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)CC1)CN1C(=O)\C=C\c1ccccc1 AYKODDZXSBIGNF-FMNOIEFDSA-N 0.000 claims 1
• DGDYQDFFMDXMMC-OBJZWFGXSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-pyridin-2-ylprop-2-en-1-one Chemical compound C([C@@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)CC1)CN1C(=O)\C=C\c1ccccn1 DGDYQDFFMDXMMC-OBJZWFGXSA-N 0.000 claims 1
• KOBDYDNTSDZCJR-QCTVPTJMSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-pyridin-3-ylprop-2-en-1-one Chemical compound C([C@@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)CC1)CN1C(=O)\C=C\c1cccnc1 KOBDYDNTSDZCJR-QCTVPTJMSA-N 0.000 claims 1
• VZLOWTRBTAVFKG-KPCIDIGQSA-N (E)-1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-pyridin-4-ylprop-2-en-1-one Chemical compound C([C@@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)CC1)CN1C(=O)\C=C\c1ccncc1 VZLOWTRBTAVFKG-KPCIDIGQSA-N 0.000 claims 1
• VTBKQXLQPRMVAZ-YQQQUEKLSA-N (E)-1-[(3aR,8aS)-2-(4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1CCC(C2)C(=O)N2C[C@@H]1CCN(CC[C@@H]1C2)C(C=CC2=CC=C(C=C2)OC(F)(F)F)=O VTBKQXLQPRMVAZ-YQQQUEKLSA-N 0.000 claims 1
• LGHHNFJRSZVWRQ-JALZMNGHSA-N (E)-1-[(3aR,8aS)-2-[(6S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carbonyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one hydrochloride Chemical compound Cl.c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)[C@@H]3Cc4[nH]cnc4CN3)C[C@@H]2CC1 LGHHNFJRSZVWRQ-JALZMNGHSA-N 0.000 claims 1
• UMCIUDSHRWZTQS-KDURUIRLSA-N (E)-1-[(3aR,8aS)-6-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-2-yl]-3-(4-chlorophenyl)prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2CC[C@H]1[C@@H](CC2)CN(C1)C(C=CC1=CC=C(C=C1)Cl)=O UMCIUDSHRWZTQS-KDURUIRLSA-N 0.000 claims 1
• XGQHZYCSTGJVPK-KDURUIRLSA-N (E)-1-[(3aR,8aS)-6-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-2-yl]-3-[3-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2CC[C@H]1[C@@H](CC2)CN(C1)C(C=CC1=CC(=CC=C1)OC(F)(F)F)=O XGQHZYCSTGJVPK-KDURUIRLSA-N 0.000 claims 1
• IRQRNOAIHFJXDB-KDURUIRLSA-N (E)-1-[(3aR,8aS)-6-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2CC[C@H]1[C@@H](CC2)CN(C1)C(C=CC1=CC=C(C=C1)OC(F)(F)F)=O IRQRNOAIHFJXDB-KDURUIRLSA-N 0.000 claims 1
• UTYYEESWVZZXSP-QHKPGKFVSA-N (E)-1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1C[C@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2C1 UTYYEESWVZZXSP-QHKPGKFVSA-N 0.000 claims 1
• DQWFEVXIWPSMCM-QZTJIDSGSA-N (E)-1-[(3aS,7aS)-5-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]-3-[4-(difluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1[C@H](CC2)CN(C1)C(C=CC1=CC=C(C=C1)OC(F)F)=O DQWFEVXIWPSMCM-QZTJIDSGSA-N 0.000 claims 1
• ZEQSRRYGNINHHP-WLHPFZOASA-N (E)-1-[(3aS,8aR)-2-(2,1,3-benzoxadiazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4nonc4c3)C[C@@H]2CC1 ZEQSRRYGNINHHP-WLHPFZOASA-N 0.000 claims 1
• ZXSMMCUJUXTZLM-VJIVJOAFSA-N (E)-1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-chloro-5-(trifluoromethyl)phenyl]prop-2-en-1-one Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)/C=C/C5=CC(=CC(=C5)Cl)C(F)(F)F ZXSMMCUJUXTZLM-VJIVJOAFSA-N 0.000 claims 1
• JFJQSXUEMNPVEF-KDURUIRLSA-N (E)-1-[(3aS,8aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(4-fluorophenyl)prop-2-en-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1CCN(CC[C@H]1C2)C(C=CC2=CC=C(C=C2)F)=O JFJQSXUEMNPVEF-KDURUIRLSA-N 0.000 claims 1
• JDGXFSOXRRFNCH-XBJXIVSDSA-N (E)-1-[(3aS,8aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[2-fluoro-4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound Fc1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 JDGXFSOXRRFNCH-XBJXIVSDSA-N 0.000 claims 1
• OTLINPKWWCLGCU-WLHPFZOASA-N (E)-1-[(3aS,8aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 OTLINPKWWCLGCU-WLHPFZOASA-N 0.000 claims 1
• PEQOQILADRLYJC-KDURUIRLSA-N (E)-1-[(3aS,8aR)-2-(3,4,6,7-tetrahydroimidazo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound N1C=NC=2CN(CCC21)C(=O)N2C[C@@H]1CCN(CC[C@@H]1C2)C(C=CC2=CC=C(C=C2)OC(F)(F)F)=O PEQOQILADRLYJC-KDURUIRLSA-N 0.000 claims 1
• LOMIYDJERGFPTO-KRVRZWEOSA-N (E)-3-[(3aR,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-1-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1CN(C[C@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)/C=C/C(=O)C5=CC=C(C=C5)OC(F)(F)F LOMIYDJERGFPTO-KRVRZWEOSA-N 0.000 claims 1
• GEKGTPSHIQSRRQ-WJDRZHERSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-2-ylphenyl)prop-2-en-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)\C=C\C(C=C1)=CC=C1C1=CC=CC=N1 GEKGTPSHIQSRRQ-WJDRZHERSA-N 0.000 claims 1
• NHTWIEYCWKJKNR-HIPQDABWSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-3-ylphenyl)prop-2-en-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)\C=C\C(C=C1)=CC=C1C1=CC=CN=C1 NHTWIEYCWKJKNR-HIPQDABWSA-N 0.000 claims 1
• GTKLJISGTMYCOA-WRQNGROTSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-4-ylphenyl)prop-2-en-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)\C=C\C(C=C1)=CC=C1C1=CC=NC=C1 GTKLJISGTMYCOA-WRQNGROTSA-N 0.000 claims 1
• FDHYQNNIJGOVLL-PVZIKCEPSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(5-phenylpyridin-2-yl)prop-2-en-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)\C=C\C(N=C1)=CC=C1C1=CC=CC=C1 FDHYQNNIJGOVLL-PVZIKCEPSA-N 0.000 claims 1
• JGJZGPPIWAOWEP-IFKUSUNXSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(6-phenylpyridin-3-yl)prop-2-en-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)\C=C\C(C=N1)=CC=C1C1=CC=CC=C1 JGJZGPPIWAOWEP-IFKUSUNXSA-N 0.000 claims 1
• NPDJYJXVWZWURW-WYVSAIIBSA-N (e)-1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[5-(trifluoromethyl)pyridin-2-yl]prop-2-en-1-one Chemical compound N1=CC(C(F)(F)F)=CC=C1\C=C\C(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 NPDJYJXVWZWURW-WYVSAIIBSA-N 0.000 claims 1
• DYIPUVROGBUQLY-TUIVBMQRSA-N (e)-1-[(3ar,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-fluoro-5-(trifluoromethyl)phenyl]prop-2-en-1-one Chemical compound FC(F)(F)C1=CC(F)=CC(\C=C\C(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 DYIPUVROGBUQLY-TUIVBMQRSA-N 0.000 claims 1
• UTYYEESWVZZXSP-FZMSVCIDSA-N (e)-1-[(3ar,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@@H]2C1 UTYYEESWVZZXSP-FZMSVCIDSA-N 0.000 claims 1
• HEEPPCGGDGLPGG-LOHMXVOOSA-N (e)-1-[(3ar,7as)-2-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-5-yl]-3-(3,5-dichlorophenyl)prop-2-en-1-one Chemical compound ClC1=CC(Cl)=CC(\C=C\C(=O)N2C[C@@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 HEEPPCGGDGLPGG-LOHMXVOOSA-N 0.000 claims 1
• UOJXYFNKEFJFEC-WMCSQPJLSA-N (e)-1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2-propan-2-ylphenyl)prop-2-en-1-one Chemical compound CC(C)C1=CC=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 UOJXYFNKEFJFEC-WMCSQPJLSA-N 0.000 claims 1
• KZXYQAXVCANZTN-WLHPFZOASA-N (e)-1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(4-chlorophenyl)prop-2-en-1-one Chemical compound C1=CC(Cl)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 KZXYQAXVCANZTN-WLHPFZOASA-N 0.000 claims 1
• DHPFCUFDSSGWBG-DEHXBRSFSA-N (e)-1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-fluoro-4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=C(OC(F)(F)F)C(F)=CC(\C=C\C(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 DHPFCUFDSSGWBG-DEHXBRSFSA-N 0.000 claims 1
• OHYYTDZSPBJKSS-WLHPFZOASA-N (e)-1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethylsulfanyl)phenyl]prop-2-en-1-one Chemical compound C1=CC(SC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 OHYYTDZSPBJKSS-WLHPFZOASA-N 0.000 claims 1
• ORBRTJHOQNHLDO-WLHPFZOASA-N (e)-1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethylsulfonyl)phenyl]prop-2-en-1-one Chemical compound C1=CC(S(=O)(=O)C(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 ORBRTJHOQNHLDO-WLHPFZOASA-N 0.000 claims 1
• HICPQBVSXBCPSM-QCTVPTJMSA-N (e)-1-[(3ar,8as)-2-(6,7-dihydro-4h-triazolo[1,5-a]pyrazine-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)N3CC4=CN=NN4CC3)C[C@H]2CC1 HICPQBVSXBCPSM-QCTVPTJMSA-N 0.000 claims 1
• GQIHGPQIVPPQFW-LOHMXVOOSA-N (e)-1-[(3as,7as)-5-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-2-yl]-3-(3,5-dichlorophenyl)prop-2-en-1-one Chemical compound ClC1=CC(Cl)=CC(\C=C\C(=O)N2C[C@H]3CN(CC[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 GQIHGPQIVPPQFW-LOHMXVOOSA-N 0.000 claims 1
• LMIRKDDTIRWLSJ-DSCOKBBTSA-N (e)-1-[(3as,7as)-5-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-2-yl]-3-[3-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound FC(F)(F)OC1=CC=CC(\C=C\C(=O)N2C[C@H]3CN(CC[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 LMIRKDDTIRWLSJ-DSCOKBBTSA-N 0.000 claims 1
• YXAAKUPHUOLWSD-LOHMXVOOSA-N (e)-1-[(3as,7as)-5-(2h-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-2-yl]-3-[3-chloro-5-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound FC(F)(F)OC1=CC(Cl)=CC(\C=C\C(=O)N2C[C@H]3CN(CC[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 YXAAKUPHUOLWSD-LOHMXVOOSA-N 0.000 claims 1
• SGSLOGUTEGSHOI-LIRJPCNASA-N (e)-1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(4-methylphenyl)prop-2-en-1-one Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 SGSLOGUTEGSHOI-LIRJPCNASA-N 0.000 claims 1
• RMRBDBNWVHRCMI-NPYXICJMSA-N (e)-1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound FC(F)(F)OC1=CC=CC(\C=C\C(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 RMRBDBNWVHRCMI-NPYXICJMSA-N 0.000 claims 1
• ADMJGENJCMUCFW-NBQNMSJZSA-N (e)-1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethylsulfinyl)phenyl]prop-2-en-1-one Chemical compound C1=CC(S(=O)C(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 ADMJGENJCMUCFW-NBQNMSJZSA-N 0.000 claims 1
• RXRAWJLOJHQISL-XBJXIVSDSA-N (e)-1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]prop-2-en-1-one Chemical compound FC(F)(F)C1=CC(F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 RXRAWJLOJHQISL-XBJXIVSDSA-N 0.000 claims 1
• VTBKQXLQPRMVAZ-MZOVKYRZSA-N (e)-1-[(3as,8ar)-2-[(5r)-4,5,6,7-tetrahydro-2h-benzotriazole-5-carbonyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)[C@H]3CC4=NNN=C4CC3)C[C@H]2CC1 VTBKQXLQPRMVAZ-MZOVKYRZSA-N 0.000 claims 1
• VTBKQXLQPRMVAZ-WWSKMKHJSA-N (e)-1-[(3as,8ar)-2-[(5s)-4,5,6,7-tetrahydro-2h-benzotriazole-5-carbonyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-en-1-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)[C@@H]3CC4=NNN=C4CC3)C[C@H]2CC1 VTBKQXLQPRMVAZ-WWSKMKHJSA-N 0.000 claims 1
• UAUCFCZIBHRJEZ-HZPDHXFCSA-N 1-[(3aR,6aR)-5-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC=2CN(CCC21)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(CCC1=CC=C(C=C1)OC(F)(F)F)=O UAUCFCZIBHRJEZ-HZPDHXFCSA-N 0.000 claims 1
• NISLNLXAAPPIMR-FGZHOGPDSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-2-ylphenyl)propan-1-one Chemical compound O=C(CCc1ccc(cc1)-c1ccccn1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 NISLNLXAAPPIMR-FGZHOGPDSA-N 0.000 claims 1
• WKJSILVVTYLJGP-DHIUTWEWSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-3-ylphenyl)propan-1-one Chemical compound O=C(CCc1ccc(cc1)-c1cccnc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 WKJSILVVTYLJGP-DHIUTWEWSA-N 0.000 claims 1
• QFEZYJKUGIXUKZ-DHIUTWEWSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-pyridin-4-ylphenyl)propan-1-one Chemical compound O=C(CCc1ccc(cc1)-c1ccncc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 QFEZYJKUGIXUKZ-DHIUTWEWSA-N 0.000 claims 1
• CWGGNSBFDHPJEM-FGZHOGPDSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(5-phenylpyridin-2-yl)propan-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N1C[C@@H]2[C@@H](C1)CN(C2)C(CCC1=NC=C(C=C1)C1=CC=CC=C1)=O CWGGNSBFDHPJEM-FGZHOGPDSA-N 0.000 claims 1
• QLXPRIUHGYNFAZ-FGZHOGPDSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(6-phenylpyridin-3-yl)propan-1-one Chemical compound O=C(CCc1ccc(nc1)-c1ccccc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 QLXPRIUHGYNFAZ-FGZHOGPDSA-N 0.000 claims 1
• UOJHNYNMRWUBDB-HZPDHXFCSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-fluoro-4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound Fc1cc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)ccc1OC(F)(F)F UOJHNYNMRWUBDB-HZPDHXFCSA-N 0.000 claims 1
• UHEIYZBVUJHBGO-IAGOWNOFSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-methoxy-5-(trifluoromethoxy)phenyl]propan-1-one Chemical compound COc1cc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc(OC(F)(F)F)c1 UHEIYZBVUJHBGO-IAGOWNOFSA-N 0.000 claims 1
• RSDWGSOUKPBSSA-HUUCEWRRSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[5-(trifluoromethyl)pyridin-2-yl]propan-1-one Chemical compound FC(F)(F)c1ccc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)nc1 RSDWGSOUKPBSSA-HUUCEWRRSA-N 0.000 claims 1
• HGLLLBSBCQEVPX-HZPDHXFCSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-one Chemical compound FC(F)(F)c1ccc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cn1 HGLLLBSBCQEVPX-HZPDHXFCSA-N 0.000 claims 1
• ZUAKHTKRLZCWHJ-QZTJIDSGSA-N 1-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-phenylpropan-1-one Chemical compound O=C(CCc1ccccc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 ZUAKHTKRLZCWHJ-QZTJIDSGSA-N 0.000 claims 1
• OJDJMKORPFBRSK-HUUCEWRRSA-N 1-[(3aR,6aR)-5-(2H-triazolo[4,5-b]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound FC(F)(F)Oc1ccc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3n2)cc1 OJDJMKORPFBRSK-HUUCEWRRSA-N 0.000 claims 1
• MHLFJAVGUHIUHH-BZUAXINKSA-N 1-[(3aR,6aR)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[2-fluoro-4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC2=C1CC[C@H](C2)C(=O)N1C[C@@H]2[C@@H](C1)CN(C2)C(CCC1=C(C=C(C=C1)OC(F)(F)F)F)=O MHLFJAVGUHIUHH-BZUAXINKSA-N 0.000 claims 1
• OMMWZLSQRHGDLY-BRWVUGGUSA-N 1-[(3aR,6aR)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC2=C1CC[C@H](C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(CCC1=CC=C(C=C1)OC(F)(F)F)=O OMMWZLSQRHGDLY-BRWVUGGUSA-N 0.000 claims 1
• ZGLNQZXXNDFZHI-QZTJIDSGSA-N 1-[(3aR,7aS)-2-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1CN(CC[C@@H]1C2)C(CCC2=CC=C(C=C2)OC(F)(F)F)=O ZGLNQZXXNDFZHI-QZTJIDSGSA-N 0.000 claims 1
• JVYJMHPYQFEHCG-SEZDCWQMSA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-(2-chloro-4-fluorophenoxy)ethanone Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=C(C=C(C=C5)F)Cl JVYJMHPYQFEHCG-SEZDCWQMSA-N 0.000 claims 1
• OXSRYXCXSTVGOF-UDMDOTTCSA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-(2-tert-butyl-4-methoxyphenoxy)ethanone Chemical compound CC(C)(C)C1=C(C=CC(=C1)OC)OCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5 OXSRYXCXSTVGOF-UDMDOTTCSA-N 0.000 claims 1
• AECJRZROHKAUDH-UDMDOTTCSA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-(4-chloro-5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC1=CC(=C(C=C1Cl)C(C)C)OCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5 AECJRZROHKAUDH-UDMDOTTCSA-N 0.000 claims 1
• QNXYQQRIYJGIGR-FCKXHAKASA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[(3,3-dimethyl-6-propan-2-yl-1,2-dihydroinden-5-yl)oxy]ethanone Chemical compound CC(C)C1=C(C=C2C(=C1)CCC2(C)C)OCC(=O)N3CC[C@@H]4CN(C[C@@H]4CC3)C(=O)C5CCC6C(C5)NNN6 QNXYQQRIYJGIGR-FCKXHAKASA-N 0.000 claims 1
• AKGXMCYWNPBGET-IWTAKMAVSA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[2-(trifluoromethoxy)phenoxy]ethanone Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=CC=CC=C5OC(F)(F)F AKGXMCYWNPBGET-IWTAKMAVSA-N 0.000 claims 1
• MPSIBOKZXLQIBE-SEZDCWQMSA-N 1-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[2-fluoro-4-(trifluoromethoxy)phenoxy]ethanone Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=C(C=C(C=C5)OC(F)(F)F)F MPSIBOKZXLQIBE-SEZDCWQMSA-N 0.000 claims 1
• FQCOGGLZGAGHGQ-OYRHEFFESA-N 1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-(5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)c1ccc(C)cc1OCC(=O)N1CC[C@@H]2CN(C[C@@H]2CC1)C(=O)c1ccc2[nH]nnc2c1 FQCOGGLZGAGHGQ-OYRHEFFESA-N 0.000 claims 1
• SPXHSVLQLKSVHT-SZPZYZBQSA-N 1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2-cyclopropylphenyl)propan-1-one Chemical compound O=C(CCc1ccccc1C1CC1)N1CC[C@@H]2CN(C[C@@H]2CC1)C(=O)c1ccc2[nH]nnc2c1 SPXHSVLQLKSVHT-SZPZYZBQSA-N 0.000 claims 1
• IVIOCJCUWRVGOC-KDURUIRLSA-N 1-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-methoxy-2-(trifluoromethyl)phenyl]propan-1-one Chemical compound COc1ccc(CCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)c2ccc3[nH]nnc3c2)c(c1)C(F)(F)F IVIOCJCUWRVGOC-KDURUIRLSA-N 0.000 claims 1
• CRBLYFVTCRENGL-IYBDPMFKSA-N 1-[(3aS,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(3,5-dichlorophenyl)propan-1-one Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1[C@@H](C2)CN(C1)C(CCC1=CC(=CC(=C1)Cl)Cl)=O CRBLYFVTCRENGL-IYBDPMFKSA-N 0.000 claims 1
• FTVJLCFAVBLLBK-NVWPYFDLSA-N 1-[(3aS,6aS)-5-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-pyridin-3-ylphenoxy)ethanone Chemical compound C1CC2C(CC1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)COC5=CC=CC=C5C6=CN=CC=C6)NNN2 FTVJLCFAVBLLBK-NVWPYFDLSA-N 0.000 claims 1
• ILEUNZXKOYPYNQ-IAGOWNOFSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-acetylphenoxy)ethanone Chemical compound C(C)(=O)C1=C(OCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2)C=CC=C1 ILEUNZXKOYPYNQ-IAGOWNOFSA-N 0.000 claims 1
• DSJUAJBZUMOPTB-NHCUHLMSSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-phenylphenoxy)ethanone Chemical compound O=C(COc1ccccc1-c1ccccc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 DSJUAJBZUMOPTB-NHCUHLMSSA-N 0.000 claims 1
• IIVNXUCEFFXXBM-RTBURBONSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-pyrrol-1-ylphenoxy)ethanone Chemical compound O=C(COc1ccccc1-n1cccc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 IIVNXUCEFFXXBM-RTBURBONSA-N 0.000 claims 1
• DCMQKASWGSGAGF-QZTJIDSGSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-tert-butyl-4-methoxyphenoxy)ethanone Chemical compound COc1ccc(OCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c(c1)C(C)(C)C DCMQKASWGSGAGF-QZTJIDSGSA-N 0.000 claims 1
• ZGCXKSYMNMASDO-QZTJIDSGSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(2-tert-butylphenoxy)ethanone Chemical compound CC(C)(C)c1ccccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 ZGCXKSYMNMASDO-QZTJIDSGSA-N 0.000 claims 1
• DMKKTHZXENNVGX-IAGOWNOFSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-bromo-2-tert-butylphenoxy)ethanone Chemical compound CC(C)(C)c1cc(Br)ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 DMKKTHZXENNVGX-IAGOWNOFSA-N 0.000 claims 1
• PBJQFFXIRSEQOW-IAGOWNOFSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)c1cc(Cl)ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 PBJQFFXIRSEQOW-IAGOWNOFSA-N 0.000 claims 1
• WJGMAMCBHVTZMK-RTBURBONSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-methoxynaphthalen-2-yl)oxyethanone Chemical compound [H][C@]12CN(C[C@]1([H])CN(C2)C(=O)C1=CC=C2NN=NC2=C1)C(=O)COC1=CC(OC)=C2C=CC=CC2=C1 WJGMAMCBHVTZMK-RTBURBONSA-N 0.000 claims 1
• CQWZVPOSOHCVQP-RTBURBONSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)c1ccc(C)cc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 CQWZVPOSOHCVQP-RTBURBONSA-N 0.000 claims 1
• BRZPXPCFHMGSIK-XWATYHNTSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[2-(oxolan-2-yl)phenoxy]ethanone Chemical compound O=C(COc1ccccc1C1CCCO1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 BRZPXPCFHMGSIK-XWATYHNTSA-N 0.000 claims 1
• YRAZUUFRMNTWQC-HUUCEWRRSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[2-(trifluoromethyl)phenoxy]ethanone Chemical compound FC(F)(F)c1ccccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 YRAZUUFRMNTWQC-HUUCEWRRSA-N 0.000 claims 1
• PKQFYWRSLXCVAC-ZIAGYGMSSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[2-bromo-4-(trifluoromethoxy)phenoxy]ethanone Chemical compound FC(F)(F)Oc1ccc(OCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c(Br)c1 PKQFYWRSLXCVAC-ZIAGYGMSSA-N 0.000 claims 1
• PJHGSIBKHPYITE-ZIAGYGMSSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[2-chloro-4-(trifluoromethoxy)phenoxy]ethanone Chemical compound FC(F)(F)Oc1ccc(OCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c(Cl)c1 PJHGSIBKHPYITE-ZIAGYGMSSA-N 0.000 claims 1
• MSGLQAQVSCJECL-WOJBJXKFSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-naphthalen-2-yloxyethanone Chemical compound [H][C@]12CN(C[C@]1([H])CN(C2)C(=O)C1=CC=C2NN=NC2=C1)C(=O)COC1=CC=C2C=CC=CC2=C1 MSGLQAQVSCJECL-WOJBJXKFSA-N 0.000 claims 1
• FETUTYDSWXDOKG-HZPDHXFCSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-phenoxyethanone Chemical compound O=C(COc1ccccc1)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 FETUTYDSWXDOKG-HZPDHXFCSA-N 0.000 claims 1
• YVIMXMIOEDDRKU-IRXDYDNUSA-N 1-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound FC(F)(F)Oc1ccc(CCC(=O)N2C[C@H]3CN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1 YVIMXMIOEDDRKU-IRXDYDNUSA-N 0.000 claims 1
• YNOIVBRSCCINLK-BRWVUGGUSA-N 1-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-bromo-2-tert-butylphenoxy)ethanone Chemical compound N1N=NC2=C1CC[C@H](C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(COC1=C(C=C(C=C1)Br)C(C)(C)C)=O YNOIVBRSCCINLK-BRWVUGGUSA-N 0.000 claims 1
• MLFYTGBTTBULOI-RBSFLKMASA-N 1-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[4-(trifluoromethoxy)phenoxy]ethanone Chemical compound N1N=NC2=C1CC[C@H](C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(COC1=CC=C(C=C1)OC(F)(F)F)=O MLFYTGBTTBULOI-RBSFLKMASA-N 0.000 claims 1
• MPMPAFLDTGKZEU-MSIAFNQFSA-N 1-[(3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-2-[4-(trifluoromethoxy)phenoxy]ethanone Chemical compound C1CN(C[C@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=CC=C(C=C5)OC(F)(F)F MPMPAFLDTGKZEU-MSIAFNQFSA-N 0.000 claims 1
• MKKOFUIYATWPCT-MOPGFXCFSA-N 1-[(3aS,7aS)-2-(2H-benzotriazol-5-ylmethyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-5-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound N1N=NC2=C1C=CC(=C2)CN2C[C@H]1CN(CC[C@@H]1C2)C(CCC2=CC=C(C=C2)OC(F)(F)F)=O MKKOFUIYATWPCT-MOPGFXCFSA-N 0.000 claims 1
• JFJMXZGDJFMTQM-SEZDCWQMSA-N 1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[2-chloro-4-(trifluoromethyl)phenoxy]ethanone Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=C(C=C(C=C5)C(F)(F)F)Cl JFJMXZGDJFMTQM-SEZDCWQMSA-N 0.000 claims 1
• QVLWECHSWNIFOE-AFXXOPAESA-N 1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[4-methyl-2-(1-methylpyrrolidin-3-yl)phenoxy]ethanone Chemical compound CC1=CC(=C(C=C1)OCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5)C6CCN(C6)C QVLWECHSWNIFOE-AFXXOPAESA-N 0.000 claims 1
• AUMQPPHDEIFDJZ-SEZDCWQMSA-N 1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-[5-chloro-2-(trifluoromethyl)phenoxy]ethanone Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=C(C=CC(=C5)Cl)C(F)(F)F AUMQPPHDEIFDJZ-SEZDCWQMSA-N 0.000 claims 1
• PRDDTAZEDPWCQW-ZKCLFHTISA-N 1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]propan-1-one Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)CCC5=C(C=C(C=C5)OCC(F)(F)F)F PRDDTAZEDPWCQW-ZKCLFHTISA-N 0.000 claims 1
• GRDNCLBWUCRKJA-XWEJCUFVSA-N 1-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]propan-1-one Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)CCC5=CC(=C(C=C5)OCC(F)(F)F)F GRDNCLBWUCRKJA-XWEJCUFVSA-N 0.000 claims 1
• QQULXJWMAFKIEQ-BGYRXZFFSA-N 1-[(3aS,8aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(3-chlorophenyl)-2,2-dimethylpropan-1-one Chemical compound CC(C)(Cc1cccc(Cl)c1)C(=O)N1CC[C@@H]2CN(C[C@@H]2CC1)C(=O)c1ccc2[nH]nnc2c1 QQULXJWMAFKIEQ-BGYRXZFFSA-N 0.000 claims 1
• XLZUSVVFRHSSJD-DNQXCXABSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-(4-phenylphenyl)propan-1-one Chemical compound C([C@@H]1CN(C[C@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)CCC(C=C1)=CC=C1C1=CC=CC=C1 XLZUSVVFRHSSJD-DNQXCXABSA-N 0.000 claims 1
• JPRROPNERKTTNV-HZPDHXFCSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[2-fluoro-4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound FC1=CC(OC(F)(F)F)=CC=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 JPRROPNERKTTNV-HZPDHXFCSA-N 0.000 claims 1
• YTCDCHJBDFUITI-HZPDHXFCSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]propan-1-one Chemical compound FC1=CC(C(F)(F)F)=CC=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 YTCDCHJBDFUITI-HZPDHXFCSA-N 0.000 claims 1
• AMINCTHDUMWESA-HZPDHXFCSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[3-fluoro-4-(trifluoromethyl)phenyl]propan-1-one Chemical compound C1=C(C(F)(F)F)C(F)=CC(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 AMINCTHDUMWESA-HZPDHXFCSA-N 0.000 claims 1
• FFLBOPUGZPIDIS-IAGOWNOFSA-N 1-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-[4-(difluoromethoxy)phenyl]propan-1-one Chemical compound C1=CC(OC(F)F)=CC=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 FFLBOPUGZPIDIS-IAGOWNOFSA-N 0.000 claims 1
• URSWAYKUVGOSPB-CALCHBBNSA-N 1-[(3ar,6as)-2-(2h-benzotriazol-5-ylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-3-(3,5-dichlorophenyl)propan-1-one Chemical compound ClC1=CC(Cl)=CC(CCC(=O)N2C[C@H]3CN(CC4=CC5=NNN=C5C=C4)C[C@H]3C2)=C1 URSWAYKUVGOSPB-CALCHBBNSA-N 0.000 claims 1
• VQCXQKSVJKXTLZ-HDICACEKSA-N 1-[(3ar,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-5-methyl-2-propan-2-ylphenoxy)ethanone Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1OCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@@H]2C1 VQCXQKSVJKXTLZ-HDICACEKSA-N 0.000 claims 1
• KABLLMNFLXDZMW-GASCZTMLSA-N 1-[(3ar,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[3-(trifluoromethoxy)phenoxy]ethanone Chemical compound FC(F)(F)OC1=CC=CC(OCC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 KABLLMNFLXDZMW-GASCZTMLSA-N 0.000 claims 1
• XYUBGQMDZYDGHC-KDURUIRLSA-N 1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(3-fluoro-4-methoxyphenyl)propan-1-one Chemical compound C1=C(F)C(OC)=CC=C1CCC(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 XYUBGQMDZYDGHC-KDURUIRLSA-N 0.000 claims 1
• BZHDRTXKYTWGBC-BGYRXZFFSA-N 1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[2-methyl-4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound CC1=CC(OC(F)(F)F)=CC=C1CCC(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 BZHDRTXKYTWGBC-BGYRXZFFSA-N 0.000 claims 1
• VFWVBZCFPJMYTJ-HDICACEKSA-N 1-[(3ar,8as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[3-fluoro-4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound C1=C(OC(F)(F)F)C(F)=CC(CCC(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 VFWVBZCFPJMYTJ-HDICACEKSA-N 0.000 claims 1
• HCBXAWYMDDPJIM-IYBDPMFKSA-N 1-[(3as,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-2-methylphenoxy)ethanone Chemical compound CC1=CC(Cl)=CC=C1OCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@@H]2C1 HCBXAWYMDDPJIM-IYBDPMFKSA-N 0.000 claims 1
• XDRWGVAJBCZWCF-IYBDPMFKSA-N 1-[(3as,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-(4-chloro-3-methylphenoxy)ethanone Chemical compound C1=C(Cl)C(C)=CC(OCC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 XDRWGVAJBCZWCF-IYBDPMFKSA-N 0.000 claims 1
• HVULMZFELFVBMC-HUUCEWRRSA-N 1-[(3as,6as)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-[4-(trifluoromethoxy)phenoxy]ethanone Chemical compound C1=CC(OC(F)(F)F)=CC=C1OCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 HVULMZFELFVBMC-HUUCEWRRSA-N 0.000 claims 1
• CDHXCIOEUBZRAC-SZPZYZBQSA-N 1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-(2-propan-2-ylphenyl)propan-1-one Chemical compound CC(C)C1=CC=CC=C1CCC(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 CDHXCIOEUBZRAC-SZPZYZBQSA-N 0.000 claims 1
• XMTSEUDSJCLFAR-HDICACEKSA-N 1-[(3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]propan-1-one Chemical compound FC(F)(F)C1=CC(F)=CC=C1CCC(=O)N1CC[C@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2CC1 XMTSEUDSJCLFAR-HDICACEKSA-N 0.000 claims 1
• UWXSQTWOTITKRA-UFVPIABZSA-N 1-adamantylmethyl (3aR,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound O=C(OCC12CC3CC(CC(C3)C1)C2)N1C[C@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 UWXSQTWOTITKRA-UFVPIABZSA-N 0.000 claims 1
• VLHUVCWISWEECA-KJHOQLPVSA-N 2-(1-adamantyl)ethyl (3aR,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound O=C(OCCC12CC3CC(CC(C3)C1)C2)N1C[C@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 VLHUVCWISWEECA-KJHOQLPVSA-N 0.000 claims 1
• YKMZGJXIKNSBJK-HZPDHXFCSA-N 2-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-5-(trifluoromethoxy)benzonitrile Chemical compound FC(F)(F)Oc1ccc(OCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)c(c1)C#N YKMZGJXIKNSBJK-HZPDHXFCSA-N 0.000 claims 1
• PQCIEBBUPOXTMT-MJWXWIRYSA-N 2-adamantyl (3aS,6aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound [H][C@@]12CN(C[C@]1([H])CN(C2)C(=O)C1=CC=C2NN=NC2=C1)C(=O)OC1C2CC3CC(C2)CC1C3 PQCIEBBUPOXTMT-MJWXWIRYSA-N 0.000 claims 1
• VUCFFHBUQHQXOX-RMDKKWAASA-N 2-adamantylmethyl (3as,6ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1=CC2=NNN=C2C=C1C(=O)N(C[C@H]1C2)C[C@@H]1CN2C(=O)OCC1C(C2)CC3CC2CC1C3 VUCFFHBUQHQXOX-RMDKKWAASA-N 0.000 claims 1
• JJKCGIGXTLHMCG-HDICACEKSA-N 2-cyclohexylethyl (3as,6ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C([C@@H]1CN(C[C@@H]1C1)C(=O)C2=CC3=NNN=C3C=C2)N1C(=O)OCCC1CCCCC1 JJKCGIGXTLHMCG-HDICACEKSA-N 0.000 claims 1
• UKPJVILVDPYTHM-PESVTJQDSA-N 3-[(E)-3-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxoprop-1-enyl]-5-chlorobenzonitrile Chemical compound c1c(C#N)cc(Cl)cc1\C=C\C(=O)N1C[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@H]2C1 UKPJVILVDPYTHM-PESVTJQDSA-N 0.000 claims 1
• QISSXZCWGODGKR-SJDASUONSA-N 3-[(E)-3-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-oxoprop-1-enyl]benzonitrile Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1CCN(CC[C@H]1C2)C(/C=C/C=2C=C(C#N)C=CC2)=O QISSXZCWGODGKR-SJDASUONSA-N 0.000 claims 1
• AFSDOEKKLODHFB-UUOJUMCQSA-N 4-[(E)-3-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxoprop-1-enyl]-3-fluorobenzonitrile Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(/C=C/C1=C(C=C(C#N)C=C1)F)=O AFSDOEKKLODHFB-UUOJUMCQSA-N 0.000 claims 1
• HRELELMDSLNSQL-HRNLXLLQSA-N 4-[(E)-3-[(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxoprop-1-enyl]benzonitrile Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(/C=C/C1=CC=C(C#N)C=C1)=O HRELELMDSLNSQL-HRNLXLLQSA-N 0.000 claims 1
• BSNJURZHLJLWNX-JKOSIECOSA-N 4-[(E)-3-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-oxoprop-1-enyl]-3-fluorobenzonitrile Chemical compound Fc1cc(C#N)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 BSNJURZHLJLWNX-JKOSIECOSA-N 0.000 claims 1
• FGNLTQZWSNNXOI-XGIORVJPSA-N 4-[(E)-3-[(3aR,8aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-oxoprop-1-enyl]benzonitrile Chemical compound C([C@@H]1[C@@H](CN(C1)C(=O)c1ccc2[nH]nnc2c1)CC1)CN1C(=O)\C=C\c1ccc(C#N)cc1 FGNLTQZWSNNXOI-XGIORVJPSA-N 0.000 claims 1
• QORAKWNEIUXETR-QNFQMBCCSA-N 4-[(E)-3-[(3aS,7aS)-5-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl]-3-oxoprop-1-enyl]benzonitrile Chemical compound C([C@@H]1[C@H](CCN(C1)C(=O)c1ccc2[nH]nnc2c1)C1)N1C(=O)\C=C\c1ccc(C#N)cc1 QORAKWNEIUXETR-QNFQMBCCSA-N 0.000 claims 1
• GUVAQKUPIAXCMU-YGTHNOBOSA-N 4-[(E)-3-[(3aS,8aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-oxoprop-1-enyl]-N,N-dimethylbenzenesulfonamide Chemical compound c1cc(S(=O)(=O)N(C)C)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)c3ccc4[nH]nnc4c3)C[C@@H]2CC1 GUVAQKUPIAXCMU-YGTHNOBOSA-N 0.000 claims 1
• VYTPJSDUXMNCIS-HJKNQERESA-N 4-[(e)-3-[(3as,8ar)-2-(2h-benzotriazol-5-ylmethyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-3-oxoprop-1-enyl]benzonitrile Chemical compound C([C@H]1CN(CC2=CC3=NNN=C3C=C2)C[C@H]1CC1)CN1C(=O)\C=C\C1=CC=C(C#N)C=C1 VYTPJSDUXMNCIS-HJKNQERESA-N 0.000 claims 1
• FEXPCVLLHQMWRW-CIZJQDALSA-N 4-[2-[(3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-oxoethoxy]-3-(trifluoromethyl)benzonitrile Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)COC5=C(C=C(C=C5)C#N)C(F)(F)F FEXPCVLLHQMWRW-CIZJQDALSA-N 0.000 claims 1
• CUFAZAZRADSCKQ-WOJBJXKFSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-2-methyl-5-propan-2-ylbenzonitrile Chemical compound CC(C)c1cc(C#N)c(C)cc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 CUFAZAZRADSCKQ-WOJBJXKFSA-N 0.000 claims 1
• NNDNLOKQJXEPBX-QZTJIDSGSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-ethoxybenzonitrile Chemical compound CCOc1cc(ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C#N NNDNLOKQJXEPBX-QZTJIDSGSA-N 0.000 claims 1
• NFFRAUFULPHCBT-IAGOWNOFSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-methoxybenzonitrile Chemical compound COc1cc(ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C#N NFFRAUFULPHCBT-IAGOWNOFSA-N 0.000 claims 1
• DTBPTCOZSBAJPS-RTBURBONSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-propan-2-ylbenzonitrile Chemical compound CC(C)c1cc(ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C#N DTBPTCOZSBAJPS-RTBURBONSA-N 0.000 claims 1
• YYPMGHIKYVSVJU-RTBURBONSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-tert-butylbenzonitrile Chemical compound CC(C)(C)c1cc(ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C#N YYPMGHIKYVSVJU-RTBURBONSA-N 0.000 claims 1
• UGIPYZQQHOTCPK-IAGOWNOFSA-N 4-[2-[(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]benzonitrile Chemical compound O=C(COc1ccc(cc1)C#N)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 UGIPYZQQHOTCPK-IAGOWNOFSA-N 0.000 claims 1
• BEENYYWDJCGYGL-MISYRCLQSA-N 4-[2-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-2-methyl-5-propan-2-ylbenzonitrile Chemical compound CC(C)c1cc(C#N)c(C)cc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)[C@@H]1CCc2[nH]nnc2C1 BEENYYWDJCGYGL-MISYRCLQSA-N 0.000 claims 1
• DQZQVLRLTZOPOE-GUDVDZBRSA-N 4-[2-[(3aS,6aS)-5-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-2-oxoethoxy]-3-tert-butylbenzonitrile Chemical compound CC(C)(C)c1cc(ccc1OCC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)[C@@H]1CCc2[nH]nnc2C1)C#N DQZQVLRLTZOPOE-GUDVDZBRSA-N 0.000 claims 1
• NAQTYLMJCAUPNU-KPRFXOCXSA-N 4-[2-[(3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepin-6-yl]-2-oxoethoxy]-3-propan-2-ylbenzonitrile Chemical compound CC(C)C1=C(C=CC(=C1)C#N)OCC(=O)N2CC[C@@H]3CN(C[C@@H]3CC2)C(=O)C4CCC5C(C4)NNN5 NAQTYLMJCAUPNU-KPRFXOCXSA-N 0.000 claims 1
• LSYRFSVBETUOKC-FGZHOGPDSA-N 4-[3-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxopropyl]-2-methyl-5-propan-2-ylbenzonitrile Chemical compound CC(C)C1=CC(C#N)=C(C)C=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 LSYRFSVBETUOKC-FGZHOGPDSA-N 0.000 claims 1
• LHQPBFQSXDGJAN-NHCUHLMSSA-N 4-[3-[(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxopropyl]-3-propan-2-ylbenzonitrile Chemical compound CC(C)C1=CC(C#N)=CC=C1CCC(=O)N1C[C@@H]2CN(C(=O)C3=CC4=NNN=C4C=C3)C[C@H]2C1 LHQPBFQSXDGJAN-NHCUHLMSSA-N 0.000 claims 1
• IQUJPELACACQKR-IAGOWNOFSA-N 6-[(3aR,6aR)-2-[3-[4-(trifluoromethoxy)phenyl]propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carbonyl]-3H-1,3-benzoxazol-2-one Chemical compound FC(F)(F)Oc1ccc(CCC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]c(=O)oc3c2)cc1 IQUJPELACACQKR-IAGOWNOFSA-N 0.000 claims 1
• DZVJLOYQTSXIAE-NWBRZFPCSA-N 6-[(3aR,8aS)-6-[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carbonyl]-3a,4,5,6,7,7a-hexahydro-3H-1,3-benzoxazol-2-one Chemical compound c1cc(OC(F)(F)F)ccc1\C=C\C(=O)N1CC[C@@H]2CN(C(=O)C3CCC4NC(=O)OC4C3)C[C@@H]2CC1 DZVJLOYQTSXIAE-NWBRZFPCSA-N 0.000 claims 1
• RNWDOADRFZRGQW-WLHPFZOASA-N 6-[(3as,8ar)-6-[(e)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-2-carbonyl]-3h-1,3-benzoxazol-2-one Chemical compound C1=CC(OC(F)(F)F)=CC=C1\C=C\C(=O)N1CC[C@H]2CN(C(=O)C=3C=C4OC(=O)NC4=CC=3)C[C@H]2CC1 RNWDOADRFZRGQW-WLHPFZOASA-N 0.000 claims 1
• HWHNDCYMJKFZNL-CALCHBBNSA-N 6-[[(3as,6ar)-5-[3-(3,5-dichlorophenyl)propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]-3h-1,3-benzoxazol-2-one Chemical compound ClC1=CC(Cl)=CC(CCC(=O)N2C[C@H]3CN(CC=4C=C5OC(=O)NC5=CC=4)C[C@H]3C2)=C1 HWHNDCYMJKFZNL-CALCHBBNSA-N 0.000 claims 1
• CKSZBFPKZIDWJX-BOAJJUGWSA-N 7-bicyclo[4.1.0]heptanylmethyl (3ar,6as)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1=CC2=NNN=C2C=C1C(=O)N(C[C@H]1C2)C[C@@H]1CN2C(=O)OCC1C2CCCCC21 CKSZBFPKZIDWJX-BOAJJUGWSA-N 0.000 claims 1
• LMWLKVFQHLDRNG-RLHTVVPMSA-N [(1R,4S)-2-bicyclo[2.2.1]heptanyl]methyl (3aR,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound O=C(OCC1C[C@H]2CC[C@@H]1C2)N1C[C@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 LMWLKVFQHLDRNG-RLHTVVPMSA-N 0.000 claims 1
• SNXMMIMDMDYOIE-JEPNVDBWSA-N [(3aR,6aR)-5-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[1-(4-chlorophenyl)piperidin-4-yl]methanone Chemical compound C1CC2C(CC1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)C5CCN(CC5)C6=CC=C(C=C6)Cl)NNN2 SNXMMIMDMDYOIE-JEPNVDBWSA-N 0.000 claims 1
• JLMNCPWXRMABPO-NHCUHLMSSA-N [(3aR,6aR)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[4-(4-chlorophenyl)phenyl]methanone Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1CN(C[C@@H]1C2)C(=O)C2=CC=C(C=C2)C2=CC=C(C=C2)Cl JLMNCPWXRMABPO-NHCUHLMSSA-N 0.000 claims 1
• OFGYEQIUHWWSBV-RTBURBONSA-N [(3aR,6aR)-5-(4-methoxynaphthalene-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1CN(C[C@H]1C2)C(=O)C2=CC1=CC=CC=C1C(=C2)OC OFGYEQIUHWWSBV-RTBURBONSA-N 0.000 claims 1
• MLZNGGOFDIBJHD-IXHKABCMSA-N [(3aS,6aR)-5-[2-(3-chlorophenyl)ethylsulfonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazol-5-yl)methanone Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)S(=O)(=O)CCC5=CC(=CC=C5)Cl)NNN2 MLZNGGOFDIBJHD-IXHKABCMSA-N 0.000 claims 1
• TXIYXYZMRJCOJH-SQNIBIBYSA-N [(3aS,6aS)-5-(1-ethoxyisoquinoline-3-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazol-5-yl]methanone Chemical compound N1N=NC2=C1CC[C@H](C2)C(=O)N2C[C@@H]1[C@@H](C2)CN(C1)C(=O)C=1N=C(C2=CC=CC=C2C1)OCC TXIYXYZMRJCOJH-SQNIBIBYSA-N 0.000 claims 1
• JLMNCPWXRMABPO-SFTDATJTSA-N [(3aS,6aS)-5-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[4-(4-chlorophenyl)phenyl]methanone Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@@H]1CN(C[C@H]1C2)C(=O)C2=CC=C(C=C2)C2=CC=C(C=C2)Cl JLMNCPWXRMABPO-SFTDATJTSA-N 0.000 claims 1
• KXRPBZGGWKKJHM-IRXDYDNUSA-N [(3aS,6aS)-5-(4-ethoxyquinoline-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound [H][C@@]12CN(C[C@@]1([H])CN(C2)C(=O)C1=CC(OCC)=C2C=CC=CC2=N1)C(=O)C1=CC=C2NN=NC2=C1 KXRPBZGGWKKJHM-IRXDYDNUSA-N 0.000 claims 1
• SGRDLIQDRQYXFI-DPUFVJOFSA-N [(3aS,6aS)-5-(4-ethoxyquinoline-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(4-fluoro-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazol-5-yl)methanone Chemical compound CCOC1=CC(=NC2=CC=CC=C21)C(=O)N3C[C@@H]4CN(C[C@H]4C3)C(=O)C5CCC6C(C5F)NNN6 SGRDLIQDRQYXFI-DPUFVJOFSA-N 0.000 claims 1
• NOVFYPXDSKQQNL-NPZDEFLLSA-N [(3aS,6aS)-5-(4-ethoxyquinoline-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazol-5-yl]methanone Chemical compound CCOC1=CC(=NC2=CC=CC=C21)C(=O)N3C[C@@H]4CN(C[C@H]4C3)C(=O)[C@@H]5CCC6C(C5)NNN6 NOVFYPXDSKQQNL-NPZDEFLLSA-N 0.000 claims 1
• SMCJRSDJIDLWCH-KEKYASOWSA-N [(3aS,6aS)-5-[1-methyl-5-(trifluoromethoxy)indole-2-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazol-5-yl]methanone Chemical compound CN1C2=C(C=C(C=C2)OC(F)(F)F)C=C1C(=O)N3C[C@@H]4CN(C[C@H]4C3)C(=O)[C@@H]5CCC6C(C5)NNN6 SMCJRSDJIDLWCH-KEKYASOWSA-N 0.000 claims 1
• PNENDHTYPWTEAK-HOTGVXAUSA-N [(3aS,6aS)-5-[4-(2,2,2-trifluoroethoxy)quinoline-2-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound [H][C@@]12CN(C[C@@]1([H])CN(C2)C(=O)C1=CC(OCC(F)(F)F)=C2C=CC=CC2=N1)C(=O)C1=CC=C2NN=NC2=C1 PNENDHTYPWTEAK-HOTGVXAUSA-N 0.000 claims 1
• YEPXSEBLPNEQIN-NJDAHSKKSA-N [(3aS,6aS)-5-[4-(4-chlorophenyl)benzoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazol-5-yl]methanone Chemical compound ClC1=CC=C(C=C1)C1=CC=C(C=C1)C(=O)N1C[C@H]2[C@H](C1)CN(C2)C(=O)[C@H]2CC1=C(NN=N1)CC2 YEPXSEBLPNEQIN-NJDAHSKKSA-N 0.000 claims 1
• PMFCAEWPJRXRCJ-GJZGRUSLSA-N [(3aS,6aS)-5-[5-(trifluoromethoxy)-1H-indole-2-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound N1N=NC2=C1C=CC(=C2)C(=O)N2C[C@H]1CN(C[C@@H]1C2)C(=O)C=2NC1=CC=C(C=C1C2)OC(F)(F)F PMFCAEWPJRXRCJ-GJZGRUSLSA-N 0.000 claims 1
• KBVYBFMWFDOMCJ-GJZGRUSLSA-N [(3aS,6aS)-5-[6-(trifluoromethoxy)-1H-indole-2-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound FC(F)(F)Oc1ccc2cc([nH]c2c1)C(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 KBVYBFMWFDOMCJ-GJZGRUSLSA-N 0.000 claims 1
• KSMKKCLACOIJRE-HOTGVXAUSA-N [(3aS,6aS)-5-[6-cyclobutyloxy-5-(trifluoromethyl)pyridine-3-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2H-benzotriazol-5-yl)methanone Chemical compound [H][C@@]12CN(C[C@@]1([H])CN(C2)C(=O)C1=CC(=C(OC2CCC2)N=C1)C(F)(F)F)C(=O)C1=CC=C2NN=NC2=C1 KSMKKCLACOIJRE-HOTGVXAUSA-N 0.000 claims 1
• PDUTXZRZTNPUIS-JBBFKITRSA-N [(3ar,6ar)-5-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[4-(4-chlorophenyl)cyclohexyl]methanone Chemical compound C1=CC(Cl)=CC=C1C1CCC(C(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)CC1 PDUTXZRZTNPUIS-JBBFKITRSA-N 0.000 claims 1
• HNFVATNXJWSBKC-GASCZTMLSA-N [(3ar,6as)-5-(5-chloro-1h-indole-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-(2h-benzotriazol-5-yl)methanone Chemical compound C1=CC2=NNN=C2C=C1C(=O)N(C[C@H]1C2)C[C@@H]1CN2C(=O)C1=CC2=CC(Cl)=CC=C2N1 HNFVATNXJWSBKC-GASCZTMLSA-N 0.000 claims 1
• IDNWFRLMLSYKEB-GIVPXCGWSA-N [(3as,6as)-5-(4-propan-2-yloxynaphthalene-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5r)-4,5,6,7-tetrahydro-2h-benzotriazol-5-yl]methanone Chemical compound C1CC2=NNN=C2C[C@@H]1C(=O)N(C[C@H]1C2)C[C@H]1CN2C(=O)C1=CC2=CC=CC=C2C(OC(C)C)=C1 IDNWFRLMLSYKEB-GIVPXCGWSA-N 0.000 claims 1
• VEOZDXLZOPGHMT-SQNIBIBYSA-N [(3as,6as)-5-(4-propan-2-yloxyquinoline-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-[(5r)-4,5,6,7-tetrahydro-2h-benzotriazol-5-yl]methanone Chemical compound C1CC2=NNN=C2C[C@@H]1C(=O)N(C[C@H]1C2)C[C@H]1CN2C(=O)C1=NC2=CC=CC=C2C(OC(C)C)=C1 VEOZDXLZOPGHMT-SQNIBIBYSA-N 0.000 claims 1
• RADRPDHGKOJUEC-HZPDHXFCSA-N [(3as,7as)-2-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-3,3a,4,6,7,7a-hexahydro-1h-pyrrolo[3,4-c]pyridin-5-yl]-(2h-benzotriazol-5-yl)methanone Chemical compound C1=CC(Cl)=CC=C1C1=NN=C(N2C[C@H]3CN(CC[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)O1 RADRPDHGKOJUEC-HZPDHXFCSA-N 0.000 claims 1
• LPDGRVWLRBGYQI-VCOPVKRASA-N [(4S,6S)-3-methyl-1-tricyclo[2.2.1.02,6]heptanyl]methyl (3aS,6aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound [H][C@@]12C[C@@]3([H])CC1(COC(=O)N1C[C@@]4([H])CN(C[C@@]4([H])C1)C(=O)C1=CC=C4NN=NC4=C1)C2C3C LPDGRVWLRBGYQI-VCOPVKRASA-N 0.000 claims 1
• CAFLTUQLSFBPKR-FMZDRFFOSA-N [(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazol-5-yl]-[(3aS,6aS)-5-[1-(2,2,2-trifluoroethoxy)isoquinoline-3-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]methanone Chemical compound C1CC2C(C[C@@H]1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)C5=CC6=CC=CC=C6C(=N5)OCC(F)(F)F)NNN2 CAFLTUQLSFBPKR-FMZDRFFOSA-N 0.000 claims 1
• OEZNQJYBWKRALQ-SEZDCWQMSA-N [1-(3-chlorophenyl)cyclopropyl] (3aR,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OC5(CC5)C6=CC(=CC=C6)Cl)NNN2 OEZNQJYBWKRALQ-SEZDCWQMSA-N 0.000 claims 1
• ZVMCHDIDQNESBQ-ZFFQVENESA-N [2-cyclopropyl-4-(trifluoromethyl)phenyl]methyl (3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound C1CN(C[C@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=C(C=C(C=C5)C(F)(F)F)C6CC6 ZVMCHDIDQNESBQ-ZFFQVENESA-N 0.000 claims 1
• PNIFKOCUUGSBRN-YXRVXCSSSA-N [2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]methyl (3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=C(C=C(C=C5)OCC(F)(F)F)F PNIFKOCUUGSBRN-YXRVXCSSSA-N 0.000 claims 1
• UHMNVMOWCPUBNZ-FCRPHAPYSA-N [2-fluoro-4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(C[C@@H]1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)OCC5=C(C=C(C=C5)OC(F)(F)F)F)NNN2 UHMNVMOWCPUBNZ-FCRPHAPYSA-N 0.000 claims 1
• MEOGBSKOIZFWRR-GJZGRUSLSA-N [2-fluoro-4-(trifluoromethyl)phenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Fc1cc(ccc1COC(=O)N1C[C@@H]2CN(C[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1)C(F)(F)F MEOGBSKOIZFWRR-GJZGRUSLSA-N 0.000 claims 1
• QKDICJQVLOZAMA-KNVXOLTISA-N [2-methoxy-4-(trifluoromethoxy)phenyl]methyl (3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound COC1=C(C=CC(=C1)OC(F)(F)F)COC(=O)N2CC[C@@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5 QKDICJQVLOZAMA-KNVXOLTISA-N 0.000 claims 1
• OGYMVOREYWRERT-CQMOGXOGSA-N [3-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]methyl (3aR,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC=C5)C(C(F)(F)F)O)NNN2 OGYMVOREYWRERT-CQMOGXOGSA-N 0.000 claims 1
• KEQBSEUMXOXDFQ-QEOAPFKGSA-N [3-(2,2,2-trifluoro-1-methoxyethyl)phenyl]methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound COC(C1=CC=CC(=C1)COC(=O)N2C[C@H]3CN(C[C@H]3C2)C(=O)C4CCC5C(C4)NNN5)C(F)(F)F KEQBSEUMXOXDFQ-QEOAPFKGSA-N 0.000 claims 1
• VJOASQCLFAIKMM-BRMDDGIZSA-N [3-(trifluoromethoxy)phenyl]methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC=C5)OC(F)(F)F)NNN2 VJOASQCLFAIKMM-BRMDDGIZSA-N 0.000 claims 1
• QRVMQRSMJJFVNO-NSHIMCJJSA-N [3-chloro-5-(trifluoromethoxy)phenyl]methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC(=C5)Cl)OC(F)(F)F)NNN2 QRVMQRSMJJFVNO-NSHIMCJJSA-N 0.000 claims 1
• SHKHJFFDICGDPY-CIZJQDALSA-N [3-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]methyl (3aS,8aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=CC(=C(C=C5)OCC(F)(F)F)F SHKHJFFDICGDPY-CIZJQDALSA-N 0.000 claims 1
• FPLSNXWGMDWCPE-GJZGRUSLSA-N [3-fluoro-4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC=1C=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2)C=CC1OC(F)(F)F FPLSNXWGMDWCPE-GJZGRUSLSA-N 0.000 claims 1
• AHGPWKDUHFSKEV-STQMWFEESA-N [3-fluoro-4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2H-triazolo[4,5-b]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC=1C=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC=C3C(=N2)N=NN3)C=CC=1OC(F)(F)F AHGPWKDUHFSKEV-STQMWFEESA-N 0.000 claims 1
• QHRBBUVGQVWPAE-BVBWDCQLSA-N [3-fluoro-4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-[(5R)-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(C[C@@H]1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=C(C=C5)OC(F)(F)F)F)NNN2 QHRBBUVGQVWPAE-BVBWDCQLSA-N 0.000 claims 1
• IHVQYENKHZFPQF-NSHIMCJJSA-N [3-fluoro-5-(trifluoromethoxy)phenyl]methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC(=C5)F)OC(F)(F)F)NNN2 IHVQYENKHZFPQF-NSHIMCJJSA-N 0.000 claims 1
• QNBMMNQIXVRBCZ-NSHIMCJJSA-N [3-fluoro-5-(trifluoromethyl)phenyl]methyl (3aS,6aR)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC(=CC(=C5)F)C(F)(F)F)NNN2 QNBMMNQIXVRBCZ-NSHIMCJJSA-N 0.000 claims 1
• GFEQLFKBNJMNIP-IAGOWNOFSA-N [3-methylsulfonyl-5-(trifluoromethyl)phenyl]methyl (3aR,7aS)-5-(2H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate Chemical compound CS(=O)(=O)c1cc(COC(=O)N2C[C@H]3CCN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc(c1)C(F)(F)F GFEQLFKBNJMNIP-IAGOWNOFSA-N 0.000 claims 1
• LDOWBCAXRWWBLX-IYBDPMFKSA-N [3-methylsulfonyl-5-(trifluoromethyl)phenyl]methyl (3as,6ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(COC(=O)N2C[C@@H]3CN(C[C@@H]3C2)C(=O)C2=CC3=NNN=C3C=C2)=C1 LDOWBCAXRWWBLX-IYBDPMFKSA-N 0.000 claims 1
• HKNDTSOFORHYQO-HDICACEKSA-N [3-methylsulfonyl-5-(trifluoromethyl)phenyl]methyl (3as,8ar)-2-(2h-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound FC(F)(F)C1=CC(S(=O)(=O)C)=CC(COC(=O)N2CC[C@H]3CN(C[C@H]3CC2)C(=O)C2=CC3=NNN=C3C=C2)=C1 HKNDTSOFORHYQO-HDICACEKSA-N 0.000 claims 1
• CAACNQZPGSKTJF-HOTGVXAUSA-N [4-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(C(F)F)(OC1=CC=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2)C=C1)F CAACNQZPGSKTJF-HOTGVXAUSA-N 0.000 claims 1
• WRHBBZHTPNFAJC-XWEJCUFVSA-N [4-(2,2,2-trifluoroethoxy)phenyl]methyl (3aR,8aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,5,7,8,8a-octahydropyrrolo[3,4-d]azepine-6-carboxylate Chemical compound C1CN(CC[C@@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=CC=C(C=C5)OCC(F)(F)F WRHBBZHTPNFAJC-XWEJCUFVSA-N 0.000 claims 1
• RDMZTYYQULMLQN-IRXDYDNUSA-N [4-(2,2,2-trifluoroethoxy)phenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)COc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1 RDMZTYYQULMLQN-IRXDYDNUSA-N 0.000 claims 1
• KMQJYQQZGUFRAV-GJZGRUSLSA-N [4-(difluoromethoxy)-3-fluorophenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1F KMQJYQQZGUFRAV-GJZGRUSLSA-N 0.000 claims 1
• BANABPGCERRWAX-HOTGVXAUSA-N [4-(difluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1 BANABPGCERRWAX-HOTGVXAUSA-N 0.000 claims 1
• ACVHZRVJGDQWNB-HZPDHXFCSA-N [4-(trifluoromethoxy)phenyl]methyl (3aR,6aR)-2-(2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@H]3CN(C[C@@H]3C2)C(=O)c2ccc3[nH]nnc3c2)cc1 ACVHZRVJGDQWNB-HZPDHXFCSA-N 0.000 claims 1
• JTOQFRMBJYPMHP-IRXDYDNUSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound [H][C@]12CN(C[C@]1([H])CN(C2)C(=O)C1=CN=C2NN=CC2=C1)C(=O)OCC1=CC=C(OC(F)(F)F)C=C1 JTOQFRMBJYPMHP-IRXDYDNUSA-N 0.000 claims 1
• NZBDNYLTRFFILT-DVLWVLGCSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C1CC2C(CC1C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC=C(C=C5)OC(F)(F)F)NNN2 NZBDNYLTRFFILT-DVLWVLGCSA-N 0.000 claims 1
• JYGFCTBSIRCBGD-GJZGRUSLSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)N2CCc3[nH]nnc3C2)cc1 JYGFCTBSIRCBGD-GJZGRUSLSA-N 0.000 claims 1
• BSIUDNCEWDJHIK-HOTGVXAUSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2-oxo-3H-1,3-benzoxazole-6-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]c(=O)oc3c2)cc1 BSIUDNCEWDJHIK-HOTGVXAUSA-N 0.000 claims 1
• QFAMZUAFVVDGGO-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2H-triazolo[4,5-b]pyridine-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3n2)cc1 QFAMZUAFVVDGGO-KBPBESRZSA-N 0.000 claims 1
• DZFNJALKIVJBKM-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(2H-triazolo[4,5-c]pyridine-6-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2cc3nn[nH]c3cn2)cc1 DZFNJALKIVJBKM-KBPBESRZSA-N 0.000 claims 1
• UYYIKRALYZSIGZ-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(4-chloro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)c2ccc3[nH]nnc3c2Cl)cc1 UYYIKRALYZSIGZ-KBPBESRZSA-N 0.000 claims 1
• ZHNDMUVKPOVORF-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(4-fluoro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Fc1c(ccc2[nH]nnc12)C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 ZHNDMUVKPOVORF-KBPBESRZSA-N 0.000 claims 1
• IIUZDKHYFRRJAQ-TXQUERKESA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(4-methoxy-2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound COC1C(CCC2C1NNN2)C(=O)N3C[C@H]4CN(C[C@@H]4C3)C(=O)OCC5=CC=C(C=C5)OC(F)(F)F IIUZDKHYFRRJAQ-TXQUERKESA-N 0.000 claims 1
• OJRPQQBPAWHEEP-HOTGVXAUSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(4-methyl-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Cc1c(ccc2[nH]nnc12)C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 OJRPQQBPAWHEEP-HOTGVXAUSA-N 0.000 claims 1
• NBLCCWNRAJIHHT-HOTGVXAUSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(4-sulfamoylpiperidine-1-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound NS(=O)(=O)C1CCN(CC1)C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 NBLCCWNRAJIHHT-HOTGVXAUSA-N 0.000 claims 1
• TYFFUPMJZSEBKQ-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(6-fluoro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Fc1cc2[nH]nnc2cc1C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 TYFFUPMJZSEBKQ-KBPBESRZSA-N 0.000 claims 1
• BYSFXEXFSUTJOY-HOTGVXAUSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(6-methyl-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Cc1cc2[nH]nnc2cc1C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 BYSFXEXFSUTJOY-HOTGVXAUSA-N 0.000 claims 1
• RCJRBCOWZWXTMR-GJZGRUSLSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-(7-fluoro-2H-benzotriazole-5-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound Fc1cc(cc2nn[nH]c12)C(=O)N1C[C@H]2CN(C[C@@H]2C1)C(=O)OCc1ccc(OC(F)(F)F)cc1 RCJRBCOWZWXTMR-GJZGRUSLSA-N 0.000 claims 1
• LSUVFNHPOQJAGY-PMPSAXMXSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-[(5R)-4,5,6,7-tetrahydro-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(F)(F)Oc1ccc(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)[C@@H]2CCc3[nH]nnc3C2)cc1 LSUVFNHPOQJAGY-PMPSAXMXSA-N 0.000 claims 1
• MSFMOBDXAFDSPJ-KBPBESRZSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,6aS)-2-[6-(trifluoromethyl)-2H-benzotriazole-5-carbonyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound FC(OC1=CC=C(COC(=O)N2C[C@@H]3CN(C[C@H]3C2)C(=O)C2=CC3=C(NN=N3)C=C2C(F)(F)F)C=C1)(F)F MSFMOBDXAFDSPJ-KBPBESRZSA-N 0.000 claims 1
• GCRYTDBVSAGTOZ-VDQBREKLSA-N [4-(trifluoromethoxy)phenyl]methyl (3aS,7aS)-2-(2,3,3a,4,5,6,7,7a-octahydro-1H-benzotriazole-5-carbonyl)-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridine-5-carboxylate Chemical compound C1CN(C[C@H]2[C@H]1CN(C2)C(=O)C3CCC4C(C3)NNN4)C(=O)OCC5=CC=C(C=C5)OC(F)(F)F GCRYTDBVSAGTOZ-VDQBREKLSA-N 0.000 claims 1
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