CA2874774C - Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof - Google Patents
Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof Download PDFInfo
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- CA2874774C CA2874774C CA2874774A CA2874774A CA2874774C CA 2874774 C CA2874774 C CA 2874774C CA 2874774 A CA2874774 A CA 2874774A CA 2874774 A CA2874774 A CA 2874774A CA 2874774 C CA2874774 C CA 2874774C
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- cancer
- compound
- alkyl
- pharmaceutically acceptable
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- 229950009819 zotarolimus Drugs 0.000 description 1
- 229940039925 zyprexa Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656205P | 2012-06-06 | 2012-06-06 | |
| US61/656,205 | 2012-06-06 | ||
| PCT/US2013/044444 WO2013184876A1 (en) | 2012-06-06 | 2013-06-06 | Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2874774A1 CA2874774A1 (en) | 2013-12-12 |
| CA2874774C true CA2874774C (en) | 2022-10-04 |
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| CA2874774A Active CA2874774C (en) | 2012-06-06 | 2013-06-06 | Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof |
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| EP (1) | EP2859000B1 (instruction) |
| JP (1) | JP6154004B2 (instruction) |
| KR (1) | KR20150023562A (instruction) |
| CN (1) | CN104428304B (instruction) |
| AR (1) | AR091285A1 (instruction) |
| AU (1) | AU2013271569B2 (instruction) |
| BR (1) | BR112014030165A2 (instruction) |
| CA (1) | CA2874774C (instruction) |
| EA (1) | EA026894B1 (instruction) |
| ES (1) | ES2632774T3 (instruction) |
| IL (1) | IL235844A (instruction) |
| IN (1) | IN2014DN10386A (instruction) |
| MX (1) | MX360598B (instruction) |
| NZ (1) | NZ702458A (instruction) |
| SG (1) | SG11201407900WA (instruction) |
| TW (1) | TWI602820B (instruction) |
| WO (1) | WO2013184876A1 (instruction) |
| ZA (1) | ZA201408720B (instruction) |
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| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| EP2864336B1 (en) | 2012-06-06 | 2016-11-23 | Constellation Pharmaceuticals, Inc. | Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| JP2016511247A (ja) | 2013-02-19 | 2016-04-14 | バイエル ファーマ アクチエンゲゼルシャフト | ビシクロ２，３−ベンゾジアゼピン類及びスピロ環式置換２，３−ベンゾジアゼピン類 |
| US20150376196A1 (en) | 2013-02-22 | 2015-12-31 | Bayer Pharma Aktiengesellschaft | 4-substituted pyrrolo- and pyrazolo-diazepines |
| CN105189514A (zh) | 2013-02-22 | 2015-12-23 | 拜耳医药股份有限公司 | 作为bet-蛋白抑制剂用于治疗过度增殖性疾病的吡咯并-和吡唑并-三唑并二氮杂卓 |
| ES2755827T3 (es) | 2013-03-15 | 2020-04-23 | Incyte Holdings Corp | Heterciclos tricíclicos como inhibidores de proteína BET |
| US9290514B2 (en) | 2013-07-08 | 2016-03-22 | Incyte Holdings Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| EP3125896A2 (en) * | 2014-04-04 | 2017-02-08 | Constellation Pharmaceuticals, Inc. | EXPRESSION LEVELS OF BCL-xL, BCL2, BCL-w, AND BAD AND CANCER THERAPIES |
| RS64231B1 (sr) | 2014-04-23 | 2023-06-30 | Incyte Holdings Corp | 1h-pirolo[2,3-c]piridin-7(6h)-on i pirazolo[3,4-c]piridin-7(6h)-on kao inhibitori bet proteina |
| WO2015195863A1 (en) * | 2014-06-20 | 2015-12-23 | Constellation Pharmaceuticals, Inc. | Hydrated 2-((4s)-6-(4-chlorophenyl)-1 -methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| JP6599979B2 (ja) | 2014-09-15 | 2019-10-30 | インサイト・コーポレイション | Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物 |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| AR105124A1 (es) | 2015-06-26 | 2017-09-06 | Tensha Therapeutics Inc | Tratamiento de carcinoma de la línea media nut |
| RS61803B1 (sr) * | 2015-09-09 | 2021-06-30 | Jubilant Biosys Ltd | Triciklični fuzioni piridin-2-on derivati i njihova upotreba kao inhibitora brd4 |
| TW201722966A (zh) | 2015-10-29 | 2017-07-01 | 英塞特公司 | Bet蛋白質抑制劑之非晶固體形式 |
| WO2017114843A1 (en) | 2015-12-29 | 2017-07-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Xanthine derivative inhibitors of bet proteins |
| PE20190623A1 (es) | 2016-06-20 | 2019-04-26 | Incyte Corp | Formas solidas cristalinas de un inhibidor de bet |
| WO2018133139A1 (zh) | 2017-01-21 | 2018-07-26 | 宁波知明生物科技有限公司 | 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用 |
| CA3081753A1 (en) | 2017-11-06 | 2019-05-09 | Centre National De La Recherche Scientifique | Xanthine derivatives and uses thereof as inhibitors of bromodomains of bet proteins |
| KR102026243B1 (ko) * | 2018-01-19 | 2019-09-27 | 연세대학교 산학협력단 | 백혈병 치료용 약학적 조성물 |
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| CN111518045A (zh) * | 2019-02-02 | 2020-08-11 | 博诺康源(北京)药业科技有限公司 | 一种具有苯并七元环结构的化合物、其制备方法及用途 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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| JP6154004B2 (ja) | 2017-06-28 |
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| US20150148337A1 (en) | 2015-05-28 |
| AR091285A1 (es) | 2015-01-21 |
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| EA201492216A1 (ru) | 2015-03-31 |
| IN2014DN10386A (instruction) | 2015-08-14 |
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| ES2632774T3 (es) | 2017-09-15 |
| MX360598B (es) | 2018-11-08 |
| US9493483B2 (en) | 2016-11-15 |
| WO2013184876A8 (en) | 2014-11-27 |
| US20170079984A1 (en) | 2017-03-23 |
| ZA201408720B (en) | 2018-05-30 |
| US9925197B2 (en) | 2018-03-27 |
| AU2013271569A1 (en) | 2014-12-18 |
| HK1207372A1 (en) | 2016-01-29 |
| IL235844A (en) | 2017-04-30 |
| CN104428304B (zh) | 2016-09-21 |
| TW201402580A (zh) | 2014-01-16 |
| EP2859000A1 (en) | 2015-04-15 |
| NZ702458A (en) | 2016-11-25 |
| BR112014030165A2 (pt) | 2017-06-27 |
| CA2874774A1 (en) | 2013-12-12 |
| WO2013184876A1 (en) | 2013-12-12 |
| EA026894B1 (ru) | 2017-05-31 |
| CN104428304A (zh) | 2015-03-18 |
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