AR105124A1 - Tratamiento de carcinoma de la línea media nut - Google Patents
Tratamiento de carcinoma de la línea media nutInfo
- Publication number
- AR105124A1 AR105124A1 ARP160101908A ARP160101908A AR105124A1 AR 105124 A1 AR105124 A1 AR 105124A1 AR P160101908 A ARP160101908 A AR P160101908A AR P160101908 A ARP160101908 A AR P160101908A AR 105124 A1 AR105124 A1 AR 105124A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycle
- patient
- formulas
- drug
- nut line
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
- G01N2333/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
Reivindicación 1: Un método de tratamiento de un paciente que padece carcinoma de la línea media (CLM) de la proteína nuclear de testículo (NUT), que comprende: administrar al paciente una cantidad eficaz de un inhibidor del bromodominio en un ciclo actual de un régimen de tratamiento de múltiples ciclos, incluyendo cada ciclo un segmento con fármaco y uno sin fármaco, en el que el paciente exhibe una reducción de la expresión de CD11b de menos de aproximadamente un 50% con respecto a un nivel basal y en el que la expresión de CD11b se mide durante el ciclo actual o un ciclo previo. Reivindicación 15: El método de una cualquiera de las reivindicaciones 1 - 9 ó 13, en el que el inhibidor de bromodominio es un compuesto representado por una cualquiera de las fórmulas del grupo de fórmulas (1), o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185203P | 2015-06-26 | 2015-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105124A1 true AR105124A1 (es) | 2017-09-06 |
Family
ID=56409188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101908A AR105124A1 (es) | 2015-06-26 | 2016-06-24 | Tratamiento de carcinoma de la línea media nut |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20180193350A1 (es) |
| EP (1) | EP3314005A1 (es) |
| JP (1) | JP2018520124A (es) |
| KR (1) | KR20180035785A (es) |
| CN (1) | CN107787227A (es) |
| AR (1) | AR105124A1 (es) |
| AU (1) | AU2016283020A1 (es) |
| BR (1) | BR112017028178A2 (es) |
| CA (1) | CA2989313A1 (es) |
| HK (1) | HK1252062A1 (es) |
| IL (1) | IL256186A (es) |
| MA (1) | MA42249A (es) |
| MX (1) | MX2017016337A (es) |
| WO (1) | WO2016210275A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011252799B2 (en) | 2010-05-14 | 2015-05-14 | Cold Spring Harbor Laboratory | Compositions and methods for treating leukemia |
| ES2534521T3 (es) | 2010-05-14 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Composiciones y su uso en el tratamiento de neoplasia, enfermedades inflamatorias y otras enfermedades |
| CN105849110B (zh) | 2013-11-08 | 2019-08-02 | 达纳-法伯癌症研究所有限公司 | 使用溴结构域和额外终端(bet)蛋白抑制剂的用于癌症的组合疗法 |
| MX2016011160A (es) | 2014-02-28 | 2017-04-27 | Tensha Therapeutics Inc | Tratamiento de afecciones asociadas con la hiperinsulinemia. |
| EP3212654B1 (en) | 2014-10-27 | 2020-04-08 | Tensha Therapeutics, Inc. | Bromodomain inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| WO2009084693A1 (ja) | 2007-12-28 | 2009-07-09 | Mitsubishi Tanabe Pharma Corporation | 抗癌剤 |
| GB0919431D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| CA2779423C (en) | 2009-11-05 | 2018-08-14 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| GB0919426D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| ES2652304T3 (es) | 2009-11-05 | 2018-02-01 | Glaxosmithkline Llc | Compuesto de benzodiacepina novedoso |
| JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
| ES2534521T3 (es) | 2010-05-14 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Composiciones y su uso en el tratamiento de neoplasia, enfermedades inflamatorias y otras enfermedades |
| WO2011161031A1 (en) | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| MX2016011160A (es) | 2014-02-28 | 2017-04-27 | Tensha Therapeutics Inc | Tratamiento de afecciones asociadas con la hiperinsulinemia. |
-
2016
- 2016-06-24 WO PCT/US2016/039270 patent/WO2016210275A1/en active Application Filing
- 2016-06-24 KR KR1020187000569A patent/KR20180035785A/ko unknown
- 2016-06-24 BR BR112017028178A patent/BR112017028178A2/pt not_active Application Discontinuation
- 2016-06-24 MA MA042249A patent/MA42249A/fr unknown
- 2016-06-24 CA CA2989313A patent/CA2989313A1/en not_active Abandoned
- 2016-06-24 AU AU2016283020A patent/AU2016283020A1/en not_active Abandoned
- 2016-06-24 US US15/739,905 patent/US20180193350A1/en not_active Abandoned
- 2016-06-24 MX MX2017016337A patent/MX2017016337A/es unknown
- 2016-06-24 CN CN201680036201.4A patent/CN107787227A/zh active Pending
- 2016-06-24 JP JP2017563973A patent/JP2018520124A/ja active Pending
- 2016-06-24 AR ARP160101908A patent/AR105124A1/es unknown
- 2016-06-24 EP EP16738292.8A patent/EP3314005A1/en not_active Withdrawn
-
2017
- 2017-12-07 IL IL256186A patent/IL256186A/en unknown
-
2018
- 2018-09-05 HK HK18111394.9A patent/HK1252062A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN107787227A (zh) | 2018-03-09 |
| AU2016283020A1 (en) | 2018-01-04 |
| HK1252062A1 (zh) | 2019-05-10 |
| JP2018520124A (ja) | 2018-07-26 |
| KR20180035785A (ko) | 2018-04-06 |
| IL256186A (en) | 2018-02-28 |
| BR112017028178A2 (pt) | 2018-08-28 |
| MA42249A (fr) | 2018-05-02 |
| MX2017016337A (es) | 2018-11-22 |
| EP3314005A1 (en) | 2018-05-02 |
| CA2989313A1 (en) | 2016-12-29 |
| US20180193350A1 (en) | 2018-07-12 |
| WO2016210275A1 (en) | 2016-12-29 |
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