AT350056B - Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen - Google Patents

Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen

Info

Publication number
AT350056B
AT350056B AT837275A AT837275A AT350056B AT 350056 B AT350056 B AT 350056B AT 837275 A AT837275 A AT 837275A AT 837275 A AT837275 A AT 837275A AT 350056 B AT350056 B AT 350056B
Authority
AT
Austria
Prior art keywords
diazepines
salts
optical isomers
producing new
new pyrido
Prior art date
Application number
AT837275A
Other languages
English (en)
Other versions
ATA837275A (de
Inventor
Bebenburg Walter Dr Von
Norbert Schulmeyer
Vladimir Dr Jakovlev
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Priority to AT837275A priority Critical patent/AT350056B/de
Priority claimed from AT492877A external-priority patent/AT344710B/de
Priority claimed from US05/926,327 external-priority patent/US4207322A/en
Publication of ATA837275A publication Critical patent/ATA837275A/de
Application granted granted Critical
Publication of AT350056B publication Critical patent/AT350056B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
AT837275A 1975-11-04 1975-11-04 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen AT350056B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT837275A AT350056B (de) 1975-11-04 1975-11-04 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen

Applications Claiming Priority (38)

Application Number Priority Date Filing Date Title
AT837275A AT350056B (de) 1975-11-04 1975-11-04 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen
RO7697708A RO77294A (ro) 1975-11-04 1976-06-02 Procedeu de prepararea 6-fenil-s-triazolo-(4,3-a)-pirido-(2,3-f)-1,4-diazepinelor
SU762414098A SU667137A3 (ru) 1975-11-04 1976-10-26 Способ получени производных 6-фенил- -триазоло(4,3- ) пиридо(2,3 )-1,4-диазепинов
US05/735,894 US4110455A (en) 1975-11-04 1976-10-26 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines
FR7632326A FR2330404B1 (de) 1975-11-04 1976-10-27
DE19762649116 DE2649116A1 (de) 1975-11-04 1976-10-28 Neue 6-aryl-s-triazolo-(4,3-a)- pyrido-(2,3-f)-1,4-diazepine
EG76673A EG12280A (en) 1975-11-04 1976-11-02 Process for preparing neue 6-aryl-s-triazolo-(4,3-a)pyrido-(2,3-f)-1,4-diazepine
IL50816A IL50816A (en) 1975-11-04 1976-11-02 6-aryl-s-triazolo(4,3-a)-(or tetrazolo(1,5-a)pyrido(2,3-f)-diazepines, their preparation and pharmaceutical compositions containing them
YU02691/76A YU269176A (en) 1975-11-04 1976-11-02 Process for the manufacture of new 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-4-diazepine
GB45476/76A GB1562800A (en) 1975-11-04 1976-11-02 Fused pyridodiazepines
DD7600195560A DD128178A5 (de) 1975-11-04 1976-11-02 Verfahren zur herstellung neuer 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepine
HU76DE927A HU177422B (en) 1975-11-04 1976-11-03 Process for preparing new 6-phenyl-s-triazolo/4,3-a/pyrido/2,3-f/ /1,4/-diazepines
PL1976193439A PL113803B1 (en) 1975-11-04 1976-11-03 Process for preparing novel 6-aryl-s-triazolo-/4,3-a/-pyrido-/2,3-f/-1,4-diazepines
NL7612187A NL7612187A (nl) 1975-11-04 1976-11-03 Nieuwe diazepinen met anti-convulsieve activiteit.
PL1976223070A PL118308B1 (en) 1975-11-04 1976-11-03 Process for preparing novel 6-aryl-s-triazolo/4,3-a/-pyrido/2,3-f/-1,4-diazepinesdo/2,3-ehf/-1,4-diazepinov
SE7612260A SE7612260L (sv) 1975-11-04 1976-11-03 Forfarande for framstellning av nya 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepiner.
FI763158A FI62088C (fi) 1975-11-04 1976-11-03 Foerfarande foer framstaellning av farmakodynamiskt verkande 6-fenyl-s-triazolo-(4,3-a)pyrido(2,3-f)(1,4)diazepiner och deas 5-n-oxider samt optiska isomerer och salter
BE6045743A BE847952A (fr) 1975-11-04 1976-11-03 6-ARYL-S-TRIAZOLO-(4,3-A)PYRIDO-(2,3-f)-1,4-DIAZEPINES,
PT65787A PT65787B (de) 1975-11-04 1976-11-03 Neue 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepine
CS767096A CS191181B2 (en) 1975-11-04 1976-11-03 Method of producing 6-phenyl-s-triazolo-/4,3-a/-pyrido-/2,3-f/-/1,4/diazepines
RO7688309A RO70245A (ro) 1975-11-04 1976-11-03 Procedeu de preparare a 6-fenil-s-triazolo-(4,3-a)-pirido-(2,3-f)-1,4-diazepinelor
ES452969A ES452969A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de 6-aril-s-triazolo-(4,3-a)-pirido-(2,3-f)-(1-4) diazepinas.
AR265336A AR217814A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de 6-fenil-s-triazol-(4,3-a)-pirido-(2,3-f)(c1,4)-diazepinas
ES452971A ES452971A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de g-aril-s-triazolo-(4,3-a)-pirido - (2,3,f)-(1,4)-diazepinos.
DK497076A DK142324C (de) 1975-11-04 1976-11-03
CH1386976A CH630920A5 (de) 1975-11-04 1976-11-03 Verfahren zur herstellung neuer 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepine.
MX765041U MX4284E (es) 1975-11-04 1976-11-03 Procedimiento para preparar 6-fenil-s-triazol-(4,3-a) pirido-(2,3-f)-1,4-diazepinas
NO763739A NO146470C (no) 1975-11-04 1976-11-03 Analogifremgangsmaate til fremstilling av terapeutisk aktive nye 6-fenyl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepiner
JP51132728A JPS5831351B2 (de) 1975-11-04 1976-11-04
AU19311/76A AU504228B2 (en) 1975-11-04 1976-11-04 6-aryl-s-triazolo-(4, 3-a) pyrido-(2, 3-f)-(1, 4) -diazepine
ZA766620A ZA766620B (en) 1975-11-04 1976-11-04 New 6-aryl-s-triazolo(4,3-a)-pyrido(2,3-f)-1,4-diazepines their preparations and their use
CA264,849A CA1076111A (en) 1975-11-04 1976-11-04 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines
IN2062/CAL/76A IN144289B (de) 1975-11-04 1976-11-17
AR268052A AR216915A1 (es) 1975-11-04 1977-06-14 Procedimiento para la preparacion de 1-ceto-6(2-halofenil)-8-halo-s-triazol(4,3-a)-pirido-(2,3-f)-(1,4)-diazepinas-2-sustituidas
AR268053A AR216916A1 (es) 1975-11-04 1977-06-14 Procedimiento para la elaboracion de nuevas 1-ceto-6-fenil-s-triazol-(4,3-a)-pirido-(2,3-f)o de 6-fenil-s-triazol-(4,3-a)-pirido-(2,3-f)o 1-mercapto alquil(c1-c4)-6-fenil-s-triazol-(4,3-a)-pirido-(2,3-f)o 1-alcoxi-(c1-c4)-6-fenil-s-triazol(4,3-a)-pirido-(2,3-f)-(1,4)-diazepinas y sus sales
AT492877A AT344710B (de) 1975-11-04 1977-07-08 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)- diazepinen, deren optischen isomeren und salzen
SU772532701A SU676165A3 (ru) 1975-11-04 1977-10-17 Способ получени 6-фенил- триазоло-(4,3-а)пиридо-(2,3- ) -(1,4)-диазепинов или их солей
US05/926,327 US4207322A (en) 1975-11-04 1978-07-20 6-Aryl-s-triazolo-(4,3-alpha)-pyrido-(2,3-f)-(1,4)-diazepines

Publications (2)

Publication Number Publication Date
ATA837275A ATA837275A (de) 1978-10-15
AT350056B true AT350056B (de) 1979-05-10

Family

ID=3604891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT837275A AT350056B (de) 1975-11-04 1975-11-04 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen

Country Status (30)

Country Link
US (1) US4110455A (de)
JP (1) JPS5831351B2 (de)
AR (3) AR217814A1 (de)
AT (1) AT350056B (de)
AU (1) AU504228B2 (de)
BE (1) BE847952A (de)
CA (1) CA1076111A (de)
CH (1) CH630920A5 (de)
CS (1) CS191181B2 (de)
DD (1) DD128178A5 (de)
DE (1) DE2649116A1 (de)
DK (1) DK142324C (de)
EG (1) EG12280A (de)
ES (2) ES452969A1 (de)
FI (1) FI62088C (de)
FR (1) FR2330404B1 (de)
GB (1) GB1562800A (de)
HU (1) HU177422B (de)
IL (1) IL50816A (de)
IN (1) IN144289B (de)
MX (1) MX4284E (de)
NL (1) NL7612187A (de)
NO (1) NO146470C (de)
PL (2) PL118308B1 (de)
PT (1) PT65787B (de)
RO (2) RO77294A (de)
SE (1) SE7612260L (de)
SU (2) SU667137A3 (de)
YU (1) YU269176A (de)
ZA (1) ZA766620B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1185601A (en) * 1981-02-27 1985-04-16 Walter Hunkeler Imidazodiazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
TW201201813A (en) * 2010-03-31 2012-01-16 Arqule Inc Substituted benzo-pyrido-triazolo-diazepine compounds
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (de) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendung
EP2721031B1 (de) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendungen
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
DK3157928T3 (da) 2014-06-20 2019-05-20 Constellation Pharmaceuticals Inc Krystallinske former af 2-((4s)-6-(4-chlorphenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT327917B (de) * 1973-04-12 1976-02-25 Degussa Verfahren zur herstellung von neuen 5-aryl-pyrido- (b-6,7) -1,4-diazepinen und deren salzen
US4039551A (en) * 1976-03-15 1977-08-02 The Upjohn Company 1-[(Hydroxyamino)methyl]-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
NO763739L (de) 1977-05-05
GB1562800A (en) 1980-03-19
SU676165A3 (ru) 1979-07-25
NO146470C (no) 1982-10-06
PL113803B1 (en) 1981-01-31
BE847952A (fr) 1977-05-03
US4110455A (en) 1978-08-29
PT65787B (de) 1978-05-10
SU667137A3 (ru) 1979-06-05
SE7612260L (sv) 1977-05-05
NL7612187A (nl) 1977-05-06
EG12280A (en) 1978-12-31
NO146470B (no) 1982-06-28
FI62088B (fi) 1982-07-30
FI62088C (fi) 1982-11-10
IL50816A (en) 1980-09-16
FI763158A (de) 1977-05-05
PT65787A (de) 1976-12-01
CA1076111A (en) 1980-04-22
ATA837275A (de) 1978-10-15
DE2649116A1 (de) 1977-05-18
ES452969A1 (es) 1977-11-16
AU504228B2 (en) 1979-10-04
YU269176A (en) 1983-02-28
FR2330404A1 (fr) 1977-06-03
PL118308B1 (en) 1981-09-30
JPS5831351B2 (de) 1983-07-05
DK142324C (de) 1981-03-02
RO70245A (ro) 1981-06-30
DD128178A5 (de) 1977-11-02
MX4284E (es) 1982-03-12
CS191181B2 (en) 1979-06-29
CH630920A5 (de) 1982-07-15
RO77294A (ro) 1982-09-09
AR216916A1 (es) 1980-02-15
IL50816D0 (en) 1977-01-31
DK142324B (da) 1980-10-13
ES452971A1 (es) 1978-10-16
PL193439A1 (pl) 1979-07-16
ZA766620B (en) 1977-12-28
AU1931176A (en) 1978-05-11
DK497076A (de) 1977-05-05
AR217814A1 (es) 1980-04-30
FR2330404B1 (de) 1979-07-20
JPS5259194A (en) 1977-05-16
AR216915A1 (es) 1980-02-15
IN144289B (de) 1978-04-22
HU177422B (en) 1981-10-28

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