ES452971A1 - Procedimiento para la preparacion de g-aril-s-triazolo-(4,3-a)-pirido - (2,3,f)-(1,4)-diazepinos. - Google Patents

Procedimiento para la preparacion de g-aril-s-triazolo-(4,3-a)-pirido - (2,3,f)-(1,4)-diazepinos.

Info

Publication number
ES452971A1
ES452971A1 ES452971A ES452971A ES452971A1 ES 452971 A1 ES452971 A1 ES 452971A1 ES 452971 A ES452971 A ES 452971A ES 452971 A ES452971 A ES 452971A ES 452971 A1 ES452971 A1 ES 452971A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
alcohol
diazepines
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452971A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DEUTSCHE GOLD-UND SILBER-SCHEIDEAUSTALT VORMALS R
Evonik Operations GmbH
Original Assignee
DEUTSCHE GOLD-UND SILBER-SCHEIDEAUSTALT VORMALS R
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DEUTSCHE GOLD-UND SILBER-SCHEIDEAUSTALT VORMALS R, Degussa GmbH filed Critical DEUTSCHE GOLD-UND SILBER-SCHEIDEAUSTALT VORMALS R
Publication of ES452971A1 publication Critical patent/ES452971A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de 6-aril-s-triazolo-(4,3- a)-pirido-(2,3-f)-(1,4)-diazepinas de la fórmula general I en la que R1 significa un átomo de hidrógeno, un átomo de halógeno, un grupo alcohilo con 1 a 6 átomos de carbono, un grupo hidroxi, un grupo alcoxi con 1-6 átomos de carbono, un grupo mercapto, un grupo alcohilmercapto con 1-6 átomos de carbono, un grupo alcohilsulfóxido con 1-6 átomos de carbono, un grupo alcohilsulfono con 1-6 átomos de carbono, un grupo amino, un grupo acilamino alifático con 2-6 átomos de carbono, un grupo monoalcohilamino con 1-6 átomos de carbono, o un grupo dialcohilamino con radicales alcohilo de 1-6 átomos de carbono.
ES452971A 1975-11-04 1976-11-03 Procedimiento para la preparacion de g-aril-s-triazolo-(4,3-a)-pirido - (2,3,f)-(1,4)-diazepinos. Expired ES452971A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT837275A AT350056B (de) 1975-11-04 1975-11-04 Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen

Publications (1)

Publication Number Publication Date
ES452971A1 true ES452971A1 (es) 1978-10-16

Family

ID=3604891

Family Applications (2)

Application Number Title Priority Date Filing Date
ES452971A Expired ES452971A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de g-aril-s-triazolo-(4,3-a)-pirido - (2,3,f)-(1,4)-diazepinos.
ES452969A Expired ES452969A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de 6-aril-s-triazolo-(4,3-a)-pirido-(2,3-f)-(1-4) diazepinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES452969A Expired ES452969A1 (es) 1975-11-04 1976-11-03 Procedimiento para la preparacion de 6-aril-s-triazolo-(4,3-a)-pirido-(2,3-f)-(1-4) diazepinas.

Country Status (30)

Country Link
US (1) US4110455A (es)
JP (1) JPS5831351B2 (es)
AR (3) AR217814A1 (es)
AT (1) AT350056B (es)
AU (1) AU504228B2 (es)
BE (1) BE847952A (es)
CA (1) CA1076111A (es)
CH (1) CH630920A5 (es)
CS (1) CS191181B2 (es)
DD (1) DD128178A5 (es)
DE (1) DE2649116A1 (es)
DK (1) DK142324B (es)
EG (1) EG12280A (es)
ES (2) ES452971A1 (es)
FI (1) FI62088C (es)
FR (1) FR2330404A1 (es)
GB (1) GB1562800A (es)
HU (1) HU177422B (es)
IL (1) IL50816A (es)
IN (1) IN144289B (es)
MX (1) MX4284E (es)
NL (1) NL7612187A (es)
NO (1) NO146470C (es)
PL (2) PL113803B1 (es)
PT (1) PT65787B (es)
RO (2) RO77294A (es)
SE (1) SE7612260L (es)
SU (2) SU667137A3 (es)
YU (1) YU269176A (es)
ZA (1) ZA766620B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1185601A (en) * 1981-02-27 1985-04-16 Walter Hunkeler Imidazodiazepines
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
US4798896A (en) * 1988-01-19 1989-01-17 American Home Products Corporation Antipsychotic gamma-carboline N-oxides
WO2011123678A2 (en) * 2010-03-31 2011-10-06 Arqule, Inc. Substituted benzo-pyrido-triazolo-diazepine compounds
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
ES2725928T3 (es) 2014-06-20 2019-09-30 Constellation Pharmaceuticals Inc Formas cristalinas de 2-((4S)-6-(4-clorofenil)-1-metil-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT327917B (de) * 1973-04-12 1976-02-25 Degussa Verfahren zur herstellung von neuen 5-aryl-pyrido- (b-6,7) -1,4-diazepinen und deren salzen
US4039551A (en) * 1976-03-15 1977-08-02 The Upjohn Company 1-[(Hydroxyamino)methyl]-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
ES452969A1 (es) 1977-11-16
NL7612187A (nl) 1977-05-06
SU667137A3 (ru) 1979-06-05
EG12280A (en) 1978-12-31
AR216916A1 (es) 1980-02-15
YU269176A (en) 1983-02-28
FR2330404B1 (es) 1979-07-20
NO146470B (no) 1982-06-28
AU1931176A (en) 1978-05-11
AT350056B (de) 1979-05-10
IL50816A0 (en) 1977-01-31
SE7612260L (sv) 1977-05-05
AU504228B2 (en) 1979-10-04
CS191181B2 (en) 1979-06-29
PL118308B1 (en) 1981-09-30
JPS5831351B2 (ja) 1983-07-05
DK142324B (da) 1980-10-13
PT65787A (de) 1976-12-01
AR217814A1 (es) 1980-04-30
IL50816A (en) 1980-09-16
CA1076111A (en) 1980-04-22
AR216915A1 (es) 1980-02-15
ZA766620B (en) 1977-12-28
FI763158A (es) 1977-05-05
JPS5259194A (en) 1977-05-16
CH630920A5 (de) 1982-07-15
DK497076A (es) 1977-05-05
US4110455A (en) 1978-08-29
SU676165A3 (ru) 1979-07-25
ATA837275A (de) 1978-10-15
DE2649116A1 (de) 1977-05-18
DK142324C (es) 1981-03-02
BE847952A (fr) 1977-05-03
PL193439A1 (pl) 1979-07-16
FI62088C (fi) 1982-11-10
DD128178A5 (de) 1977-11-02
HU177422B (en) 1981-10-28
RO70245A (ro) 1981-06-30
FI62088B (fi) 1982-07-30
MX4284E (es) 1982-03-12
PT65787B (de) 1978-05-10
RO77294A (ro) 1982-09-09
IN144289B (es) 1978-04-22
PL113803B1 (en) 1981-01-31
NO763739L (es) 1977-05-05
NO146470C (no) 1982-10-06
GB1562800A (en) 1980-03-19
FR2330404A1 (fr) 1977-06-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103