CA2866381C - 2'- substituted carba-nucleoside analogs for antiviral treatment - Google Patents

2'- substituted carba-nucleoside analogs for antiviral treatment Download PDF

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Publication number
CA2866381C
CA2866381C CA2866381A CA2866381A CA2866381C CA 2866381 C CA2866381 C CA 2866381C CA 2866381 A CA2866381 A CA 2866381A CA 2866381 A CA2866381 A CA 2866381A CA 2866381 C CA2866381 C CA 2866381C
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compound
pharmaceutically acceptable
acceptable salt
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formula
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CA2866381A
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English (en)
French (fr)
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CA2866381A1 (en
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Michael O'Neil Hanrahan Clarke
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Gilead Sciences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2866381A 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment Active CA2866381C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261610411P 2012-03-13 2012-03-13
US61/610,411 2012-03-13
PCT/US2013/030196 WO2013138236A1 (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment

Publications (2)

Publication Number Publication Date
CA2866381A1 CA2866381A1 (en) 2013-09-19
CA2866381C true CA2866381C (en) 2020-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2866381A Active CA2866381C (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment

Country Status (18)

Country Link
US (4) US9481704B2 (enExample)
EP (4) EP3932931B1 (enExample)
JP (3) JP6242378B2 (enExample)
KR (1) KR102068856B1 (enExample)
CN (2) CN104185638A (enExample)
AU (2) AU2013232378B2 (enExample)
CA (1) CA2866381C (enExample)
EA (2) EA201791916A1 (enExample)
ES (4) ES3005115T3 (enExample)
IL (2) IL234586A (enExample)
IN (1) IN2014DN08505A (enExample)
MD (1) MD4496C1 (enExample)
MX (1) MX355267B (enExample)
NZ (1) NZ629996A (enExample)
PL (1) PL2834258T3 (enExample)
PT (1) PT2834258T (enExample)
SI (1) SI2834258T1 (enExample)
WO (1) WO2013138236A1 (enExample)

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Also Published As

Publication number Publication date
JP2017206528A (ja) 2017-11-24
JP2019069986A (ja) 2019-05-09
US20130243725A1 (en) 2013-09-19
PT2834258T (pt) 2017-04-07
AU2013232378B2 (en) 2017-09-28
EP3932931C0 (en) 2024-11-20
WO2013138236A1 (en) 2013-09-19
HK1256856A1 (en) 2019-10-04
EP3932931A1 (en) 2022-01-05
CN106749272A (zh) 2017-05-31
AU2017279590A1 (en) 2018-01-18
AU2013232378A1 (en) 2014-09-25
SI2834258T1 (sl) 2017-04-26
EA028928B9 (ru) 2018-05-31
ES3005115T3 (en) 2025-03-13
ES2621217T3 (es) 2017-07-03
EP3351552A1 (en) 2018-07-25
EP3210993A1 (en) 2017-08-30
KR102068856B1 (ko) 2020-01-21
MX355267B (es) 2018-04-12
ES2878087T3 (es) 2021-11-18
US20170114086A1 (en) 2017-04-27
US20210253622A1 (en) 2021-08-19
US9481704B2 (en) 2016-11-01
CN106749272B (zh) 2019-08-30
EP2834258A1 (en) 2015-02-11
EA201791916A1 (ru) 2018-07-31
MD20140112A2 (ro) 2015-02-28
HK1207083A1 (en) 2016-01-22
EP2834258B1 (en) 2017-01-04
IL256397A (en) 2018-02-28
ES2709071T3 (es) 2019-04-15
PL2834258T3 (pl) 2017-07-31
JP6525441B2 (ja) 2019-06-05
EP3210993B1 (en) 2018-12-12
NZ629996A (en) 2016-10-28
KR20140135820A (ko) 2014-11-26
IL234586A (en) 2017-12-31
EP3932931B1 (en) 2024-11-20
MD4496C1 (ro) 2018-02-28
MX2014011009A (es) 2014-10-13
JP6242378B2 (ja) 2017-12-06
CN104185638A (zh) 2014-12-03
CA2866381A1 (en) 2013-09-19
US11787832B2 (en) 2023-10-17
IN2014DN08505A (enExample) 2015-05-15
EP3351552B1 (en) 2021-05-19
JP2015509983A (ja) 2015-04-02
EA028928B1 (ru) 2018-01-31
MD4496B1 (ro) 2017-07-31
US20190016749A1 (en) 2019-01-17
EA201491548A1 (ru) 2015-02-27
US10941177B2 (en) 2021-03-09

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